Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

“…In the work presented here, molecular docking suggested a suitable paratope combination targeting c-MET, but hydrophobic patches in essential binding regions of one moiety necessitated engineering. …”
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Fatal Feline Leukemia Virus-Associated Enteritis in a Wild Eurasian Lynx (<i>Lynx lynx</i>) in Germany by Katharina M. Gregor, Monica Mirolo, Florian Brandes, Sonja T. Jesse, Franziska Kaiser, Jutta Verspohl, Sybille Wölfl, Albert D. M. E. Osterhaus, Wolfgang Baumgärtner, Martin Ludlow, Andreas Beineke

“…Macroscopic and histologic examination revealed hemorrhagic-necrotizing enteritis and typhlocolitis, with the degeneration of crypts and crypt abscesses, as well as depleted Peyer’s patches. In addition, the animal showed lymphoid depletion (lymph nodes, thymus, and spleen) and hypocellularity of the bone marrow. …”
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A transcription factor ensemble orchestrates bundle sheath expression in rice by Lei Hua, Na Wang, Susan Stanley, Ruth M. Donald, Satish Kumar Eeda, Kumari Billakurthi, Ana Rita Borba, Julian M. Hibberd

“…Oligomerisation of the CRM and fusion to core promoters containing Y-patches allow activity to be increased 220-fold. This CRM generates bundle sheath-specific expression in Arabidopsis indicating deep conservation in function between monocotyledons and dicotyledons. …”
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Infrared and visible image fusion based on multi-scale transform and sparse low-rank representation by Yangkun Zou, Yangkun Zou, Jiande Wu, Jiande Wu, Bo Ye, Bo Ye, Honggui Cao, Honggui Cao, Jiqi Feng, Zijie Wan, Zijie Wan, Shaoda Yin, Shaoda Yin

“…In order to improve the computational efficiency and learn a universal dictionary, low-pass bands are separated into several image patches using a sliding window prior to sparse and low rank representation. …”
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Acquisition of Crop Spatial Patterns Based on Remote Sensing Data from Sentinel-2 Satellite by Yinan Wang, Kai Guo, Xiangbing Kong, Jintao Zhao, Buhui Chang, Chunjing Zhao, Fengying Jin

“…Utilizing the characteristic representation of the Normalized difference vegetation index (NDVI) temporal data from Sentinel-2 satellite imagery, a multi-scale segmentation of patches is conducted based on spatiotemporal fusion images. …”
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LRD-RB: The First Large-Scale Dataset With Rotated Bounding Boxes for Automated Lunar Rockfall Detection by Dingruibo Miao, Jianguo Yan, Zhigang Tu, Jean-Pierre Barriot

“…The dataset comprises 11 697 image patches containing 58 298 lunar rockfall features annotated with rotated bounding boxes. …”
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An integrated coastal exposure modelling approach to assist mangrove ecosystem based disaster risk reduction (Eco-DRR) in Tamil Nadu, India by Pankaj Singha, Rajarshi Dasgupta, Shizuka Hashimoto, Bijon Kumer Mitra

“…The model demonstrated that having the existing mangrove patches in the Pichavaram and Muthpet regions significantly reduces the exposure value from 3.47 to 2.80 and 4.78 to 2.10, respectively. …”
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Climate change threatens old-growth forests in the Northern Alps by Rupert Seidl, Dominik Thom, Sebastian Seibold, Michael Maroschek, Werner Rammer

“…Under climate change, old-growth decreased by up to 21% relative to simulations under baseline climate, with decreasing size and cohesion of old-growth patches on the landscape. Climate-mediated increases in disturbance were driving the decline in old-growth forests, with a near complete loss in old-growth beyond disturbance rates of 1.5% yr ^−1 . …”
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A species under siege: modelling habitat suitability for the bear cuscus Ailurops ursinus in South Sulawesi by Rahmia Nugraha, Siti Nurleily Marliana

“…Our model predicted only 7.5% (143,682 ha) of the total study area to be potentially suitable habitat for the bear cuscus, predominantly in scattered forest patches, some of which are in areas affected by active mining or frequent poaching. …”
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Priority areas and implementation of ecological corridor through forest restoration to safeguard biodiversity by Mayara Guimarães Beltrão, Camila Francisco Gonçalves, Pedro H. S. Brancalion, Ana Paula Carmignotto, Luis Fábio Silveira, Pedro Manoel Galetti, Mauro Galetti

“…Landscape features (e.g. size, edge density, number of patches), land use and cover, and Enhanced Vegetation Index data were obtained from remote sensing. …”
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Galectin-3 organizes histological compartments associated with inflammatory reaction induced by gliadin in BALB/c mice by PAULA C.P. SILVA, VICTOR F.S. FERREIRA, NATÁLIA G. MAÇÃO, RAFAEL M.S. LIMA, FELIPE S. LEMOS, FELIPE L. OLIVEIRA

“…In parallel, gliadin supplemented Lgals3-/- mice showed significant inflammatory signals in the mucosa, including leukocyte infiltration in mucosal sites, hyperplasia of crypts, enhance of intraepithelial lymphocytes, and hypertrophy linked to accumulation of apoptotic bodies in the Peyer’s patches. These data suggested that galectin-3 plays protective roles in the gut submitted an inflammatory stress after gluten intake.…”
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Concurrent chronic follicular conjunctivitis and conjunctival MALT lymphoma potentially caused by Chlamydia pneumoniae by Yueh-Ling Chen, Shih-Ming Jung, Ching-Hsi Hsiao

“…Examination of the conjunctiva revealed large follicles and a salmon-patched lesion over inferior fornix. Chlamydial antigen testing from conjunctival swab was positive, so the patient underwent a 3-week course of oral doxycycline (100 mg, twice daily), after which the discharge resolved, but the conjunctival mass persisted. …”
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Bilateral nevus of Ota in association with nevus flammeus: a case report by Lulwa Alogayel, Sara Alrashid, Renad AlKanaan, Raneem Alnajjar, Ghaida Almarshoud

“…The nevus of Ota manifested as well-defined blue-gray macules and patches symmetrically distributed across her face, involving both nasal nostrils and conjunctiva. …”
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Accelerating Stellar Photometric Distance Estimates with Neural Networks by Karlo Mrakovčić, Željko Ivezić, Lovro Palaversa

“…This computation is done in patches of about 10 deg ^2 due to the variation of Bayesian priors across the sky. …”
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Exploring the influence of natural features on soil mesofaunal communities in agricultural landscapes through DNA metabarcoding by Angeli Sahdra, Angeli Sahdra, Monica R. Young, Lori A. Phillips, Niloofar Alavi, David R. Lapen, Jeremy T. Kerr, Marla D. Schwarzfeld

“…Maintaining heterogeneous natural and semi-natural features appears to increase the overall diversity of mesofauna on the landscape, and even small forest patches support forest-associated soil biodiversity in this agricultural region.…”
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Responses of ground and dung beetle assemblages to extreme events: the case of the windstorm “Vaia” in the Italian Alps by R. Panza, A. Laini, A. Roggero, A. Rolando, C. Palestrini, M. Gobbi

“…Indeed, the resilience of dung beetles is due to their dependence on ephemeral resource patches, the serial colonization of which is denoted as heterotrophic succession. …”
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Mapping the invasive Spartina alterniflora in sub-meter level with improved phenological spectral features and deep learning method by Bingfeng Zhou, Meng Xu, Jinyan Tian, Yue Huang, Jie Song, Lin Zhu, Xiumin Zhu, Xinyuan Qu, Liyan Zhang, Xiaojuan Li, Huili Gong

“…Existing studies mainly rely on moderate-resolution remote sensing imagery, like Landsat and Sentinel-2, but caused by the limitations of spatial resolution, mixed pixels have led to the misclassification of small patches and boundaries. This study developed sub-meter phenological spectral features of S. alterniflora and improved the DeepLabv3+ model with a Class Feature Attention Mechanism (CFAM) to produce the first sub-meter S. alterniflora product for the Beibu Gulf of China in 2020-2021. …”
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Investigating the Genetic Association of Selected Candidate Loci with Alopecia Areata Susceptibility in Jordanian Patients by Laith N. AL-Eitan, Maryam K. Alasmar, Hanan A. Aljamal, Ahmad H. Mihyar, Mansour A. Alghamdi

“…<i>Background and Objectives</i>: Alopecia areata (AA) is a common cell-mediated autoimmune disease of the hair follicle that results in hair loss patches, affecting males and females of all ages and ethnicities. …”
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DEVELOPMENT OF OPERATING DRIVE SYSTEMS IN ENGINEERING EQUIPMENT by A. A. Kotlobai, A. Ja. Kotlobai, Yu. Sh. Yunusov, V. F. Tamelo

“…Usage of hydraulic units in drive systems being in mass production for replacement of mechanical systems manufactured earlier in small batches makes it possible to reduce labour inputs for maintenance and repair of machines. …”
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Improving process aspect of oral examination as assessment tool in undergraduate biochemistry by introducing structured oral examination: an observational study in India based on a... by Rinchu Loomba, Nandita Maini Jindal

“…Conclusion The examiners have accepted it as one of the formative assessment tools for future batches of students and are ready to explore its utility as a summative assessment tool.…”
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