Identification of C/EBPα as a novel target of the HPV8 E6 protein regulating miR-203 in human keratinocytes. by Anna M Marthaler, Marta Podgorska, Pascal Feld, Alina Fingerle, Katrin Knerr-Rupp, Friedrich Grässer, Hans Smola, Klaus Roemer, Elke Ebert, Yoo-Jin Kim, Rainer M Bohle, Cornelia S L Müller, Jörg Reichrath, Thomas Vogt, Magdalena Malejczyk, Sławomir Majewski, Sigrun Smola

“…In conclusion our study has unraveled a novel p300/C/EBPα/mir-203-dependent mechanism, by which the cutaneous HPV8 E6 protein may expand p63-positive cells in the epidermis of EV-patients and disturbs fundamental keratinocyte functions. This may drive HPV-mediated pathogenesis and may potentially also pave the way for skin carcinogenesis in EV-patients.…”
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Population responses of Chinook salmon to two decades of restoration of estuary nursery habitat by Correigh M. Greene, Eric M. Beamer, Stuart H. Munsch, Joshua W. Chamberlin, Michael T. LeMoine, Joseph H. Anderson

“…These findings provide empirical support for restoring estuaries in human-stressed landscapes to rehabilitate nursery habitat functions for Chinook salmon and, potentially, other species and life stages.…”
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Arsenic Trioxide Enhances the Efficacy of PD‐1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway by Xionghui Wang, Simo Cheng, Yannan Xu, Tianxiao Zheng, Changquan Ling, Juan Du

“…ATO‐treated HCC cells exhibited enhanced immunogenicity, functioning as prophylactic and therapeutic vaccines to stimulate antitumor immunity. …”
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Negative effects of forest harvest on coastal tailed frog (Ascaphus truei) emerge after a decade‐long experiment by Aimee P. McIntyre, Reed Ojala‐Barbour, Jay E. Jones, Andrew J. Kroll, Eric M. Lund, Timothy Quinn, William J. Ehinger, Stephanie M. Estrella, Dave E. Schuett‐Hames, Marc P. Hayes

“…Abstract Perennial, low‐order headwater streams provide critical ecosystem functions, including habitat for specialized aquatic species. …”
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Co-Designed Mobile-Based Cognitive Training for Older Chinese Americans: Protocol for a Pilot Randomized Controlled Trial Assessing Feasibility and Acceptability by Tingzhong Xue, Aybey Amy Wei, Bei Wu, Camilla Sanders, Eleanor Schildwachter McConnell, Hanzhang Xu

“…Global cognition, mental health, physical functioning, and quality of life will be assessed at baseline, 8, and 12 weeks. …”
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Peranan Tanaman terhadap Pencemaran Udara di Jalan Protokol Kota Semarang by Nana Kariada Tri Martuti

“…It was presumed that the kind and the number of plants along each ain road in Semarang was not appropriately functioning as the absorbants of the air pollutants.…”
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Numerical Simulation and Optimization of Water Hammer Protection Schemes for Long-Distance Gravity-Pressurized Water Conveyance Systems by HUANG Wei, LIAO Chen-xi, HUANG Xin, GU Ping, LIU Bin, HUANG Zi-yang

“…[Conclusions] The air valve surge chamber, combining a surge pipe and an air valve with both water and air compensation functions, is used in combination with an air valve to form a protection scheme that effectively controls both positive and negative pressures in the pipeline. …”
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Perennial disaster patterns in Central Europe since 2000 and implications for hospital preparedness planning – a cross-sectional analysis by Maik von der Forst, Maximilian Dietrich, Felix C. F. Schmitt, Erik Popp, Markus Ries

“…Disaster planning for hospitals is crucial to ensure their functionality under special circumstances. But the impact of climate change and seasonal variations in the utilization of hospital services are raising challenges. …”
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Correlations between expression levels of genes encoding multifunctional YB-1 protein, inflammatory cytokines and multidrug resistance P-gp protein in surgical material from patien... by M. V. Erokhina, E. N. Pavlova, E. A. Scherbakova, E. Yu. Rybalkina, L. N. Lepekha, R. V. Tarasov, E. K. Tarasova

“…We suggest that the YB-1 protein can potentially have different functions: (1) being a participant in tuberculous inflammation via the cytokine expression; (2) modulating the P-gp activity and changing the pharmacokinetics of anti-tuberculosis drugs, thus requiring future studies.…”
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Determinação da condutividade hidráulica e da sorvidade de um solo com infiltrômetro a disco Determination of hydraulic conductivity and sorptivity of soil using a disk infiltromet... by Antonio C. D. Antonino, Rafael Angulo-Jaramillo, Eduardo S. de Souza, André Maciel Netto, Clemente J. G. Carneiro, Abelardo A. A. Montenegro

“…These methods based on the previous knowledge of the soil-moisture characteristic curve, which were obtained by the adjustment of the functions proposed by each method. The equation of cumulative infiltration described with precision the infiltration experiments, and yielded determination coefficients (R²) greater than 0.995. …”
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The optimal system of care for the management of delayed sleep onset in adult ADHD in the UK: a modified Delphi consensus by Philip Asherson, Giovanni Giaroli, Paul Gringras, Heidi Phillips, Hugh Selsick, Michael Smith, Dietmar Hank

“…The presence of a sleep disorder can exacerbate ADHD symptoms and impair cognitive functions. Despite the significance of these issues, they are often overlooked, potentially leading to unsafe self-medication practices and illicit substance abuse. …”
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The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination by Jie Yang, Zhongfei Jia, Juan Li, Chao Jiang, Xin Zhao, Yuxiang Wang, Xiaoguo Ma, Xinjian Xu

“…Conclusions This study demonstrates the functionality of SH3RF2 in both potentiating tumor progression and inducing M2 macrophage polarization through coordinated regulation of LZTS2 degradation and β-catenin nuclear translocation. …”
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Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E by Junqian Zhang, Xiaobo Zhang, Ruixin Wu, Chang-Sheng Dong

“…The by-products of purine metabolic reprogramming are extensively engaged in tumor immune modulation, influencing the functions and recruitment of immune cells and molding an immune microenvironment that is propitious for tumor growth.MethodsWe harnessed single-cell transcriptomics and spatial transcriptomics to concurrently analyze the purine metabolism (PM) features of the PC microenvironment. …”
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Reduced apple crop density enhances total polyphenol accumulation via upregulation of anthocyanidin reductase and other phenylpropanoid pathway genes by Shanthanu Krishna Kumar, Kamal Tyagi, Michael Brown, Lailiang Cheng, Zhangjun Fei, Gregory Peck

“…The transcriptome profile of the low crop density ‘Porter’s Perfection’ treatment indicated that genes encoding enzymes that catalyze critical functions in the phenylpropanoid pathway such as hydroxylation, methylation, and glycosylation were upregulated compared to the control at 27 DAFB and 81 DAFB. …”
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Differential neuropilin isoform expressions highlight plasticity in macrophages in the heterogenous TME through in-silico profiling by Hyun-Jee Han, Marcos Rubio-Alarcon, Thomas Allen, Sunwoo Lee, Taufiq Rahman

“…Coupled with the previously uncharacterised NRP isoform specific- subpopulations within these cancers identified by DEGA, co-enrichment analyses demonstrated that the upregulation of gene-sets associated with NRP1 is associated with angiogenesis and tumour progression through VEGF signalling, while gene-sets with NRP2 showed dual functionality in the TME-dependent manner. Their distinct roles in regulating macrophage plasticity, tumour invasion, and metastasis were highlighted.DiscussionThese findings underscore distinct isoform-specific mechanisms by which NRP1 and NRP2 contribute to TAM-mediated cancer progression. …”
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Psychometric evaluation of the Chinese version of the Patient Self-Advocacy Scale using classical test theory and item response theory by Jialu Cui, Jing Wang, Ailin Yue, Jiayan Cao, Zhijie Zhang, Baoxin Shi

“…The Wright map showed good matching between item difficulty and person ability. Differential item functioning (DIF) analysis revealed no significant differences across gender. …”
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Summarizing Online Patient Conversations Using Generative Language Models: Experimental and Comparative Study by Rakhi Asokkumar Subjagouri Nair, Matthias Hartung, Philipp Heinisch, Janik Jaskolski, Cornelius Starke-Knäusel, Susana Veríssimo, David Maria Schmidt, Philipp Cimiano

“…Furthermore, the results hold only for the examined models and prompting strategies, potentially not generalizing to other models and strategies.…”
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Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…ABSTRACT Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era. CdnP (Rv2837c) functions as a bifunctional oligoribonuclease and 3′(2′)-phosphoadenosine 5′-phosphate-phosphatase that impedes host immune responses by recognizing bacterial cyclic dinucleotides such as c-di-AMP, which serve as pathogen-associated molecular patterns. …”
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Effects of Mango Seed (<i>Mangifera indica</i>) Powder on Growth Performance, Immune Response, Gut Morphology, and Gene Expression of Nile Tilapia (<i>Oreochromis niloticus</i>) by Camilla Maria Fontana, Md Afsar Ahmed Sumon, Supreya Wannavijit, Anisa Rilla Lubis, Nuttapon Khongdee, Nguyen Vu Linh, Yuthana Phimolsiripol, Seyed Hossein Hoseinifar, Hien Van Doan

“…These results emphasize mango seed (MS) as a promising natural supplement for improving the diet of Nile tilapia and, potentially, other freshwater fish widely used in aquaculture.…”
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3D graphene paper-based tandem metal-free thin-film supercapacitors with integrated 200 V output by Huilong Liu, Litian Gan, Renji Chen, Zhiwen Xiao, Yun Chen, Hongzuo Yang, Yahang Liu, Baisheng Wu, Ching-Ping Wong, Xin Chen

“…The active area of electrodes is defined by a PI mask, with the help of which a hydrogel electrolyte functions as a separator. The assembled graphene paper-based TFSCs demonstrate outstanding electrochemical performance and mechanical flexibility, with the areal capacitance of 54.5 mF·cm ^−2 , energy density of 10.9 μWh·cm ^−2 , and cycle stability retention of 86.9% over 15 000 cycles. …”
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