A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12 by Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod, Ariel Ruiz i Altaba

“…Abstract The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastatic behavior, and the majority of studies have used cloned cell lines, which do not reflect primary tumor heterogeneity. …”
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The Novel PKCθ from Benchtop to Clinic by Rouba Hage-Sleiman, Asmaa B. Hamze, Lina Reslan, Hadile Kobeissy, Ghassan Dbaibo

“…Thereafter, PKCθ interacts physically and functionally with downstream effectors to mediate T cell activation and differentiation, subsequently leading to inflammation. …”
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Transportation Mode Selection Using Reinforcement Learning in Simulation of Urban Mobility by Mehmet Bilge Han Taş, Kemal Özkan, İnci Sarıçiçek, Ahmet Yazici

“…As a result of the models created using the applied reward–penalty functions, it was determined that the best means of transportation in areas with a low traffic density is cycling, and in areas with high traffic density, the optimal mode of transportation is motorbiking.…”
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Regulatory T cells define affinity thresholds for CD8+ T cell tumor infiltration by Mona O. Mohsen, Romano Josi, Sanjana V. Marar, Anish Ghimire, Lan Yang, Pascal S. Krenger, Arnau Solé Casaramona, Daniel E. Speiser, Simone De Brot, Martin F. Bachmann

“…However, combining A4Y-vaccine with Treg depletion triggered a robust immune response, characterized by increased CD8+ T cell infiltration, enhanced T cell functionality, and tumor-free survival. Infiltrating T cells also exhibited closer spatial proximity and heightened migration from blood vessels. …”
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The Perils of Perfection: Navigating the Ripple Effects of Organizational Perfectionism on Employee Misbehavior through Job Insecurity and the Buffering Role of AI Learning Self-Ef... by Byung-Jik Kim, Hyun-Joo Oh, Min-Jik Kim, Dong-gwi Lee

“…Moreover, AI learning self-efficacy functions as a moderator in the OPP–job insecurity link, such that the positive link is weaker for members with higher levels of AI learning self-efficacy. …”
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Exact Analytical Solutions for Modelling the Speed-Time Characteristics of Direct-Start Induction Machines under Various Operational Conditions on Ships: Review and Experimental Va... by Ilija Knezevic, Martin Calasan, Tatijana Dlabac, Filip Filipovic, Nebojsa Mitrovic

“…Induction machines (IMs) are crucial to driving auxiliary machinery and devices of ships, such as pumps, fans, winches, and elevators, which are essential for maintaining the operational functions of a ship and are characterised by various types of loads. …”
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Configuration and dimension optimization of active power Filter in distribution networks using a Multi-Strategy improved algorithm by Tang Bo, Liang Haidong, Yue Xiwen, Zhu Ruijin

“…Initially, based on Beluga Whale Optimization, a multi-strategy Improved algorithm is introduced, and through verification on benchmark test functions, this method effectively improves convergence speed and accuracy. …”
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SIRT3 Inhibits Cell Proliferation of Nonsmall Cell Lung Carcinoma by Inducing ROS Production by Ze Yu, Hongtao Liao, Guanhuai Wu, Ying Liu, Guoqiang Zhang, Liang Xiao, Shuibo Yang, Jia Liu, Guocai Yang

“…Conclusions Overall, our findings suggested that SIRT3 functions as a tumor suppressor that can suppress the progression of NSCLC via stimulating ROS production.…”
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Clinical and cost-effectiveness of teen online problem-solving for adolescents who have survived an acquired brain injury in the UK: protocol for a randomised, controlled feasibili... by Patricia Jane Vickery, Tamsin Ford, Fiona C Warren, Jenny Limond, Shari L. Wade, A Jeffery, Annie Hawton, Janet Smithson, Sarah Haworth, Anna-Lynne Ruth Adlam

“…Improved treatment during the acute phase has led to increased survival rates, although with life-long morbidity in terms of social and emotional functioning. This is the protocol for a feasibility randomised controlled trial with an embedded qualitative study and feasibility economic evaluation. …”
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Understanding Shock Response of Body-Centered Cubic Molybdenum from a Specific Embedded Atom Potential by Yichen Jiang, Yanchun Leng, Xiaoli Chen, Chaoping Liang

“…Nonequilibrium molecular dynamics (MD) simulations are one of the best ways to describe material behavior under shock but are limited by the availability and reliability of potential functions. In this work, a specific embedded atom (EAM) potential of molybdenum (Mo) is built for shock and tested by quasi-isentropic and piston-driven shock simulations. …”
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Improved Hermite–Hadamard Inequality Bounds for Riemann–Liouville Fractional Integrals via Jensen’s Inequality by Muhammad Aamir Ali, Wei Liu, Shigeru Furuichi, Michal Fečkan

“…The existing Hermite–Hadamard inequalities in classical or fractional calculus have been proved for convex functions, typically involving only two points as in Jensen’s inequality. …”
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Evaluation of the effectiveness of a modified liposuction protective device: an experimental study in swine by Luiz Roberto Reis Araújo, Marcelo de Paula Loureiro; Bruno Hirt, Gabriela Sgrance Cruz, Luigia Maria Nardi Santos, Mateus Herculano Bonifácio Santos

“…This study aims to create a skin protective device prototype from an old model, which serves this purpose, and to observe its functionality and its effects on the pigskin. The tests were carried out on dead animals without suffering provided by the Veterinary Medicine sector at Universidade Positivo. …”
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Hybrid harbor seal and jellyfish optimization technique for selecting the optimal location of hybrid renewable energy system by Radwa S. A. Gad, Hegazy Zaher, H. Al-Wahsh, M. H. Eid, Wael M. AlMetwaly, Islam M. Abdelqawee

“…The effectiveness of HHSJS is tested using 50 benchmark functions. Recent hourly wind speed data from two meteorological stations in Egypt: the Northwest Coast area and the New Valley Governorate. …”
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The Connection between the Toxicity of Anthracyclines and Their Ability to Modulate the P-Glycoprotein-Mediated Transport in A549, HepG2, and MCF-7 Cells by Aneta Rogalska, Marzena Szwed, Błażej Rychlik

“…This research aimed at determining the relation between the toxicity of ACL and DOX, their cell accumulation, and then effect on P-glycoprotein functionality. ACL is more cytotoxic for tumor cells compared to DOX. …”
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A high-entropy image encryption scheme using optimized chaotic maps with Josephus permutation strategy by Nawal El Ghouate, Mohamed Amine Tahiri, Ahmed Bencherqui, Hanaa Mansouri, Ahmed El Maloufy, Hicham Karmouni, Mhamed Sayyouri, Sameh Askar, Mohamed Abouhawwash

“…Key generation is enhanced with MD5 and SHA-256 hash functions, providing increased resistance to collisions and attacks. …”
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Effect of triclosan on phosphate solubilising bacteria in mangrove ecosystem: In-vitro and In-vivo by R.K. Dash, K. Kumar, S.P. Shukla, S. Kumar, S. Kumar H, S. Karmakar, T. Paul

“…Triclosan (TCS) is a widely used biocide found in medicinal, household, and personal care products, frequently detected in various environmental matrices, posing significant threats to microbial communities and overall ecosystem functioning. This study evaluates the in vivo and in vitro effects of triclosan (TCS) on phosphate-solubilising bacteria (PSB) in mangrove ecosystems. …”
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The epithelial era of asthma research: knowledge gaps and future direction for patient care by Christopher E. Brightling, Gianni Marone, Helena Aegerter, Pascal Chanez, Enrico Heffler, Ian D. Pavord, Klaus F. Rabe, Lena Uller, Del Dorscheid, the Epithelial Science Expert Group, Helena Aegerter, Arnaud Bourdin, Christopher E Brightling, Marco Caminati, Pascal Chanez, Del Dorscheid, Julia Eckl-Dorna, Ibon Eguiluz-Gracia, Enrico Heffler, Pieter Hiemstra, Gianni Marone, Oscar Palomares, Ian D. Pavord, Remo Poto, Klaus F. Rabe, Lena Uller, Gilda Varricchi

“…As an introduction to the epithelial era of research, the evolution of asthma management throughout the ages was discussed and the role of the epithelium as an immune-functioning organ was elucidated. The role of the bronchial epithelial cells in lower airway diseases beyond severe asthma was considered, as well as the role of the epithelium in upper airway diseases such as chronic rhinosinusitis. …”
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E-didactics design of differential calculus based on TPACK to overcome learning obstacles for mathematics pre-service teachers by Ika Meika, Nenden Suciyati Sartika, Asep Sujana, Jarinah Jarinah, Zaenal Hakim, Ika Safitri Windiarti, Hendra Hendra

“…The improvement in learning outcomes demonstrates the effectiveness of the e-didactics design: 52% in real number systems and functions, 74% in limits, 88% in derivatives, and 65% in the application of derivatives. …”
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Fabric integrated wearable glove with a twisted string actuator for manual handling tasks by Jinhui An, Soah Park, Jeongmin Kim, Dongun Lee, Yumin Cho, Sumin Helen Koo, Dongjun Shin

“…Abstract Wearable robotic gloves with grip-assistive functionality offer a promising solution for high-intensity manual tasks. …”
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Landscape Composition and Forest Structure Shape Phyllostomid Bat Assemblages in the Atlantic Forest Remnants by Ricardo Bovendorp, Eduardo Mariano-Neto, Albérico Queiroz, Deborah Faria

“…Conservation strategies that integrate habitat protection with sustainable land-use practices are crucial to maintaining biodiversity and the ecological functions provided by bats in this globally threatened biome.…”
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