Drivers of the rare persistence of sea ice in the western Chukchi Sea in summer 2024 by Jiaxing Gong, Lijuan Song, Xi Zhao, Annette Rinke, Xiaoyu Wang, Yifan Wu, Bo Li, Xiao Cheng

“…During the 2024 Arctic summer, an unexpected sea ice patch (∼100 000 km ^2 ) survived in the western Chukchi Sea, an event that has not occurred in the past 20 years. …”
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OKEN: A Supervised Evolutionary Optimizable Dimensionality Reduction Framework for Whole Slide Image Classification by Soroush Oskouei, André Pedersen, Marit Valla, Vibeke Grotnes Dale, Sissel Gyrid Freim Wahl, Mats Dehli Haugum, Thomas Langø, Maria Paula Ramnefjell, Lars Andreas Akslen, Gabriel Kiss, Hanne Sorger

“…Automatic classification of Whole Slide Images (WSIs) typically involves extracting features from patches obtained from them. The aim of this study was to develop a WSI classification framework utilizing an optimizable kernel to encode features from each patch from a WSI into a desirable and adjustable latent space using an evolutionary algorithm. …”
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Landscape characteristics influencing habitat use of grassland birds in the Pampas ecoregion of Argentina by Clara Trofino-Falasco, María G. Pizzarello, María V Simoy, María F. Aranguren, Rosana E. Cepeda, Adrián S Di Giacomo, Claudia B. Marinelli, Gaston Moran, Maria C. Neyra, David G. Vera, Igor Berkunsky

“…During the breeding season, grassland patch metrics and matrix composition are driving factors in grassland bird habitat use. …”
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Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells by Paola Sabbatini, Sabrina Cipriani, Andrea Biagini, Luana Sallicandro, Cataldo Arcuri, Rita Romani, Paolo Prontera, Alessandra Mirarchi, Rosaria Gentile, Diletta Del Bianco, Elko Gliozheni, Sandro Gerli, Irene Giardina, Maurizio Arduini, Alessandro Favilli, Antonio Malvasi, Andrea Tinelli, Bernard Fioretti

“…In this work, we performed an electrophysiological characterization to ascertain the propensity of AF-SCs to differentiate into glial and neuronal cells by bFGF. By using patch clamp technique we characterized a fibroblast-like morphology that display a barium-sensitive inward-rectifying potassium current (Kir) and calcium-activated potassium currents (KCa). …”
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Cryo-EM structure of an activated GPR4–Gs signaling complex by Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song

“…Furthermore, we reveal a cluster of aromatic residues within the orthosteric pocket that may propagate the signaling to the intercellular region via repacking the aromatic patch at the central region. This study provides a framework for future signaling and functional investigation of psGPCRs.…”
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PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer by Laura Conforti, Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper

“…The ion channel activity of CD8+ T cells was measured by patch-clamp electrophysiology; single-cell Ca2+ fluxing abilities were measured by live microscopy. …”
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Accuracy of Rhythm Diagnostic Systems’ MultiSense^® in Detection of Arterial Oxygen Saturation and Respiratory Rate During Hypoxia in Humans: Effects of Skin Color and De... by Charles Evrard, Amina El Attaoui, Cristina Pistea, Irina Enache, Mark Marriott, Louis Mayaud, Anne Charloux, Bernard Geny

“…The average root mean square error (ARMS) of SpO₂ for Multisense^® placed on the back and chest was 2.94% and 2.98%, respectively, with permutation testing confirming a significant ARMS below 3.5% for both positions and no statistically significant difference in the ARMS between patch placements. Positive correlations and acceptable accuracy between devices were observed at both locations (r = 0.92, <i>p</i> < 0.001 and r = 0.90, <i>p</i> < 0.001 for back and chest placements, respectively). …”
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The impact of tricuspid regurgitation on timing pulmonary valve replacement in ACHD patients after tetralogy of Fallot repair by Gianluca Brancaccio, Veronica Bordonaro, Matteo Trezzi, Marcello Chinali, Delia Fugallo, Carolina D'Anna, Veronica Lisignoli, Marin Verrengia, Fabio Miraldi, Gianfranco Butera, Roberta Iacobelli, Benedetta Leonardi, Claudia Montanaro, Aurelio Secinaro, Lorenzo Galletti

“…Clinical, imaging and surgical data of adults with repaired TOF with a transannular patch repair were collected from our database. Results: 149 patients (61 % male, mean age of 26.0 years) were selected. …”
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Muriqui House: conservation management to support the recovery of the northern muriqui Brachyteles hypoxanthus in Ibitipoca, Minas Gerais, Brazil by Fabiano R. de Melo, Fernanda P. Tabacow, Priscila Maria Pereira, Marcello S. Nery, Leandro S. Moreira, Érika Procópio Tostes Teixeira, Danilo Simonini-Teixeira, Mônica Valença-Montenegro, Karen B. Strier, Leandro Jerusalinsky

“…We thus initiated a second and ongoing ex situ management project that involved constructing a complex consisting of a large, open-air enclosure abutting a small patch of forest surrounded by an open area in the process of restoration, all of which is protected by electric fencing. …”
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Targeted reproductive management for lactating Holstein cows: Economic return by Ricardo C. Chebel, Tomas Gonzalez, Ana B. Montevecchio, Klibs N. Galvão, Albert de Vries, Rafael S. Bisinotto

“…Control cows were re-inseminated based on visual or patch-aided detection of estrus, whereas TRM cows were re-inseminated as described for control cows with the aid of the AMD. …”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Results Western blot on VICs revealed TRPM4 protein expression and channel functionality was confirmed by patch‐clamp recordings exhibiting a cationic current sensitive to voltage and internal Ca2+. …”
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Systemic hormonal contraception and risk of venous thromboembolism by Oskari Heikinheimo, Elena Toffol, Timo Partonen, Anna But, Antti Latvala, Jari Haukka

“…Compared with non‐use, starting the use of gestodene and ethinylestradiol (adjusted odds ratio [aOR] 2.85; 95% CI 1.62–5.03), drospirenone and ethinylestradiol (aOR 1.55; 95% CI 0.98–2.44), desogestrel and ethinylestradiol (aOR 1.97; 95% CI 0.99–3.92), and transdermal patch releasing norelgestromin and ethinylestradiol (aOR 5.10; 95% CI 1.12–23.16), as well as continuing the use of gestodene and ethinylestradiol (aOR 2.60; 95% CI 1.61–4.21), drospirenone and ethinylestradiol (aOR 1.55; 95% CI 1.02–2.37), cyproterone‐acetate and estrogen/ethinylestradiol (aOR 1.66; 95% CI 1.06–2.61), and vaginal ring releasing etonogestrel and ethinylestradiol (aOR 3.27; 95% CI 1.95–5.48) were associated with venous thromboembolism risk. …”
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SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications by Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue

“…Variant functions were classified as LOF, GOF, or mixed, based on existing patch‐clamp data, paralog sodium channel experimental findings, and in silico prediction tools. …”
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The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition by Julie Auwercx, Bernadette Neve, Alison Vanlaeys, Mathilde Fourgeaud, Ingrid Bourrin-Reynard, Mouloud Souidi, Sylvie Brassart-Pasco, Frédéric Hague, Stéphanie Guenin, Belinda Duchene, Laurent Gutierrez, Olivier Destaing, Isabelle Dhennin-Duthille, Isabelle Van Seuningen, Nicolas Jonckheere, Mathieu Gautier

“…The effect of kinase domain deletion on channel function was studied by patch-clamp and Mn2+-quenching. The cell phenotype was studied by MTT and cell migration/invasion assays. …”
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Promoter demethylation of cerebellin 2 by ten-eleven translocation 3 contributes to peripheral sensitization in trigeminal neuropathic pain of mice by Xin-Ying Guan, Bao-Tong Yuan, Meng-Na Li, Tian Wang, Lin-Peng Zhu, Si-Yuan Song, Lu-Lu Ji, Yong-Jing Gao, Ling-Jie Ma

“…Neuronal excitability was assessed through whole-cell patch-clamp recordings. Results Integration of cross-species single-nucleus RNA sequencing (snRNA-seq) datasets identified dominant CBLN2 expression in Aδ, Aβ and c-fiber low-threshold mechanoreceptors (LTMRs), with significant upregulation observed in a murine model of inflammatory migraine. …”
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Functional Verification of Extended Kalman Filter on FPGA for Railway Wheelset Parameters Estimation by Khakoo Mal, Tayab Din Memon, Imtiaz Hussain Kalwar, Allah Rakhio Junejo, Majid Hussain Memon, Tarique Rafique Memon, Sufyan Ali Memon, Bhawani Shankar Chowdhry

“…The forces generated at the wheel-rail contact patch are important and crucial to the railway vehicle&#x2019;s operation because they control the dynamic behavior of the entire rolling stock. …”
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Enhanced Optogenetic Stimulation of Retinal Ganglion Cells With Assistive Electric Stimulation for Low Optical Power Artificial Vision by Hyeonhee Roh, Joonghoon Kang, Hyung-Min Lee, Maesoon Im

“…After <inline-formula> <tex-math notation="LaTeX">$\gt {4}\,{}$ </tex-math></inline-formula> weeks, spiking activities of retinal ganglion cells of ex-vivo retinas were recorded using a cell-attached patch clamping in response to hybrid stimulation: 3 light intensities (i.e., Levels 1, 2, and 3) for optogenetic stimulation and 3 types of assistive electric pulses (i.e., &#x2212;5 and <inline-formula> <tex-math notation="LaTeX">$-\,{10}\,{\mu }$ </tex-math></inline-formula>A square pulses, and <inline-formula> <tex-math notation="LaTeX">$-\,{20}\,{\mu }$ </tex-math></inline-formula>A increasing ramping current) were tested. …”
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Cross-survey Image Transformation: Enhancing SDSS and DECaLS Images to Near-HSC Quality for Advanced Astronomical Analysis by Zhijian Luo, Shaohua Zhang, Jianzhen Chen, Zhu Chen, Liping Fu, Hubing Xiao, Wei Du, Chenggang Shu

“…We systematically assessed the similarity between the model-generated pseudo-HSC images and actual HSC images using various metrics, including root mean squared error, peak signal-to-noise ratio, and structural similarity index, along with perceptual metrics such as learned perceptual image patch similarity and Fréchet inception distance. …”
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Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes by Luca Di Nunno, Luca Di Nunno, Veronica Pagani, Elena Canciani, Gerardina Ruocco, Gerardina Ruocco, Mattia Spedicati, Mattia Spedicati, Maria Talmon, Luca Fusaro, Dalila Di Francesco, Dalila Di Francesco, Simona Casarella, Manuela Rizzi, Francesca Boccafoschi, Francesca Boccafoschi

“…Different patch formulations to support blood clotting are characterized in the present study.MethodsThe approach used is based on electrospun decellularized bovine pericardium (dECM) blended or layered with polyvinyl alcohol (PVA) and crosslinked by (3‐Glycidyloxypropyl)trimethoxysilane (GPTMS). …”
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Deep learning-driven macroscopic AI segmentation model for brain tumor detection via digital pathology: Foundations for terahertz imaging-based AI diagnostics by Myeong Suk Yim, Yun Heung Kim, Hyeon Sang Bark, Seung Jae Oh, Inhee Maeng, Jin-Kyoung Shim, Jong Hee Chang, Seok-Gu Kang, Byeong Cheol Yoo, Jae Gwang Kwon, Jungsup Byun, Woon-Ha Yeo, Seung-Hwan Jung, Han-Cheol Ryu, Se Hoon Kim, Hyun Ju Choi, Young Bin Ji

“…By employing the Image Crop with Mask technique and patch generation method, we not only maintained an appropriate data class balance but also overcame the challenge of limited computing resources. …”
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