Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI) by Jie Liu, Heleen vanBeusekom, Xian‐Le Bu, Gong Chen, Paulo Henrique Rosado de Castro, Xiaochun Chen, Xiaowei Chen, Andrew N. Clarkson, Tracy D. Farr, Yuhong Fu, Jianping Jia, Jukka Jolkkonen, Woojin Scott Kim, Paula Korhonen, Shen Li, Yajie Liang, Guang‐Hui Liu, Guiyou Liu, Yu‐Hui Liu, Tarja Malm, Xiaobo Mao, Joaquim Miguel Oliveira, Mike M. Modo, Pedro Ramos‐Cabrer, Karsten Ruscher, Weihong Song, Jun Wang, Xuanyue Wang, Yun Wang, Haitao Wu, Lize Xiong, Yi Yang, Keqiang Ye, Jin‐Tai Yu, Xin‐Fu Zhou, Marietta Zille, Colin L. Masters, Piotr Walczak, Johannes Boltze, Xunming Ji, Yan‐Jiang Wang

“…To attain effective treatment for AD, it is necessary to (1) conduct extensive research on various mechanisms that cause neurodegeneration, including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level; (2) identify neuroprotective intervention targets against different neurodegeneration mechanisms; and (3) discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients. …”
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Detection Algorithm for Air Duct Clamp on Trains Based on RSA-YOLOv10n by WANG Dairong, ZHAO Yuhong, QU Xiaozhang, LIU Yi

“…To address challenges in the detection of air duct clamps due to factors such as dim environments and small objects in train detection, such as insufficient detection accuracy and low detection efficiency, this paper proposes a RSA-YOLOv10n-based detection algorithm, developed utilizing a dataset of air duct clamps collected from trains. …”
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Dynamic changes in brain function during sleep deprivation: Increased occurrence of non-stationary states indicates the extent of cognitive impairment by Ziliang Xu, Chaozong Ma, Chen Wang, Fan Guo, Minwen Zheng, Peng Fang, Yuanqiang Zhu

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Effects of SNX9 on the structure and function of primary cilia in autosomal dominant polycystic kidney disease by Shen Ai-wen, Hu Wan-qian, Lin Lu, Yu Sheng-qiang

“…Objective To explore the effect and mechanism of SNX9 on primary cilia in autosomal dominant polycystic kidney disease（ADPKD）and provide theoretical rationales for seeking intervention targets.Methods The localization of SNX9 in cystic lining epithelium cell line（WT9-12）was observed by immunofluorescence.And the differential expression of SNX9 between normal renal tubular epithelial cell line（RCTEC）and WT9-12 was detected by Western blot.The expression of IFT88 was detected by Western blot and the change of cilia length examined by immunofluorescence.Results SNX9 existed in both cytoplasm and membrane of WT9-12 and its expression was lower than that in RCTEC（P<0.05）.When the expression of SNX9 was down-regulated,the expression of IFT88 declined and cilia became shorter（P<0.05）.Meanwhile,after the up-regulation of SNX9 by lentivirus,the expression of IFT88 increased and cilia became longer（P<0.01）.Conclusions In ADPKD,SNX9 exists in both membrane and cytoplasm of cyst epithelium and its expression is lower than that of normal renal tubular epithelial cell.As a result,the morphology and function of primary cilia become compromised.An up-regulation of SNX9 preserves the function of primary cilia and it may become a new target for ADPKD therapy.…”
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Evaluation of the effects of group psychotherapy on cognitive function in patients with multiple sclerosis with cognitive dysfunction and depression by Emine Bilgi, Hasan Hüseyin Özdemir, Ayhan Bingol, Serpil Bulut

“…Objective This study will evaluate how decreasing depression severity via group psychotherapy affects the cognitive function of patients with multiple sclerosis (MS) who are also diagnosed with depression and cognitive dysfunction. …”
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Study on the role of FGF13 in the repair of inferior alveolar nerve injury by regulating mitochondrial function by JIAO Yi, SUN Xinrong, LIU Weicai

“…[Objective:] To explore the role and mechanism of fibroblast growth factor 13 (FGF13) in the repair of inferior alveolar nerve injury. …”
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Bonding Reactions of Dental Self-Adhesive Cements with Synthetic Hydroxyapatite as a Function of the Polymerization Protocol by Roger Borges, Carlos Frederico de Oliveira Graeff, Juliana Marchi, Paulo Henrique Perlatti D'Alpino

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Some Aspects of Pituitary-Adrenal and Autonomic Nervous Systems Functioning in Patients with Chronic Consciousness Disorders by G. Yu. Rybakov, E. A. Kondratyeva, L. M. Tsentsiper, A. A. Denisova, N. V. Dryagina, N. A. Lesteva, A. O. Ivanova, A. N. Kondratyev

“…Patients with chronic disorders of consciousness (CDoC) have various variants of the pathological organization of functions including sympathetic hyperactivity and hormonal changes.The objective: to determine the severity of paroxysmal sympathetic hyperactivity (PSH), the function of the pituitary-adrenal system in patients with CDoC.Subjects and Methods. 54 patients with CDoC were enrolled in the study. …”
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Correlation of Arterial Stiffness with Left Ventricular Global Longitudinal Strain and Diastolic Function in Hypertensive Patients by Ethar Saad Abbas, Oday J. Al-Salihi, Abdulhadi Hameed Alkaaby

“…It is a hallmark of vascular aging, and when assessed with the carotid–femoral-pulse wave velocity (cf-PWV), it is predictive of outcome regardless of blood pressure components. Objectives: To detect subclinical involvement of left ventricular (LV) systolic and diastolic dysfunction in hypertensive patients in whom arterial stiffness is high. …”
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Impact of High Epidural Block on Left Ventricular Myocardial Function after Aortocoronary Bypass Surgery by L. A. Kolevatova, A. N. Korniyenko, M. V. Ketskalo

“…Objective. To improve the outcomes of surgical treatment of coronary heart disease, by using high epidural block on the basis of evaluation of myocardial diastolic function in the preoperative and early postoperative periods. …”
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Carbohydrate metabolism, pancreas functional activity and diet in young residents of two ethnic groups in the North by Inessa V. Averyanova

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Functional state of coronary shunts from the radial artery in the presence of morphological changes in its wall by S. M. Khokhlunov, D. V. Kuznetsov, A. A. Gevorgyan, K. M. Mikhailov, I. F. Nefedova, E. N. Nikolaeva, G. H. Taumova, O. V. Garbuz, M. M. Yokubov

“…The OBJECTIVE of the research was to study the patency of coronary shunts from the radial artery in the presence of morphological changes in its wall in the period from 40 to 52 months after surgery.METHODS AND MATERIALS. …”
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Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function by Fengzhi Yu, Dandan Jia, Ru Wang

“…Recent studies have shown that the activation or inhibition of these receptors modulates a number of arterial functions, including angiogenesis, arterial relaxation, and arterial inflammation. …”
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Functional analysis of stress-related transcription factor gene PsDREB from Paeonia suffruticosa by LIU Huichun, MA Guangying, ZHU Kaiyuan, ZOU Qingcheng, ZHOU Jianghua, TIAN Danqing

“…Subsequently, the PsDREB gene was transferred into tobacco and was mediated by Agrobacterium to determine its biological function in response to adversity. Thereafter, the tolerance ability of the transgenic tobacco was detected under manipulated drought, low temperature, high salt, and abscisic acid (ABA) treatments, as compared to controls.In conclusion, the PsDREB protein has strong binding and transcriptional activities. …”
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Effects of microbial fermentation on nutrients and flavor substances of cottonseed kernel and functional properties of derived peptides by Na Liu, Yuan Wang, Xiaoping An, Jingwei Qi, Yang Jia

“…Microbial fermentation is an effective processing approach to reduce gossypol, improve nutritional value and produce functional peptides of cottonseed by-product. The objective of this study was to evaluate the influence of microbial fermentation on the free gossypol, nutrients and flavor substances of CK. …”
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Effect of Aerobic Treadmill Exercise Regulating Glucose Transporter 9 on Renal Function in Hyperuricemia Rats by LIANG Jiarong, YANG Huan, CUN Yongdan, WANG Lihuan, LI Yijie, YE Bin

“…ObjectiveTo explore the possible mechanism of aerobic treadmill exercise in improving renal function in hyperuricemia (HUA) rats.MethodsA total of 24 male SD rats were randomly divided into the Control group, the Model group and the Exercise group according to the random number table method, with 8 rats in each group. …”
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Proteolysis and volatile compounds in Mediterranean buffalo milk blue cheese: Quality determinants and functional peptides by Federica Della Cerra, Giuseppina Garro, Rosaria Cozzolino, Sabrina De Pascale, Mariapia Esposito, Gianluca Picariello, Simonetta Caira, Andrea Scaloni, Francesca Marino, Francesco Addeo

“…This study explores the proteolytic changes and volatile organic compound (VOC) profiles occurring during the ripening of Mediterranean buffalo milk blue cheese.The main objective was to characterize bioactive peptides, casein phosphopeptides, and volatile compounds and to assess their potential implications for functional food development.Peptide profiling was conducted using nanoLC-ESI-MS/MS and MALDI-TOF-MS, while VOCs were analyzed via headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME)-GC-MS.β-casein emerged as the predominant source of bioactive peptides, including sequences with predicted ACE-inhibitory, antimicrobial, and antioxidant activities. …”
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Effect of Levothyroxine Replacement on Cognitive Function Impairment in a Sample of Egyptian Population with Subclinical Hypothyroidism by Salwa Seddik Hosny El-khwaga, Dina Ahmed Marwan, Nahla Nader Adly, Marina El-Amir Hakim, Ahmed Mohamed Bahaaeldin

“…Our study showed a statistically significant inverse correlation between TSH level and mild cognitive impairment before and after treatment with levothyroxine at 3 and 6 months intervals as when TSH increased, results of Addenbrooke’s questionnaire decreased and, so, cognitive impairment increased, while when TSH decreased in response to thyroxine replacement, cognitive impairment improved as detected by an increase in the patient’s score. Conclusion: SHT has a great effect on cognitive impairment, as normalization in TSH level results in improvement in cognitive function. …”
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Gross-Motor Coordination and Executive Functions Development in Soccer and Artistic Gymnastics Preadolescent Female Athletes by Fioretta Silvestri, Matteo Campanella, Lorenzo Marcelli, Dafne Ferrari, Maria Chiara Gallotta, Faten Hamdi, Maicon Rodrigues Albuquerque, Maurizio Bertollo, Davide Curzi

“…<b>Background/Objectives</b>: The characteristics of open- and closed-skill sports can have a significant impact on the development of both motor and cognitive functions during late childhood and early adolescence. …”
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Impact of Emphysema Subtypes and Volume on Lung Ventilation and Gas Exchange Functions as Evidenced by Computed Tomography by N. A. Griva, P. V. Gavrilov, I. A. Nikitina, L. D. Kiryukhina, A. N. Narkevich, E. G. Sokolovich

“…Objective: to characterize the relationship between the subtype and volume of pulmonary emphysema on the indicators of lung ventilation and gas exchange functions. …”
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