Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction by Tianyue Xu, Yu Xiang, Zichao Huang, Qi Zhu, Honghui Wu, Jieyu Cai, Linglin Weng, Hongshan Ge

“…Although the exact connection between hyperandrogenism and inflammation in PCOS remains unclear, the Hippo pathway, also seems to be involved in the inflammatory response through YAP. …”
Get full text

Quantitative multiorgan proteomics of fatal COVID‐19 uncovers tissue‐specific effects beyond inflammation by Lisa Schweizer, Tina Schaller, Maximilian Zwiebel, Özge Karayel, Johannes Bruno Müller‐Reif, Wen‐Feng Zeng, Sebastian Dintner, Thierry M Nordmann, Klaus Hirschbühl, Bruno Märkl, Rainer Claus, Matthias Mann

“…Beyond systemic inflammation, we differentiated between systemic and true tissue‐specific effects to reflect distinct COVID‐19‐associated damage patterns. …”
Get full text

From sting to STING: role of inflammation in wasp sting induced AKI - a narrative review by Liang Xu, Zilin Zhou, Ying Lv, Ling Li, Hai Yuan, Yaping Sun, Fengqi Hu

“…Basic studies have confirmed that inflammation plays a crucial role in such injuries. Importantly, mitochondrial DNA release and the cyclic GMP-AMP synthase-stimulator of interferon genes (STING) signaling axis have been identified as key regulators of the inflammatory response in wasp sting-induced AKI. …”
Get full text

Genetic mechanisms of disorders in the metabolism of polyunsaturated fatty acids in the development of chronic inflammation in bronchial asthma by O. Yu. Kytikova, T. P. Novgorodtseva, T. T. Bogomaz

“…This raises the question of the need to study the genetic component in the formation of the body’s response to the development of systemic inflammation in asthma and methods of its correction through nutritional PUFAs. …”
Get full text

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation by Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin

“…Intriguingly, X‐ray and γ‐ray radiation consistently induce prominent sterile inflammation responses, especially type I interferon response, in the BBB MPS. …”
Get full text

Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model by Xu Li, Zizhuo Li, Mindan Tang, Kaoyuan Zhang, Kaoyuan Zhang, Kaoyuan Zhang, Ting Yang, Weilong Zhong, Bo Yu, Bo Yu, Bo Yu, Fang Wang, Xia Dou, Xia Dou, Xia Dou

“…Basophil depletion attenuated the eosinophilic lung inflammation. TSLP levels increased with topical MC903, and TSLPR knockout reduced lung inflammation, suggesting TSLP is involved in basophil activation.ConclusionBasophils play a crucial role in OVA-induced lung inflammation in the context of AD-like skin lesions, and TSLP appears to drive basophil activation. …”
Get full text

Evaluation of the state of small intestinal microbiota, pro- and anti-inflammatory cytokines, short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease in... by Yu.M. Stepanov, V.I. Didenko, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko, R.M. Kyslova

Get full text

Investigating the role of information technology system integration, user acceptance and information technology satisfaction and security on efficiency and accuracy of immigration... by Wilonotomo Wilonotomo, Mochamad Ryanindityo, Koesmoyo Ponco Aji, Anindito Rizki Wiraputra, Sri Kuncoro Bawono, Intan Nurkumalawati, Trisapto Wahyudi Agung Nugroho, Budy Mulyawan

“…One manifestation of this transformation is the implementation of Information Systems (IS) for public services, to provide services that are more efficient, transparent, and responsive. …”
Get full text

Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation by Himadri B. Thapa, Christina A. Passegger, Dominik Fleischhacker, Paul Kohl, Yi-Chi Chen, Ratchara Kalawong, Carmen Tam-Amersdorfer, Michael R. Gerstorfer, Jana Strahlhofer, Kristina Schild-Prüfert, Ellen L. Zechner, Andreas Blesl, Lukas Binder, Georg A. Busslinger, Leo Eberl, Gregor Gorkiewicz, Herbert Strobl, Christoph Högenauer, Stefan Schild

“…Further studies show that IgA-coated BEVs, but not host-derived vesicles nor soluble IgA, are potent activators of pro-inflammatory responses in CD89+ cells. IgA-coated BEVs also exacerbate intestinal inflammation in a dextran sodium sulfate colitis model using transgenic mice expressing human CD89. …”
Get full text

Multipotent mesenchymal stem cells in renal transplantation by N. V. Borovkova, M. Sh. Khubutiya, O. N. Rzhevskaya, A. V. Pinchuk, D. A. Vasil’chenkov

Subjects: Get full text

Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation by Masahiro Ikeda, Shinpei Yamaguchi, Shigeki Takaoka, Yasuko Sakaguchi, Shunki Yasui

Get full text

Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia by Madison N. Myers, Miguel Chirivi, Jose M. dos Santos Neto, Jair Parales-Girón, Lynn C. Worden, Adam L. Lock, G. Andres Contreras

“…However, the dynamics of OXL production during systemic inflammation remain poorly defined, particularly in large animals.MethodsTo investigate OXL responses to endotoxemia, mature Holstein cows were administered intravenous infusions of either LPS or sterile saline (SAL). …”
Get full text

Cannabidiol Mitigates Deoxynivalenol-Induced Intestinal Toxicity by Regulating Inflammation, Oxidative Stress, and Barrier Integrity by Lingchen Yang, Tristan Decas, Yuhang Zhang, Imourana Alassane-Kpembi

“…Conversely, in proliferating cells, CBD exacerbated apoptosis (elevated <i>Bax</i>/<i>Bcl-2</i> ratio) and inflammatory responses (upregulated <i>IL-6</i> and <i>COX-2</i>) at subtoxic levels of DON (2 μM). …”
Get full text

Assessment of Retrieval and Generative Chatbots in Tourism Information Service by Sharfina Febbi Handayani, Dairoh Dairoh, Dwi Intan Af'idah

“…Chatbots are essential for improving the customer experience on tourism websites, especially when it comes to arranging travel and offering precise information. The purpose of this study is to evaluate the effectiveness of generative and retrieval-based chatbots in the tourism information service. …”
Get full text

Projection of ENSO using observation-informed deep learning by Yuchao Zhu, Rong-Hua Zhang, Fan Wang, Wenju Cai, Delei Li, Shoude Guan, Yuanlong Li

“…Here, we show that deep learning informed by the observed response of ENSO SST variability to tropical Pacific warming patterns reduces projection uncertainty by 54% under a high-emission scenario. …”
Get full text

Atypical automatic processing of interoceptive information in adolescents with alexithymia by Lorenz Rapp, Sandra A. Mai-Lippold, Eleana Georgiou, Olga Pollatos

Get full text

Regulatory t cells in immune response to infection by G. F. Zheleznikova

“…The revue includes the contemporary information about regulatory T cells (Treg), that regulate the inflammatory responses and adaptive immune response in defense against infection. …”
Get full text

Responsible Boating Protects Coral Reefs by Ana Zangroniz, Savanna C. Barry, Joy Hazell

Get full text

Information literacy as part of an interdisciplinary approach to combat misinformation by Laura Saunders

“…As professionals who support information access and evaluation across fields and have long-championed information literacy, librarians could be well-situated to facilitate collaborative responses. …”
Get full text

Informality and migrant entrepreneurs in Cape Town’s inner city by Rogerson Christian M.

“…Policy responses by governments towards the informal economy impact the livelihoods of informal entrepreneurs. …”
Get full text