Non-neutralizing monoclonal antibody targeting VP2 EF loop of Coxsackievirus A16 can protect mice from lethal attack via Fc-dependent effector mechanism by Ruixiao Du, Chaoqiang An, Xin Yao, Yiping Wang, Ge Wang, Fan Gao, Lianlian Bian, Yalin Hu, Siyuan Liu, Qiaohui Zhao, Qunying Mao, Zhenglun Liang

“…The linear epitope of DMA2017 was mapped by phage display technique to a conserved patch spanning residues 143–148 (NSHPPY) of the VP2 EF-loop of CA16. …”
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Distribution Characteristics and Source Analysis of “Three Nitrogen” in Shallow Groundwater in Hailun Area of Heilongjiang Province by Lijun LI, Qiang LIU

“…The quality control of the “three nitrogen” test in groundwater was based on the requirements of the national standard GB/T 14848—2017, the technical requirements for analytical quality control of groundwater pollution investigation (DD 2014-15), and the specification of testing quality management for geological laboratories (DZ/T 0130—2006). Each batch contained twenty samples and the test process of each batch was equipped with laboratory blank, reference materials, laboratory duplicate samples and quality control of external monitoring samples. …”
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Cestode larvae excite host neuronal circuits via glutamatergic signalling by Anja de Lange, Hayley Tomes, Joshua S Selfe, Ulrich Fabien Prodjinotho, Matthijs B Verhoog, Siddhartha Mahanty, Katherine Ann Smith, William Horsnell, Chummy Sikasunge, Clarissa Prazeres da Costa, Joseph V Raimondo

“…To address this, we used whole-cell patch-clamp electrophysiology and calcium imaging in rodent and human brain slices to identify direct effects of cestode larval products on neuronal activity. …”
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Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. by Carey E Gleason, N Maritza Dowling, Firat Kara, Taryn T James, Hector Salazar, Carola A Ferrer Simo, Sherman M Harman, JoAnn E Manson, Dustin B Hammers, Frederick N Naftolin, Lubna Pal, Virginia M Miller, Marcelle I Cedars, Rogerio A Lobo, Michael Malek-Ahmadi, Kejal Kantarci

“…<h4>Methods and findings</h4>The KEEPS-Cog (2005-2008) was an ancillary study to the KEEPS (NCT00154180), in which participants were randomized into 3 groups: oCEE (Premarin, 0.45 mg/d), tE2 (Climara, 50 μg/d) both with micronized progesterone (Prometrium, 200 mg/d for 12 d/mo) or placebo pills and patch for 48 months. KEEPS Continuation (2017-2022), an observational, longitudinal cohort study of KEEPS clinical trial, involved recontacting KEEPS participants approximately 10 years after the completion of the 4-year clinical trial to attend in-person research visits. …”
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Novel sponge formulation of mesenchymal stem cell secretome and hyaluronic acid: a safe and effective topical therapy for Psoriasis vulgaris by Estefanía Elgueta, Catalina P. Prieto, Dan Hartmann, Daniela Carrillo, Natalie Edwards, Constanza Martínez, Dan Pérez, Bárbara Casas, Luis Vergara, Fernando Valenzuela, Verónica Catalán, José Lattus, Felipe Oyarzun-Ampuero, Verónica Palma

“…To assess safety, we selected doses (based on total protein content) that were applied to three patients with atopic dermatitis (42 µg of protein, patch test, 5 days) and four healthy volunteers (210 µg, 15 days) with no observed adverse topical or systemic effects. …”
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Temperature-responsive self-contraction nanofiber/hydrogel composite dressing facilitates the healing of diabetic-infected wounds by Yakun Huang, Meilin Song, Xianchao Li, Yanran Du, Zhongfei Gao, Yu-Qing Zhao, Chengbo Li, Huanhuan Yan, Xiumei Mo, Chunhua Wang, Guige Hou, Xianrui Xie

“…Here, an asymmetric composite dressing was created by combining biaxially oriented nanofibers and hydrogel, inspired by the double-layer structure of the traditional Chinese medicinal plaster patch, for managing chronic wounds. Specifically, electrospun Poly-(lactic acid-co-trimethylene carbonate) (PLATMC) nanofibers and methacrylate gelatin (GelMa) hydrogel loaded with Epinecidin-1@chitosan (Epi-1@CS) nanoparticles are assembled as the temperature-responsive self-contracting nanofiber/hydrogel (TSNH) composite dressing. …”
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PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection by Narongrid Seesawad, Piyalitt Ittichaiwong, Thapanun Sudhawiyangkul, Phattarapong Sawangjai, Peti Thuwajit, Paisarn Boonsakan, Supasan Sripodok, Kanyakorn Veerakanjana, Komgrid Charngkaew, Ananya Pongpaibul, Napat Angkathunyakul, Narit Hnoohom, Sumeth Yuenyong, Chanitra Thuwajit, Theerawit Wilaiprasitporn

“…<italic>Background:</italic> Deep learning models for patch classification in whole-slide images (WSIs) have shown promise in assisting follicular lymphoma grading. …”
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Artificial-Intelligence-Based Automatic Analysis of Urothelial Carcinomas – Our Experience by Sabina ZURAC, Bogdan CEACHI, Luciana NICHITA, Mirela CIOPLEA, Cristian MOGODICI, Cristiana POPP, Liana STICLARU, Mihai BUSCA, Alexandra CIOROIANU, Alexandra VILAIA, Julian GERALD DCRUZ, Petronel MUSTATEA, Carmen DUMITRU, Victor CAUNI, Oana STEFAN, Irina TUDOR, Alexandra BASTIAN

“…The results on test set are: high-grade tumor (0.66 DCC/0.49 IoU), low-grade tumors (0.82 DCC/0.70 IoU), stroma (0.84 DCC/0.73 IoU), vessels (0.75 DCC/0.60 IoU) and LVI (0.77 DCC/0.62 IoU). We evaluated each patch of the test set; apparently low DCC and IoU scores are consequences of human inability in precise drawing of the classes and/or impossibility of annotation of very small vessels. …”
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Critical contributions of neuronal subtypes to pediatric drug-resistant focal dysplasia by Yujie Zhang, Lin Li, Fengjun Zhu, Xinyang Zhang, Dan Xia, Qiuling Miao, Cheng Zhong, Cheng Zhong, Shuli Liang, Dezhi Cao, Dezhi Cao, Huafang Zou, Jing Duan, Yousheng Shu, Yi Yao, Jianming Song, Songnian Hu, Jianxiang Liao, Jianxiang Liao, Qiang Zhou

“…We performed single-nucleus RNA sequencing (snRNA-seq) and patch-clamp recording of fresh brain tissue samples that were obtained from pediatric FCD patients during surgery. …”
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The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential by Aurélie Antunes, Aurélie Antunes, Aurélie Antunes, Jérôme Montnach, Kuldip Khakh, Ludivine Lopez, Baptiste Thomas, Barbara Ribeiro Oliveira-Mendes, Lucie Jaquillard, Denis Servent, Rémy Béroud, Rémy Béroud, Charles J. Cohen, Evelyne Benoit, Michel De Waard, Michel De Waard, Michel De Waard

“…We confirm the identity of previously discovered peptides active on these ion channels type (huwentoxin (HwTx)-I, HwTx-II and HwTx-IV), indicating the efficacy of the screening process by automated patch-clamp. We also identified a novel analogue of HwTx-IV that differs by the absence of amidation and the presence of an extra C-terminal Gly residue. …”
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Polysomnography validation of SANSA to detect obstructive sleep apnea by Cathy Goldstein, Hamid Ghanbari, Surina Sharma, Nancy Collop, Andrew Namen, Douglas B. Kirsch, Michael Drucker, Rami Khayat, Mark Pollock, Brennan Torstrick, Colleen Walsh, Emily Herreshoff, David S. Frankel, Ilene M. Rosen

“…SANSA TST highly correlated with PSG TST (R = 0.82, 95% CI: 0.78, 0.85) and classified sleep epochs with an accuracy of 87.2% (95% CI: 87.0, 87.5%).ConclusionThe SANSA home sleep apnea test demonstrated robust diagnostic performance for OSA detection including measurement of sleep compared to PSG. Its patch morphology and embedded ECG confer ease of use and multi-diagnostic potential in sleep medicine and cardiology for the detection of OSA and cardiac arrhythmias across diverse clinical populations.Clinical trial registration[https://www.clinicaltrials.gov/study/NCT06070389], identifier [NCT06070389]…”
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Linking landscape patterns to rainfall-runoff-sediment relationships: A case study in an agriculture, forest, and urbanization-dominated mountain watershed by Chong Wei, Xiaohua Dong, Yaoming Ma, Xingyun Huang, Jianfeng Gou, Dan Yu, Wenyi Zhao, Bob Su

“…Key contributors to RRSR variability included Shannon’s Diversity Index, the percentage of cultivated and forest land, and patch density of cultivated and constructed land. …”
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Granulomatous cheilitis after treatment of venous malformations of the upper lip: a case report and literature review by YANG Yang, ZHOU Haiwen, GE Shuyun

“…At the time of consultation, the swelling of the upper lip and perilabial skin was obvious, and there was a red patch on the right side of the upper lip, that was congested with blood. …”
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Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF by Nanxi Zheng, Shilin Luo, Xin Zhang, Ling Hu, Muzhi Huang, Mingyu Li, Colin McCaig, Yu-Qiang Ding, Bing Lang

“…Using AAV-mediated sparse labeling, electron microscopic examination, patch clamp and local field potential recording, western blot, luciferase reporter assay, chromatin immunoprecipitation, and neuropharmacological approach, we investigated the underlying mechanisms for the aberrant phenotypes presented by Ift172+/- mice. …”
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Feasibility and Surgical Effect of Annulus Sparing in Consecutive Patients with Tetralogy of Fallot: A Retrospective Cohort Study by Lizhi Lv, Jinyang Liu, Xianchao Jiang, Yang Liu, Yanjin Tian, Hong Cao, Zhimin Liu, Qiang Wang

“…This study aimed to assess the feasibility and surgical effect of AS repair versus transannular patch enlargement (TAPE) repair, especially in individuals with dysplastic pulmonary valves. …”
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Investigating the role of typhoon-induced waves and stratospheric hydration in the formation of tropopause cirrus clouds observed during the 2017 Asian monsoon by A. K. Pandit, J.-P. Vernier, J.-P. Vernier, T. D. Fairlie, K. M. Bedka, M. A. Avery, H. Gadhavi, M. Venkat Ratnam, S. Dwivedi, K. Amar Jyothi, F. G. Wienhold, H. Vömel, H. Liu, H. Liu, B. Zhang, B. Zhang, B. S. Kumar, T. Dinh, A. Jayaraman, A. Jayaraman

“…This caused a hydration patch that followed the Asian summer monsoon anticyclone to subsequently move towards Hyderabad. …”
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Characterization of feeding damage by tea mosquito bug, Helopeltis theivora Waterhouse (Hemiptera: Miridae) on Hainan Dayezhong tea cultivar by Qi Yao, Qi Yao, Qi Yao, You-Ze Lin, You-Ze Lin, You-Ze Lin, Shuang Qin, Shuang Qin, Shuang Qin, Zhu-Feng Lin, Zhu-Feng Lin, Zhu-Feng Lin, Xun-Cong Ji, Xun-Cong Ji, Xun-Cong Ji

“…Furthermore, the adjacent scattered spots would connect after 48 hours, resulting in a necrotic patch on the leaves by 72 hours. The peak feeding time for H. theivora occurred at night, specifically from 7:00 PM to 1:00 AM. …”
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Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8 by Zhong-He Zhang, Zhong-He Zhang, Zhong-He Zhang, Hector Barajas-Martinez, Hector Barajas-Martinez, Hector Barajas-Martinez, Hong-Yi Duan, Hong-Yi Duan, Hong-Yi Duan, Guo-Hua Fan, Hong Jiang, Hong Jiang, Hong Jiang, Charles Antzelevitch, Charles Antzelevitch, Hao Xia, Hao Xia, Hao Xia, Dan Hu, Dan Hu, Dan Hu

“…The present study aims to explore the functional significance of Nav1.8 expression among different cell types present in the ventricular myocardium.MethodsThe effect of the specific Nav1.8 blocker, A-803467, on action potential was recorded from epicardial, mid-myocardial (M cells) and Purkinje tissue slices isolated from the canine left ventricle using standard microelectrode techniques and on late sodium current from Purkinje cells using patch-clamp techniques.ResultsA-803467 treatment did not significantly affect maximum diastolic potential, action potential amplitude or maximum rate of rise of the action potential upstroke in epicardial cells, M cells or Purkinje fibers. …”
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A Dual-Band Multi-Linear Polarization Reconfigurable Antenna for Body-Centric Wireless Communication Systems by Dingzhao Chen, Foxiang Liu, Xuexuan Ruan, Yanhui Liu

“…The design comprises five symmetrically arranged multi-branch radiating units, each integrating an elliptical patch and curved spring branch for the Medical Implant Communication Service (MICS) band (403–405 MHz), and a pair of orthogonal strip patches for the Industrial, Scientific and Medical (ISM) <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2.45</mn></mrow></semantics></math></inline-formula> GHz band (2.40–2.48 GHz). …”
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Coupling African elephant movement and habitat modeling for landscape availability-suitability-connectivity assessment in Kruger National Park by Wenjing Xu, Richard Fayrer-Hosken, Marguerite Madden, Chenay Simms, Lan Mu, Andrea Presotto

“…However, a key limitation of these methods is the use of thresholding to define either habitat patches or links between patches. We explore how to incorporate African elephants’ (Loxodonta africana) movement data into an “Availability-Suitability-Connectivity (ASC)” framework which integrates habitat suitability modeling and graph-based network analysis, and how to implement connectivity results to inform conservation management that addresses locally intensive habitat utilization by elephants. …”
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