Non-Invasive Cardiac and Vascular Monitoring in Systemic Sclerosis: Impact of Therapy on Subclinical Dysfunction by Ștefania Lucia Magda, Ana Maria Gheorghiu, Raluca Ileana Mincu, Andrea Olivia Ciobanu, Tudor Constantinescu, Elisa Cristina Popa, Carina Mihai, Dragoș Vinereanu

“…Non-invasive assessment methods do not detect a functional cardiovascular decline in patients on classical therapy. …”
Get full text

SGF-SLAM: Semantic Gaussian Filtering SLAM for Urban Road Environments by Zhongliang Deng, Runmin Wang

“…Furthermore, we present a map update function, which is aimed at updating areas occluded by dynamic objects by using semantic information. …”
Get full text

Mathematical Formalization and Algorithmization of the Main Modules of Organizational and Technical Systems by A. A. Solodov

“…The research method is the application of the principles of the theory of statistical estimates of random processes occurring in the organizational and technical systems against the background of interference and the synthesis of algorithms for the functioning of the status assessment module on this basis. …”
Get full text

Total hip replacement after prior of the core decompression of the femoral head: efficacy and complications by M. A. Panin, N. V. Zagorodnii, A. V. Boiko, A. S. Petrosyan

“…Twelve months after THA, osteolysis around the hip replacement element was detected by X-ray in 6.7 % of group I patients.Conclusion. …”
Get full text

A comprehensive assessment of physical image quality of five different scanners for head CT imaging as clinically used at a single hospital centre-A phantom study. by Patrizio Barca, Fabio Paolicchi, Giacomo Aringhieri, Federica Palmas, Daniela Marfisi, Maria Evelina Fantacci, Davide Caramella, Marco Giannelli

“…CT image quality for each scanner/acquisition protocol was assessed through noise level, noise power spectrum (NPS), contrast-to-noise ratio (CNR), modulation transfer function (MTF), low contrast detectability (LCD) and non-uniformity index analyses. …”
Get full text

Emergence and characterization of a ST852 Klebsiella quasipneumoniae clinical isolate coharboring blaNDM-1 and blaKPC-2 in China by Chongmei Tian, Yaping Zhao, Su Dong, Zhixin You, Jingbai Chen, Hongfeng Xu, Yuejuan Fang, Yapei Zhang

“…The results of the COG and KEGG functional classifications showed that most of the functions were associated with metabolism. pKPSY-2 is a 239,226-bp IncU plasmid carrying the carbapenem resistance gene blaNDM-1. pKPSY-3 is a smaller plasmid belonging to the IncN-type conjugative plasmid with blaKPC-2. …”
Get full text

Longitudinal Trend Monitoring of Multiple Sclerosis Ambulation Using Smartphones by Andrew P. Creagh, Frank Dondelinger, Florian Lipsmeier, Michael Lindemann, Maarten De Vos

“…<italic>Goal:</italic> Smartphone and wearable devices may act as powerful tools to remotely monitor physical function in people with neurodegenerative and autoimmune diseases from out-of-clinic environments. …”
Get full text

Assessment of non-tumor liver parenchyma damage in advanced gastric cancer treatment with transarterial infusion chemotherapy: a study using imaging and hepatic injury indicators by Yifan Jing, Jian Jing, Xiaokang Sun, Yong Jin, Xuming Bai

“…The combination of CT imaging and APRI/FIB-4 provides a sensitive method for detecting subclinical liver injury, reflecting pathological changes earlier than traditional liver function scores.…”
Get full text

LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells by Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin

“…ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and induced to differentiate into Th17 cells.XIST was over-expressed and silenced by plasmid transfection.Proliferation and apoptosis of Th17 cells with different levels of XIST expression were detected by flow cytometry and CCK-8 assay.Levels of XIST，TLR9 mRNA and protein were detected by quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blot.The effect of XIST on TLR9 expression was predicted by luciferase report analysis and TLR9 mRNA half-life detection.Potential RNA-binding proteins interacting with XIST were searched through Starbase database and detected by RNA immunoprecipitation and Western blot.GraphPad8.0 was utilized for statistical analysis and variables were expressed as average±SD.Student T test or one-way ANOVA was employed.ResultsXIST was distributed predominantly in cytoplasm.It hinted that XIST might be involved in post-transcriptional regulation.A down-regulation of lncRNA XIST expression promoted apoptosis and DNA damage and arrested cell proliferation by regulating TLR9.With an over-expression of lncRNA XIST，TLR9 expression spiked and XIST up-regulated the expression of TLR9 by promoting the stability of TLR9 mRNA.As an RNA-binding protein （RBP），FUS interacted with XIST and FUS antibodies could significantly enrich XIST transcripts.A down-regulation of lncRNA XIST expression had no effect on FUS protein expression.It suggested that XIST might affect FUS function rather than expression.It was further confirmed that a down-regulation of XIST significantly reduced FUS-TLR9 mRNA binding and FUS over-expression rescued a down-regulation and degradation of TLR9 mediated by si-XIST.ConclusionlncRNA XIST and TLR9 play a critical role in Th17 cell proliferation in IgAN through a FUS-mediated signaling pathway.This finding provides new therapeutic ideas for IgAN..…”
Get full text

Targeting MAD2B as a strategy for ischemic stroke therapy by Lijing Zhang, Hengzhen Cui, Wandi Hu, Xianfang Meng, Chun Zhang

“…We constructed MAD2B-cKO-specific knockout mice, knocked down and overexpressed MAD2B in mouse hippocampus by lentiviral injection in brain stereotaxis, modeled cerebral ischemia by using MCAO, and explored the role of MAD2B in post-stroke cognitive impairment (PSCI) by animal behaviors such as Y-maze and Novel object recognition test. Then the expression of MAD2B/ROCK2, downstream molecules and apoptosis-related molecules was detected. …”
Get full text

The Use of Transmissibility Properties to Estimate FRFs on Modified Structures by R.A.B. Almeida, A.P.V. Urgueira, N.M.M. Maia

“…The authors have shown in previous works that the estimation of such FRFs can be made possible by invoking important properties associated with the transmissibility function. The objective of this work is to evaluate different sets of FRFs, estimated by using the transmissibility concept and its associated properties, in an actual continuous structure to which different patterns of structural modification are applied. …”
Get full text

Acute gastrointestinal injury in the intensive care unit: diagnosis, severity assessment, and general approaches to correction by M. M. Sokolova, T. N. Semenkova, I. S. Zabaldin, V. V. Kuzkov, M. Yu. Kirov

“…In this review, we present the scores for assessment of the severity of acute gastrointestinal tract injury, clinical symptoms, as well as new laboratory and instrumental diagnostic approaches.Conclusion. Early detection of this category of patients is vital to provide a personalized intensive therapy aimed at restoration of adequate function of the gastrointestinal tract.…”
Get full text

Increasing the Uptake of Breast and Cervical Cancer Screening Via the MAwar Application: Stakeholder-Driven Web Application Development Study by Nurfarhana Nasrudin, Shariff-Ghazali Sazlina, Ai Theng Cheong, Ping Yein Lee, Soo-Hwang Teo, Abdul Rashid Aneesa, Chin Hai Teo, Fakhrul Zaman Rokhani, Nuzul Azam Haron, Noor Harzana Harrun, Bee Kiau Ho, Salbiah Mohamed Isa

“…The Quality Function Deployment method facilitated the translation of stakeholder perspectives into app features. …”
Get full text

The possible impact of pre-transfusion laboratory interference by Luís Moura, Liliana Fonseca, Emanuel Rodrigues, Rui Lobo, Arnaldo Brito, Mariana Costa

“…Objective: To describe a clinical case treated with plasmapheresis and immunosuppression. …”
Get full text

Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer by Dunja Pavlovic, Tamara Babic, Sofija Ignjatovic, Katarina Pavlovic, Sandra Dragicevic, Aleksandra Nikolic

“…One of these promoters upregulated in colon cancer leads to the expression of the PHF19-207 transcript, suggesting its potential role in tumor promotion. The objective of this study was to investigate the function of PHF19-207 using in silico tools and publicly available data, as well as to assess its expression in colon cancer. …”
Get full text

Isolation, Identification, Whole-genome Characterization, and Comparative Genomic Analysis of Pathogenic Aeromonas hydrophila A01 from Pelteobagrus fulvidraco by Wei GAO, Ling SHAO

“…Strain A01 underwent whole-genome sequencing using the Illumina platform, followed by genome assembly with SPAdes, gene prediction via Prokka, and functional annotation through KEGG, GO, and COG databases. …”
Get full text

Prevalence, care-seeking practices and impact of self-reported vision impairment in Southwest Cameroon: a community-based study by Melissa Carvalho, Susan N Mbeboh, Sabrinah Ariane Christie, Drusia Dickson, Theophile Nana, Frida Embolo, Rochelle Dicker, Catherine Juillard, Alain Chichom Mefire

“…Objectives To establish the prevalence of self-reported vision impairment (VI) in Southwest Cameroon and describe associated care-seeking practices, functional limitations and economic hardships.Design A three-stage clustered sampling household community-based survey.Setting The Southwest region of Cameroon.Participants 8046 individuals of all ages residing in the Southwest region of Cameroon.Primary and secondary outcome measures Prevalence of self-reported VI, onset of vision loss, care-seeking practices, diagnosis and treatment, functional limitations, economic hardships on household, beliefs about surgical treatability of blindness and barriers to surgical care.Results The estimated prevalence of self-reported VI in Southwest Cameroon was 0.87% (95% CI 0.62 to 1.21). …”
Get full text

Rolling Cargo Management Using a Deep Reinforcement Learning Approach by Rachid Oucheikh, Tuwe Löfström, Ernst Ahlberg, Lars Carlsson

“…The agent is equipped with sensors for obstacle detection and is provided with real-time feedback from the environment thanks to its own reward function, allowing it to dynamically adapt its policies and navigation strategy. …”
Get full text

A Ship Underwater Radiated Noise Prediction Method Based on Semi-Supervised Ensemble Learning by Xin Huang, Rongwu Xu, Ruibiao Li

“…First, an anti-perturbation regularization is constructed using unlabeled data to optimize the objective function of EL, which is then used in the Genetic algorithm to adaptively optimize base learner weights, to enhance pseudo-label quality. …”
Get full text

Extraction Method of Driver’s Mental Component Based on Empirical Mode Decomposition and Approximate Entropy Statistic Characteristic in Vehicle Running State by Shuan-Feng Zhao, Wei Guo, Chuan-wei Zhang

“…The objective is to extract the effective component of the driving behavior information and to weaken the road information component. …”
Get full text