A lactate-related tSNE signature defines prognostic subtypes of bladder cancer and reveals LINC01094-mediated VIM stabilization in metastasis and drug resistance by Pu Zhang, Hegan Zhang, Wanli Yu, Dage Fan, Yao Pan, Wei Zhuang, Fangzhen Cai, Qingliu He

“…This score demonstrated prognostic value and was integrated into a nomogram confirmed by a calibration curve. Functionally, higher tSNE scores correlated with immune- and inflammation-related pathways, as well as with immunotherapy efficacy in BLCA. …”
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The use of linear programming approach in diet optimization among children under five: a scoping review by Yee Xuen Miow, Wilfred Kok Hoe Mok, Wan Ying Gan, Poh Ying Lim, Geeta Appannah, Siti Nur ‘Asyura Adznam

“…Results Fourteen studies were included after a systematic literature search. The objective functions and the final set of FBRs of the included studies were summarized. …”
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Bizarre behavior during intracarotid sodium amytal testing (Wada test): are they predictable? Reações bizarras durante o teste do amital sódico intracarotídeo (TASI ou Teste de Wad... by Luciano de Paola, Maria Joana Mäder, Francisco M.B. Germiniani, Patrícia Coral, Jorge A.A. Zavala, Djon J. Watzo, Jorge Kanegusuku, Carlos E.S. Silvado, Lineu C. Werneck

“…Its goal is to promote selective and temporary interruption of hemispheric functioning, seeking to define language lateralization and risk for memory compromise following surgery. …”
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Lipid-Polymer Hybrid Nanoparticles as a Smart Drug Delivery System for Peptide/Protein Delivery by Alharith A. A. Hassan, Eslam Ramadan, Katalin Kristó, Géza Regdon, Tamás Sovány

“…Recently, lipid-polymer hybrid nanoparticles (LPHNs) have emerged as an advanced solution combining the structural stability of polymers and the biocompatibility and surface functionalities of lipids to enhance the controlled release, stability, and bioavailability of protein and peptide drugs. …”
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VIBE: an R-package for VIsualization of Bulk RNA Expression data for therapeutic targeting and disease stratification by Indu Khatri, Saskia D. van Asten, Leandro F. Moreno, Brandon W. Higgs, Christiaan Klijn, Christiaan Klijn, Francis Blokzijl, Iris C. R. M. Kolder

“…VIBE’s versatility proves pivotal for disease stratification and therapeutic targeting in cancer and other diseases.ResultsVIBE offers a wide array of functions that streamline the visualization and analysis of transcriptomic data for single- and dual-targeting therapies. …”
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Technology-Enabled Workplace Learning Through Rethinking Electronic Health Records to Support Performance Feedback: Protocol for a Mixed Methods Study by Anna Janssen, Mia Nazir

“…Phase 2 will involve surveying health care professionals about specific EHR features, and phase 3 will encompass workshopping discussions around EMR functionality and design with key informants. Participants for phases 1 and 2 will be a convenience sample of health care professionals who self-select and volunteer to participate in the study. …”
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Resilience testing in action – piloting the health system resilience testing tool with a pandemic scenario in Finland by Liina-Kaisa Tynkkynen, Soila Karreinen, Markku Satokangas, Marjaana Viita-aho, Ilmo Keskimäki, Julia Zimmermann, Philip Haywood, Jonathan Cylus, Marina Karanikolos

“…Conclusions The main benefit of the resilience testing methodology is the ability to bring key actors together to exchange different perspectives on how a health system functions during a crisis. The discussions at the high-level dialogue revealed the need for a mechanism, such as a resilience testing tool, to elucidate the range of practical challenges and how to potentially address them. …”
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Dietary inclusion of Hermetia illucens larvae meal modifies caecal microbiota diversity and composition in barbary partridges (Alectoris barbara) by Elie Atallah, Tiziana Maria Mahayri, Jakub Mrázek, Fulvia Bovera, Giovanni Piccolo, Kateřina Olša Fliegerová, Giuseppe Moniello

“…Several of these taxa are associated with gut health, fiber fermentation, and metabolic functions, indicating a biological importance of the observed microbial shifts. …”
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Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology. by Fanggeng Zou, Olivia Belbin, Olivia Belbin, Minerva M Carrasquillo, Oliver J Culley, Talisha A Hunter, Li Ma, Gina D Bisceglio, Mariet Allen, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Kevin Morgan, Steven G Younkin

“…In summary, we hypothesise that GAB2 variants that are protective against LOAD in some populations may act functionally to increase GAB2 mRNA levels (in lymphoblastoid cells) and that increased GAB2 mRNA levels are associated with significantly decreased LOAD pathology. …”
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PO68 | Whole blood hypercoagulable profiles in a patient with markedly elevated lipoprotein(A) plasma levels and thrombotic complications: a case report

“…The possible role of whole blood rotational thromboelastometry and impedance aggregometry to evaluate hemostatic system functions in these patients is unknown. Case Report: A 64-year-old woman with arterial hypertension and type 2 diabetes complicated by chronic kidney disease since the age of 45 yrs, was referred to our department to study her extensive ASCVD. …”
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Evaluation of the effectiveness of combination therapy for post-occlusive retinal changes by A.G. Shchuko, S.I. Zhukova, M.V. Akulenko

“…The volume of therapeutic measures in patients with macular edema on the background of BRVO and the possibility of improving visual functions depends not only on the degree of ischemia of the peripheral retina, but also on the initial area of ischemia of the macular zone according to OCT angiography, the amplitude of the b-wave ERG and oscillatory potentials, which can be considered as markers that allow predicting the effectiveness of combined therapy of post-occlusive retinal changes.…”
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Development of a novel SupraChoroidal-to-Optic-NervE (SCONE) drug delivery system by Bryce Chiang, Kathleen Heng, Kyeongwoo Jang, Roopa Dalal, Yaping Joyce Liao, David Myung, Jeffrey L Goldberg

“…In eyes with successful SCONE delivery, latency and amplitude of visual evoked potentials was not different than the naïve untreated eye.Conclusions SCONE delivery can be used for targeted drug delivery to the optic nerve head of rabbits without measurable toxicity measured anatomically or functionally. …”
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The role of neutrophil extracellular traps in cancer progression and thrombosis development by J. Kh. Khizroeva, Z. D. Aslanova, A. G. Solopova, V. O. Bitsadze, А. V. Vorobev, А. Yu. Tatarintseva, J.-С. Gris, I. Elalamy, N. А. Makatsariya, D. V. Blinov

“…NETs components (myeloperoxidase, citrullinated histones, cell-free DNA) exhibit manifold effects on tumor cells, thereby emphasizing a need to be aware of the features of biological functions related to their constituents and their place in carcinogenesis to identify major molecular targets for targeted therapy of gynecologic cancers in the future.Aim: to determine an impact of NETs on tumor progression/metastasis and thrombosis risk in gynecologic cancer.Materials and Methods. …”
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Drosophila melanogaster as a model system for studying the effects of porcine rotavirus on intestinal immunity by Xiao Chun Wang, Xiao Chun Wang, Shuang Deng, Liyun Yu, Rongan Cao, Rongan Cao, Liangyu Li

“…The composition of the intestinal microbiota also underwent changes, potentially playing a role in intestinal immune defense. …”
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Cross-validation for training and testing co-occurrence network inference algorithms by Daniel Agyapong, Jeffrey Ryan Propster, Jane Marks, Toby Dylan Hocking

“…These complex microbial communities form intricate ecological networks that are fundamental to ecosystem functioning and host health. Understanding these networks is crucial for developing targeted interventions in both environmental and clinical settings. …”
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Synergistic effect of biochar and post-thermophilic stage application of supplemental Tithonia diversifolia on compost nutrient dynamics by Felix Matheri, Collins Musafiri, David Bautze, Chloé Durot, Milka Kiboi

“…Ultimately, the low quality of compost can potentially reduce soil fertility and crop productivity. …”
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Integration of Microarray Data and Single-Cell Sequencing Analysis to Explore Key Genes Associated with Macrophage Infiltration in Heart Failure by Rao J, Wang X, Wang Z

“…Cellular communication revealed that macrophages form a network of interactions with neutrophils to support each other’s functions and maintenance. The complex efferent and afferent signals are closely associated with myocardial fibrosis.Conclusion: SERPINA3, GPAT3, ANPEP, and FCER1G can potentially serve as immune therapeutic targets and central biomarkers. …”
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FSI modeling and simulation of blood viscosity impacts on cavitation in mechanical heart valves by Joseph Amponsah, Archibong Archibong-Eso, Aliyu M. Aliyu, Tabbi Wilberforce Awotwe

“…However, mechanical issues like cavitation can undermine the valve's functionality, posing risks to both its longevity and the overall efficacy of cardiovascular treatments. …”
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Modified Xi-Jiao-Di-Huang Decoction Alleviates Sepsis via Regulating Macrophage Polarization by Inhibiting the PIM2/NF-κB Pathway by Ge F, Tian F, Zhu Y, Yan Q, Sun Q, Lu J

“…This transformation is potentially mediated through the Pim2/NF-κB signaling pathway. …”
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Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitus by Zhuo Chen, Li Yang, Li Geng, Xinwen Zhang, Mingyu Du, Yonghu Sun, Lin Zhao, Bing Bai, Xiaohong Li

“…In summary, genes related to placental cell functions are inhibited in PE, while autoimmune abnormalities may play a role in LO-PE and GDM pathogenesis.…”
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