Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy by Hui Tang, Lilach O Lerman, Xiaohui Bian, Tomás P Griffin, Xiangyang Zhu, Md Nahidul Islam, Sabena M Conley, Alfonso Eirin, Paula M O’Shea, Allyson K Palmer, Sandra M Herrmann, Ramila A Mehta, John R Woollard, Andrew D Rule, James L Kirkland, Tamar Tchkonia, Stephen C Textor, Matthew D Griffin, LaTonya J Hickson

“…Following in vitro HK-2 injury, activin, inflammatory, EMT genes and supernatant activin levels were increased.Conclusions Circulating activin A is increased in human DKD and correlates with reduced kidney function and kidney injury markers. DKD-injured human renal tubule cells develop a profibrotic and inflammatory phenotype with activin A upregulation. …”
Get full text

A smartphone-enabled wireless and batteryless implantable blood flow sensor for remote monitoring of prosthetic heart valve function. by Bernhard Vennemann, Dominik Obrist, Thomas Rösgen

Get full text

Dynamics of clinical-laboratory markers of cholestasis on the ursosan therapy in patients with organic abnormalities of the bile-excreting tracts drainage function by A. L. Korkin, Ye. A. Ugorelova

“…Study of the ursosan therapy influence on the efficiency of the surgical resolution of cholestasis in the early postoperative period on the bile-excreting tracts. 19 healthy people and 24 patients with organic abnormalities of the drainage function of the bile ducts are examined. The analysis of the clinical, laboratory and instrumental criteria of cholestasis is carried out in the tested groups before and after ursosan’s therapy and the surgical treatment. …”
Get full text

Cerebral hemodynamics and functional connectivity changes in stroke patients with dysphagia under acidic taste stimulation: a preliminary study by Jiliang Kang, Jiliang Kang, Junyue Lu, Mengbi Gu, Shuang Gong, Xiaohan Li, Xiaojuan Li, Lifeng Tang, Lifeng Tang, Yu Jin, Youliang Wen, Min Tang

“…Functional connectivity analysis revealed that the average functional connectivity strength of the cortical network during acidic taste stimulation was significantly higher than during the neutral water condition (acidic taste: 0.337 ± 0.134; neutral water: 0.249 ± 0.142, p = 0.03).ConclusionThis study demonstrates that acidic taste stimulation can significantly activate multiple cortical regions in stroke patients with dysphagia and enhance the connectivity strength of brain functional networks, which may have a positive effect on swallowing function regulation. …”
Get full text

Functional antibody responses to SARS-CoV-2 variants before and after booster vaccination among adults in Ghana by F. D. Partey, A. N. A. Pobee, I. K. Damptey, F. Osei, M. M. A. K. Owusu-Amponsah, Y. A. A. Ansah, C. Ye, S. Bradfute, I. Hurwitz, P. K. Quashie, M. F. Ofori, A. K. Kusi, D. J. Perkins, G. A. Awandare

“…This study examined the functional activity of vaccine-induced antibody responses against different variants before and after booster vaccinations in adults in Ghana, between November 2022 and February 2023. …”
Get full text

Comparative analysis of cognitive functions in patients with episodic and chronic tension-type headache combined with psychovegetative syndrome and cerebrovascular disorders by Ye. A. Yegorova, V. N. Grigoriyeva

“…The purpose of the study was to compare cognitive functions in patients with episodic tension-type headache (EpTTH) and chronic tension-type headache (ChTTH).EpTTH was diagnosed in 34 patients in which it combined with psychovegetative syndrome in 17 persons and with cerebrovascular disorders in 28 persons. …”
Get full text

Assessing individual head and neck squamous cell carcinoma patient response to therapy through integration of functional and genomic data by Daniel Bottomly, Chase Mathieson, Myles Vigoda, Sophia Jeng, Nathaniel Evans, Ashley Anderson, Aurora Blucher, Aletha Lesch, Christina Zheng, Ted Laderas, James Jacobs, Molly Kulesz-Martin, Shannon McWeeney

“…This provides a functional context to the multi-omic readouts conducted on these samples (mutations, protein expression and copy number alterations). …”
Get full text

Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4 by Avit Su Suchitra

“…Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. …”
Get full text

A shortened 10-item Spine Functional Index: clinimetric properties indicate a reliable, responsive and practical measure by Hamid Reza Mokhtarinia, Antonio Cuesta-Vargas, Almir Vieira Dibai-Filho, Markus Melloh, Agnieszka Bejer

“…Abstract Background To assess the 10-item Spine Functional Index (SFI-10) clinimetric properties in a general musculoskeletal disorder (MSD) spine population. …”
Get full text

The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. by Brett A McKinney, Caleb Lareau, Ann L Oberg, Richard B Kennedy, Inna G Ovsyannikova, Gregory A Poland

“…We test this method for augmenting variant-based network analyses with functional interactions by applying it to a smallpox vaccine immune response GWAS. …”
Get full text

COMPARISON OF RANKING, PREPARATION AND FUNCTIONAL PARAMETERS OF DEAF AND HEARING WRESTLERS FROM THE BULGARIAN NATIONAL GRECO-ROMAN WRESTLING TEAMS by D. Chamishki

“…Results: In addition to sport results and the methodology of preparation, from the functional parameters (physiological and biochemical), we are using the maximum oxygen consumption (VO2max), the maximum oxygen consumption per kilogram (VO2max/kg), the heart rate values and the lactate concentration in the peripheral blood from conducting functional tests. …”
Get full text

Impact on physical function of the +AGIL Barcelona program in community-dwelling older adults with cognitive impairment: an interventional cohort study by Cristina Arnal, L Monica Pérez, Luís Soto, Álvaro Casas Herrero, Joan Ars, Sonia Baró, Francisco Díaz, Araceli Abilla, M Belén Enfedaque, Matteo Cesari, Marco Inzitari

“…The pre-post impact on physical function was assessed by paired sample t-test for repeated samples. …”
Get full text

Structure dependent optical and conductive properties of HPMC:CoCl2 composites: A functional data analysis study by Gowtham G K, Thejas G. Urs

“…Alongside experimental evidence, we employ a robust calculation method using functional data analysis to draw clear relationships among the parameters under study, further emphasizing the scientific rigor and significance of our findings.…”
Get full text

Long-term persistence of functional thymic epithelial progenitor cells in vivo under conditions of low FOXN1 expression. by Xin Jin, Craig S Nowell, Svetlana Ulyanchenko, Frances H Stenhouse, C Clare Blackburn

“…Here, we have used a revertible severely hypomorphic allele of Foxn1, Foxn1R, to test the stability of the common TEPC in vivo. By reactivating Foxn1 expression postnatally in Foxn1R/- mice we demonstrate that functional TEPCs can persist in the thymic rudiment until at least 6 months of age, and retain the potential to give rise to both cortical and medullary thymic epithelial cells (cTECs and mTECs). …”
Get full text

The Effectiveness of Transcranial Direct Current Stimulation and Multi- Component Cognitive Stimulation Programs on Cognitive Functions and Quality of Life in Elderly by Bakhtiar Moslemi, Gholamreza Chalabianloo

“…Experimental group received Transcranial Direct Current Stimulation (tDCS) on the prefrontal cortex, for the second group, multi-component cognitive stimulation software was used for three months and control group did not receive any intervention. The CANTAB test was used to evaluate cognitive function as well as  QOL-SF 36 questionnaire. …”
Get full text

Levodopa induces thyroid function regulation in a patient with thyroid hormone resistance and Parkinson’s disease: a case report by Gabriela Rozo-Paz, Clara Maria Ruiz-Forero, José David Suárez-Mera, Guillermo Monsalve Duarte, William Kattah Calderón

“…This entity commonly has abnormal thyroid function tests and can be confirmed by molecular analyses.Case presentationThe present study describes a 55 year-old female diagnosed with surgically resected papillary thyroid carcinoma. …”
Get full text

Prediction of functional outcomes in aneurysmal subarachnoid hemorrhage using pre-/postoperative noncontrast CT within 3 days of admission by Pengzhan Yin, Jiaqi Wang, Chao Zhang, Yongxiang Tang, Xiankuo Hu, Hongmin Shu, Jun Wang, Bin Liu, Yongqiang Yu, Yunfeng Zhou, Xiaohu Li

“…Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition, and accurate prediction of functional outcomes is critical for optimizing patient management within the initial 3 days of presentation. …”
Get full text

From Nanoindentation to Microhardness to Tensile Strength: Correlation Coefficients Estimates as a Function of Microstructure in Eutectic SnBi Alloy by Nataliya Starostina, Aja Hartman, Rosemary Cole, Dongmeng Li, Jong W. Park

Get full text

Aggregated approach for interstitial lung diseases classification using attention based CNN and radial basis function neural network by S. Kumarganesh, K.V.M. Shree, P. Rishabavarthani, C. Ganesh, S. Anthoniraj, B. Thiyaneswaran, Lam Dang, K. Martin Sagayam, Linh Dinh, Hien Dang

“…Here, radiomic features were extracted using gray-level properties and reduced using Particle Swarm optimization with inverse maximization of accuracy and precision as objective functions. The reduced features were then trained and tested using a radial basis function neural network (RBFNN). …”
Get full text

ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM., THE CLINICAL COURSE AND THE STRUCTURAL AND FUNCTIONAL STATE OF THE HEART AT THE UZBEK PATIENTS WITH DILATED CARDIOMYOPATHY by R. D. Kurbanov, N. A. Kurbanov, T. A. Abdullayev

Get full text