Placental Mesenchymal Stromal Cells (PMSCs) and PMSC-Derived Extracellular Vesicles (PMSC-EVs) Attenuated Renal Fibrosis in Rats with Unilateral Ureteral Obstruction (UUO) by Regul... by Zhu Zhu, Chaonan Han, Shuli Xian, Feng Zhuang, Feng Ding, Wei Zhang, Yingli Liu

“…PMSCs can convert the inflammatory environment into an anti-inflammatory environment by affecting the polarization of CD4+ T cells and macrophages, inhibiting the inflammatory factors IFN-γ and IL-17, and upregulating the expression of the anti-inflammatory factors TGF-β and IL-10, ultimately leading to renal protection. Such functions may be mediated by the paracrine activity of PMSC-EVs.…”
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Antioxidant and <i>In Vitro</i> Hepatoprotective Activities of a Polyphenol-Rich Fraction from the Peel of <i>Citrus lumia</i> Risso (Rutaceae) by Vincenzo Musolino, Antonio Cardamone, Rosario Mare, Anna Rita Coppoletta, Francesca Lorenzo, Francesca Rita Noto, Angelo Galluccio, Luigi Tucci, Carmine Lupia, Cristina Carresi, Mariangela Marrelli, Samantha Maurotti, Micaela Gliozzi, Tiziana Montalcini, Arturo Pujia, Vincenzo Mollace

“…In particular, the polyphenolic fraction of <i>Citrus lumia</i> peel showed promising effects on lipid metabolism and cellular energy balance and may prove valuable in the treatment of metabolic disorders such as MASLD, where lipid accumulation disrupts normal cellular functions.…”
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Improving recombinant protein secretion in Aspergillus nidulans by targeting the N-glycosylation machinery by Jaqueline Aline Gerhardt, Marcelo Ventura Rubio, Cesar Rafael Fanchini Terrasan, Natalia Sayuri Wassano, Aryadne Rodrigues, Fernanda Lopes de Figueiredo, Everton Paschoal Antoniel, Fabiano Jares Contesini, Artur Hermano Sampaio Dias, Uffe Hasbro Mortensen, Munir Salomão Skaf, André Damasio

“…N-glycosylation can significantly affect protein stability, production yield, and functionality. This study investigated the isolated and combined deletion of genes involved in N-glycan assembly on protein production in Aspergillus nidulans. …”
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Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer by Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong

“…Here, we aimed to examine whether IDO1 activity is correlated with OS in NSCLC patients with brain metastasis (Bramet) and has negative effect on modulating the anti-tumor functions of immune cells. Methods: This study was a part of a prospective clinical trial in circulating biomarkers. …”
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SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…IntroductionThis randomized clinical trial (RCT) compared the efficacy of two cognitive rehabilitation (CR) protocols—Strategic Memory Advanced Reasoning Training (SMART) and Study of Cognitive Rehabilitation Effectiveness (SCORE)—in improving higher-order cognitive functions among active-duty service members (ADSMs) with mild traumatic brain injury (mTBI) and varying levels of post-traumatic stress disorder (PTSD) symptoms. …”
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Metabarcoding-based characterization of soil nematode communities to assess soil health in viticulture by Rubén Blanco-Pérez, María de Toro, Sergio Álvarez-Ortega, Alícia Pou, Sara Sánchez-Moreno, Raquel Campos-Herrera

“…We applied HTS metabarcoding to test this, identifying 114 nematode taxa to assess nematode diversity, trophic composition, and network connectivity across 57 vineyards. …”
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Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification by Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang

“…Abstract Background Lysosomal homeostasis and functions are essential for the survival of neural cells. …”
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Novel artificial tricalcium phosphate and magnesium composite graft facilitates angiogenesis in bone healing by Yuan-Hsin Tsai, Chun-Chieh Tseng, Yun-Chan Lin, Howida M. Nail, Kuan-Yu Chiu, Yen-Hao Chang, Ming-Wei Chang, Feng-Huei Lin, Hui-Min David Wang

“…Conclusion: In summary, we introduced a novel CPC sponge, which had a similar property to human bone promoted the biological functions of bone cells, and could serve as a promising material used in bone regeneration for critical bone defects.…”
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A Novel Cystatin Gene from Sea Cucumber (<i>Apostichopus japonicus</i>): Characterization and Comparative Expression with Cathepsin L During Early Stage of Hypoxic Exposure-Induced... by Siyu Yao, Rui Zhang, Siyuan Ma, Ting Zhao, Qinhao Liu, Lin Zhu, Chang Liu, Liming Sun, Ming Du

“…The results of this study indicated that the anti-autolytic regulation of SjCyt functions at the very early stage of hypoxic exposure, exerting effects at both the transcriptional and translational levels. …”
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Polyphosphate-enriched algae fertilizer as a slow-release phosphorus resource can improve plant growth and soil health by Jiahong Yu, Bingbing Luo, Yujie Yang, Suna Ren, Lei Xu, Long Wang, Xianqing Jia, Yiyong Zhu, Keke Yi

“…Soil cultivation experiments showed that PEA released twice as much labile P as initially available in the soil, and it functioned as a slow-release P source. In contrast, soils treated with CP initially exhibited high levels of labile P, which was gradually converted to stable forms, but it dropped to 30% of the labile P level in PEA after three months. …”
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Vitamin D receptor genetic variations in association to the susceptibility to prostate cancer: a case-control study in a Moroccan population by Kawtar Nabil, Abdelilah Laraqui, Ikram Tiabi, Kaoutar Anouar Tadlaoui, Mohammed Mrabti, Ahmed Ameur, Khalid Ennibi, Mustapha Benhessou, Moulay Mustapha Ennaji

“…Aim: It has been shown that the vitamin D receptor (VDR) gene and its biological functions can be affected by genetic alterations in the VDR gene. …”
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The Efficacy of Hyaluronic Acid in Reducing Pelvic Adhesions in Patients Undergoing Gynecologic Laparoscopic Surgery: A Meta‐Analysis of Randomized Clinical Trials by Maryam Mazloomi, Arash Mohazzab, Kobra Tahermanesh, Maliheh Fakehi, Maryam Saeedzarandi, Zahra Kooshari, Paria Dehesh, Seyede Razieh Ghaffari

“…Hyaluronic acid gel functions as a physical barrier, potentially reducing the formation of postoperative adhesions by minimizing tissue contact during the healing process. …”
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Development and Validation of a New LC-MS/MS Method for Simultaneous Quantification of Ivacaftor, Tezacaftor and Elexacaftor Plasma Levels in Pediatric Cystic Fibrosis Patients by Alessandro Mancini, Raffaele Simeoli, Luca Cristiani, Sara Cairoli, Fabiana Ciciriello, Alessandra Boni, Federico Alghisi, Chiara Rossi, Giacomo Antonetti, Carlo Dionisi Vici, Alessandro Giovanni Fiocchi, Renato Cutrera, Bianca Maria Goffredo

“…<b>Background</b>: “CFTR modulators” (also named “caftor”) have been developed and introduced into clinical practice to improve the functionality of defective CFTR protein. Therapeutic drug monitoring (TDM) is not currently used for CFTR modulators in routine clinical practice and there is still much to learn about the pharmacokinetic/pharmacodynamic (PK/PD) and the safety profiles of these drugs in a real-world setting. …”
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Virtual reality solution to promote adapted physical activity in older adults: outcomes from VR2Care project exploratory study by Vincenzo De Luca, Malak Qbilat, Alessandra Cuomo, Antonio Bianco, Francesca Cesaroni, Chiara Lanari, Ad van Berlo, Telma Mota, Lucia Pannese, Michael Brandstötter, Matthieu Arendse, Vania Mota, Willeke van Staalduinen, Hugo Paredes, Guido Iaccarino, Guido Iaccarino, Maddalena Illario

“…Within the group, baseline to end of observation differences were assessed by paired sample t-test. A p = 0.05 was considered significant.ResultsNo significant improvements in quality of life and physical activity were found. …”
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Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma by Krasimira Aleksandrova, Jana Leise, Christoph Priesner, Murat Aktas, Michael Apel, Mario Assenmacher, Iris Bürger, Anne Richter, Pia Altefrohne, Christine Schubert, Astrid Holzinger, Markus Barden, Valerie Bezler, Michael von Bergwelt-Baildon, Peter Borchmann, Lilia Goudeva, Wolfgang Glienke, Lubomir Arseniev, Ruth Esser, Hinrich Abken, Ulrike Koehl, Ulrike Koehl, Ulrike Koehl

“…Using a second-generation lentiviral vector for the production of the CD20 CAR T cells on the CliniMACS Prodigy®.ResultsWe demonstrated consistency in cell composition and functionality of the products manufactured at two different production sites. …”
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Contribution of Human Resources for Health competence and skill mix on compliance with healthcare quality standards among Primary Healthcare Facilities in Tanzania: evidence from d... by Syabo M. Mwaisengela, Patricia A. Materu, Chrisogone J. German, Issa I. Mmbaga, Danny J. Temba, Raymond R. Kiwesa, Martin S. Mapunda, Erick S. Kinyenje, Nathanael Sirili, Pankras W. Luoga, Simon P. Ernest, Joseph M. Burra, Joseph C. Hokororo, Godfrey Kacholi, Ntuli A. Kapologwe, Mackfallen G. Anasel, Claud J. Kumalija, Michael Habtu, Grace E. Saguti, Janeth S. Masuma, Talhiya A. Yahya, Eliudi S. Eliakimu

“…Inadequate numbers with poor skill mix compromise health system functioning that negatively affect delivery of quality healthcare services. …”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…One manifestation of violation of protective functions in this group of patients are changes in the synthesis of interleukin blood. …”
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Influence of drought stress on phosphorus dynamics and maize growth in tropical ecosystems by Mohsin Mahmood, Junjie Wang, Sajid Mehmood, Waqas Ahmed, Anam Ayyoub, Mahmoud F. Seleiman, Ahmed Salah Elrys, Ahmed S. M. Elnahal, Adnan Mustafa, Xiuwen Wei, Weidong Li

“…Abstract Drought has a significant impact on ecosystem functions, especially on the biogeochemical cycling of phosphorus (P), which is a crucial nutrient for plant growth and productivity. …”
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Washback of a High-stakes Language Exam on Spanish Teachers' Practice in Brazil by Yasser Abdullah Al Tamimi, Gladys Quevedo-Camargo, Rafael Sena Raposo de Melo

“…The Serial Assessment Program (PAS) is an annual reading test in Spanish, French or English functioning as a diagnostic, summative, and formative assessment tool and offering an entry opportunity for low-income students. …”
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