Mutation of the histone demethylase Gasc1 causes ASD-like symptoms in mice by Tetsushi Kagawa, Yuhei Yamaguchi, Yasuhiro Kokubu, Genki Sudo, Aoi Ebisawa, Satoko Hattori, Keizo Takao, Kohtarou Konno, Naomi Nakagata, Takafumi Inoue, Masahiko Watanabe, Johji Inazawa, Tsuyoshi Miyakawa, Tetsuya Taga

“…Conclusion Taken together, our data suggest that histone demethylation plays a pivotal role in normal brain development and higher-order brain functions in both mice and humans.…”
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Study on the effects of extreme climate and human activities on the growth mechanisms of Zostera japonica in the Yellow River estuary by Yanning Gao, Yanning Gao, Yanning Gao, Kebing Chen, Kebing Chen, Zixuan Ma, Yujun Yi, Yujun Yi

“…The Water and Sediment Regulation Scheme (WSRS) dramatically alters water quality by reducing salinity and increasing turbidity, thus inhibiting photosynthesis and disrupting the physiological functions of Zostera japonica. Additionally, WSRS introduces an increase in heavy metals, which could potentially impact plant health and stress levels. …”
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Electronic Medical Record Inaccuracies: Multicenter Analysis of Challenges with Modified Lung Cancer Screening Criteria by Candice L. Wilshire, Carson C. Fuller, Christopher R. Gilbert, John R. Handy, Kimberly E. Costas, Brian E. Louie, Ralph W. Aye, Alexander S. Farivar, Eric Vallières, Jed A. Gorden

“…Each individual’s EMR was searched for COPD diagnostic terms and the presence of a diagnostic pulmonary functionality test (PFT). An unsubstantiated COPD diagnosis was defined by an individual’s EMR containing a COPD term with no PFTs present, or the presence of PFTs without evidence of obstruction. …”
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Machine learning developed an immune evasion signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma by Dongxiao Ding, Gang Huang, Liangbin Wang, Ke Shi, Junjie Ying, Wenjun Shang, Li Wang, Chong Zhang, Maofen Jiang, Yaxing Shen

“…Low IRS-based risk score indicated higher level of NK cells, CD8+ T cells, and immune activation-related functions. The C-index of IRS was higher than that of many developed signatures for LUAD and clinical stage. …”
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Drosophila Toxicogenomics: genetic variation and sexual dimorphism in susceptibility to 4-Methylimidazole by Katelynne M. Collins, Elisabeth Howansky, Sarah C. Macon-Foley, Maria E. Adonay, Vijay Shankar, Richard F. Lyman, Nestor Octavio Nazario-Yepiz, Jordyn K. Brooks, Rachel A. Lyman, Trudy F. C. Mackay, Robert R. H. Anholt

“…The network genes were significantly over-represented for gene ontology terms involving all aspects of development (including nervous system development) and cellular and organismal functions as well as canonical signaling pathways, and most had human orthologs. …”
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Restoration of natural somatic sensations to the amputees: finding the right combination of neurostimulation methods by Gurgen Soghoyan, Artur R. Biktimirov, Nikita S. Piliugin, Yury Matvienko, Alexander Y. Kaplan, Alexander Y. Kaplan, Mikhail Y. Sintsov, Mikhail A. Lebedev, Mikhail A. Lebedev

“…Limb amputation results in such devastating consequences as loss of motor and sensory functions and phantom limb pain (PLP). Neurostimulation-based approaches have been developed to treat this condition, which provide artificial somatosensory feedback such as peripheral nerve stimulation (PNS), spinal cord stimulation (SCS), and transcutaneous electrical nerve stimulation (TENS). …”
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Unveiling the Complexities of Hereditary Angioedema by Cristina Violeta Tutunaru, Oana Maria Ică, George G. Mitroi, Carmen Daniela Neagoe, George F. Mitroi, Olguța Anca Orzan, Beatrice Bălăceanu-Gurău, Simona Laura Ianoși

“…Despite the differences in C1-INH functionality, all three types of HAE manifest with similar clinical symptoms. …”
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Justifying the structure of the improved mechanism for manual control of motor vehicles’ pedals by Vitaliy Korendiy, Nazarii Fedunyshyn, Vasyl Kozub

“…Therefore, improving existing designs of the mechanisms for controlling three pedals by transferring all control functions to one hand of a driver remains relevant. …”
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Plastome and transcriptome analysis reveals a degenerated photosynthesis-related pathway in the mycoheterotrophic vanilloid orchid Cyrtosia lindleyana by Shiou Yih Lee, Peishan Zou, Zhihui Chen, Kenji Suetsugu, Wenbo Liao

“…Intriguingly, these putative plastid genes, absent from the plastome of C. lindleyana, also proved undetectable at the transcriptomic level, implying their non-functionality. Conclusion Our plastome and transcriptome analyses highlight evidence of gene degradation and loss in C. lindleyana, mirroring a process of photosynthetic capability degeneration. …”
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CORRECTION OF DISTURBED NEUROIMMUNE INTERACTIONS IN EXPERIMENTAL TRAUMATIC BRAIN INJURY BY MEANS OF RECOMBINANT INTERLEUKIN 2 by S. N. Shanin, E. E. Fomicheva, T. A. Filatenkova, N. B. Serebryanaya

“…TBI is associated by multidirectional abnormalities of immune system, which affect quantity and functions of T-, B-, and NK-lymphocytes leading to infectious complications or autosensibilization. …”
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Cortical layer-specific abnormalities in auditory responses in a mouse model of Fragile X Syndrome by Katrina E. Deane, Devin K. Binder, Khaleel A. Razak

“…Sensory sensitivity and temporal processing deficits in the auditory domain will affect development of language and cognitive functions. The mouse model for FXS, Fmr1 KO, has shown remarkably similar auditory processing phenotypes to patients with FXS. …”
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Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus by Diego Currò, Raj Makwana, Gareth J. Sanger

“…When exogenously administered, they contract stomach muscle in several species, but their ability to modulate enteric nerve functions has rarely been studied. We investigated the effects of GRP on cholinergic‐mediated contractions of the stomach, after first characterizing the contractile effects of GRP, NMB, and bombesin (BB). …”
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A Pilot Study of Compensatory Strategies for Reach-to-Grasp-Pen in Patients with Stroke by Qiurong Xie, Bo Sheng, Jia Huang, Qi Zhang, Yanxin Zhang

“…In clinical practice, the reach-to-grasp-pen task using markless sensing technology can effectively distinguish patients with stroke from healthy individuals and evaluate the recovery and compensation strategies of upper limb and hand functions. It can potentially become an evaluation tool in hospital and community scenes. …”
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Sex differences in schizophrenia: symptomatology, treatment efficacy and adverse effects by Ivi Moniem, Vasilios Kafetzopoulos

“…Men typically experience illness onset approximately 3–5 years earlier than women, with more severe negative symptoms, worse social functioning, and higher rates of comorbid substance use disorders. …”
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TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa by Julia Knaup, Christina Gruber, Barbara Krammer, Verena Ziegler, Johann Bauer, Thomas Verwanger

“…Methods: We applied cDNA arrays comprising 9738 human expressed sequence tags (EST) with various functions. Selected results were verified by Real-time RT PCR. …”
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PyAMARES, an Open-Source Python Library for Fitting Magnetic Resonance Spectroscopy Data by Jia Xu, Michael Vaeggemose, Rolf F. Schulte, Baolian Yang, Chu-Yu Lee, Christoffer Laustsen, Vincent A. Magnotta

“…<b>Methods</b>: PyAMARES was developed as a Python library, implementing the AMARES algorithm with additional features such as multiprocessing capabilities and customizable objective functions. The software was validated against established AMARES implementations (OXSA and jMRUI) using both simulated and in vivo MRS data. …”
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Mapping the evolution of digital human resource management: a systematic review and bibliometric analysis by Md. Nazmus Sakib, Muhammad Shariat Ullah, Md. Mahbubur Rahman

“…The content analysis conducted on bibliographic-coupling-based clusters suggests that research in this scholarly area highlights the integration of digital technologies and data-driven strategies in HR processes, emphasizes the strategic use of data analytics in decision-making, and shows the adaptation of HR functions through digital interfaces, along with the alignment of HRM with organizational strategies through comprehensive resource management. …”
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The burden of insomnia among public health sector nurses in KwaZulu-Natal, South Africa by Phatheka P. Ntaba, Sibongile Mashaphu, Kalpesh Narsi

“…Background: Insomnia is defined as poor quantity or quality of sleep resulting in impaired daytime functioning and distress. Insomnia has been found to occur at higher rates in health care workers and has been associated with physiological dysfunction, illness and distress as well as many socio-demographic and lifestyle-related factors. …”
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Development of inclusive education in the Republic of Kazakhstan: an inside view (case of the Karaganda region) by Zhanat Mamerkhanova, Alfina Sakayeva, Kulbarshyn Akhmetkarimova, Dana Assakayeva, Valentina Bobrova

“…The process approach allows us to design a model of the system of conditions for the functioning of the inclusive education process with a feedback mechanism. …”
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Satellite traceology: experience of using in the interests of mammalogy for protection of ice-associated marine mammals by Vladimir V. Melentyev, Vladimir I. Chernook, Konstantin V. Melentyev, Alexandr A. Startsev, Tatiyana A. Zakharova

“…Advanced technology of satellite traceology is presented on the base of using the synthetic aperture radar (SAR) with high space and deep resolution installed for the first time onboard Soviet space station Almaz and now functioning successfully onboard the satellites Envisat and RADARSAT. …”
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