Toward a sustained recovery of the lodging sector: a management path to lessen the Corona Variants upshots by Ola Abdel Moneim Emara, Hazem Tawfik Halim, Mohamed Samy El-Deeb, Yasser Tawfik Halim

“…The paper’s scientific value is that it functionalizes a broad inductive method of qualitative research in which a merge of the interpretation of management enabling factors and health enabling trends in the lodging sector and luxury hotel managers’ responses obtained through exploratory qualitative research is utilized to cluster the managers’ responses and thus generalize the information in the setting of a Framework for Health Crisis Management in the lodging sector. …”
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A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study by Shahzad Mumtaz, Megan McMinn, Christian Cole, Chuang Gao, Christopher Hall, Magalie Guignard-Duff, Huayi Huang, David A McAllister, Daniel R Morales, Emily Jefferson, Bruce Guthrie

“…An exemplary result for gout as an index condition is presented to demonstrate the tool’s functionality. Guideline developers from the National Institute for Health and Care Excellence and the Scottish Intercollegiate Guidelines Network provided positive feedback on the tool. …”
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Copula Approximate Bayesian Computation Using Distribution Random Forests by George Karabatsos

“…Ongoing modern computational advancements continue to make it easier to collect increasingly large and complex datasets, which can often only be realistically analyzed using models defined by intractable likelihood functions. This <i>Stats</i> invited feature article introduces and provides an extensive simulation study of a new approximate Bayesian computation (ABC) framework for estimating the posterior distribution and the maximum likelihood estimate (MLE) of the parameters of models defined by intractable likelihoods, that unifies and extends previous ABC methods proposed separately. …”
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Qizhi Jieyu Pill for the Treatment of Cerebral Infarction During the Recovery Phase: Protocol for a Randomized Controlled Clinical Trial by Xuedong An, Liangqing Yu, Yuqin Ma, Junwei Zhang, Shiping Guo, Jilong Xu, Ping Zhao, Hongyan Xu, Feng Gao, Xueqin Wu, Yanlan Gao, Yao Jiang, Yali Liu

“…The recovery phase is a critical period for patients to regain cognitive ability, memory, and motor functions and to improve their ability to perform daily activities. …”
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Computational modeling of superparamagnetic nanoparticle-based (affinity) diagnostics by Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Antoine A. Ruzette, Vlad Tereshenko, Haïzam Oubari, Haïzam Oubari, Haïzam Oubari, Yanis Berkane, Yanis Berkane, Jonathan Cornacchini, Jonathan Cornacchini, Filip Thiessen EF, Filip Thiessen EF, Filip Thiessen EF, Filip Thiessen EF, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Korkut Uygun, Korkut Uygun, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch

“…Superparamagnetic IONPs, which exhibit magnetization only in the presence of an external field, can be functionalized with ligands for targeted affinity diagnostics. …”
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Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants by Yao Peng, Yao Peng, Yao Peng, Tian-Tian Tong, Qiu-Yu Deng, Lee-Fong Yau, Jia-Qi Qiu, Qing Zhao, Jia-Qi Wu, Zhi-Qiang Xin, Man-Ci Guan, Yue Li, Zhi-Hong Jiang, Hu-Dan Pan, Hu-Dan Pan, Liang Liu, Liang Liu, Liang Liu, Jing-Rong Wang, Jing-Rong Wang

“…UHPLC-TOF MS analysis revealed unoccupied N-glycosylation sites in S1-Gamma (N657), S1-Delta (N61), and S1-Lambda (N17, N61, N657), with N17 and N61 showing low glycan occupancy (0%-3.4%), suggesting these sites may lack glycan shield protection.DiscussionThis study provides a comprehensive N-glycosylation profile of the S1 protein across different variants, offering an essential structural basis for future vaccine development and research on viral functions.…”
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Multiomics insights into BMI-related intratumoral microbiota in gastric cancer by Kang Liu, Zhengchen Jiang, Zhengchen Jiang, Yubo Ma, Ruihong Xia, Yingsong Zheng, Kailai Yin, Chuhong Pang, Li Yuan, Li Yuan, Xiangdong Cheng, Xiangdong Cheng, Zhuo Liu, Bo Zhang, Shi Wang

“…This study aimed to compare and analyze the differences in and functions of intratumoral microbiota among GC patients with varying BMIs, aiming to ascertain whether specific microbial features are associated with prognosis in low-BMI (LBMI) gastric cancer patients.MethodsA retrospective analysis of the clinicopathological features and prognosis of 5567 patients with different BMIs was performed between January 2010 and December 2019. …”
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Features of hydration of the composite system based on methyl silica AM-1 and dispersed Amanita muscaria mushrooms by T. V. Krupska, A. M. Datsiuk, M. I. Terebinska, S. O. Tellis, N. V. Vitiuk, I. V. Laguta, Qiliang Wei, Jinju Zheng, Weiyou Yang, V. V. Turov

“…At the same time, it performs several functions at once: mechanically separates particles of biomaterial from each other, which prevents them from caking and becoming infected with fungal spores; transforms interfacial water into a clustered state (radius of water clusters 1–50 nm), which is characterized by excess free energy, and due to air microbubbles, does not allow rapid desorption of biologically active substances into the aqueous environment. …”
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First results of long-term follow-up of children in Russia after gene therapy for hereditary retinal dystrophies associated with biallelic mutations in the RPE65 gene by V. V. Neroev, L. A. Katargina, M. P. Kharlampidi, L. V. Kogoleva, I. V. Zolnikova, P. A. Ilyukhin, E. V. Denisova, S. V. Milash, N. A. Osipova, S. I. Kutsev, A. V. Polyakov, R. A. Zinchenko, V. V. Kadyshev, Yu. A. Bobrovskaya

“…The results of a one-year post VN treatment follow-up of Russian patients with RPE65-associated inherited retinal disease demonstrate stabilization and improvement of visual functions, which is especially important for otherwise incurable patients with a progressive course of the disease.…”
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Decreased Protein C Pathway Activity in COVID-19 Compared to Non-COVID Sepsis: An Observational and Comparative Cohort Study by Heiko Rühl, Christian Bode, Tobias Becher, Sebastian Eckert, Ghaith Mohsen, Hannah L. McRae, Jens Müller, Sara Reda, Dirk Loßnitzer, Johannes Oldenburg, Christian Putensen, Bernd Pötzsch

“…This study assessed the functionality of this pathway in COVID-19 and non-COVID sepsis by measuring its key enzymes, thrombin and activated PC (APC). …”
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Multi-omics analysis reveals the role of ribosome biogenesis in malignant clear cell renal cell carcinoma and the development of a machine learning-based prognostic model by Zhouzhou Xie, Zhouzhou Xie, Shansen Peng, Shansen Peng, Jiongming Wang, Jiongming Wang, Yueting Huang, Yueting Huang, Xiaoqi Zhou, Xiaoqi Zhou, Guihao Zhang, Guihao Zhang, Huiming Jiang, Huiming Jiang, Kaihua Zhong, Kaihua Zhong, Lingsong Feng, Lingsong Feng, Nanhui Chen, Nanhui Chen

“…However, its role in ccRCC pathogenesis and prognosis remains poorly defined.MethodsWe integrated bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptomics sequencing data to dissect the biological functions and clinical relevance of Ribosis-related genes in ccRCC. …”
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The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis by Xiaoxi Fan, Zhenfeng Cheng, Ruiyin Shao, Keke Ye, Xudong Chen, Xueli Cai, Shanshan Dai, Zhixuan Tang, Si Shi, Wenyuan Zheng, Weijian Huang, Jibo Han, Bozhi Ye

“…Mechanistically, GI‐Y2 directly interacts with the Arg10 residue of GSDMD and reduces the membrane binding of GSDMD‐N. Functionally, we revealed that GI‐Y2 inhibits the formation of atherosclerotic plaques by targeting GSDMD. …”
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Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes by Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman, Júlia Faura, Sara Alidadiani, Claudia Schrauwen, Billie J. Matchett, Bavo Heeman, Marleen Van den Broeck, Wouter De Coster, Thuy Nguyen, Julie S. Lau, Saurabh Baheti, Tim de Pooter, Peter De Rijk, Mojca Strazisar, Matt Baker, Mariely DeJesus-Hernandez, NiCole A. Finch, Cyril Pottier, Marka van Blitterswijk, Yan Asmann, Melissa E. Murray, Leonard Petrucelli, Andrew King, Claire Troakes, Safa Al-Sarraj, Robert A. Rissman, Annie Hiniker, Margaret Flanagan, Bret M. Evers, Charles L. White, Carlos Cruchaga, Rudolph Castellani, Jeroen G.J. van Rooij, Merel O. Mol, Harro Seelaar, John C. van Swieten, Björn Oskarsson, Robert Ross Reichard, Aivi T. Nguyen, Keith A. Josephs, Ronald C. Petersen, Nilüfer Ertekin-Taner, Bradley F. Boeve, Neill R. Graff-Radford, Sarah Weckhuysen, Dennis W. Dickson, Rosa Rademakers

“…Abstract Background In the last decade, the importance of DNA methylation in the functioning of the central nervous system has been highlighted through associations between methylation changes and differential expression of key genes involved in aging and neurodegenerative diseases. …”
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Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…These conditions can have lasting consequences on their wellbeing, ability to return to their pre-illness level of functioning and health-related quality of life. There is a paucity of South African data in terms of the psychological aspects of the post-intensive care unit (ICU) syndrome. …”
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The role of proline P325 residue in the recognition of the MX35 epitope of the sodium-dependent phosphate transporter NaPi2b by monoclonal antibodies in ovarian carcinoma cells by L. F. Bulatova, I. A. Slidzuk, A. V. Kilunov, V. S. Skripova, R. G. Kiyamova

“…One of the key components of cell membranes are membrane proteins, which provide a wide range of functions – from transport and signal transmission to coordination of intercellular interactions. …”
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Postgraduate Clinical Residency: The Impact of Multiple-Choice Question Quality on Exam Success Rates by Mohammed OEAH, Srinivasamurthy SK, Bhat R, Alhassan YAM, Hamdy Elshamly HA, Mohammed F, Hamad B

“…MCQs were evaluated using standard item analysis parameters: questions were considered acceptable range if they had a difficulty index (DIF) between 0.30– 0.70, a discrimination index ≥ 0.2, and at least two functioning distractors.Results: Out of 175 candidates who appeared for the QRE, only 19 (10.86%) passed. …”
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D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation by Honglin Liu, Huimin Huang, Zhen Huang, Yingxuan Chen, Deyou Tan, Xiaoni Wang, Xiaoni Pang, Shuwen Chen, Lianhui Liang, Haihui Yang

“…Conclusion Our findings suggest that PC‐PLC plays a critical role in the functionality of DCs, including the production of chemokines and pro‐inflammatory cytokines, migration to lymph nodes, and antigen presentation to T cells, which collectively contribute to T cell activation and effective clearance of Mycobacterium tuberculosis. …”
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Long-Term Outcomes Associated with Traumatic Brain Injury in Childhood and Adolescence: A Nationwide Swedish Cohort Study of a Wide Range of Medical and Social Outcomes. by Amir Sariaslan, David J Sharp, Brian M D'Onofrio, Henrik Larsson, Seena Fazel

“…TBI exposure was associated with elevated risks of impaired adult functioning across all outcome measures. After a median follow-up period of 8 y from age 26 y, we found that TBI contributed to absolute risks of over 10% for specialist diagnoses of psychiatric disorders and low educational attainment, approximately 5% for disability pension, and 2% for premature mortality. …”
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Enhancing Food Safety: Adapting to Microbial Responses Under Diverse Environmental Stressors by Imran Mohammad, Mohammed Sarosh Khan, Mohammad Rizwan Ansari, Mohammad Azhar Kamal, Mohammad Nadeem Bari, Mohammad Anwar

“…At the same time, microbial adaptation is an integral part of ecosystem functioning, profoundly influencing processes such as nutrient cycling, decomposition, and soil fertility. …”
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Regarder au-delà des élections : l’historicité complexe de la participation politique dans la Libye contemporaine by Chiara Loschi, Chiara Pagano

“…To shed light on the current political scenario, we propose here to reconsider the political from below, and namely by looking where only disruptions to the neo-liberal model of functioning democracies have been detected so far - and thus in most manifestations referred to as 'chaos', 'statelessness' or absence of 'political culture'. …”
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