Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain by Xin He, Owen Dando, Jing Qiu

“…Surprisingly, after systemic inflammation, microglia, and astrocytes lacking Nrf2 showed reduced inflammatory responses, unlike endothelial cells. …”
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High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα by Yu Zhang, Beixi Shi, Yaxin Bi, Xiaxin Wu, Xiangning Li, Jinfeng Wu, Jiahui Qiu, Zhijie Lin, Guotao Lu, Weijuan Gong

“…However, the specific role and underlying mechanisms of different doses of IL-37 in macrophage inflammatory response in T2DM remain to be discovered. …”
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Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis by Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang

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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

Subjects: “…inflammatory bowel disease…”
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Risk Factors for Postoperative Neurologic Dysfunction in Patients with Spinal Tuberculosis: A Retrospective Study by Shao P, Wang Y, Dong M, Fan H, Gao Y, Gao Y, Hao Z, Lv J, Bai J, Wu Z, Feng Y

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Prognostic model integrating histology, systemic inflammation, and recurrence status predicts immunotherapy response in advanced non-small-cell lung cancer patients by F. V. Moiseenko, M. A. Krasavina, I. R. Agranov, E. V. Artemieva, A. P. Oganesian, A. S. Gabina, M. L. Makarkina, E. O. Elsakova, V. A. Henshtein, N. M. Volkov, V. V. Egorenkov, V. M. Moiseenko, M. Yu. Fedyanin, G. S. Kopeina, B. Zhivotovsky, A. V. Zamaraev

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Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models by Linyu Zhu, Menger Guo, Ling Wang, Shaomin Chen, Zhiyu Ye, Yuansheng Wu

“…Keratinocyte hyperproliferation and excessive inflammatory responses are associated with psoriasis pathogenesis. …”
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EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV by Jeffrey Koury, Hina Singh, Samantha N. Sutley-Koury, Dominic Fok, Xinru Qiu, Ricky Maung, Benjamin B. Gelman, Iryna M. Ethell, Marcus Kaul

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The role of inflammation in myopic retinopathy by Tianxiang Yang, Jinyan Qi, Jinyan Qi, Heping Xu, Heping Xu, Heping Xu

“…The inflammatory response involves signaling pathways such as JAK-STAT and complement cascades. …”
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Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections by José De Jesus Bravo-Silva, Ricardo Jimenez-Camacho, Magda Lizbeth Benítez-Vega, Jonathan Hernández-Castillo, Carlos Daniel Cordero-Rivera, Carlos Noe Farfan-Morales, Marcos Pérez-García, Raymundo Cruz, Rosa María del Ángel

“…Microglial activation and polarization were also analyzed in brain tissues.ResultsMelatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. In AG129 mice, melatonin increased survival, attenuated clinical signs during DENV-4 infection, and reduced viral genome copies of both viruses. …”
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Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury by Eric Cortada, Jun Yao, Yu Xia, Friederike Dündar, Paul Zumbo, Boris Yang, Alfonso Rubio-Navarro, Björn Perder, Miaoyan Qiu, Anthony M. Pettinato, Edwin A. Homan, Lisa Stoll, Doron Betel, Jingli Cao, James C. Lo

“…Abstract The immune system coordinates the response to cardiac injury and controls regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade inflammation associated with heart failure. …”
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Redox-sensitive system of the antioxidant-responsive element as a new target for tuberculosis treatment by P. M. Kozhin, N. K. Zenkov, A. V. Chechushkov, N. S. Zaytseva, N. V. Kandalintseva, E. B. Menshchikova

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ALKBH5 suppresses miR-29a-3p expression, thereby exacerbating the inflammatory response associated with spinal tuberculosis by Mengqi Zhu, Zhengyong Tao, XingYu Duan, Lijun Feng, Xiaojun Ma, Jiong Wang, ZhiYun Shi, Xu Zhang, NingKui Niu

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Pannexin channels in inflammation and tumorigenesis by Mengmeng Jiang, Mengmeng Jiang, Xiaojia Li, Xiaojia Li, Keping Xie, Keping Xie

“…These signaling molecules can activate receptors either on their cells of origin or neighboring cells, triggering downstream signaling cascades that mediate various physiological responses. Current pharmacological inhibitors of Panx channels include Food and Drug Administration (FDA)-approved drugs such as Carbenoxolone (CBX), Probenecid (PBN), and Spironolactone, along with chemically synthetic compounds 10Panx. …”
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Cross-sectional analysis of blood leukocyte responsiveness to interleukin-10 and interleukin-6 across age and physical activity level by Islam Hashim, Boultbee Jordan, Jackson Garett S., Mui Alice L., Little Jonathan P.

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Serum LACC1 level is a predictor of response to upadacitinib treatment in patients with rheumatoid arthritis: a prospective observational cohort study by Zhou Yang, YuWei Zhan, ShuDian Lin

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Time Course of Changes in LipopolysaccharideBinding Protein and Lactate in the Blood of Patients with Polytrauma by I. M. Ustyantseva, O. I. Khokhlova, O. V. Petukhova, Yu. A. Zhevlakova

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DYNAMICS OF SURFACE EXPRESSION OF TRIGGER RECEPTOR, EXPRESSED BY MYELOID CELLS-1 (TREM-1) ON VARIOUS SUBPOPULATIONS OF MONOCYTES IN EARLY POSTOPERATIVE PERIOD OF DIRECT REVASCULARI... by V. G. Matveyeva, A. S. Golovkin, M. N. Chernova, D. L. Shukevich, E. V. Grigoryev

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Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis by E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova

“…Evaluation of the expression of B7 (CD80/86) and HLA-DR membrane molecules on macrophages in TB patients allows to conclude that anti-TB immune response is impaired at stages of antigen presentation (in all examined patients with TB) and co-stimulation (in DTB and DS TB). …”
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Bark Extracts of <i>Chamaecyparis obtusa</i> (Siebold & Zucc.) Endl. Attenuate LPS-Induced Inflammatory Responses in RAW264.7 Macrophages by Bo-Ae Kim, Ji-A Byeon, Young-Ah Jang, Yong-Jin Kwon

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