Ion channel classification through machine learning and protein language model embeddings by Ghazikhani Hamed, Butler Gregory

“…Ion channels are critical membrane proteins that regulate ion flux across cellular membranes, influencing numerous biological functions. The resource-intensive nature of traditional wet lab experiments for ion channel identification has led to an increasing emphasis on computational techniques. …”
Get full text

Regularized K-Means Clustering via Fully Corrective Frank-Wolfe Optimization by Ahmed Yacoub Yousif, Basad Al-Sarray

“…The proposed method uses probabilistic cluster assignments to enable each data point to join multiple clusters at different membership levels, thus supporting clusters with overlapping boundaries. The Kruskal-Wallis test functions as a feature selection method to identify crucial genes, which then guide the clustering operation toward important features in high-dimensional datasets. …”
Get full text

Technical, forensic and organisational aspects of work with Monero cryptocurrency by V. V. Nosov, O. V. Manzhai, V. O. Kovtun

“…Examples of criminal offences in which Monero is used are presented. The functionality of OpenAlias to facilitate the work with Monero addresses is disclosed. …”
Get full text

Pea and Lentil Flours Increase Postprandial Glycemic Response in Adults with Type 2 Diabetes and Metabolic Syndrome by Donna M. Winham, Mariel Camacho-Arriola, Abigail A. Glick, Clifford A. Hall, Mack C. Shelley

“…Pea and lentil flours are added to baked foods, pastas, and snacks to improve nutritional quality and functionality compared to products made solely with refined wheat flour. …”
Get full text

Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells. by Anne S Fleiner, Daniel Kolnier, Nicholas Hagger-Vaughan, Johan Ræder, Johan F Storm

“…According to leading theories of access consciousness and working memory, L2/3PCs are particularly important for these cognitive functions. We found that muscarine induced long-lasting depolarising plateau potentials (PPs) and spiking following brief depolarising current injections in the L2/3PCs. …”
Get full text

Rationalization of diagnostic examination periods for metalwork elements of subway escalators by V. N. Dyatlov, D. P. Kononov

“…The main element of the subway escalator is a supporting metal structure, on which all elements, components and assemblies are installed, ensuring its functioning as a continuous lifting machine. The supporting metal structure must withstand not only its own weight and the total weight of the components and mechanisms attached to it, but also provide resistance to dynamic loads arising during their operation. …”
Get full text

Data for local decision-making, not a mere reporting requirement: development of an index to measure facility-level use of HMIS data by Jiage Qian, Solomon Shiferaw, Assefa Seme, Ousman E. Esmale, Wubshet Denboba, Elizabeth Stierman, Linnea Zimmerman, Andreea A. Creanga

“…# Background Well-functioning health management information systems (HMIS) enable decision-making at all health system levels. …”
Get full text

Behavior Modeling and Bio-Hybrid Systems: Using Reinforcement Learning to Enhance Cyborg Cockroach in Bio-Inspired Swarm Robotics by Le Minh Triet, Nguyen Truong Thinh

“…By defining precise state-action spaces and reward functions, the RL model effectively learned to influence cockroach behavior via electrical stimulation of their antennae, guiding them to perform complex navigational tasks. …”
Get full text

An Explainable AI Application (AF’fective) to Support Monitoring of Patients With Atrial Fibrillation After Catheter Ablation: Qualitative Focus Group, Design Session, and Intervie... by Wan Jou She, Panote Siriaraya, Hibiki Iwakoshi, Noriaki Kuwahara, Keitaro Senoo

“…ResultsThe final progressive web application prototype received above-average user experience evaluations and effectively motivated physicians to adopt it owing to its ease of use, reliable information, and explainable functionality. In addition, we gathered in-depth field insights from cardiologists who used the system in clinical contexts. …”
Get full text

An Enhanced Semisteady-State Jaya Algorithm With a Control Coefficient and a Self-Adaptive Multipopulation Strategy by Joshua Churchill Ankrah, Francis Boafo Effah, Elvis Twumasi

“…It also features a self-adaptive multipopulation strategy and removes absolute value operators in its update equation for improved performance. Using 20 benchmark functions, the ESJaya algorithm is compared with the traditional Jaya, SJaya, and elitism-based self-adaptive multipopulation Jaya (SAMPEJaya) algorithms. …”
Get full text

Nurses’ Knowledge and Practice of Body Mechanic Techniques at Emergency Teaching Hospitals in Erbil City/Kurdistan region – Iraq by Kameran Wzw Rasoul, Ronak Nematalah Hussain

“… Background and Objectives: Body mechanics is a term that indicates a coordinated effort between the neurological and musculoskeletal systems to maintain balance, posture, and body alignment in daily activities, which is essential for efficient bodily functioning. The study aimed to assess nurses’ knowledge and practice regarding mechanical body movement at emergency hospitals in Erbil City. …”
Get full text

Modulating bacterial nanocellulose crystallinity through post-transcriptional repression in Komagataeibacter xylinus by Rahul Mangayil, Essi Sarlin, Tom Ellis, Ville Santala

“…Bacterial nanocellulose (BC) is a versatile biomaterial, with its microstructural features fundamentally influencing its properties and functionality across various applications. Conventional BC modifying methods typically require additives or extra steps. …”
Get full text

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. by Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler, Mark J Daly

“…GRAIL offers a statistically robust approach to identifying functionally related genes from across multiple disease regions--that likely represent key disease pathways. …”
Get full text

Effect of Respiratory Muscle Stretch Gymnastic on Peak Expiratory Flow Rate, Exercise Capacity, Rate of Perceived Exertion, Pain, and Posture in Computer Workers: An Interventional... by Jil Chokshi, Ayesha Mulla, Falak Oza, Nidhi Mevada

“…It is observed that energy expenditure and pulmonary functions are compromised due to the forward head and rotated neck posture. …”
Get full text

Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate. by Yueh-Fu O Wu, Annamarie T Bryant, Nora T Nelson, Alexander G Madey, Gail F Fernandes, Holly V Goodson

“…Moreover, bioinformatic studies demonstrate that the presence of intrinsically disordered regions is conserved in key +TIPs, implying that these regions are functionally significant. Together, these results indicate that the CLIP-170 induced patches in cells are phase-separated liquid condensates and raise the possibility that the endogenous +TIP network might form a liquid droplet at MT ends or other +TIP locations.…”
Get full text

Modern Views on the Neuropeptide Oxytocin. Part I. Oxytocin Structure, Synthesis, Excretion, Regulation, Inhibition and Metabolism. Oxytocin Receptors (Review) by Elena A. Leonova, Albina A. Bakhova, Irina L. Cherednik, Yulia V. Kashina, Aleksandr N. Ardelyan

“…This article examines the modern views of scientists on the physiological effects of oxytocin and its influence on the social behaviour, psychological state and somatoautonomic functions of humans and animals. In addition, the paper looks into studies on the correlation between insufficient oxytocin production and the pathogenesis of various mental diseases. …”
Get full text

HERGAI: an artificial intelligence tool for structure-based prediction of hERG inhibitors by Viet-Khoa Tran-Nguyen, Ulrick Fineddie Randriharimanamizara, Olivier Taboureau

“…It also demonstrated superior screening power compared to virtual screening schemes that used existing scoring functions. This model, named “HERGAI,” along with relevant input/output data and user-friendly source code, is available in our GitHub repository ( https://github.com/vktrannguyen/HERGAI ) and can be used to predict drug-induced hERG blockade, even on large data sets.…”
Get full text

Physicochemical and electrical properties of DPPC bilayer membranes in the presence of oleanolic or asiatic acid by Katarzyna Karwowska, Maciej Gniadek, Wiesław Urbaniak, Aneta D. Petelska

“…Each model was modified with the tested sapogenin compounds, and the change in their physicochemical and electrical parameters was analyzed. …”
Get full text

Glucose Oxidation Performance of Zinc Nano-Hexagons Decorated on TiO₂ Nanotube Arrays by Ke Wang, Hoda Amani Hamedani

“…Zinc nanohexagons (NHexs) with a mean diameter of ~300 nm and thickness of 10–20 nm were decorated on the surface of TiO₂ NTAs (with a pore diameter of ~80 nm and tube length of ~5 µm) via an electrodeposition process using a zinc-containing deep eutectic solvent. EIS and CV tests were performed to evaluate the functionality of zinc-decorated TiO₂ NTAs (Zn/TiO₂ NTAs) for glucose oxidation applications. …”
Get full text

THE SOCIAL THEORY OF MAX WEBER IN CONFLICT OF INTERPRETATIONS by Zenonas Norkus

“…The confrontation of the system functionalism and conflict sociology during the first post-war decades led to "translation wars" in USA and gave rise to two competing images of Weber - a theorist of social order painted by T. …”
Get full text