A New Preclinical Surgical Model for the Assessment of Dental Implant Tissue Integration by Ryan Noh, Nahrain Warda, Charles Tremblay, John E. Davies

“…However, SEM images showed that at all three time points, topographically complex nanotube surfaces had a profound effect on soft tissue peri-implant deposition, although functionally oriented collagen fibers were not identified attached to the implant surface. …”
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Implementation of an information system for tuberculosis in healthcare facilities in Indonesia: evaluation of its effectiveness and challenges by Rita Dian Pratiwi, Bachti Alisjahbana, Yanri Wijayanti Subronto, Sigit Priyanta, Suharna Suharna

“…The overarching assessment of the SITB reveals persistent challenges in data entry, attributed to the functionality of the application, thereby potentially impacting user satisfaction. …”
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Cytokine and Chemokine Responses of Peripheral Blood Mononuclear Cells from Dogs Infected with <i>Mycobacterium bovis</i> by Tyler Morrison, Danielle A. Gunn-Moore, Jayne C. Hope, Conor O’Halloran

“…Finally, the IL-18 response of seropositive dogs was reduced compared to those that were seronegative in response to PPDB, potentially suggesting that these dogs have a reduced macrophage functionality. …”
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MyCare study: protocol for a controlled trial evaluating the effect of a community-based intervention on psychosocial, clinical outcomes and hospital admission rates for adults wit... by Dave Vicary, Renée O'donnell, Helen Skouteris, Melissa Savaglio, Debra Fast, Ash Vincent

“…The primary outcome includes psychosocial and clinical functioning and the secondary outcome will examine hospital admission rates and duration of stay. …”
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Challenges and Strategies for Expanding Enterprise-Based Training to Develop Skills for the ICT Industry in the Philippines by Jooyoung Voeller

“…In the Philippines, structural challenges such as wage requirements, insufficient program duration, and inefficient tax benefits currently prevent EBT from effectively functioning as a private good for building company talent pipelines. …”
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Impact and effect mechanisms of mass campaigns in resource-constrained health systems: quasi-experimental evidence from polio eradication in Nigeria by Olakunle Alonge, Svea Closser, Marco J Haenssgen

“…In contrast, regions with relatively strong health systems and few campaigns experienced beneficial effects on maternal healthcare service utilisation.Conclusions As we provide evidence that well-functioning health systems can benefit from mass campaigns under Global Health Initiatives, our work also challenges the established wisdom to intensify mass campaigns in weaker health systems to bypass service provision bottlenecks. …”
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HAKEKAT PENDIDIK DALAM PANDANGAN ISLAM by Mukroji Mukroji

“… Basically, Islamic education is a continuous, sustainable, and everlasting process of human life. Duties and functions of education are targeted at learners who continue to grow and evolve dynamically, starting from the womb until the end of life. …”
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Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis by Yang Zou, He Ma, Xing Yang, Xin-Yu Wei, Chao Chen, Jing Jiang, Tao Jiang

“…Gene ontology (GO) enrichment analysis further revealed the stage-specific features of liver functionality. Specifically, during the acute stage of infection, pathways associated with inflammation were significantly enriched. …”
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A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis by Wen Zhang, Rui Xiang, Wang Gu, Qiang Zhang, Lei Liu, Chenglin Wang, Muhu Chen, Yingchun Hu, Guihong Chen

“…Enrichment analysis demonstrated the molecular functions, biological processes involved, and related pathways of the intersection targets. …”
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Off-targets effects of CNO on somatosensory and anxiety-related behaviors in rats by Xuan Li, Juan Yao, Lian-lin Zeng, Jia Huang, Xiao-qian Jiang, Jin-he Xu, Bing Wu, Hong-li Li, Ke-hui Hu

“…Designer receptors exclusively activated by designer drugs (DREADDs) are a powerful chemogenetic tool for controlling targeted cell populations and manipulating brain functions. As a typical chemogenetic actuator in DREADD systems, clozapine-N-oxide (CNO) is widely utilized in neurobiological and pharmacological research. …”
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O6-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo, and sensitivity to alisertib-carbo... by Müge Sak, Müge Sak, Brian J. Williams, Brian J. Williams, Andrew J. Hey, Mayur Sharma, Leslie Schier, Megan J. Wilson, Mahatma Ortega, Alyssa I. Lara, Mikaela N. Brentlinger, Norman L. Lehman, Norman L. Lehman, Norman L. Lehman, Norman L. Lehman, Norman L. Lehman

“…MGMT thus possesses cellular functions related to tumor cell engraftment and anchorage-independent growth beyond guanine methyltransferase repair. …”
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From Congress to disadvantaged communities: an analysis of federal water infrastructure investments distributed to Alabama through state revolving funds by Victoria Miller, Lacey Christian, Mark A Elliott, Cindy Lowry, Jillian Maxcy-Brown

“…However, accessing the SRF program is complicated and can prove insurmountable for the millions of residents living in rural, small, or otherwise disadvantaged communities (DACs) without reliable and affordable access to clean piped drinking water and functioning wastewater treatment systems. This study analyzed the $3.3 billion in funding requests to Alabama’s SRF to reveal that 69.6% of drinking water utilities and 70.3% of wastewater utilities have sought SRF funding for infrastructure upgrades since 2022. …”
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Data enhanced iterative few-sample learning algorithm-based inverse design of 2D programmable chiral metamaterials by Zhao Zeyu, You Jie, Zhang Jun, Du Shiyin, Tao Zilong, Tang Yuhua, Jiang Tian

“…Meanwhile, according to the impact of geometric parameters on the chiroptical response, a new functionality is added to interpret the experimental results of DEIFS algorithm from the perspective of data, improving the interpretability of the DEIFS. …”
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An interactive care plan plus remote blood pressure monitoring in a rural primary care clinic: a pilot study by Ramona S. DeJesus, Jane W. Njeru, Mark R. Beahm, Rachel E. Gullerud, Jessica A. Grimm, Barbara J. Copeland, Julianne J. Lunde, Ivana T. Croghan

“…Background Remote blood pressure monitoring (RBPM), an effective method of enhancing BP control for patients with hypertension, can potentially helpovercome geographic limitations of health care services. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…The SARS-CoV-2 main protease (Mpro or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2 Mpro. …”
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Mass transport and fluid flow-induced wall shear stress in auxetic bone scaffolds during deformation process: a numerical study by Xuezheng Geng, Nan Li, Huiwen Huang, Ruiqi Zhang, Yan Yao, Lizhen Wang, Yubo Fan

“…However, their biological functions, including nutrient transport, metabolic waste removal, and cell proliferation and differentiation, remain unexplored. …”
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Enhanced Hydrologic Connectivity and Solute Dynamics Following Wildfire and Drought in a Contaminated Temperate Peatland Catchment by Abbey L. Marcotte, Juul Limpens, João Pedro Nunes, Ben C. Howard, Alexander G. Hurley, Kieran Khamis, Stefan Krause, Danny Croghan, Angeliki Kourmouli, Samantha Leader, Tanu Singh, Cathelijne R. Stoof, Sami Ullah, Nicholas Kettridge

“…Climate change impacts including drought and wildfire may impair their functioning, potentially impacting ecosystem service delivery. …”
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Gait-Based AI Models for Detecting Sarcopenia and Cognitive Decline Using Sensor Fusion by Rocío Aznar-Gimeno, Jose Luis Perez-Lasierra, Pablo Pérez-Lázaro, Irene Bosque-López, Marina Azpíroz-Puente, Pilar Salvo-Ibáñez, Martin Morita-Hernandez, Ana Caren Hernández-Ruiz, Antonio Gómez-Bernal, María de la Vega Rodrigalvarez-Chamarro, José-Víctor Alfaro-Santafé, Rafael del Hoyo-Alonso, Javier Alfaro-Santafé

“…<b>Background/Objectives</b>: Sarcopenia and cognitive decline (CD) are prevalent in aging populations, impacting functionality and quality of life. The early detection of these diseases is challenging, often relying on in-person screening, which is difficult to implement regularly. …”
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Missed Nursing Care and its relationship with Nurses’ Perceptions of Professional Practice Environment during Hajj Season by Faisal A. Alasmari, Ebtisam A. Ebrahim, Hawazin Y. Alhawasawi, Hussam Z. Abujaab, Mohamed P. Shahid, Naif A. Alduaiji, Alaa S. Sheikh, Mazen Z. Abo Jaab, Marwan S. Hawsawei, Dania A. Fatani, Amani M. Tukruni

“…The highest reason for missed nursing care was the inadequate staff (2.85±1.12), supplies/equipment not functioning properly when needed (2.74±1.07), and not being available when needed (2.70±1.10). …”
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Dual CD47 and PD‐L1 blockade elicits anti‐tumor immunity by intratumoral CD8+ T cells by Susan N Christo, Keely M McDonald, Thomas N Burn, Nadia Kurd, Jessica Stanfield, Megan M Kaneda, Ruth Seelige, Christopher P Dillon, Timothy S Fisher, Bas Baaten, Laura K Mackay

“…Conclusions Engagement of innate and adaptive immune checkpoint molecules via CD47 × PD‐L1 BisAb treatment resulted in robust CD8+ T cell responses, including the induction of tumor‐resident CD8+ T cells that exhibited functionally superior anti‐tumor immunity. These results demonstrate that innate immune activation potentiates anti‐tumor adaptive responses, highlighting the use of dual checkpoint blockade as an optimal strategy for promoting CD8+ T cell‐mediated protection.…”
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