Methylation of a group of microRNA genes as a marker for the diagnosis and prognosis of non-small cell lung cancer by V. I. Loginov, M. S. Gubenko, A. M. Burdennyy, I. V. Pronina, P. V. Postnikov, Yu. A. Efimova, F. V. Radus, E. S. Mochalova, T. P. Kazubskaya

“…Objectives. Lung cancer, representing a difficult-to-diagnose heterogeneous malignant neoplasm, is characterized by an asymptomatic course up to late stages, a high incidence of adverse outcomes, and a high probability of metastasis. …”
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Expert consensus on the technical specifications of the in vitro skin penetration test of cosmetic product by Franz diffusion cell by Bingwen Liang, Liling Zhou, Chuanbin Wu, Liang Fang, Lisheng Wang, Lihua Peng, Peng Shu, Lifeng Tang, Yu Bei, Xiaodong Cui, Xiaojia Chen, Yuan Gao, Chong Han, Yan Jia, Huaqing Lin, Yifang Li, Ying Liu, Yiguang Li, Zhiwei Li, Zixiu Liu, Shaohua Ren, Jun Shi, Wanyang Sun, Lijuan Tian, Qun Wang, Yuan Wang, Yuehong Xu, Ming Zeng, Quangang Zhu, Shu Zhang, Yifan Zhang, Qi Xiang

“…Background: Diffusion cell test is one of the most commonly used in vitro model to detect the percutaneous absorption of cosmetic ingredients. …”
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Genotype-specific retinal and choroidal perfusion patterns in inherited retinal diseases: an SS-OCTA analysis by Yu Rong, Junfeng Li, Jianquan He, Daowei Zhang, Jiawen Wu, Hongli Liu, Ting Li, Ping Xu, Qing Chang, Jihong Wu

“…Considering the correlation between patients’ retinal blood volume and their visual function, OCT angiography (OCTA) can be a good choice for monitoring RP progression by objectively quantifying vascular changes. …”
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Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection i... by Nico Marr, Aaron F Hirschfeld, Angie Lam, Shirley Wang, Pascal M Lavoie, Stuart E Turvey

“…Each of the SNPs tested had previously been established to have a functional impact on immune responsiveness and two of the SNPs in the IL4 and IL4R genes had previously been associated with severe RSV bronchiolitis. …”
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The Inhibitory Effect of the Active Ingredients in the Bushen Huoxue Formula on the IL-17A Signaling Pathway and Its Alleviating Effect on Osteoarthritis by Wang X, Zhang Y, Chang X, Wen X, Tian F, Yu H, Li Y

“…Xuan Wang,1,* Yunheng Zhang,1,* Xin Chang,1 Xiaodong Wen,1 Feng Tian,1 Hanjie Yu,2 Yi Li1 1Department of Foot and Ankle Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Li, Email footankle08@126.comObjective: Osteoarthritis (OA) stands as a prevalent degenerative disease worldwide. …”
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TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study by Mitchell Emmers, Marij J. P. Welters, Michelle V. Dietz, Saskia J. Santegoets, Sanne Boekesteijn, Anouk Stolk, Nikki M. Loof, Daphne W. Dumoulin, Annemarie L. Geel, Lauri C. Steinbusch, A. Rob P. M. Valentijn, Danielle Cohen, Noel F. C. C. de Miranda, Egbert F. Smit, Hans Gelderblom, Thorbald van Hall, Joachim G. Aerts, Sjoerd H. van der Burg

“…Abstract Functional loss of the intracellular peptide Transporter associated with Antigen Processing (TAP) fosters resistance to T-cell based immunotherapy. …”
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Efficacy of Shengxuening tablets combined with erythropoietin in treatment of renal anemia of diabetic kidney disease stage V patients by ZHANG Jian-wei, XU Lu-jun

“…Objective To observe the efficacy of Shengxuening tablets combined with erythropoietin in treatment of renal anemia of diabetic kidney disease stage V patients.Methods Sixty patients with stage-V diabetic kidney disease were randomly divided into treatment group and control group.The treatment group was given Shengxuening tablets combined with erythropoietin,and the control group given ferrous succinate combined with erythropoietin.The patients were followed up for 3 months.Hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF),and transferrin saturation(TSAT) were detected before and after the treatment The indexes of ALT,SCr and K~+ were detected before and after the treatment Results The efficacy in the treatment group was more satisfactory than the control group.The total effective rate in the control group was 83.3%,and that in the treatment group reached 90%(P<0.05).The indexes of ALT,SCr and K~+ showed no obvious change before and after the treatment(P>0.05).Conclusions The effect of Shengxuening combined with erythropoietin in treating renal anemia of stage-V diabetic nephropathy is evident.Shengxuening combined with erythropoietin can significantly increase hemoglobin(Hb),Hct,serum iron(SF) and transferrin saturation(TAST) levels,improve the iron metabolism and correct the renal anemia,but has no significant impact on liver function,renal function and serum potassium.Shengxuening combined with erythropoietin is safe and effective,and has less adverse reaction.…”
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Methods of Screening for Meibomian Gland Dysfunction by V. N. Trubilin, E. G. Polunina, E. Yu. Markova, D. V. Andzhelova, S. V. Kurenkova, L. Yu. Bezmel’nitsyna

“…A slit lamp is used for examination. Furthermore, objective data characterizing the morpho-functional state of the meibomian glands, can be obtained by carrying out meibography. …”
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Motivation and stimulation of employment specialists in the sphere of information technologies by S. Bazhenov

“…The characteristic of the labor specialists in the sphere of information technologies, namely the characteristics of the object, means and product of their labor. The author of the article deals with the specifics of specialists of the topic. …”
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Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice by Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Heike Heuer

“…Conclusions: Altogether, our data point to a largely unaffected sciatic nerve structure and function in the absence of MCT8 and OATP1C1.…”
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Two-year longitudinal and prospective electroencephalographic follow-up in patients with TBI: can early EEG and CT findings predict post-traumatic epilepsy? by João Paulo Santiago de Oliveira, Viviam Sanabria, Carla Baise, Rafael P. S. Valeriano, Gustavo Mercenas dos Santos, Natália Mata Longo, Joaquina C. Q. F. Andrade, Gesael Passos Ferreira Junior, Carlos André Oshiro, Claudia Costa Leite, Maira L. Foresti, Maira L. Foresti, Luiz Eugênio Mello, Luiz Eugênio Mello, Eliana Garzon, Eliana Garzon

“…The incidence of PTE varies widely, underscoring the need for early detection and treatment.ObjectiveThrough prospective electroencephalography (EEG) evaluations over a two-year period, our study aims to identify electrographic patterns indicative of PTE development, offering crucial insights for timely intervention and improved patient outcomes.MethodsSeventy-three adult participants with acute TBI, admitted to a reference hospital in Brazil between 2018 and 2020, were recruited based on eligibility criteria. …”
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Task-Driven Real-World Super-Resolution of Document Scans by Maciej Zyrek, Tomasz Tarasiewicz, Jakub Sadel, Aleksandra Krzywon, Michal Kawulok

“…We propose to incorporate auxiliary loss functions derived from high-level vision tasks, including text detection using the connectionist text proposal network (CTPN), text recognition via a convolutional recurrent neural network (CRNN), keypoints localization using Key.Net, and hue consistency. …”
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Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Aged Mice with Postoperative Cognitive Dysfunction Based on BDNF/TrkB Signaling Pathway by LI Min, YANG Xiao, REN Lulu, WU Tingmei, ZHANG Hong

“…Open field test was used to evaluate motor function (percentage of time spend in the central area, total distance traveled, and average speed of movement) at the 3rd day after operation; Y-maze test was used to evaluate cognitive function (the percentage of entries into the novel arm, the percentage of time to stay in the novel arm and the total distance moved in the novel arm) at the 4th day after operation; Western blot was used to detect the protein expression levels of brain-derived neurotrophic factor (BDNF), tropomyosin related kinase B (TrkB) and nerve growth factor (NGF) in the hippocampal tissue of the mice.Results(1) Motor function: there were no significant differences in the percentage of time spent in the central area of the open field, total distance traveled and average speed of movement among the three groups (<italic>P</italic>&gt;0.05). (2) Cognitive function: there was no significant difference in the percentage of entries into the novel arm among the three groups (<italic>P</italic>&gt;0.05); compared with the control group, the percentage of time spent in the novel arm and the total distance moved in the novel arm in the operation group decreased significantly, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
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Clinical Molecular Immunohistochemistry Mismatch Repair Mutations in Lynch Syndrome in Patients Under 50 Years: A Systematic Review by Bogdan Adrian Manta, Adrian Cosmin Ilie, Felicia Marc, Daciana Nistor, Patricia Octavia Mazilu, Claudia Borza

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Myocardial Perfusion Imaging with Cardiovascular Magnetic Resonance in Nonischemic Cardiomyopathies: An In-Depth Review of Techniques and Clinical Applications by Ilir Sharka, Giorgia Panichella, Chrysanthos Grigoratos, Matilda Muca, Carmelo De Gori, Petra Keilberg, Giovanni Novani, Valerio Barra, Hana Hlavata, Matteo Bianchi, Denisa Simona Zai, Francesca Frijia, Alberto Clemente, Giancarlo Todiere, Andrea Barison

“…<i>Background and Objectives</i>: Nonischemic cardiomyopathies comprise a wide spectrum of heart muscle disorders characterized by different morphological, functional, and tissue abnormalities. …”
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Multisystem Evaluation of the Physiological Effects of the Grape seed by Amira Mohammed

“…Serum was collected to detect the concentration of ALT and TSB (liver functions). …”
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Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis by Marco R. Pastore, Serena Milan, Stefano Gouigoux, Olimpia Colombo, Silvia Rinaldi, Gabriella Cirigliano, Daniele Tognetto

“…<b>Objectives</b>: The objectives of this study were to evaluate the structural and functional outcomes after the loading phase with brolucizumab in switched patients with diabetic macular edema (DME) and to identify potential predictive biomarkers of treatment response. …”
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Translation and validation of the Saint Louis University Mental Status (SLUMS) Exam for older adults in Thailand: The SLUMS-Thai by Komwat Rungruang, Pornpun Manasatchakun, Sarinya Polsingchan

“…Background: The Saint Louis University Mental Status (SLUMS) Exam is a commonly used tool for screening cognitive function, particularly for detecting mild cognitive impairment (MCI) and early dementia. …”
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Optimal intestinal graft selection for reconstruction of extended ureteral stricture: an animal model study by S. V. Kotov, R. I. Guspanov, A. G. Yusufov, O. V. Gaina, A. L. Aprosimov, I. V. Lapin, M. M. Zobnin, N.  O. Larionova, N. V. Trykina, T. Yu. Luskatova, O. V. Bogdanova

“…The absence of foci of necrosis and fibrosis in the renal parenchyma indicates the preserved functional potential, which suggests the stabilization of renal function in the long term.…”
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Characterization of sacha inchi (Plukenetia volubilis) and taro (Colocasia esculenta) flours with potential application in the preparation of both gluten-free and high protein food... by Jesús Eduardo Bravo Gómez, Ruby Aracely Narváez Cadena, Angie Paola Salas Zambrano, Karen Sofia Muñoz Pabon, Diego Fernando Roa-Acosta

“…Background Interest in alternative sources of tubers and legumes has increased due to the search for raw materials with bioactive antioxidant compounds. The objective of this study was to characterize taro (TF) and sacha inchi (Plukenetia volubilis) flours obtained by the wet (SIF-WM) and defatted (SIF-DM) methods, as alternatives for the formulation of functional foods. …”
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