Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis by Yao S, Li Y, Ruan H, Wu L, Zeng H

“…After 8 weeks of LSI modeling, the therapeutic efficacy on IVDD was evaluated through changes in lumbar spine function, histopathological morphology, extracellular matrix (ECM) metabolism, nucleus pulposus (NP) cell viability, and cartilage endplate (CEP) cell pyroptosis; at 4 weeks after modeling, the activation of NF-κB signaling was detected.Results: GBD can attenuate the progression of IVDD in mice, resulting in substantially increases disc height index (DHI) and NP matrix, reduced the degree of annulus fibrosus (AF) tear and the formation of cavity in CEP. …”
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Changes in 25-hydroxy-vitamin D3 level and relevant factors in chronic kidney disease by SUN Da, WANG Jiao-jiao, WANG Li-ning, WANG Juan, LIU Lin-lin, LI Zi-long

“…Objective To measure the plasma level of 25-hydroxy-vitamin D3[25(OH)D3]in non-dialysis patients with chronic kidney disease(CKD) at different stages,and to investigate the correlations between the levels of 25(OH)D3 and the progression of CKD.Furthermore,we explored the effective application of active vitamin D in CKD.Methods We included 885 non-dialysis CKD patients and 11 patients with acute kidney disease(AKI) hospitalized in the Department of Nephrology in the First Affiliated Hospital of China Medical University from Nov.2014 to Nov.2015.Serum 25(OH)D3 levels and other clinical parameters were detected.We further analyzed the prevalence rate of vitamin D insufficiency and deficiency at different stages of CKD,the trend of other relevant biochemical parameters at various groups of vitamin D level,and the correlations between 25(OH) D3 level and the factors.Results(1) With the progression of kidney disease,remarkable increasing trend was found in prevalence rate of vitamin D severe deficiency..The 25(OH) D3 concentration in AKI was(15.8 ±9.16) ng/mL,which was significantly higher than that of each stages of CKD(P<0.05).With the decrease of 25(OH) D3 concentration,the level of blood pressure(systolic pressure and diastolic pressure) increased,proteinuria deteriorated,the level of serum albumin decreased,calciumphosphorus metabolic disorder(blood calcium decreased,blood phosphorus elevated) and lipid metabolic abnormality aggravated.The differences in 25(OH) D3 levels among the groups were statistically significant(P<0.05).But age,left ventricular ejection fraction,the kidney function indexes,bone metabolism indexes,serum uric acid,hemoglobin and C-ractive protein were not statistically significant(P>0.05).(2) 25(OH) D3 levels were correlated with proteinuria.The concentrations of 25(OH) D3 in moderate proteinuria group and massive proteinuria group were remarkably lower than those in micro-proteinuria group and normal group- respectively(P<C0.05).Remarkable distinction was.found in prevalence rate of vitamin D severe deficiency at various groups,and higher prevalence rate tended to favor more advanced proteinuria group.The discrepancies in deficiency prevalence were statistically significant(χ~2 = 251.75,P= 0.000).(3) Pearson’s correlation analyses revealed that serum albumin,calcium and hemoglobin were positively correlated with serum 25(OH) D3,whereas systolic pressure,diastolic pressure,24-h urine protein,serum phosphorous and blood lipids(TC,TG,LDL-C,and HDL-C) were negatively correlated with 25(OH) D3.Multiple linear regression analyses demonstrated that serum albumin,systolic pressure,24-h urine protein and hemoglobin were the independent risk factors of vitamin D deficiency in non-dialysis CKD patients.Conclusions In the northeast of China,vitamin D deficiency in non-dialysis CKD patients was frequent and serious.The change in 25(OH) D3 concentration was correlated with the clinical parameters of CKD.Serum albumin,systolic pressure,24-h urine protein and hemoglobin were the independent risk factors of vitamin D deficiency.…”
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Supersaturated oxygen therapy using radial artery access to prevent left ventricular remodeling after anterior ST-segment elevation myocardial infarction: a randomized, controlled... by Francis R. Joshi, Maria Petty, Yen Wing Ng, Hamish Elliott, Ross Anderson, Douglas Gordon, Rebecca Hanna, Robert Sykes, Shaun Leonard, Andrew Morrow, Dylan Tan, Anna Kamdar, Ramu Perumal, Jeffrey L. Creech, Peter Kellman, Paul Welsh, Alex McConnachie, Colin Berry

“…Secondary outcome assessments include coronary microcirculatory function, infarct size, microvascular obstruction, myocardial hemorrhage, left ventricular remodeling, myocardial blood flow, quality of life (EQ-5D-5L), Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Duke Activity Status Index. …”
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Acute Liver Failure Triggered by Idiosyncratic Drug-Induced Liver Injury Associated with Ibuprofen Consumption. Case Report. by Luis R. Alvarez-Martín, Luis A. Esquivel-Pacheco, Alexis V. Hinostroza-Pezo, Karla J. Arroyo-García, Montserrat D. Moreno-Huesca, Adrian Z. Feria-Avendaño, Carlos A. Galván-Castro

“…Introduction and Objectives: Drug-induced liver injury (DILI) refers to hepatic function alterations associated with drugs. …”
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Expression pattern and clinical significance of MerTK on circulating NK cells in systemic lupus erythematosus by Jianping Guo, Yin Su, Xiao Han, Yin Zhu, Haojie Xu, Ranran Yao, Ziye Wang, Ruyu Liang, Wenwen Pei, Renge Liang

“…Bioinformatic analysis was conducted to explore the potential function of MERTK in NK cells in SLE.Results MerTK expression on circulating NK cells was significantly higher in patients with SLE than that in HCs. …”
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Serum angiopoietin-2/angiopoietin-1 ratio is associated with cardiovascular and all-cause mortality in peritoneal dialysis patients: a prospective cohort study by Han Li, Qianhui Song, Xinyu Su, Yiwei Shen, Hao Yan, Zanzhe Yu, Zhenyuan Li, Jiangzi Yuan, Jiaying Huang, Zhaohui Ni, Leyi Gu, Wei Fang

“…Multiple linear regression showed pulse pressure (β = 0.206, p < .001) and high-sensitivity C-reactive protein (hs-CRP) (β = 0.149, p = .011) were positively correlated with serum Angpt-2/Angpt-1 ratio, while residual renal function (RRF) (β= −0.219, p < .001) was negatively correlated with serum Angpt-2/Angpt-1 ratio. …”
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Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models by Chuanbin Chen, Qingmin Chen, Shenghai Liu, Guoxi Li, Jiawei Zhao, Jingting Huang, Tianyi Ye, Xinting Yang, Zigui Huang, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Weizhong Tang, Jungang Liu, Xiaoliang Huang

“…Abstract Objective This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI). …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Total number of major adverse cardiovascular events. Lung function (NB, during the COVID-19 pandemic, lung function could not be assessed in participants). …”
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miR‐92a aggravates metabolic syndrome via KLF2/miR‐483 axis by Zhe Zhao, Chaofeng Ma, Longzhi Wang, Yuhang Xia, Jun Li, Wei Yang, Juan Pang, Hui Ding, Haifeng Wang, Liang Bai, Fenqing Shang, Feng Zhang

“…ABSTRACT Objective To exam the role of miR‐92a/KLF2/miR‐483 in the pathogenesis of metabolic syndrome. …”
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Ameliorative Effects of Selenium-Containing Proteins and Peptides from Selenium-Enriched Cardamine L. against Ulcerative Colitis in Mice by MENG Yao, HE Ziyan, LUO Ying, ZHANG Zhong, LI Jianke, YUAN Li

“…Objective: To assess the mitigative effects of plant-derived organic selenium on ulcerative colitis (UC). …”
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Construction and evaluation of nomogram for risk prediction of cognitive impairment in chronic obstructive pulmonary disease comorbidity by JiaFeng Luo, Wen Yang, Yang Liu, HongLian Ji, XinRan Li, Jing Bai, TieJun Liu, WeiBin Chen, Li Xiao, GuoXin Mo, JingShan Bai, CongHui Liu, WenQiang Li, AiShuang Fu, YanLei Ge

“…Abstract Objectives Chronic Obstructive Pulmonary Disease (COPD) remains a serious public health problem globally, and the mortality rate for older COPD patients with cognitive impairment is almost three times that of older patients with cognitive impairment or COPD. …”
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Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation by Wencheng Zhang, Shuo Yang, Xinwen Yu, Shanshan Zhu, Xin Wang, Fei Sun, Shengru Liang, Xiaoguang Wang, Guohong Zhao, Bin Gao

“…<b><b>Background/Objectives</b></b>: This study aims to investigate the effects of 4-methylumbelliferone (4-MU) on islet morphology, cell phenotype and function, and to explore possible mechanisms of β cell regeneration. …”
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The role of mitophagy in cognitive impairment in aluminum-exposed rats by Xiaoyu ZHANG, Yan LIU, Chaoqun XU, Xia YUAN, Kaiwen TAN, Jiacheng ZHOU, Binhong WANG, Xinru CHEN, Bin JIANG, Huan CHEN, Li LIN, Jing ZHANG, Huan LI

“…ConclusionsSubchronic aluminum exposure can impair learning and memory function in rats, activate the PINK1/Parkin pathway LC3B/P62/COXIV pathway, and induce mitophagy.…”
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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…<b>Background/Objectives:</b> Dry eye (DE) is mainly characterized by dryness, foreign body sensation, eye pain and visual impairment. …”
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Platelet membrane-modified catalase/silica nanoparticles inhibit radiation infection by XIONG Tainong, LI Chenwenya, CHEN Yin

“…Objective‍　‍To provide an effective strategy for the prevention and treatment of radiation-induced infections by preparing platelet membrane-modified catalase/silica nanoparticles (PCNP) capable of targeting leukocytes. …”
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Renalase Overexpression-Mediated Excessive Metabolism of Peripheral Dopamine, DOPAL Accumulation, and α-Synuclein Aggregation in Baroreflex Afferents Contribute to Neuronal Degener... by Xue Xiong, Yin-Zhi Xu, Yan Zhang, Hong-Fei Zhang, Tian-Min Dou, Xing-Yu Li, Zhao-Yuan Xu, Chang-Peng Cui, Xue-Lian Li, Bai-Yan Li

“…<b>Background/Objectives</b>: Increasing evidence reveals the likely peripheral etiology of Parkinson’s disease; however, the mechanistic insight into α-Synuclein aggregation in the periphery remains unclear. …”
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Improving consistency in methane emission quantification from the natural gas distribution systems across measurement devices by J. Tettenborn, D. Zavala-Araiza, D. Zavala-Araiza, D. Stroeken, H. Maazallahi, H. Maazallahi, C. van der Veen, A. Hensen, I. Velzeboer, P. van den Bulk, F. Vogel, L. Gillespie, L. Gillespie, S. Ars, J. France, J. France, D. Lowry, R. Fisher, T. Röckmann

“…Indeed, when different analysers were measuring in the same vehicle and from the same air inlet, the integrated spatial peak area was found to be a more robust metric across different methane gas analyser devices than the maximum methane enhancement. A statistical function based on integrated spatial peak area is proposed for more consistent emission estimations when using different instruments. …”
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Trend analysis of the application of multispectral technology in plant yield prediction: a bibliometric visualization analysis (2003–2024) by Jiahui Xu, Jiahui Xu, Jiahui Xu, Yalong Song, Yalong Song, Yalong Song, ZhaoYu Rui, ZhaoYu Rui, Zhao Zhang, Zhao Zhang, Can Hu, Can Hu, Can Hu, Long Wang, Long Wang, Long Wang, Wentao Li, Wentao Li, Wentao Li, Jianfei Xing, Jianfei Xing, Jianfei Xing, Xufeng Wang, Xufeng Wang, Xufeng Wang

“…Multispectral imaging technology uses sensors capable of detecting spectral information across various wavelength ranges to acquire multi-channel target data. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…The key findings in this segment were: Organizational The practice of reuse currently functions as an appendix of the demolition industry, bringing benefits as well as disadvantages. …”
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Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol by Christine Mouton, Nicolas Nesseler, Antoine Bénard, Mathieu Pernot, Alexandre Ouattara, Antoine Beurton, Alexandre Mansour, Victor-emmanuel Brett, Corinne Batsale, Anais Aitgougam, Anais Cordon, Aurelie Fresselinat, Geraldine Robert, Julien Imbault

“…Ancillary studies will be performed to evaluate cell recovery and washing performance, the viscoelastic properties of retransfused blood (Quantra Qplus; Stago, Asnières-sur-Seine, France), and the effect of salvaged leucocytes on postoperative inflammation and immune function.Ethics and dissemination This trial has received a favourable opinion from the Committee for the Protection of Persons and authorisation from the French authorities (Comité de protection des personnes Nord Ouest, IDRCB: 2023-A02566-39). …”
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