Size-dependent effects of oxo-degradable plastic contamination on soil quality and the growth of Zea mays by Do Thi Kim THANH, Robert W. BROWN, Martine GRAF, Michaela K. REAY, Charlotte E. M. LLOYD, Gupeng LI, David R. CHADWICK, Davey L. JONES

“…These findings indicate that at realistic field concentrations, ODPs are likely to have little effect on agroecosystem functioning in the short-term but might persist in soil for long periods of time, leading to their progressive accumulation in agricultural soils if used over repeated cropping cycles.…”
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An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont by Stephen Lu, David M. Bland, Eric Dahlstrom, Neelam Redekar, Melina G. Guizzo, Kent Barbian, B. Joseph Hinnebusch, José M. C. Ribeiro

“…Results Sequencing data from both long and short reads were assembled into 7,694 contigs, from which 95,638 putative coding sequences (CDSs) were extracted and functionally annotated, providing insights into various aspects of flea physiology. …”
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Chicken chemerin alone or in mixture with adiponectin-visfatin impairs progesterone secretion by primary hen granulosa cells by Ophélie Bernardi, Mathias Fréville, Christelle Ramé, Maxime Reverchon, Joëlle Dupont

“…ABSTRACT: Adipokines including adiponectin (ADIPO), chemerin (CHEM) and visfatin (VISF) are involved in metabolism and reproductive functions. These 3 adipokines are present in ovarian cells in different preovulatory follicles in hens. …”
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The process of nitrogen-adaptation root endophytic bacterial rather than phosphorus-adaptation fungal subcommunities construction unveiled the tomato yield improvement under long-t... by Xiaoxia Li, Xiaoxia Li, Xiaoxia Li, Muhammad Awais, Muhammad Awais, Muhammad Awais, Shuang Wang, Shuang Wang, Shuang Wang, Shuang Wang, Zhu Zhang, Zhu Zhang, Zhu Zhang, Shuning Zhao, Shuning Zhao, Shuning Zhao, Yufeng Liu, Yufeng Liu, Yufeng Liu, Zhouping Sun, Zhouping Sun, Zhouping Sun, Hongdan Fu, Hongdan Fu, Hongdan Fu, Tianlai Li, Tianlai Li, Tianlai Li

“…Rare bacterial and fungal subcommunities complemented the ecological niches of abundant subcommunities in the co-occurrence network, supporting community functions and enhancing network stability. Nitrogen-adapting abundant and rare bacterial subcommunities provided a stronger predictive correlation for tomato yield than phosphorus-adapting fungal subcommunities. …”
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Comprehensive Analysis of the Complete Mitochondrial Genome of <i>Paeonia ludlowii</i> Reveals a Dual-Circular Structure and Extensive Inter-Organellar Gene Transfer by Zhefei Zeng, Zhengyan Zhang, Ngawang Norbu, Ngawang Bonjor, Xin Tan, Shutong Zhang, Norzin Tso, Junwei Wang, La Qiong

“…This multipartite genome structure is characterized by abundant repetitive elements (112 functionally annotated SSRs, 33 tandem repeats, and 945 dispersed repeats), which potentially drive genome rearrangements and facilitate adaptive evolution. …”
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FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…Mouse orthotopic HCC models and a coculture system were constructed, and cytometry by time-of-flight analysis was performed to investigate the functions and mechanisms of specific CAFs in the immune context of HCC.Results We identified a distinct flavin-containing monooxygenase 2 (FMO2)+ CAF subset associated with a favorable response to anti-PD-1 therapy and better clinical outcomes. …”
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Thinning intensity influences the C:N:P stoichiometry in forest ecosystems: A global synthesis by Chongwei Fan, Guiyao Zhou, Hongyang Chen, Zhenggang Du, Ruiqiang Liu, Yanghui He, Changjiang Huang, Shuying Qiu, Yimin Zhu, Jie Li, Xuhui Zhou

“…Future forest management could implement an appropriate forest thinning intensity to ensure ecosystem functionality and maintain the balance and stability of ecosystem elements.…”
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Validity and reliability of the diagnostic codes for hypochondriasis and dysmorphophobia in the Swedish National Patient Register: a retrospective chart review by David Mataix-Cols, Oskar Flygare, Volen Z Ivanov, Christian Rück, Lorena Fernández de la Cruz, Kayoko Isomura, Jens Högström, Daniel Rautio, Alba Vilaplana-Pérez, Martina Gumpert, Johanna Linde, Susanna Österman, Josef Isung, Sonja Krig

“…Raters also completed the Clinical Global Impression–Severity (CGI-S) and the Global Assessment of Functioning (GAF).Primary outcome measure Per cent between-rater agreement and positive predictive value (PPV). …”
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SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice by Huahai Chen, Huahai Chen, Huahai Chen, Huahai Chen, Huahai Chen, Liu Wu, Liu Wu, Xiongyu Cao, Xiongyu Cao, Zongyan Li, Zongyan Li, Renjun Zhu, Renjun Zhu, Xiaojing Wang, Jun Li, Jun Li, Jun Li, Zuzhang Wei, Zuzhang Wei, Dengfeng Yang, Dengfeng Yang, Dengfeng Yang, Yeshi Yin, Yeshi Yin

“…Given this, the present study specifically examined the functions of SFB flagellin in bacterial adhesion, cellular internalization, and immune modulation.MethodsLactococcus lactis and Escherichia coli were engineered to express murine and rat SFB flagellin genes. …”
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Genome-wide association study reveals the genetic basis of vitamin C content in rapeseed (Brassica napus L.) seedlings by Chao Wang, Lieqiong Kuang, Ze Tian, Xinfa Wang, Xinfa Wang, Hanzhong Wang, Hanzhong Wang, Xiaoling Dun

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses of the 2365 annotated genes near associated SNPs revealed significant involvement in diverse metabolic pathways including peroxisome, ascorbate, secondary metabolites, and terpenoid biosynthesis, as well as biological processes such as hydrogen peroxide/lactate metabolism and ROS biosynthesis, along with associations with specific cellular components and molecular functions. Furthermore, we identified six candidate genes that exhibit significant differences in expression between low and high Vc accessions, which are potentially involved in Vc biosynthesis but require further experimental validation. …”
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Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer by Yongzhi Wu, Chengen Deng, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Weizhong Tang, Xiaoliang Huang

“…Furthermore, using transcriptome data from 23 CRC patients, we constructed an immune cell infiltration matrix to deeply explore the biological functions associated with LNM. Eventually, using the characteristics of the gut microbiota associated with LNM, we developed random forest (RF) and multilayer perceptron (MLP) machine learning models to predict the LNM status of CRC patients. …”
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Phase 1 trial of durvalumab (anti–PD-L1) combined with lenalidomide in relapsed/refractory cutaneous T-cell lymphoma by Christiane Querfeld, Joycelynne Palmer, Zhen Han, Xiwei Wu, Yate-Ching Yuan, Min-Hsuan Chen, Chingyu Su, Ni-Chun Tsai, D. Lynne Smith, Samantha N. Hammond, Liliana Crisan, Joo Y. Song, Raju Pillai, Steven T. Rosen, Jasmine Zain

“…Abstract: Selective targeting of the functionally exhausted malignant T cells in cutaneous T-cell lymphoma (CTCL) and distinct cells within the tumor microenvironment (TME) via programmed cell death 1/programmed cell death ligand 1 blockade (durvalumab) may restore an antitumor immune response. …”
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Prevalence of hepatitis B virus infection and associated factors among students living on campus in South-eastern Gabon by Augustin Mouinga-Ondeme, Moussa Yaro, Guy-Roger Ndong Atome, Madeleine Meba, Neil Michel Longo-Pendy, Roseanne Mounanga Mourimarodi, Christ Eddy Ognari Ayoumi, Abdoulaye Diane, Jeordy Dimitri Engone-Ondo, Eldridge Fedricksen Oloumbou, Ivan S. Mfouo Tynga

“…Abstract Background The Hepatitis B-virus is the etiological agent of an infection that affects liver functions and potentially causes disorders. Approximately, 300 million people are living with acute or chronic HBV-infections worldwide, and only a fraction of them have access to medical care. …”
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Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis by Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibáñez, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno

“…This blood supply is structured into three main arterial groups, each serving different regions of the pancreas to effectively support its endocrine and exocrine functions. <i>Materials and Methods</i>: The databases Medline, Scopus, Web of Science, Google Scholar, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Latin American and the Caribbean Literature in Health Sciences (LILACS) were searched until January 2025. …”
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Transcriptomic Differences by RNA Sequencing for Evaluation of New Method for Long-Time In Vitro Culture of Cryopreserved Testicular Tissue for Oncologic Patients by Cheng Pei, Plamen Todorov, Qingduo Kong, Mengyang Cao, Evgenia Isachenko, Gohar Rahimi, Frank Nawroth, Nina Mallmann-Gottschalk, Wensheng Liu, Volodimir Isachenko

“…Background: Earlier studies have established that culturing human ovarian tissue in a 3D system with a small amount of soluble Matrigel (a basement membrane protein) for 7 days in vitro increased gene fusion and alternative splicing events, cellular functions, and potentially impacted gene expression. …”
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Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration by Annika Breuer, Delara Kamalizade, Tobias Baumgartner, Juliane L. Berns, Thoralf Opitz, Franziska S. Thaler, Susanne Schoch, Lars Komorowski, Christoph Helmstaedter, Rainer Surges, Albert J. Becker, Julika Pitsch

“…Limbic encephalitis was more often diagnosed in anti-CN1A/anti-GAD65-positive compared to the anti-GAD65-positive patients. Functionally, incubation of primary hippocampal neurons with anti-GAD65, but not with anti-CN1A, resulted in uptake into GABAergic neurons, neuronal cell death, and increased neuronal network activity. …”
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Substituting ethoxyquin with tea polyphenols and propyl gallate enhanced feed oxidative stability, broiler hepatic antioxidant capacity and gut health by Yong Xiao, Xuyang Gao, Jianmin Yuan

“…This study evaluated the effects of partially substituting ethoxyquin with tea polyphenols and propyl gallate on feed oxidative stability, hepatic antioxidant properties, intestinal morphology and barrier functions, as well as the antioxidant and anti-inflammatory profiles of the intestinal mucosa in broilers. …”
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Influence of load-bearing wall material properties on building mine-induced dynamic response by Maciej Zajac, Krystyna Kuzniar, Tadeusz Tatara

“…They may also face extreme conditions, such as seismic activity, which can threaten their safety and functionality. Few publications address how construction material choice affects a building’s dynamic response to seismic impacts, including mining tremors. …”
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The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation. by Mark Jeffries, Nde-Eshimuni Salema, Libby Laing, Azwa Shamsuddin, Aziz Sheikh, Anthony Avery, Antony Chuter, Justin Waring, Richard N Keers

“…Engagement between stakeholders was considered important for the intervention in ensuring prescribers continued to utilise its functionality. Sustained implementation might be enhanced by careful profile management of the suite of alerts in the system. …”
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CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants by Na Qiu, Akshaya Srikanth, Medhanie Mulaw, Umesh Tharehalli, Shanthiya Selvachandran, Martin Wagner, Thomas Seufferlein, Katja Stifter, André Lechel, Reinhold Schirmbeck

“…HBV developed immune-suppressive functions to escape from the host immune system, but their link to liver tumor development is not well understood. …”
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