Click on Click: Click-Flavone Glycosides Encapsulated in Click-Functionalised Polymersomes for Glioblastoma Therapy by Nuno M. Saraiva, Ana Alves, Ana Isabel Barbosa, Andreia Marinho, Salette Reis, Marta Correia-da-Silva, Paulo C. Costa

“…To enhance therapeutic effect, improve local drug delivery, and overcome solubility issues of these high molecular weight compounds, the synthesised compounds were encapsulated in polymeric particles (polymersomes, PMs) composed of polylactic acid-polyethylene glycol (PEG-PLA) functionalized, once more by click chemistry, with 0.1 mol% transferrin mimetic (T7—HRPYIAH) peptide. …”
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Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis by Suyin Feng, Suyin Feng, Suyin Feng, Long Zhu, Long Zhu, Long Zhu, Jinyuan Gu, Kun Kou, Yongtai Liu, Guangmin Zhang, Hua Lu, Honglai Zhang, Runfeng Sun, Runfeng Sun

“…Subsequently, the clusterProfiler package was employed to functionally annotate the genes specifically highly expressed in the cells. …”
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Co-design and prototype development of MedManageSCI: a medication self-management toolkit for adults with spinal cord injury/dysfunction by Lauren Cadel, Rasha El-Kotob, Sander L. Hitzig, Lisa M. McCarthy, Shoshana Hahn-Goldberg, Tanya L. Packer, Tejal Patel, Stephanie R. Cimino, Aisha K. Lofters, Chester H. Ho, Maliha Asif, Sara J.T. Guilcher

“…In Stage 3, participants provided recommendations to improve the website’s functionality and navigation. Conclusions The co-design of the MedManageSCI prototype is a significant step toward addressing the medication self-management needs of adults with SCI/D. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Yet, the molecular and cellular mechanisms by which either receptor functions to mediate its inhibitory effects are still poorly understood. …”
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Rapid Detection of Trace Toxicants in Blood Using Thermal Desorption Coupled to Continuous Atmospheric Pressure Interfaced Ion Trap Mass Spectrometry by Hui-wen RUAN, Gui-yun SONG, Zhi-gang FAN, Suo-suo YANG, Jian KANG, Lei HUA, Wei-guo WANG

“…Miniaturized ion trap mass spectrometers have characteristics of high working pressure, tandem-in-time mass spectrometry functions, and field-portable design, which represent a promising approach for rapid on-site detection and hold significant potential for supporting the diagnosis and treatment of acute poisoning. …”
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How trait mindfulness protects late adolescents from stress-induced sleep problems: the unique role of mindfulness facets and gender differences by Huiting Cao, Jing Qian, Fenghua Tang, Yunyan Dong, Haining Ren, Xiaoran Xue, Ningning Mao, Xiaoyu Liu

“…While previous research has demonstrated the potential protective effect of trait mindfulness, facets of mindfulness were found to have unique functions against the negative impact of stress, and the unique impact of each facet of mindfulness on the sleep problems caused by the negative impact of stress remains unclear. …”
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Balancing act: Studying the effect of perch space allowance on welfare in Canadian laying strain pullets raised in floor pens with access to a single-tier perch system to 18 wk of... by Carolin A.B. Adler, Tory Shynkaruk, Samantha McPhee, Kailyn Buchynski, Adelle Herr, Eugenia Herwig, Karen Schwean-Lardner

“…Data were collected for basic health and functioning (body weight, mortality, pullet width, keel bone damage, and tibia bone parameters), affective states (comb damage, heterophil-to-lymphocyte (H/L) ratios, and behavior), and natural living (perch usage and jumping success). …”
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CONFRONTATION AND MUTUAL REFLECTION OF TWO WORLDS IN “THE GRASS DANCER” BY SUSAN POWER by Oksana G. Shostak

“…The main purpose of this article is to outline a coherent theoretical and empirical model of multi-level functioning of Dakota national identity concept in the novel “The Grass Dancer” by Susan Power. …”
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The Proportion of Regulatory T Cells in Patients with Systemic Lupus Erythematosus: A Meta-Analysis by Sheng-Xiao Zhang, Xiao-Wen Ma, Yu-Feng Li, Na-Ling Lai, Ze-Hao Huang, Kai Fan, Cai-Hong Wang, Xiao-Feng Li

“…The proportions of Tregs that were accurately identified and functionally validated fell among patients with SLE. …”
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Human Tapeworm from Simalungun, Indonesia by Umar Zein, Sahat Siregar, Hadiki Habib, Indra Janis, Abdul H Pane, Teguh W Sardjono

“…A segment called ‘snout’ was found at the apex. The functions were probably as a sense of smell and vacuum organ. …”
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Sleep in Juvenile Idiopathic Arthritis: An Exploratory Investigation of Heart Rate Variability by M. C. Lopes, S. Roizenblatt, L. M. A. Soster, K. Spruyt

“…<b>Conclusions:</b> Patients with JIA exhibited sleep disruption and alterations in cardiovascular autonomic functioning during sleep. Reduced HRV across all sleep stages in these patients suggests underlying autonomic nervous dysfunction. …”
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Enhanced Dermal Delivery of Nanoparticulate Formulation of Cutibacterium acnes Using Sponge Spicules for Atopic Dermatitis Treatment by Jin Y, Zhang C, Jia M, Chen M

“…In vitro cytotoxicity tests showed that NFCA had low toxicity to HaCaT cells (IC50=63.8 mg/mL). …”
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Child and adolescent sleep disturbances and psychopathology in a mental health clinic sample by Aviva Blacher, Katarina N. A. McKenzie, Shannon L. Stewart, Shannon L. Stewart, Shannon L. Stewart, Graham J. Reid, Graham J. Reid, Graham J. Reid, Graham J. Reid

“…., age, sex, sensory sensitivity, pain) and family-level variables (family functioning, caregiver distress, parenting strengths). …”
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The impact of a hazardous external environment on the quality of life, physical activity, and health of students in Ukraine, Poland, and Romania by Vladimir Potop, Igor Vypasniak, Iryna Ivanyshyn, Vasyl Lutskyi, Iryna Kryventsova, Lyudmila Shesterova, Krzysztof Prusik

“…In Romania, men showed better results in the psychological health component (42.79±8.61) compared to women (39.67±8.70) and higher physical functioning scores. Conclusions. The results of the analysis highlight that the war in Ukraine significantly impacts the physical and mental health of Ukrainian students. …”
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Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration by QianKun Yang, XianJie Zhu, Li Zhang, Fei Luo

“…Finally, network pharmacology analysis identified INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, and SERPINE1 as core targets in biological aging, which were functionally linked to key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. …”
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Discussion on Monitoring Methods for the Temperature Difference Between Upper and Lower Layers of Mass Concrete by HUANG Yao-ying, FU Yu-chen, ZHUANG Wei, TU Yue-tong, HU Yu

“…Subsequently, statistical tests were conducted on the above samples to derive the corresponding probability density distribution functions of the maximum tensile stress and temperature difference between upper and lower layers. …”
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Diversity of performance patterns in dairy goats: multi-scale analysis of the lactation curves of milk yield, body condition score and body weight by Gafsi, Nicolas, Martin, Olivier, Bidan, Fabrice, Grimard, Bénédicte, Puillet, Laurence

“…At the lactation scale, no major association was found among phenotypic curves suggesting a diversity of energy partitioning strategies between life functions. At the lifetime scale, change among clusters occurred primarily between first and second lactation, whereas a pattern of stable cluster membership appeared for multiparous goats. …”
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Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. by Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue

“…Further, we found minimal enrichment between ALS and the immune-mediated diseases tested, with the highest levels of enrichment between ALS and RA (up to 20-fold). …”
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Cross-lagged analysis of physical fitness and cognitive control in Chinese early adolescents by Lei Xu, Fengling Zhang, Jianbo Zhu

“…Cross-lagged path modeling in Mplus 8.0 examined bidirectional causation relationships between fitness domains and cognitive functions, supplemented by SPSS 26.0-based correlational analyses. …”
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Association of weekend catch-up sleep ratio with depressive risk: insights from NHANES 2021–2023 by Shilin Sun, Min Liu, Han Liu, Runzhou Li, Qun Liang, Weiwei Quan

“…It significantly impacts quality of life and social functioning, posing a major public health challenge. …”
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