Loss of CFHR5 function reduces the risk for age-related macular degeneration by Mary Pat Reeve, Stephanie Loomis, Eija Nissilä, Thomas W. Soare, Tobias Rausch, Zhili Zheng, Pietro DELLA BRIOTTA PAROLO, Daniel Ben-Isvy, Elias Aho, Emilia Cesetti, Yoko Okunuki, Helen McLaughlin, Johanna Mäkelä, FinnGen, Mitja Kurki, Michael E. Talkowski, Jan O. Korbel, Kip Connor, Seppo Meri, Mark J. Daly, Heiko Runz

“…We demonstrate through a FinnGen sample recall study that CFHR5 variant carriers exhibit dose-dependent reductions in serum levels of the CFHR5 gene product FHR-5 and two functionally related proteins at the locus. Genetic reduction in FHR-5 correlates with higher complement activation capacity and a thicker retinal photoreceptor layer. …”
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The influence of drying methods on the physicochemical, functional, and antioxidant properties of passion fruit peel by LIU Zhaohan, YANG Tongxiang, XU Hanshan, LI Xuejing, CHEN Junliang, REN Guangyue, DUAN Xu

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Establishment of an Acute Karoshi Rat Model and Its Metabolic， Functional and Morphological Changes by LIU Xia, LI Jia-min, ZHENG Yong-xia, XIAO Xu-dong, YU Xiao-jun

“…Their daily activities, diets, weight, respiratory functions, electrocardiogram and echocardiography were recorded. …”
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Lead (Pb) Exposure on Hemoglobin Levels and Decreasing Lung Function of Fuel Station Workers Banjarmasin by Muhamad Taufiqurrahman, Isa Ansori, Meitria Syahadatina Noor, Haryati Haryati, Ali Assagaf, Mohamad Isa

“…Urinary Pb measurement was carried out by spectrophotometry, then the relationship to peripheral blood hemoglobin (Hb) levels and lung function was analyzed based on FEV1 (%), FVC (%), and FEV1/FVC ratio with a simple linear regression test. …”
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Study on Point Spread Function of Perovskite Fast Neutron Scintillation Imaging Screen by FENG Zhelin1, LIU Linyue2, , SONG Yan2, DUAN Baojun2, BAO Zizhen3, OUYANG Xiaoping2

“…The point spread function can be used for theoretical simulation of the scintillator imaging capability. …”

Exploring the rumen microbial function in Angus bulls with divergent residual feed intake by Taylor Sidney, Emily Treon, Godstime Taiwo, Eugene Felton, Peixin Fan, Ibukun M. Ogunade

“…This study leverages Shotgun metagenomics to assess the rumen microbial community and functionality in Angus bulls with differing residual feed intake-expected progeny difference (RFI-EPD) values, aiming to elucidate the microbial contributions to feed efficiency. …”
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The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis by Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen

“…We have recently shown that preserving H3K27 and H3K4 methylation using the lysine demethylase inhibitor GSK-J4 reduces cytokine-induced destruction of beta-cells and improves beta-cell function. Here, we investigate the therapeutic potential of GSK-J4 to prevent diabetes development and examine the importance of H3K4 methylation for islet function. …”
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Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack by Philip M. Bath, Jane May, Katie Flaherty, Lisa J. Woodhouse, Natalia Dovlatova, Sue C. Fox, Timothy J. England, Kailash Krishnan, Thompson G. Robinson, Nikola Sprigg, Stan Heptinstall, TARDIS Investigators

“…Aspirin and clopidogrel suppress stimulated platelet P-selectin, although one-quarter of patients on clopidogrel have high on-treatment platelet reactivity. Platelet function testing may be performed remotely in the context of a large multicentre trial. …”
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Expression of MTA1 in preeclamptic placental tissue and its effects on trophoblast function by GENG Yao, ZHANG Yang, ZHAO Jie, LI Wei, CAI Guoqing

“…Objective·To investigate the expression of metastasis-associated protein 1 (MTA1) in placental tissues of preeclampsia (PE) patients and its impact on trophoblast cell function.Methods·Placental specimens were collected from pregnant women with PE (PE group, 20 cases) patients and healthy pregnant women as controls (control group, 35 cases). …”
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Function Follows Form: Assessing the Functionality of Shells and Greenstone Shell Effigies as Formative Period Mesoamerican Textile Fabrication Tools, Part 1: Tagelus plebeius Atla... by Billie J. A. Follensbee

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Base editors in zebrafish: a new era for functional genomics and disease modeling by Yuwen Liu, Chao Li, Yiren Qiu, Sihong Chen, Yijun Luo, Donghua Xiong, Jun Zhao, Jianmin Ye, Xuegeng Wang, Wei Qin, Fang Liang

“…As a powerful and efficient gene-editing tool, base editors (BEs) have been widely applied in various model organisms, including zebrafish (Danio rerio), to facilitate functional genomic studies and disease modeling. Zebrafish, with its genetic similarity to humans and rapid development, provides an excellent platform for testing and optimizing emerging base editing technologies. …”
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Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice by Jonathan E. Layne, Dustin M. Snapper, Dustin M. Snapper, Molly E. Czachor, Charles Lam, Jacob D. Matityahu, Dane R. G. Lind, Matthieu Huard, Johnny Huard, Kazuhito Morioka, Julian C. Motzkin, Julian C. Motzkin, Allan I. Basbaum, Jarret A. P. Weinrich, Jarret A. P. Weinrich, Chelsea S. Bahney, Chelsea S. Bahney

“…This unified approach confirmed increased severity in unstabilized fractures and identified clear functional recovery windows for both fracture groups.DiscussionThis methodology forms a foundation for future mechanistic experiments focused on biological and mechanical variables influencing functional healing and enables more rapid testing of strategies to accelerate bone healing.…”
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The discrepant effect of blood glucose on the risk of early and late lung injury: a national cohort study by Lu Wang, Yicheng Zhou, Xiaojuan Jiao, Qin Zhang, Kun Feng, Yunfeng Shen

“…Results The study involved the examination of respiratory symptoms, pulmonary function tests, and mortality analyses encompassing 3714, 3916, and 173 subjects, respectively. …”
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A Mini Review on the Effects of Experimental Design, Including Variations in Participant Baseline Performance, When Testing the Efficacy of Polyphenol Consumption to Enhance Mood and Cognitive Function in Humans from a New Researcher Perspective by Duaa Altuwairki, Kirsten Brandt

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Differences in cognitive deficits and brain functional impairments between patients with first-episode and recurrent depression by Lianzi Guan, Yifei Li, Hui Kong, Jie Fang, Jiakuai Yu, Ting Wang, Jiajia Zhu, Daomin Zhu

“…Two-sample t-tests were used to compare cognitive functioning, ERP parameters, and brain functional indices between FED and RMD groups. …”
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Comparative Analysis of the Health Status of Heart Transplant Patients with Different Levels of Physical Activity by Itziar Salas-Reguera, José I. Rodríguez-Barbosa, Peter A. Federolf, Luis Santos

“…Fifty-four HTRs and eighteen sedentary individuals (S) were assigned to four groups, according to their level of physical activity (determined with the International Physical Activity Questionnaire); patients with a low, moderate, and high level of physical activity (HTRL, HTRM, and HTRH, respectively) and S participants underwent a basic blood analysis and several tests to assess their cardiovascular, neuromuscular, and functional mobility condition and their quality of life. …”
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Effect of a physical exercise program on depression in elderlies living in nursing homes by Henrique Teixeira Pinto, Luís Azevedo, Catarina Martins, Sofia Martins, Inês Oliveira, Jorge Soares, Catarina Abrantes, Graça Pinto, Maria Paula Mota

“…Three adverse events occurred during the exercise program implementation, though they did not occur during the exercise sessions. Regarding functional tests, it was observed an average handgrip strength of HGright: 12.7±6.4; HGleft: 11.7±6.5 kg; and SPPB test of 4.9±3.9. …”
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Weibull Statistics and ANOVA Analysis of the Tensile Mechanical Characteristics of Chamaerops humilis Cellulose Fibers and Sustainable Twisted Yarns by Soumia Atoui, Ahmed Belaadi, Messaouda Boumaaza, Ibrahim M. H. Alshaikh, Djamel Ghernaout

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Contact potential difference of alloy steel after heat treatment by L. P. Aref`eva, A. G. Sukiyazov, Yu. V. Dolgachev, L. S. Shakhova

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Unravelling the interplay: brain regional atrophy and neuropsychological function in early Alzheimer’s disease by Doyun Heo, Min-Seong Kim, Yun-Jin Lee, Seon-Kyeong Kim, Yong Sung Kim, Wonjae Sung, Hee-Jin Kim

“…The results of cognitive function tests reflect structural changes in the brain in AD. …”
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