Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms by Yongjae Hong, Geon Ko, Yeong-Jae Jeon, Hyeon-Man Baek, Juni Lee, Donghun Lee, Jieun Park, Jaehong Kim, Keun-A Chang

“…Motor and cognitive functions were assessed using cylinder, rotarod, and novel object recognition (NOR) tests. …”
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Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities by Marie-Claude Bourgeois-Daigneault, Victor Mullins-Dansereau, Marie-Lou Myre, Angelina Bardoul, Karen Geoffroy, Marco J Rallo Pita, Delphine Béland, Kim Leclerc Desaulniers, Dominic Guy Roy

“…Treatment efficacy was also measured.Results Our data show that VSV-interleukin-2 is superior as a vaccine boosting adjuvant compared with the parental virus as it induces more antigen-specific CD8 T cells with enhanced effector functions that persist over time. VSV-interleukin-2 vaccination also improves tumor control and survival.Conclusions Overall, we show that engineered oncolytic virus platforms, such as VSV-interleukin-2, have the potential to improve vaccination efficacy and treatment outcomes. …”
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Starch α-glucan microparticles trigger hemocyte activation in Cherax quadricarinatus crayfish by Crystal Guluarte, Alí Pereyra, Maya Pérez-Echeverria, María Fernanda López-Galicia, Eda Patricia Tenorio, Eleazar Ramírez Hernández, Romina Rodríguez-Sanoja, Silvia Moreno-Mendieta, Carlos Angulo, Edgar Zenteno, José Luis Sánchez-Salgado

“…The immunostimulant effect of α-glucans microparticles has been tested in vertebrates to increase protection against pathogens and prevent lethal diseases, however, the effect of these particles on invertebrate organisms has not been evaluated yet. …”
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Association of D-dimer to albumin ratio with adverse cardiovascular outcomes in ischaemic heart failure patients with diabetes mellitus: a retrospective cohort study by Xiaolong Lin, Jinghua Liu, Siyuan Chen, Qiuyu Li, Xiaowen Bo, Donghui Zhao, Qian Fan

“…The cumulative incidence functions, Cox regression, restricted cubic spline and receiver operating characteristic curves were used to determine the association between DAR and outcomes. …”
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Discriminant analysis of occupational performance characteristics in patients with major depressive disorders and healthy individuals by Tomonari Hayasaka, Izumi Nagashima, Miku Hoshino, Koji Teruya, Yasuyuki Matumoto, Masami Murao, Taku Maruki, Masako Watanabe, Takeshi Katagiri, Yayoi Imamura, Mariko Kurihara, Yuki Oe, Yoshikazu Takaesu, Takashi Tsuboi, Koichiro Watanabe, Hitoshi Sakurai

“…Abstract Aim Assessing symptoms and daily functioning in patients with major depressive disorder (MDD) can be challenging, as their limited self‐monitoring abilities may result in behavior observed during structured interviews not accurately reflecting their daily lives. …”
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Neuroprotective effects of empagliflozin against scopolamine-induced memory impairment and oxidative stress in rats by Mahdieh Anoush, Neda Taghaddosi, Zahra Bokaei Hosseini, Fatemeh Rahmati, Soroush Bijani, Ali Kalantari-Hesari, Mir-Jamal Hosseini

“…Normal rats and AD rats, with each group receiving different substances for 8 consecutive days and 24 h after the accomplishment of the drug administrations, the memory functions assessed through Morris water maze (MWM) paradigm. …”
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Smartphone intervention for pregnancy smoking cessation with peer support: the study protocol of the SmokeFree Together 2.0 (SFT 2.0) randomised controlled trial by Ken Resnicow, Kristie Foley, Daniel Muresan, Oana M Blaga, Marina D Dascal, Alexandra Onișor, Teodora Frățilă, Andreea Morar, Dan Mihu, Cristian I Iuhas, Gabriela Caracostea, Cristian I Meghea

“…The app leverages the unique functionality of smartphones and reinforcement learning (RL) to provide a deeply tailored intervention that continuously adapts while emphasising positive support through reciprocal interactions between the smoker and the support person. …”
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Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode by Haeun Kwon, Hyun-U Cho, Jeongeun Sim, Kyung-Jun Boo, Kyung-Jun Boo, Yumin Kang, Sangmun Hwang, Youngjong Kwak, Jaehyun Jang, Kyung Min Kim, Se Jin Jeon, Chan Young Shin, Kevin E. Bennet, Kevin E. Bennet, Yoonbae Oh, Yoonbae Oh, Hojin Shin, Hojin Shin, Kendall H. Lee, Kendall H. Lee, Dong Pyo Jang, Dong Pyo Jang

“…To improve mechanical robustness and long-term functionality, we fabricated 30 µm diameter CFMEs and modified their geometry via electrochemical etching to form cone-shaped tips. …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Various measures were employed, including the fatigue scale for motor functioning and cognition (FSMC), the Test Battery for Attention (TAP) and the Montreal Cognitive Assessment (MoCA).ResultsOut of the 1,086 recruited participants, a total of N = 701 participants were included in the main data analysis. …”
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Prevalence of hepatitis B virus infection and associated factors among students living on campus in South-eastern Gabon by Augustin Mouinga-Ondeme, Moussa Yaro, Guy-Roger Ndong Atome, Madeleine Meba, Neil Michel Longo-Pendy, Roseanne Mounanga Mourimarodi, Christ Eddy Ognari Ayoumi, Abdoulaye Diane, Jeordy Dimitri Engone-Ondo, Eldridge Fedricksen Oloumbou, Ivan S. Mfouo Tynga

“…Abstract Background The Hepatitis B-virus is the etiological agent of an infection that affects liver functions and potentially causes disorders. Approximately, 300 million people are living with acute or chronic HBV-infections worldwide, and only a fraction of them have access to medical care. …”
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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…NeoExpand led to improved phenotypes and functions of neoantigen-reactive TILs. Our data warrant its clinical evaluation.Trial registration number NCT00068003, NCT01174121, and NCT03412877.…”
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Comparison of the Effect of Different Percentages of Sesame Oil and Soybean Oil on Growth Performance, the Weight of Internal Organs, and Serum Biochemical Parameters in Japanese q... by Maryam Karimi-Dehkordi, Forogh Mohammadi, Majid Gholami-Ahangaran

“…Sesame oil contains compounds called lignans, such as sisamin, sisamulin, and small amounts of sisamol, and has many different physiological functions, such as reducing blood fat, reducing the level of arachidonic acid, increasing antioxidant capacity, increasing the bioavailability of gamma-tocopherol, and anti-inflammatory functions. …”
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Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer’s disease by Jing Ma, Yu Tian, Chengzhong Du, Yang Zhu, Wen Huang, Chenyu Ding, Penghui Wei, Xuehan Yi, Zhangya Lin, Wenhua Fang

“…Extensive physicochemical characterization using transmission electron microscopy, X-ray photoelectron spectroscopy, and dynamic light scattering confirmed the successful synthesis of uniform nanoparticles (~ 142 nm) with preserved membrane protein functionality. In vitro studies utilizing SH-SY5Y neuroblastoma cells revealed that NM@PB-Ce effectively scavenged reactive oxygen species through multiple enzyme-mimetic activities (catalase, superoxide dismutase, and peroxidase). …”
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Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…The differential proteins between the two patient groups were identified and functionally analyzed using bioinformatics methods. Key differential proteins were further screened using machine learning models such as Extreme Gradient Boosting （XGBoost） and Least Absolute Shrinkage and Selection Operator （LASSO） regression to construct a nomogram and evaluate its diagnostic performance. …”
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Effects of Dietary Nano-Composite of Copper and Carbon on Antioxidant Capacity, Immunity, and Cecal Microbiota of Weaned Ira White Rabbits by Ying-Huan Zhou, Xiao-Ping Liu, Xiao-Ming Gu, Hai-Xuan Lv, Yun Yang, Zai-Xing Cai, Bin Di, Chang-Kang Wang, Yu-Yun Gao, Ling Jin

“…This experiment investigated the effects of dietary supplementation with nano-composites of copper and carbon (NCCC) on antioxidants, immune functions, and the cecum microbiota of weaned Ira white rabbits. …”
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Enhanced neurological anomaly detection in MRI images using deep convolutional neural networks by Ahmed Mateen Buttar, Zubair Shaheen, Abdu H. Gumaei, Mogeeb A. A. Mosleh, Mogeeb A. A. Mosleh, Indrajeet Gupta, Samah M. Alzanin, Muhammad Azeem Akbar

“…The model employs Rectified Linear Unit (ReLU) activation functions, the Adam optimizer, and a random search strategy to fine-tune hyper-parameters like learning rate, batch size, and the number of neurons in fully connected layers. …”
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Transcriptomic Differences by RNA Sequencing for Evaluation of New Method for Long-Time In Vitro Culture of Cryopreserved Testicular Tissue for Oncologic Patients by Cheng Pei, Plamen Todorov, Qingduo Kong, Mengyang Cao, Evgenia Isachenko, Gohar Rahimi, Frank Nawroth, Nina Mallmann-Gottschalk, Wensheng Liu, Volodimir Isachenko

“…Background: Earlier studies have established that culturing human ovarian tissue in a 3D system with a small amount of soluble Matrigel (a basement membrane protein) for 7 days in vitro increased gene fusion and alternative splicing events, cellular functions, and potentially impacted gene expression. …”
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Distribution patterns of fungal community diversity in the dominant tree species Dacrydium pectinatum and Vatica mangachapoi in tropical rainforests by Kepeng Ji, Yaqing Wei, Xin Wang, Yu Liu, Rui Sun, Yuwu Li, Guoyu Lan

“…This compartment-aware perspective enhances our ability to leverage microbial functions to improve the resilience of endangered trees in the face of climate change.…”
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Normothermic <i>ex vivo</i> lung perfusion using a developed solution followed by orthotopic left lung transplantation (experimental study) by I. V. Pashkov, S. V. Gautier, V. K. Bogdanov, D. O. Oleshkevich, D. M. Bondarenko, N. P. Mozheiko, N. S. Bunenkov, N. V. Grudinin

“…The ability to restore suboptimal donor lungs, previously considered unsuitable for transplantation, can improve organ functionality, and thus increase the number of lung transplants. …”
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Protective Effect of Low-molecular-weight Fucoidan on Lead-induced Oxidative Damage in HepG2 Cells Based on Cellular Metabolomics by Fan YU, Na LI, Yingying GUO, Xinyue DAI, Wenjia ZHU, Lin YAO, Yanhua JIANG, Lianzhu WANG

“…Methods: F1 was used as a test substance to establish an in vitro HepG2 cell model of Pb-induced injury with F1 intervention. …”
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