5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth by Xinning Guo, Meng Jiang, Zhengyu Tao, Huijuan Dai, Chen Wu, Yinan Wang, Zi Wang, Xiaoning Wang, Zhixuan Zhang, Kun Qian, Shanshan Zeng, Yihua Bei, Jun Pu

“…Conclusions: This study reveals a previously unrecognized dual role of 5-oxoproline, which functions both as an early biomarker for DOX-induced cardiotoxicity detection and as a therapeutic target that simultaneously inhibits cancer growth and protects the myocardium.…”
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C-Reactive Protein Monitoring Identifies Urinary Tract Infections in Ambulatory Kidney Transplant Recipients by Emily Wang, Abdelhamid Aboghanem, Niki Dacouris, Lindita Rapi, Sami Mahmud, Weiqiu Yuan, Rosane Nisenbaum, Michelle M. Nash, G. V. Ramesh Prasad

“…Measurements: Patient demographics, urine cultures, CRP, and kidney function during the first posttransplant year. Methods: We identified a cohort of KTR transplanted between January 1, 2016, and December 31, 2019. …”
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EPIDEMIOLOGICAL CHARACTERISTICS OF SUBCLINICAL HYPOTHYROIDISM by Inoyatova Nigina Azizovna, Pirmatova Makhina Abdurakhimovna, Samieva Shakhnoza Timurovna

“…Objective: To study the prevalence of subclinical hypothyroidism (SH) in the middle-aged and elderly population of Dushanbe. …”
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Effects of Electroacupuncture Preconditioning at Baihui and Zusanli Acupoints on the Expression of Inflammatory Factors in Brain and Intestines of Rats with Cerebral Ischemia/Reper... by ZHANG Jiyao, TANG Qiang, ZHU Luwen

“…Before surgery for one day, after reperfusion for 12 h and after reperfusion for 1,3,7 days, the grip tester was used to measure the forelimb grasping strength; after reperfusion for 7 days, ELISA methods was used to determine the content of IL-17A and IL-10 in serum, Western blot method was used to detect the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue, immunohistochemistry method was used to calculate the average optical density (AOD) value of IL-17A and IL-10 in ischemic cortex and colon tissue, and HE staining method was used to observe the pathological change of ischemic cortex.Results① Forelimb grasping strength: compared with the S-con group, the forelimb grasping strength of rats in the M-con group after reperfusion for 12 h, 1 d, 3 d, 7 d was decreased significantly (<italic>P</italic>&lt;0.05); compared with the M-con group, the forelimb grasping strength of rats in the EP group was increased significantly (<italic>P</italic>&lt;0.05). ② Content of IL-17A and IL-10 in serum: after reperfusion for 7 days , compared with the S-con group, the content of serum IL-17A and IL-10 of rats in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the content of serum IL-17A in the EP group were significantly decreased (<italic>P</italic>&lt;0.05), and IL-10 in the EP group were significantly increased (<italic>P</italic>&lt;0.05). ③ Expression of IL-17A and IL-10 protein: after reperfusion for 7 days, compared with the S-con group, the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the expression of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), and the expression of IL-10 protein in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ④ AOD value of IL-17A and IL-10: after reperfusion for 7 days, compared with the S-con group, the AOD value of IL-17A and IL-10 in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the AOD value of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), the AOD value of IL-10 in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ⑤ Pathological change of ischemic cortex: after reperfusion for 7 days, compared with the M-con group, the pathological change of ischemic cortex in EP group was significantly decreased (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture preconditioning at Baihui and Zusanli acupoints can reduce the pathological damage degree of the ischemic cortex and intestinal-central inflammation, improve neurobehavioral function, which may be related to brain-gut protection.…”
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Protective Effect of Resveratrol on Exercise-induced Kidney Injury in Rats by Regulating Keap1-Nrf2 Signaling Pathway by Haitao ZHOU, Ge HU, Jing ZHANG, Qiyun ZHOU, Fei QIN

“…Objective: To investigate the protective mechanism of resveratrol on exercise-induced kidney injury in rats. …”
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Mediating role of psychological resilience between depression and humoral immunological biomarkers in medical staff by Yunyun MA, Yanshuan WEI, Lili QIAN, Xiufeng ZUO, Dechao WANG, Shanfa YU

“…BackgroundAt present, high level of depression is a serious problem in medical staff and may affect their immune function. The role of psychological resilience between depression and immunity cannot be ignored. …”
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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges by Saeid Safiri, Saeid Safiri, Amir Ghaffari Jolfayi, Asra Fazlollahi, Soroush Morsali, Soroush Morsali, Aila Sarkesh, Amin Daei Sorkhabi, Behnam Golabi, Reza Aletaha, Kimia Motlagh Asghari, Sana Hamidi, Sana Hamidi, Seyed Ehsan Mousavi, Sepehr Jamalkhani, Nahid Karamzad, Nahid Karamzad, Ali Shamekh, Reza Mohammadinasab, Mark J. M. Sullman, Mark J. M. Sullman, Fikrettin Şahin, Ali-Asghar Kolahi

“…These pathological changes lead to widespread neuronal damage, significantly impacting daily functioning and quality of life.ObjectiveThis comprehensive review aims to explore various aspects of Alzheimer's disease, including its epidemiology, risk factors, clinical presentation, diagnostic advancements, management strategies, caregiving challenges, and emerging therapeutic interventions.MethodsA systematic literature review was conducted across multiple electronic databases, including PubMed, MEDLINE, Cochrane Library, and Scopus, from their inception to May 2024. …”
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Effect of Astragalus polysaccharide combined with Ginsenoside Rg3 on PD-1/PD-L1 in colon cancer by Wang Ya’nan, Zhang Zhikuan, Gao Feng

“…[Objectives] To investigate the effect of Astragalus polysaccharides (APS) combined with Ginsenoside Rg3 on PD-1/PD-L1 in colon cancer. …”
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Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke by Xi-chen Yang, Ya-ju Jin, Rong Ning, Qiu-yue Mao, Peng-yue Zhang, Li Zhou, Cheng-cai Zhang, Yi-chen Peng, Na Chen

“…Abstract Objective Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism remains poorly understood. …”
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Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study by Michelle M. Mielke, Roger A. Fielding, Elizabeth J. Atkinson, Zaira Aversa, Marissa J. Schafer, Steven R. Cummings, Marco Pahor, Christiaan Leeuwenburgh, Nathan K. LeBrasseur

“…Most studies of the SASP have focused on frailty and other functional outcomes. Senescent cells have been detected in the brains of patients with Alzheimer’s disease, but few studies have examined associations between plasma SASP markers and cognition. …”
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Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 by ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan

“…Objective To construct a molecular classification system for head and neck squamous cell carcinoma (HNSCC) utilizing hypoxia-related gene (HAG) expression profiles, and to comprehensively examine the clinicopathological significance and biological functions of the hypoxia gene stanniocalcin 2 (STC2) in HNSCC. …”
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Suaeda salsa Polysaccharide Alleviates Hepatic Injury by Regulating Macrophage Polarization in a Mouse Model of High-fat Diet-induced Non-alcoholic Fatty Liver Disease by Sisi QIN, Changyu QIN, Yongheng WANG, Jiawen NING, Ziyu DONG, Lei WU, Xiaolong MA, Fuyuan CAO, Naijun WU, Xitong ZHANG, Liying HOU, Shuang LI

“…After 12 weeks, organ function indicators, peripheral blood and liver biochemical indices, and histopathological observations were performed. …”
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Cyclodextrin host-guest complexes-derived exosomal miRNAs for enhancing the antifatigue effects of resveratrol by Hurong Ge, Peipei Ma, Qing Huang, Shijie Wei, Zhizhong Wang

“…Objectives: To study the encapsulation of resveratrol by three cyclodextrin derivatives, investigate the impact of encapsulation technology on its anti-fatigue effect, and explore the anti-fatigue mechanism of the encapsulated resveratrol via transcriptomics analysis of exosomal miRNAs. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Objectives: G protein-coupled receptors (GPCRs) are the most druggable targets in biology due to their cell-type specificity, ligand binding, and cell surface accessibility. …”
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CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…The objective of this study was to determine the role of SLC15A4 in the muramyl dipeptide (MDP)-mediated inflammatory response of bovine rumen epithelial cells (BRECs). …”
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Molecular mechanisms and cancer-promoting roles of sodium arsenite in regulating FNDC3B expression in A549 cells by Jinyun JIANG, He MA, Na LIU, Ruihuan ZHAO, Chenglan JIANG, Yuefeng HE

“…The fibronectin type III structural domain 3B protein (FNDC3B) has been shown to promote cancer cell proliferation; however, its role in arsenic-induced apoptosis remains to be elucidated. ObjectiveTo investigate the effects of sodium arsenite (NaAsO2) and its metabolites on the expression of FNDC3B gene in A549 cells and to understand the function of FNDC3B gene in A549 cells. …”
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Proinflammatory Cytokines in Women with PCOS in Atypical Pathogen Infections by Izabela Chudzicka-Strugała, Iwona Gołębiewska, Grzegorz Brudecki, Wael Elamin, Beata Banaszewska, Marta Chudzicka-Adamczak, Dominik Strugała, Barbara Zwoździak

“…<b>Background/Objectives:</b> Polycystic ovary syndrome (PCOS) is one of the most frequently diagnosed endocrine and metabolic disorders in women of reproductive age before menopause. …”
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Comprehensive Evaluation of Operation Safety of Earth-rock Dams Based on Weight Optimization-cloud Model by ZHANG Jianwei, WU Weitao, HOU Ge, HUANG Jinlin, WANG Bingpeng, LIU Hongze, HU Zixu

“…ObjectiveThe accuracy of comprehensive dam safety assessment remains critical to national economic development and the safety of people's lives and property downstream. …”
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95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa by Alessandra Orfano, Awa Cisse, Zizhang Sheng, Yicheng Guo, Leeah Han, Laty G. Thiam, Khadidiatou Mangou, Adam J. Moore, Aboubacar Ba, Rebecca Li, Mariama N. Pouye, Fatoumata Diallo, Seynabou D. Sene, Elhadji Malick Ngom, Bacary D. Sadio, Alassane Mbengue, Christopher Membi, Thomas Bazié, Fabrice Anyirékun Somé, Natalie Olson, Saurabh Patel, Lawrence Shapiro, Sunil Parikh, Brian Foy, Michael Cappello, Zul Premji, Roch K. Dabiré, Jean-Bosco Ouedraogo, Amy K. Bei

“…Objectives/Goals: Transmission-blocking vaccines hold promise for malaria elimination by reducing community transmission. …”
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ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment by Xinyue Dong, Hao Wang, Jinxuan Cai, Yichun Wang, Dezhi Chai, Zichen Sun, Jie Chen, Mengxia Li, Tianxia Xiao, Chunhua Shan, Jian V. Zhang, Ming Yu

“…Siglec-G in murine embryos was analyzed by immunofluorescence staining. The function of Siglec-G is evidenced by uterine horn injection and protein interaction assay. …”
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