Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A by Christopher A. Galifi, Ryan J. Dikdan, Divyangi Kantak, Joseph J. Bulatowicz, Krystopher Maingrette, Samuel I. Gunderson, Teresa L. Wood

“…We hypothesize that the IR-A ASO will be a useful research tool and may have therapeutic value by inhibiting the oncogenic functions of IR-A in cancer cells.…”
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Change in mental health service utilization from pre- to post-COVID-19 period in the United States by Md Rezaul Kader, Mohammod Mahmudur Rahman, Piali Dey Bristi, Foyez Ahmmed

“…Sex, age, race, education, income group, insurance coverage, birth country, marital status, limitations of social functioning, having a place for healthcare, symptoms and history of depression/anxiety, diabetes, and hypertension had significant effects on the odds of receiving mental healthcare. …”
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Evaluating the delivery of Problem Management Plus in primary care settings in rural Rwanda: a study protocol using a pragmatic randomised hybrid type 1 effectiveness-implementatio... by Christian Rusangwa, Fredrick Kateera, Stephanie L Smith, Beatha Nyirandagijimana, Janvier Hakizimana, Roger P Levy, Robert Bienvenu, Anathalie Uwamwezi, Octavien Hakizimfura, Eugenie Uwimana, Priya Kundu, Egide Mpanumusingo, Alphonse Nshimyiryo, Hildegarde Mukasakindi, Giuseppe Raviola

“…To study the clinical effectiveness of PM+, we will use a pragmatic, randomised multiple baseline design to determine whether participants experience improvement in depression symptoms (measured by the Patient Health Questionnaire-9) and functioning (measured by the WHO-Disability Assessment Scale Brief 2.0) after receiving PM+. …”
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The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress by Kunbin Li, Liming Lu, Xianli Yao, Zhiyuan Wu, Pingge Sun, Xiaopeng Wen, Xiaoxing Li, Kai Wang, Xiran Yin

“…The oxidative stress was tested by assessing ROS and MDA contents and SOD and GSH-Px activity. …”
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Waterbody Detection and Reservoir Water Level Prediction Using Bayesian Mixture Models with Sentinel-1 GRD Data by DongHyeon Yoon, Ha-Eun Yu, Euiho Hwang, Ki-mook Kang, Gibeom Nam, Jin-Gyeom Kim

“…Reservoirs serve vital functions such as flood control, drought mitigation, and ecosystem support, highlighting the importance of precise monitoring of their water surface and level variations, especially in the context of climate change and increased human impact. …”
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Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells by Nan Huang, Zhiwei Liu, Jiabei Zhu, Zhongqi Cui, Yuguang Li, Yongchun Yu, Fenyong Sun, Qiuhui Pan, Qingyuan Yang

“…In summary, our studies shed insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and provide evidence supporting sirtuin 6–based personalized therapies in esophageal carcinoma cell patients.…”
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Garlic Extracts Nanoliposome as an Enhancer of Bioavailability of ABA and Thiamine Content and as an Antifungal Agent Against <i>Fusarium oxysporum</i> f. sp. <i>pisi</i> Infecting... by Barbara Kutasy, Géza Hegedűs, Márta Kiniczky, József Péter Pallos, Ágnes Nagy, István Pócsi, Klaudia Pákozdi, Máté Kállai, Csaba Weingart, Katalin Andor, Bettina Kovács, Eszter Virág

“…Furthermore, the absence of <i>Fusarium</i> infection in the treated small-plot field cultures suggests that the tested garlic extracts formulation functions as a promising preventive biostimulant against plant fungal diseases.…”
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Changes in Selected Biochemical Markers of Honey Bees Exposed to Fermented Common Tansy Solution (<i>Tanacetum vulgare</i> L.) by Natalia Białecka, Klaudia Garbacz, Ewelina Berbeć, Agnieszka Murawska, Beata Madras-Majewska, Paweł Migdał

“…Glucose levels differed between the groups receiving 1% extract and 2% extract and between the positive control group and 1% extract. Bee body proper functioning is affected by changes in enzyme activity, especially those responsible for immunity and detoxification, such as AST, ALT, ALP, and GGTP. …”
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Targeted protein editing technique in living mammalian cells by peptide-fused PNGase by Min Wu, Guijie Bai, Ziyi Zhang, Haixia Xiao, Wenliang Sun, Chaoguang Tian

“…This tool enables editing protein sequences post-de-N-glycosylation in living human cells, shedding light on protein N-glycosylation functions, and Asn to Asp editing in organisms. It also offers the potential for developing protein degradation technologies.…”
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Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy by Anna K. Tobiasch, Georg F. Lehner, Clemens Feistritzer, Andreas Peer, Birgit Zassler, Viktoria M. Neumair, Sebastian J. Klein, Michael Joannidis

“…Only EV-associated and functionally active TF and not TF antigen levels showed a predictive potential regarding DIC. …”
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Assessment of microstructural abnormalities in gray and white matter of minimal hepatic encephalopathy patients using diffusion kurtosis imaging and their associations with neuroco... by Qing Sun, Qing Sun, Qing Sun, Wenliang Fan, Wenliang Fan, Wenliang Fan, Yuan Liu, Yuan Liu, Yuan Liu, Zhifeng Kou, Ping Han, Ping Han, Ping Han

“…Notably, lower KFA in WM regions correlated with worse neurocognitive test scores in MHE patients. For GM, MHE patients exhibited increased volume of thalamus. …”
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Therapeutic apheresis in the complex pathogenetic therapy of anti-NMDA encephalitis associated with ovarian teratoma at a late stage of the disease by S. N. Bardakov, D. I. Skulyabin, A. N. Moshnikova, S. V. Lapin, A. A. Sokolov, E. A. Kondratyeva, T. V. Bulgakova, A. S. Manuilov, M. V. Zakharov, A. N. Belskikh, V. A. Tsargush, R. V. Deev

“…Symptom regression was achieved by the end of the first cycle, and full recovery to the initial level of cognitive functions occurred after the second cycle, while maintaining the anti‑NMDA antibody titer to 1:160. …”
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TelescopeML. II. Convolutional Neural Networks for Predicting Brown Dwarf Atmospheric Parameters by Ehsan (Sam) Gharib-Nezhad, Hamed Valizadegan, Natasha E. Batalha, Miguel J. S. Martinho, Ben W.P. Lew

“…Concurrently, all modules and functions used to train, develop, and deploy the CNNs and process the spectra are consolidated into a Python PyPI package named TelescopeML , which is publicly available along with a thoroughly documented tutorial covering installation, deployment, and core concepts.…”
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Astaxanthin Mitigates ADHD Symptoms in Spontaneously Hypertensive Rats via Dopaminergic Modulation and Brain–Gut Axis Regulation by Yueyang Leng, Ning Wu, Jing Wang, Lihua Geng, Yang Yue, Quanbin Zhang

“…Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly impacts learning, daily functioning, and personal development. Astaxanthin (ASTA), a naturally occurring antioxidant, has garnered interest as a potential therapeutic agent for various diseases, particularly in mitigating oxidative stress. …”
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Features of the formation of specific immunity after vaccination against viral hepatitis B in children and young people by E. O. Kochetova, O. V. Shamsheva, I. V. Polesko, A. V. Semenenko, O. A. Maiorova, V. V. Belyakova, V. V. Gorev

“…Thus, due to the weak response to the recombinant hepatitis B vaccine and the high medical and social significance of hepatitis B infection, various approaches are currently being developed to enhance the effectiveness of vaccination: changes in the vaccination regimen; correction of immune system functions to restore an adequate response to vaccine preparations, the use of various adjuvants, including recombinant interferons.…”
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Effect of exercise intervention on quality of life and exercise capacity in patients with atrial fibrillation: a systematic review and network meta-analysis by Yaya Xi, Yinxue Zhang, Leyao Han, Meishan Zhang, Yunyun Liu, Jingying Xiong, Yingqiao Wang, Weiping Li, Feng Bai, Minmin Cai, Xinman Dou, Xinman Dou, Xinglei Wang, Xinglei Wang

“…AE significantly improved vitality, social functioning, and mental health, with particular benefits in improving vitality.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier (CRD42024628296).…”
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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…The expression of SOX10 and CMTM7 was analyzed using quantitative real-time polymerase chain reaction and western blot. To assess cell functions, cell counting kit-8, flow cytometry, scratch test, and Transwell assays were performed. …”
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Environmental enrichment affects immunity and reduces disease severity in pigs after co-infection, with stronger effects when applied from birth than from weaning by Brigitte G. C. de Bruijn, Ingrid Danielle Ellen van Dixhoorn, J. Elizabeth Bolhuis, Jan B. W. J. Cornelissen, Norbert Stockhofe-Zurwieden, Marion Kluivers, Johanna M. J. Rebel, Johanna M. J. Rebel

“…We investigated whether environmental enrichment applied at different life stages of pigs affects the susceptibility to and severity of disease by studying immune cell functions around weaning and during nursery, the effects of infection in ex vivo models and in vivo using a co-infection model of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) followed by an Actinobacillus pleuropneumoniae infection. …”
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Supramolecular nanofibers of natural asiaticoside for self-supporting gelation and enhanced transdermal delivery by Xixi Hu, Shuang Tian, Jiao Wang, Weixi Luo, Jiangli Yao, Rui Zhu, Yiyuan Dai, Hongyun Li, Yuhua Ma, Chen Liu, Wenping Wang

“…The hydrogel’s dual functionality (pH-responsive gelation and enhanced permeation) offers a sustainable platform for the transdermal delivery of hydrophobic phytochemicals, bridging phytochemistry and nanobiotechnology. …”
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A TOPSIS based multi-objective optimal deployment of solar PV and BESS units in power distribution system electric vehicles load demand by Vinod Kumar Thunuguntla, Vijayasanthi Maineni, Satish Kumar Injeti, Polamarasetty P Kumar, Ramakrishna S S Nuvvula, C Dhanamjayulu, Mostafizur Rahaman, Baseem Khan

“…The uncertain nature of arrival time and trip distance of PHEVs are addressed using probability density functions (PDFs). The 33-bus test system consists of commercial, industrial and residential buses is taken to implement the proposed methodology. …”
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