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2681
Recognition of pivotal immune genes NR1H4 and IL4R as diagnostic biomarkers in distinguishing ovarian clear cell cancer from high-grade serous cancer
Published 2025-06-01“…ObjectiveOvarian clear cell carcinoma (OCCC) is characterized by poor prognosis and limited early diagnostic markers. …”
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2682
Endothelial cells nurture stem cell-like characteristics of osteosarcoma cells in a perivascular niche by CXCL12/CXCR4 pathway
Published 2025-07-01“…Objective To investigate the effect of endothelial cells in the perivascular niche on the stem cell-like characteristics of osteosarcoma cells and primarily explore the possible molecular mechanism. …”
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2683
Encuesta Nacional de Tendencias Fitness para México en 2020 (National Survey of Fitness Trends in Mexico for 2020)
Published 2021-01-01“…Results: Principal fitness trends for Mexico are: hiring professionals graduated in physical activity or related careers; functional training; exercise programs to lose weight; multidisciplinary work teams; and strength training. …”
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2684
The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis
Published 2024-09-01“…Nevertheless, the precise function of m6A methylation in photoaging remains unknown. …”
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2685
Can Zinc Oxide Nanoparticles Alleviate the Adverse Effects of Salinity Stress in <i>Coffea arabica</i>?
Published 2025-05-01“…Furthermore, the combined effect of ZnO-NP (100 mg L<sup>−1</sup>) and salt resulted in a significant reduction in carotenoids, limiting their photoprotective function. The results obtained indicate the complex interaction between the application of ZnO-NPs and various physiological processes in coffee plants, including photosynthesis, antioxidant enzyme activity, and the generation of reactive oxygen species. …”
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2686
Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with Aβ-Induced Alzheimer’s Disease Rats Based on the Wnt/β-catenin Pathway
Published 2021-01-01“…Objective. To investigate the effects of lycopene-loaded microemulsion (LME) on the cognitive function and neurogenesis in the dentate gyrus (DG) of the hippocampus and subventricular (SVZ) region of rats with amyloid β- (Aβ-) induced Alzheimer’s disease (AD) and its mechanism based on the Wnt/β-catenin pathway. …”
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2687
Analysis of changes and influencing factors of activation rate of peripheral blood monocytes after liver transplantation
Published 2025-02-01“…The two groups were compared in terms of complete blood count, liver and kidney function, coagulation indicators, infection indicators, ICU length of stay, total length of hospitalization, and 90-day mortality. …”
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2688
Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway
Published 2025-05-01“…The asthma model was evaluated using ovalbumin (OVA) and pulmonary function tests, while pathological examination was conducted using hematoxylin and eosin (HE), periodic acid-Schiff (PAS), and Masson trichrome stains. …”
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2689
POSITION OF THE TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME AMONG FACIAL PAIN SYNDROMES
Published 2018-03-01“…The pathology of TMJ dysfunction was detected in 80% of the examined patients (Bezrukov V.M, 2002). …”
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2690
A Single-Cell Assessment of Intramuscular and Subcutaneous Adipose Tissue in Beef Cattle
Published 2025-07-01“…Accordingly, both bulk RNAseq and snRNAseq analyses identified activated pathways of inflammation and metabolic function in IM. These results demonstrate distinct transcriptional cellular heterogeneity between SAT and IM depots in beef steers, which may underly the mechanisms by which fat deposits in each depot. …”
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2691
High-load strength training compared with standard care treatment in young adults with joint hypermobility and knee pain: study protocol for a randomised controlled trial (the HIPE...
Published 2024-10-01“…Secondary outcomes include self-reported knee function and adverse events (collected at baseline, 12 weeks and 12 months), objective measurements including a 5-repetition maximum single-leg press, proprioception and single-leg-hop for distance (collected at baseline and 12 weeks), and a range of other outcome measures such as fear of movement, tendon stiffness and global perceived effect. …”
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2692
Sub-Optimal Chronic Obstructive Pulmonary Disease (COPD) Management in India: Findings from a Community-Based Study
Published 2025-06-01“…Additional cases were detected using a validated sequential screening strategy, ie, administering the Lung Function Questionnaire (LFQ) followed by the pocket spirometry and confirmation by post-bronchodilation spirometry. …”
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2693
Acoustic Features for Identifying Suicide Risk in Crisis Hotline Callers: Machine Learning Approach
Published 2025-04-01“…Basic acoustic features (eg, Mel Frequency Cepstral Coefficients, formant frequencies, jitter, shimmer) and high-level statistical function (HSF) features (using OpenSMILE [Open-Source Speech and Music Interpretation by Large-Space Extraction] with the ComParE 2016 configuration) were extracted. …”
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2694
Ameliorative Effect of Lacticaseibacillus paracasei Combined with Aerobic Exercise on Obesity in Mice
Published 2025-06-01“…Objective: To investigate the effect of Lacticaseibacillus paracasei N1115 combined with aerobic exercise on improving glucose and lipid metabolism, inflammatory response, learning and memory capacity, intestinal morphology and intestinal flora diversity in obese mice. …”
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2695
Hsa-miR-146b-3p promotes endothelial cell dysfunction and atherosclerosis development by targeting CREB3L3 to regulate the PI3K/Akt signaling pathway
Published 2025-06-01“…Objective To explore the effects of hsa-miR-146b-3p on endothelial cells and the possible roles and mechanisms of hsa-miR-146b-3p in the development of atherosclerosis. …”
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2696
Design of a monitoring program to advance nightjar conservation along the Atlantic Flyway
Published 2025-06-01“…Our objectives were to 1) examine differences in estimates of occupancy at the flyway scale derived from the NJN and BBS, 2) evaluate the probability of accurately classifying species status as a function of the number of survey routes, and 3) develop a spatial allocation of survey routes to permit accurate inference to the population. …”
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2697
Ansofaxine Hydrochloride inhibits hepatocellular carcinoma growth and enhances targeted therapy through the EGFR/MAPK pathway
Published 2025-07-01“…Hepatocellular carcinoma cells were treated with different concentrations of Ansofaxine Hydrochloride, and the effects of Ansofaxine Hydrochloride on the biological function of hepatocellular carcinoma cells were evaluated by CCK8, migration, invasion, and clonal formation tests. …”
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2698
The mitochondrial hub gene UCHL1 May serve as a potential biomarker for diagnosing diabetic cardiomyopathy: a comprehensive integration of biological pathways
Published 2025-08-01“…The diagnostic value of the hub genes for DCM was confirmed using receiver operating characteristic (ROC) curves in the test and validation groups. Moreover, the functions of the hub genes in the context of DCM were explored via gene set enrichment analysis (GSEA). …”
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2699
The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Published 2019-01-01“…RNA sequences of pathogens in nasopharyngeal swab of IPF patients were detected by PathChip. A panel of serum parameters reflecting immune function were assessed. …”
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2700
Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms
Published 2025-02-01“…It contains 29 items with the first two items assessing the patient’s general well-being and the 27 remaining items grouped into six domain scores: physical well-being (QOL-FIS), functional well-being (QOL-FUN), social/family well-being (QOL-SOC), sexual well-being (QOL-SEX), fatigue (QOL-FAT), and MDS-specific disturbances (QOL-MDSS). …”
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