Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Transforming growth factor beta 1 (TGF-β1) is a pleiotropic cytokine with a profibrogenic and immunosuppressive effect that can have a definite effect on the liver transplant functioning.Aim. To determine the diagnostic efficacy of TGF-β1 in blood when assessing the risk of developing graft dysfunction in liver recipient children. …”
Get full text

WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions by H. Huang, Y. Qian, G. Bisht, J. Wang, T. Chakraborty, D. Hao, J. Li, T. Thurber, B. Singh, Z. Yang, Y. Liu, P. Xue, P. Xue, W. J. Sacks, E. Coon, R. Hetland

“…Originating from the Community Land Model (CLM) version 4.5, ELM has been under active development, with added new features and functionality, including plant hydraulics, radiation–topography interaction, subsurface multiphase flow, and more explicit land use and management practices. …”
Get full text

Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-m... by Luiza Grycuk, Dina Monssen, Molly R. Davies, Helen Sharpe, Karina L. Allen, Vibhore Prasad, Rachel Potterton, Priya Popat, Victoria A. Mountford, Sheryllin McNeil, Vanessa Lawrence, Nina Grant, Kimberley A. Goldsmith, Danielle Glennon, Sarah Byford, Amy Brown, Ulrike Schmidt

“…Outcomes will include motivation and readiness to change, attitudes and intentions towards help-seeking, ED symptoms, mood and social functioning, and health-related quality of life. Additionally, we will carry out a qualitative evaluation of participants’ views of the intervention and study design. …”
Get full text

Distinct bone metabolic networks identified in Phospho1−/− mice vs. wild type mice using [18F]FDG total-body PET by Abigail F. Hellman, Paul S. Clegg, Colin Farquharson, José Luis Millán, Carlos J. Alcaide-Corral, Carlos J. Alcaide-Corral, Karla J. Suchacki, Karla J. Suchacki, Adriana A. S. Tavares, Adriana A. S. Tavares

“…The skeletal system provides a good model for applying network analysis to total-body PET, as bone serves many classical whole-body functions as well as being an endocrine regulator of metabolism. …”
Get full text

POLYMORPHISM OF THE TP53 GENE IN PATIENTS WITH GASTRIC CANCER IN PROSPECTIVE AND CLINICAL CASE-CONTROL STUDIES by A. V. Belkovets, S. A. Kurilovich, V. N. Maksimov, Yu. I. Ragino, L. V. Scherbakova, O. V. Cheremisina, N. V. Cherdyntseva, M. V. Parulikova, M. I. Voevoda

“…Background. A functionally significant TP53Arg72Pro polymorphism can contribute to the development of gastric cancer (GC).The aim: to study the associations of genotypes and alleles of the TP53Arg72Pro 4 polymorphism with GC and biomarkers of gastric ucosal atrophy in population-based prospective and case-control clinical trials among the population of Siberia.Material and methods. …”
Get full text

Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Although cancer cells can maintain viability independently of mitochondrial energy metabolism, they remain reliant on mitochondrial functions for the synthesis of new DNA strands. This dependency underscores a potential link between mitochondrial energy metabolism and drug resistance. …”
Get full text

Climate resilience differs across dairy sheep populations in Europe by M.J. Carabaño, V. Tsartsianidou, D. Hazard, H. Larroque, D. Buisson, C. Pineda-Quiroga, E. Ugarte, M. Serrano, M.A. Jiménez, A. Triantafyllidis, G. Arsenos, C. Díaz, M. Ramón

“…Reaction norm models with polynomial functions in mixed model settings were fitted. Substantial variability in the population response to changes in TL was observed across breeds. …”
Get full text

Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases by Rebecca Zirnbauer, Daphni Ammon, Annalena Renner, Noam Hartman, Polina Kalinina, Patrick Starlinger, Stefan Stremitzer, Christoph Schwarz, Klaus Kaczirek, Michael Bergmann, Dietmar Pils, Johannes Laengle

“…Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNAs (sncRNA), regulate gene expression, stress response, and immune functions in cancer. While increasingly implicated in CRC progression, their prognostic significance in CRLM remains unknown. …”
Get full text

AI-driven pharmacovigilance: Enhancing adverse drug reaction detection with deep learning and NLP by Dr. Bharti Khemani, Dr. Sachin Malave, Samyukta Shinde, Mandvi Shukla, Razzaq Shikalgar, Harshita Talwar

“…BERT and GPT, were also employed to provide the functionality of textual interactions over medical data. • Performance metrics such as accuracy, precision, recall, and F1-score were systematically applied to evaluate each model’s performance. …”
Get full text

Objective measurement methods for the evaluation of socket comfort in patients with transfemoral amputation: a systematic review by Lisa Marie Tiesler, Lisa Marie Tiesler, Melanie Edel, Melanie Edel, Fangxing Wang, Fangxing Wang, Philipp Pieroh, Welf-Guntram Drossel, Welf-Guntram Drossel, Alina Carabello, Alina Carabello, Daniel Zipplies, Christoph-Eckhard Heyde, Stefan Schleifenbaum, Stefan Schleifenbaum, Stefan Schleifenbaum

“…Addressing these challenges will enable the development of reliable tools for assessing socket-limb interface quality, especially prosthetic fit and comfort, and drive progress in improving prosthetic functionality and patient outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023405042, identifier, CRD42023405042…”
Get full text

The Effect of Different Levels of Galangal (Alpinia officinarum) Powder on Growth Performance, Lipid Parameters, and Liver and Aantioxidant Enzymes in Japanese Quails under Heat St... by Maryam Mahmoodinejad, Bahram Shohreh, Zarbakht Ansari Pirsaraei, Sohail Yousefi

“…By increasing the activity of digestive enzymes and neutralizing internal toxins produced by other microorganisms, probiotics cause better functioning of the intestinal absorption level and beneficial effects on poultry performance. …”
Get full text

A study on toxicity, local irritative effect of and allergic response to a novel intranasal medication containing N-phenylacetyl-L-prolylglycine ethyl ester by B. S. Burlaka, I. F. Bielenichev

“…These conditions lead to impairment of mnestic and intellectual brain functions, to a decrease in mental alertness and memory in particular, which results in deterioration in the quality of life, sometimes in disability and patients’ partial or complete dependence on other people. …”
Get full text

Quantum <i>κ</i>-Entropy: A Quantum Computational Approach by Demosthenes Ellinas, Giorgio Kaniadakis

“…Also, an operational method named “the two-temperatures protocol” is introduced that provides a way to obtain the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>κ</mi></semantics></math></inline-formula>-entropy in terms of the partition functions of two auxiliary Gibbs states with temperatures <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>κ</mi></semantics></math></inline-formula>-shifted above, the hot-system, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>κ</mi></semantics></math></inline-formula>-shifted below, the cold-system, with respect to the original system temperature. …”
Get full text

Effects of integrated exercise approach on total testosterone levels in eumenorrheic women: a randomized controlled trial by Wajiha Shahid, Rabiya Noor

“…This immediate increase in testosterone levels can lead to increased strength, cognition and sexual functions in females. Trial registration number. This clinical trial was submitted by Dr. …”
Get full text

The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and -Resistant Neuroblastoma Cells by Silvana Alfei, Paolo Giannoni, Maria Grazia Signorello, Carola Torazza, Guendalina Zuccari, Constantinos M. Athanassopoulos, Cinzia Domenicotti, Barbara Marengo

“…Triphenyl phosphonium salts (TPPs) are mitochondria-targeting compounds that exert anticancer effects, impair mitochondria functions, and damage DNA at the same time. Despite several biochemical applications, TPP-based bola-amphiphiles self-assembling nanoparticles (NPs) in water have never been tested as antitumor agents. …”
Get full text

CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA by Hao Ning, Yan Jiang, Binbin Li, Junwu Ren, Cong Wang, Ling Wei, Linfei Li, Ai Ran, Zuozhang Li, Jiao Li, Wei Li, Yongquan Wang, Bin Xiao

“…Functionally, circABCA1 enhanced the half-life of SCARB1 mRNA by forming a circABCA1-IGF2BP3-SCARB1 mRNA ternary complex, thereby increasing the expression of SCARB1 and consequent cholesterol uptake. …”
Get full text

Chinese herbal foot baths as a new strategy for diabetic foot with Wagner grade of 0 or 1: a meta-analysis and data mining by Ruifang Lin, Yunfeng Yu, Yuman Yin, Xiu Liu, Yongjun Wu, Qin Xiang, Yaoyue Luo, Rong Yu

“…Schmidt].ConclusionChinese herbal foot-baths can improve clinical symptoms as well as vascular and nerve functions in diabetic foot patients with Wagner grades 0 or 1, without increasing the incidence of adverse events. …”
Get full text

Abscisic Acid Can Improve the Salt Tolerance and Yield of Rice by Improving Its Physiological Characteristics by Xi Wang, Guohui Ma, Naijie Feng, Dianfeng Zheng, Hang Zhou, Jiahuang Li, Jiashuang Wu, Bing Xu, Weiling Su, Yixi Huang

“…Salt-induced stress clearly imposed negative impacts on these aspects of rice’s physiological functions and productivity. The exogenous application of S-ABA was highly effective in mitigating the inhibitory influence of salt stress on the growth of rice. …”
Get full text

Sol–gel auto-combustion synthesis of a novel ternary magnetic-recyclable ZnFe2O4/ZnO/CeO2 nano-photocatalyst for highly efficient visible-light-induced degradation of organic conta... by Saba Roostaei, Hanieh Ansarinejad, Elmuez A. Dawi, Forat H. Alsultany, Salman Khalaf Issa, Mina Ahmadi-Kashani, Masoud Salavati-Niasari

“…Notably, scavenger analysis revealed that hydroxyl radicals were significantly present in the ZnFe2O4/ZnO/CeO2 sample when exposed to visible light, functioning as the main oxygen-derived radicals in breaking down pollutants through photocatalysis. …”
Get full text

Influence of Urinary Incontinence Related Factors on Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study by Alrajhi NS, Albarrati A, Aldhahi MI, Gwada RF

“…Notably, greater UI severity corresponded to more substantial impairments in HRQoL, with severe cases reporting greater negative effects on daily functioning. These findings underscore the importance of routine screening for UI in COPD patients and the implementation of targeted continence care strategies to enhance overall quality of life.Plain Language Summary: This study highlights significant correlations between UI, HRQoL, and factors such as age, BMI, and breathlessness. …”
Get full text