Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants. by Mengmeng Du, Shuo Jiao, Stephanie A Bien, Manish Gala, Goncalo Abecasis, Stephane Bezieau, Hermann Brenner, Katja Butterbach, Bette J Caan, Christopher S Carlson, Graham Casey, Jenny Chang-Claude, David V Conti, Keith R Curtis, David Duggan, Steven Gallinger, Robert W Haile, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, John L Hopper, Thomas J Hudson, Mark A Jenkins, Sébastien Küry, Loic Le Marchand, Suzanne M Leal, Polly A Newcomb, Deborah A Nickerson, John D Potter, Robert E Schoen, Fredrick R Schumacher, Daniela Seminara, Martha L Slattery, Li Hsu, Andrew T Chan, Emily White, Sonja I Berndt, Ulrike Peters

“…Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. …”
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Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites by Pei Xiao, Ting Song, Xiao Lu Li, Yong Mei Xiao, Rui Xue Wang, Fei Fei Song, Dan Li, Ai Hua Zhang, Ying Wang, Ting Zhang, Ting Zhang

“…BackgroundAlthough dietary fiber is widely recommended for preventing and treating functional constipation (FC), clinical trial evidence remains limited and the efficacy has not been sufficiently tested in children.PurposeThis study aimed to evaluate the effects of dietary fiber on FC symptoms, while identifying modulations in gut microbiota and associated metabolic changes.ResultsBetween January 1, 2024, and June 1, 2024, a total of 60 patients diagnosed with FC were enrolled in the study across three centers; however, 54 children completed the study. …”
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Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression by Xiaoxu Yang, Qian Du, Rui Xie, Jianhong Ding, Weixi Shan, Jingyu Xu, Changmei Chen, Qiushi Liao, Jun Lou, Zhe Jin, Mingkai Chen

“…Oral glucose tolerance test was used to detect the glucose tolerance of OVX mice and women aged 20–30 years. …”
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Altered brain glymphatic function on diffusion-tensor MRI in patients with spontaneous intracerebral hemorrhage: an exploratory study by Xiaona Xia, Qingguo Ren, Juntao Zhang, Shuai Guan, Qingjun Jiang, Ying Wei, Rui Hua, Shen Zhao, Xiangjun Hu, Xiangjun Hu, Feng Shi, Xiangshui Meng

“…ObjectivesTo investigate the function of the glymphatic system (GS) and its association with neuropsychological tests in spontaneous intracerebral hemorrhage (sICH) by diffusion tensor imaging analysis along the perivascular space (DTI-ALPS).MethodsThis retrospective study included 58 patients with sICH and 63 age- and sex-matched healthy controls (HCs). …”
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Universal Nonthermal Power-law Distribution Functions from the Self-consistent Evolution of Collisionless Electrostatic Plasmas by Uddipan Banik, Amitava Bhattacharjee, Wrick Sengupta

“…Collisionless systems often exhibit nonthermal power-law tails in their distribution functions. Interestingly, collisionless plasmas in various physical scenarios (e.g., the ion population of the solar wind) feature a v ^−5 tail in their velocity ( v ) distribution, whose origin has been a long-standing puzzle. …”
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Robust computation of subcortical functional connectivity guided by quantitative susceptibility mapping: An application in Parkinson’s disease diagnosis by Jianmei Qin, Haoting Wu, Chenqing Wu, Tao Guo, Cheng Zhou, Xiaojie Duanmu, Sijia Tan, Jiaqi Wen, Qianshi Zheng, Weijin Yuan, Zihao Zhu, Jingwen Chen, Jingjing Wu, Chenyu He, Yiran Ma, Chunlei Liu, Xiaojun Xu, Xiaojun Guan, Minming Zhang

“…Previous resting state functional MRI (rs-fMRI) analyses of the basal ganglia in Parkinson’s disease heavily relied on T1-weighted imaging (T1WI) atlases. …”
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Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation by Asif Ali, Dawood Khan, Vaibhav Dubey, Andrei I. Tarasov, Peter R. Flatt, Nigel Irwin

“…The current study compares the effects of these proglucagon-derived peptides on pancreatic beta-cell function, as well as on glucose tolerance and appetite. …”
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Association and function analysis of genetic variants and the risk of gestational diabetes mellitus in a southern Chinese population by Qiulian Liang, Yan Sun, Ming Li, Ruiqi Li, Lijie Nie, Lin Lin, Xiangyuan Yu

“…The nomogram established with factors such as age, FPG, HbA1c, 1hPG, 2hPG, TG, and rs4134819 showed a good discriminated and calibrated ability with an area under the curve (AUC) = 0.931 and a Hosmer–Lemeshow test p-value > 0.05.ConclusionThe variant rs4134819 can significantly alter the susceptibility of the Chinese population to GDM possibly by regulating the transcription of functional genes. …”
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Fortification of wheat biscuits with chia seed fiber and flower waste: Nutritional, antinutritional, functional, and storage properties by Animesh Sarkar, Md. Sumon Miah, Md. Masum, Mohammad Shaiful Alam Amin, Mahabub Alam

“…These findings underscore the potential of CS by-products as functional ingredients in baked goods, aligning with sustainability goals and consumer demand.…”
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NAALADL2-AS2 functions as a competing endogenous RNA to regulate apoptosis and drug resistance in DLBCL by Xiaoli Xu, Juan Liu, Cheng Fang, Xu Deng, Danxia Zhu, Jingting Jiang, Changping Wu

“…We discovered that NAALADL2-AS2 functions as ceRNA to inhibit expression of miR-34a, miR-125a, whereas overexpression of NAALADL2-AS2 indirectly upregulates expression of BCL-2. …”
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A changing of the garden: evaluating the performance and ecosystem functionality of alternative oyster garden structures in residential waterways by Adrian Sakr, Logan D. Mazor, Eric C. Milbrandt, Joseph P. Morton, Andrew H. Altieri

“…Oyster gardening, in which hanging oyster recruitment substrates are suspended from docks, has become an increasingly common and accessible technique for coastal communities to support local oyster populations for biodiversity enhancement, habitat restoration, and ecological functions including water filtration. However, little research has been done to evaluate materials and methods for oyster garden structures regarding cost, ease of assembly, durability, and ecosystem benefits, making it difficult to scale up efforts and maximize project success and sustainability. …”
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Machine learning model for differentiating malignant from benign thyroid nodules based on the thyroid function data by Quan Zhou, Lihua Zhang, Nan Xiang, Lele Zhang, Fuqiang Ma, Fengchang Yu, Shenhui Lv, Zhilin Lu, He-Rong Mao

“…Objectives To develop and validate a machine learning (ML) model to differentiate malignant from benign thyroid nodules (TNs) based on the routine data and provide diagnostic assistance for medical professionals.Setting A qualified panel of 1649 patients with TNs from one hospital were stratified by gender, age, free triiodothyronine (FT3), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAB).Participants Thyroid function (TF) data of 1649 patients with TNs were collected in a single centre from January 2018 to June 2022, with a total of 273 males and 1376 females, respectively.Measures Seven popular ML models (Random Forest, Decision Tree, Logistic Regression (LR), K-Neighbours, Gaussian Naive Bayes, Multilayer Perception and Gradient Boosting) were developed to predict malignant and benign TNs, whose performance indicators included area under the curve (AUC), accuracy, recall, precision and F1 score.Results A total of 1649 patients were enrolled in this study, with the median age of 45.15±13.41 years, and the male to female ratio was 1:5.055. …”
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Effect of cannabinoids CB1 receptors blockade on hemodynamic parameters and endothelial function at the immobilization stress in the experiment by S. V. Gavreliuk

“…The aim of the study was to evaluate the response of hemodynamic parameters and changes in endothelial function in modeling of CB1 cannabinoid receptors blockade in chronic stress. …”
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The mediating effect of frailty between social isolation and cognitive function in elderly patients with type 2 diabetes by Wu Nixiao, Dai Xia, Li Sulan, Xu Zilan, Huang Zheng

“…[Results] 300 elderly patients with type 2 diabetes mellitus scored 14 (9, 20) points for social isolation and 103 (34.33%) for social isolation; 5 (3, 7) points for frailty and 169 (56.33%) for frailty; 25 (23, 27) points for cognitive function and 98 (32.67%) for cognitive impairment.The frailty score was negatively correlated with the social isolation score (r=-0.327, P<0.001), the frailty score was negatively correlated with the cognitive function score (r=-0.394, P<0.001), and the social isolation was positively correlated with the cognitive function score (r=0.370,P<0.001).Bootstrap test showed that the indirect effect value was 0.071 (95%CI: 0.038-0.116), indicating that the indirect effect was established; the direct effect was 0.148 (95%CI: 0.088-0.208), indicating that weakness played a partial mediating role between social isolation and cognitive function, and the indirect effect (0.071) accounted for 32.42% of the total effect (0.219). …”
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Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults by Yu Chen, Guangfei Li, Jaime S. Ide, Xingguang Luo, Chiang-Shan R. Li

“…Although studies have implicated basal ganglia dysfunction, the functional connectivity (FC) of the dorsal striatum (DS), particularly in terms of sex differences, has not been fully investigated in ADHD. …”
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Global assessment of swallow function (GASF) following VMAT radiotherapy for head and neck squamous cell carcinoma by Kate Toft, Kirsty McLachlan, Mark Winton, Karen Mactier, Nadine Hare, Claire Nugent, Lucie Wincott, Devraj Srinivasan, Joanna Mackenzie, Bill Nailon, David Noble

“…Data were collated from the MD Anderson Dysphagia Inventory (MDADI), the Functional Oral Intake Scale (FOIS), the Performance Status Scale-Head and Neck: Normalcy of Diet scale (PSS-NoD), the 100 ml water swallow test (WST) for capacity and maximal interincisal opening (MIO). …”
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Metabolic complications and clinical outcomes of non-functioning adrenal incidentalomas: a systematic review and meta-analysis by Xiaolan Li, Huiyu Lan, Xinying Lin, Huibin Huang, Junping Wen, Gang Chen, Wei Lin

“…Abstract Background Increased detection of non-functioning adrenal incidentalomas (NFAI) due to widespread abdominal imaging may underestimate associated metabolic risks. …”
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Strain promoted azide alkyne cycloaddition, an efficient surface functionalization strategy for microRNA magnetic separation by Djamila Kechkeche, Sirine El Mousli, Claire Poujouly, Emilie Secret, Vincent Dupuis, Isabelle Le Potier, Marie-Emmanuelle Goriot, Julien Siracusa, Sébastien Banzet, Jean Gamby, Jean-Michel Siaugue

“…Two post-functionalization strategies were tested, one based on the reaction between a thiolated DNA and a maleimide group at the surface of the MNP, the other between an azide-functionalized DNA and a dibenzocyclooctyne group on the surface of the MNP. …”
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Prevalence of renal dysfunction and its influence on functional capacity in elderly patients with stable chronic heart failure by Stanojević Dragana, Apostolović Svetlana, Janković-Tomašević Ružica, Šalinger-Martinović Sonja, Pavlović Milan, Živković Milan, Božinović Nenad, Kutlešić-Kurtović Dušanka

“…The estimated glomerular filtration rate (eGRF) was determined by the abbreviated Modification of Diet in Renal Disease (MDRD2) formula, and patients were categorized using the Kidney Disease Outcomes Quality Initiative (K/DOQI) classification system. Functional capacity was determined by the 6 minute walking test (6MWT). …”
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Identification of functional near-infrared spectroscopy for older adults with mild cognitive impairment: a systematic review by Bo Yang, Xia Deng, Xianfeng Qu, Yingjie Li, Lei Guo, Nengwei Yu

“…ObjectiveMild cognitive impairment (MCI), a common state of cognitive impairment without significant impairment in daily functioning among older adults, is mainly identified using various neuropsychological tests, clinical interviews, and collateral history with some subjective interferences. …”
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