The Possibilities of Multiparametric Magnetic Resonance Imaging to Reflect Functional and Structural Graft Changes 1 Year After Kidney Transplantation by Andrejus Bura, Gintare Stonciute-Balniene, Laura Velickiene, Inga Arune Bumblyte, Ruta Vaiciuniene, Antanas Jankauskas

“…<i>Background and Objectives</i>: Non-invasive imaging biomarkers for the early detection of chronic kidney allograft injury are needed to improve long-term transplant outcomes. …”
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Myocardial Performance Index to assess cardiac function in autoimmune connective tissue disease: a systematic review and meta-analysis by Rudy Hidayat, Sally Aman Nasution, Faisal Parlindungan, Naomi Niari Dalimunthe, Steven Alvianto, Nicolas Daniel Widjanarko, Ummi Kultsum, Cristopher Efendi, Yovita Gotama

“…Objectives This study aimed to evaluate cardiac function using Myocardial Performance Index (MPI) in autoimmune connective tissue disease (ACTD) patients without cardiovascular abnormalities.Methods A systematic search of databases including Medline, Google Scholar, ProQuest, Scopus and Cochrane Library was conducted to identify relevant studies on ACTD and MPI from 1995 to 2023. …”
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Urinary Fetuin-A with Specific Post-Translational Modification in Type 1 Diabetes Patients with Normoalbuminuria and Preserved Kidney Function by Sandra Božičević, Tomislav Bulum, Lea Smirčić Duvnjak, Marijana Vučić Lovrenčić

“…<b>Background/Objectives</b>: Post-translationally modified peptide fragments of fetuin-A (FetA) were identified as a potential biomarker of diabetic kidney disease (DKD). …”
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The relationship between sarcopenia, nutritional status, physical function, and quality of life in elderly cancer patients: a path analysis by Liyi Wang, Xuejun Dai, Jiao Ai, Xiaojuan Li, Aihua Deng, Xiaomei Yang, Ying Zhang, Dujuan Tian, Lang He

“…Abstract Objective This study investigates the associations between sarcopenia and quality of life in elderly cancer patients, with nutritional status and physical function as potential mediators. …”
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Effect of melatonin, zinc sulfate, nano-melatonin, and nano-zinc oxide on mitochondria function and developmental competence of buffalo oocytes by Omaima Mohamed Kandil, Heba Elsaeed Elsehy, Nabil Mohamed Baker, Mohamed Asran Elbehiry, Sayed Ahmed Hattab

“…Objective: The aim of the current work is studying the effect of antioxidants and nano-antioxidants on in vitro development and mitochondrial function of buffalo oocytes. …”
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For Precision Animal Husbandry: Precise Detection of Specific Body Parts of Sika Deer Based on Improved YOLO11 by Jinfan Wei, Haotian Gong, Lan Luo, Lingyun Ni, Zhipeng Li, Juanjuan Fan, Tianli Hu, Ye Mu, Yu Sun, He Gong

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Associations among blood heavy metals, neurofilament light chains and cognition function in US adults: NHANES 2013–2014 by YuYan Zhou, YaKun Wang, ChunFang Qiu, YuXuan Man, XiaoNian Zhu, ShengKui Tan, HuaiCai Zeng, XueFeng Guo, ZhengBao Zhang

“…Background: Heavy metals could induce neurotoxicity, leading to cognitive function and motor deficiencies. Serum neurofilament light chain (sNfL) is a promising biomarker for neurological injury, and it may indicate nerve damage from heavy metals exposure. …”
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MoSViT: a lightweight vision transformer framework for efficient disease detection via precision attention mechanism by Yuanqi Chen, Aiping Wang, Ziyang Liu, Jie Yue, Enxu Zhang, Fei Li, Ning Zhang

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Characterization of Functional Properties and Organic Acids in Vangueria infausta Burch. (Wild Medlar/Nzvirumombe/Umviyo) Fruit(s) Found in Zimbabwe by P. Nemapare, D. T. Mugadza, T. H. Gadaga

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Effect of muscle energy technique versus Pilates on functional outcomes among physiotherapy students with non-specific neck pain by Janani Arul, Rachana R

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The Relation Between Thyroid Function and Auto-Antibodies in Graves' Disease and Non-Autoimmune Hyperthyroidism Disease in AL-Najaf Province by Mohammed A.K. Al-Saadi, Eman Thabit Nadhaif, Salman A.A. AL-Jibouri

“… Objectives: The aim of presented study was evaluated the role of some immunological parameter associated with Graves' disease and comparison that with other non-autoimmune hyperthyroidism, by the following objectives: (1) measurement T3, T4 and TSH. (2) Evaluation of Anti-TSHR-antibody. (3) Estimation Anti-TPO antibody. …”
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High-intensity intermittent exercise regulates oxidative stress and improves endothelial progenitor cell function in patients with essential hypertension by Jixin ZHI, Tiantian WANG, Shuang REN, Chenyu WANG

“…High-intensity intermittent exercise is an effective prevention and treatment method of various chronic diseases; however, little attention has been paid to its effects and mechanisms on endothelial progenitor cells. ObjectiveTo observe the effect of high-intensity intermittent exercise on the function of endothelial progenitor cells in patients with hypertension and explore the mechanism of oxidative stress. …”
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Astragalin improved mitochondrial function through AMPK/PGC-1α pathway and alleviated renal injury in diabetic nephropathy by Yi Luo, Meng-jing Wang, Shu-fen Liu, Shuang Yuan, Hao Huang

“…Objective To explore the effect and mechanism of astragalin （AG） in alleviating renal injury in diabetic kidney disease(DKD). …”
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Simvastatin regulating DAC-PKC and MAPK signaling pathway to improve the renal function in type 2 diabetic nephropathy patients by TIAN Lu, LUO Peng-cheng, WANG Gang, LI Yi

“…Objective To investigate the effect of simvastatin on the DAG/PKC and MAPK signaling pathways in type 2 diabetic nephropathy patients.Methods 16 patients with diabetic nephropathy were treated from June 2010 to December 2014 in Huangshi Central Hospital.These patients given simvastatin.After treatment for 3 months,15 mL blood was collected from each patient.Automatic biochemical analyzer was used to determine renal function parameters,and a kit was used to detected serum lipids,IL-1α,IL-6,IL-1β and TNF-a.The expression of DAG/PKC and MAPK signaling pathway-related enzyme proteins was compared before and after treatment.Results After treatment,blood urea nitrogen,serum creatinine and serum uric acid were reduced significantly in patients after treatment as compared with in patients before treatment(P<0.05).The endogenous creinine clearance rate in patients after treatment was significantly higher than in patients before treatment(P<0.05).CHOL,TG and LDL-C levels in patients after treatment was significantly lower than in patients before treatment(P<0.05).The HDL-C level in patients after treatment was significantly higher than in patients before treatment The levels of inflammatory cytokines(IL-1α,IL-1β,IL-6and TNF-a) were significantly lower in patients after treatment than in patients before treatment(P<0.05).The expression of PKC-η and PKC-ζ protein and mRNA was significantly lower in patients after treatment than in patients before treatment The expression levels of MAPK,MKK,and MAKK protein and mRNA in patients after treatment was significantly lower than in patients before treatment(P<0.05).Conclusions Simvastatin can improve renal function in type 2 diabetic nephropathy patients by regulating DAG-PKC and MAPK signaling pathway.…”
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Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies by Raashi Chauhan, Rama Rao Damerla, Vijay Shree Dhyani

“…We aimed to summarize synthetically lethal gene pairs that could be utilized to selectively target cancer cells and minimize side effects on normal tissues. The objective of this review is to study druggable synthetically lethal gene pairs for targeted cancer therapy that have been identified through various genetic screens and functional studies. …”
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Effectiveness of Structural Couple Therapy and Intensive Short-Term Dynamic Psychotherapy on Intrapersonal-Interpersonal Skills and Family Function in Couples by Nayereh Sadat Sadatmand, Ozra Etemadi, Fatemeh Bahrami, Maryam Fatehizadeh

“…Objective: The current investigation sought to evaluate the efficacy of structural couple therapy in conjunction with Intensive Short-Term Dynamic Psychotherapy (ISTDP) regarding the enhancement of intrapersonal-interpersonal skills and family function of couples. …”
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Effect of Spinal Versus General Anesthesia on Pulmonary Functions among Adults at Al-Sadder Medical City: Comparative Study by Mohammed A. Mustafa Al-Janabi

“… Objective: The study aims to detect the effect of spinal versus general anesthesia on pulmonary function and find out the relationships between patients pulmonary functions post- surgery and their demographic and clinical characteristics. …”
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Inverted ILM Flap Technique in Idiopathic Full-Thickness Macular Hole Surgery: Functional Outcomes and Their Correlation with Morphologic Findings by Paolo Carpineto, Enrico Borrelli, Luca Cerino, Daniele Guarini, Agbeanda Aharrh-Gnama, Vincenzo Ciciarelli, Carla Iafigliola, Leonardo Mastropasqua

“…The aim of our study was to confirm the efficacy and safety of inverted ILM flap technique in idiopathic FTMHs independent of their dimensions and to assess functional outcomes and their correlation to morphologic findings. …”
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Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial by John Norrie, Graeme Maclennan, Lorna Aucott, Karen Innes, Andrew Stoddart, Seonaidh Cotton, Hugh Paterson, Doug Speake, Robert Arnott, Thenmalar Vadiveloo, Marek Atter, Angie Balfour, Zoe Batham, Irwin Foo, Susan Nimmo

“…Objectives To compare costs, health outcomes and cost-effectiveness of using intravenous lidocaine (bolus given at induction of anaesthesia, followed by infusion for 6–12 hours) during colorectal surgery to improve the return of gastrointestinal function.Design Within-trial planned analysis of data from a randomised controlled trial using an intention-to-treat approach.Setting 27 hospitals from across the UK.Participants 557 patients aged 25–91 having minimally invasive elective colorectal resection.Intervention A 1:1 randomisation between intravenous lidocaine and placebo, minimised for age (&lt;50 years, 50–74 years, ≥75 years), gender, and trial centre.Primary outcome measures Mean differences between trial arms in 30-day and 90-day quality-adjusted life-years (QALYs) and 30-day total National Health Service costs, as well as the 30-day incremental cost-effectiveness ratio.Results Compliance and data quality were high. …”
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Cardiac function unchanged following reanimation with normothermic regional perfusion in donation after circulatory deathCentral MessagePerspective by Nicholas W. Markin, MD, FASE, M. Megan Chacon, MD, Anthony W. Castleberry, MD, Lance Fristoe, CCP, Brian D. Lowes, MD, PhD, John Y. Um, MD, Marian Urban, MD, PhD

“…Objectives: To determine whether hearts reanimated with normothermic regional perfusion (NRP) have clinically detectable changes in function using echocardiography comparing the prearrest and post-NRP imaging. …”
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