Application of bioinformatics analysis to construct the prognostic model and immune-related gene characteristics of low-grade glioma by Peng Liao, Xiaocui Zhang, Ruyan Yuan, Tingjun Tang, Feng Wang, Baowei Geng

“…The growth and metastatic ability of glioma cells after down-regulation of HPSE2 was detected by biological function assay. Results We identified 37 differential genes associated with LGG prognosis. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Although phosphatase and tensin homolog (PTEN) have been recognized as a potential tumor suppressor in all kinds of cancers, its function in RCC remains to be thoroughly elucidated. …”
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Digital Image Speckle Correlation (DISC): Facial Muscle Tracking for Neurological and Psychiatric Disorders by Shi Fu, Pawel Polak, Susan Fiore, Justin N. Passman, Raphael Davis, Lucian M. Manu, Miriam Rafailovich

“…<b>Background/Objectives</b>: Quantitative assessments of facial muscle function and cognitive responses can enhance the clinic evaluations in neuromuscular disorders such as Bell’s palsy and psychiatric conditions including anxiety and depression. …”
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Features of Changes of Main Indices in Acne Patients Systemic Immunity and Their Dependence on Clinical Forms of Dermatosis Course by Syzon O., Dashko M.

“…Acne is a chronic recurrent dermatosis represented with a complex of multifactorial subjective and objective symptoms pathogenetically united in a pathologic process, which is accompanied by the functional abnormalities of sebaceous glands and propagation of Propionibacterium acne, psycho-emotional disorders, and torpidity of treatment. …”
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Virtual Coach–Guided Online Acceptance and Commitment Therapy for Chronic Pain: Pilot Feasibility Randomized Controlled Trial by Erin D Reilly, Megan M Kelly, Hannah L Grigorian, Molly E Waring, Karen S Quigley, Timothy P Hogan, Alicia A Heapy, Charles E Drebing, Matias Volonte, Ummul-Kiram Kathawalla, Hannah E Robins, Katarina Bernice, Timothy Bickmore

“…This is often accompanied by negative functional outcomes and higher mortality. Combined with research suggesting medical treatments for chronic pain are often insufficient, there is an urgent need for nonmedical pain self-management programs. …”
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Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage by TU Yingxin, JI Yilan, WANG Fei, YANG Dongming, WANG Dongdong, SUN Zhixin, DAI Yuexin, WANG Yanji, KAN Guanghan, WU Bin, ZHAO Deming, YANG Lifeng

“…Objective To establish a weightlessness simulation animal model using miniature pigs, leveraging the characteristic of multiple systems’ tissue structures and functions similar to those of humans, and to observe pathophysiological changes, providing a new method for aerospace research. …”
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Risk of Superficial Fungal Infections in WHIM Syndrome by Jennifer Strong, Rutha Adhanom, Caleb S. Kim, Yoshine Saito, Jasmine C. Meltzer, Patrick Hallaert, Sophia Martinez, Abigail Salancy, Heidi H. Kong, Edward W. Cowen, Leslie Castelo-Soccio, Philip M. Murphy, David H. McDermott, Isaac Brownell

“…Abstract Introduction WHIM syndrome is a rare autosomal dominant inborn error of immunity caused by gain-of-function mutations in the chemokine receptor CXCR4. …”
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Effects of sinomenine on PI3K/mTOR signaling pathway and mesangial hyperplasia in rats with adriamycin-induced nephropathy by Liu Yue, Li Peng-yuan, Zhang Qing-hua, Yan Dan

“…Objective To explore the effect of sinomenine on the signal pathway of phosphatidyl-3 kinase（PI3 K）/mammalian target of rapamycin（mTOR）and mesangial hyperplasia in renal tissue of rats with adriamycin-induced nephropathy and elucidate its protective mechanism.Methods A total of 50 SD rats were selected, 10 rats were randomly injected with normal saline via caudal vein as control group, the other 40 rats were injected with adriamycin 5 mg/kg via caudal vein for 7 days to prepare nephrotic syndrome（NS）model.After successful modeling, the rats were randomly divided into the groups of model（NS）,sinomenine low-dose（25 mg/kg）,medium-dose（50 mg/kg）and high-dose（100 mg/kg）（n=10 each）.Control and NS groups received normal saline through abdominal cavity and sinomenine groups were given corresponding doses of drugs once daily for 28 days.At 24 hours after the last administration, blood and urine samples of rats in each group were collected and rats sacrificed, renal tissue samples harvested, serum creatinine（Scr）and urea nitrogen（BUN）were measured by enzyme-linked immunosorbent assay（ELISA）;24-hour urine protein was detected by Coomassie brilliant blue staining; hematoxylin-eosin staining（HE）was utilized for analyzing the pathological changes of kidney and mesangial matrix index（M/G）;transmission electron microscopy for observing the thickening of glomerular basement membrane of kidney; Western blot for detecting the expressions of p-PI3 K/PI3 K,p-mTOR/mTOR,fibronectin（FN）and type IV collagen（COL4）in renal tissue.Results As compared with control group, there were pathological damages such as the increase of glomerular mesangial matrix, the expansion of renal tubule lumen and severe thickening of glomerular basement membrane.M/G and renal function indicators Scr, BUN,24-hour urine protein and renal tissue were elevated.The protein expressions of p-PI3 K,p-mTOR,FN and COL4 rose markedly in NS group（P<0.05）.As compared with NS group, sinomenine high/medium/low dose groups alleviated pathological damage such as glomerular basement membrane thickening, M/G,Scr, BUN,24-hour urine protein, renal tissue p-PI3 K,expressions of mTOR,FN and COL4 proteins declined markedly in sinomenine low/medium/high-dose groups（P<0.05）.As compared with low-dose sinomenine group, glomerular basement membrane thickening was the least pathologically damaged and M/G,Scr, BUN,24-hour urine protein, renal tissue p-PI3 K,p-mTOR,FN and COL4 declined markedly in sinomenine medium/high-dose group（P<0.05）.Conclusions Sinomenine may inhibit the activation of PI3 K/mTOR signaling pathway, reduce the proliferation of glomerular mesangial cells and delay the process of nephrotic syndrome.…”
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Study on protective effect of Salvia miltiorrhiza extract on mesangial proliferative glomerulonephritis in rats based on the NLRP3/caspase 1 pathway by QIU Peng, NI Xiao-na

“…Objective To investigate the protective effect of Salvia miltiorrhiza extract on mesangial proliferative glomerulonephritis(MsPGN) rats based on the NLRP3/caspase 1 pathway. …”
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Patients’ and Health Care Professionals’ Expectations of Virtual Therapeutic Agents in Outpatient Aftercare: Qualitative Survey Study by Diana Immel, Bernhard Hilpert, Patricia Schwarz, Andreas Hein, Patrick Gebhard, Simon Barton, René Hurlemann

“…The monitoring of health status was viewed positively by both groups. A biofeedback function was desired to detect early warning signs of disease. …”
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Treatment of extensive tumors of the jaws by hemimandibuloectomy with simultaniouse reconstruction of the mandible, arthroplasty of temporomandibular joint, orthopedic rehabilitati... by C. R. Rahimov, A. A. Ahundov, G. I. Hajiyeva, R. Ch. Rahimli, D. A. Safarov, I. M. Farzaliyev

“…In cases of extensive tumors of the jaws single-step ablative surgical procedure, reconstruction of missing anatomical structures of the jaws and simultaneous prosthodontic rehabilitation allows to prevent possible deformities of the soft tissues and due to rapid restoration of vital functions has great impact to quality of patient’s life. …”
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Brain-derived neurotrophic factor but not beta-secretase 1, vascular endothelial growth factor, glial fibrillary acidic protein and interleukin-1β correlate with cognitive impairme... by Kamini Bhavsar, Manjari Tripathi, Jyotirmoy Banerjee, Arpna Srivastava, Nidhi, Shivam Pandey, Divya Vohora

“…Noteworthy alterations were detected across various MoCA subscales, encompassing visuospatial and executive functions, attention, language, abstraction, and delayed recall, with statistical significance established (p &lt; 0.05). …”
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Exacerbating effects of circadian rhythm disruption on the systemic lupus erythematosus by Jing Wang, Qing Liu, Fang Zhou, Guangji Wang, Xuan Luo, Ning Wei, Luping Shen, Mo Han, Qixiang Zhang, Huanke Xu

“…Objective Circadian rhythm disruption (CRD) has been associated with inflammation and immune disorders, but its role in SLE progression is unclear. …”
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Circular RNA hsa_Circ_0007552 inhibits lung adenocarcinoma proliferation, migration and invasion via the miR-7974/BAP1 axis by Yanping Lin, Rong Li, Xin Shen, Mingjin Wu, Jiadai Tang, Jiangyan Guo, Caixin Yin, Tingrong Xia, Dongqi Li, Fengdi Hu, Yedan Liao, Rui Li, Lin Xie

“…ObjectivesCircular RNAs (circRNAs) are a class of non-coding RNAs with diverse pathophysiological functions. …”
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Efficacy and safety of DL‐3‐N‐butylphthalide in the treatment of ischemic poststroke aphasia: A randomized clinical trial by Jing Tian, Peng Yang, Jianing Yang, Rui Wang, Biyi Zhou, Kun Zhang, Yanying Zhao, Binbin Wang, Lijuan Liu, Ruomeng Chen, Haoran Wu, Ruihan Miao, Li Guo, Xiaoyun Liu

“…Abstract Objective Poststroke aphasia (PSA) has a high prevalence and requires a long recovery period, severely impairing life and work. …”
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A High-Affinity Monoclonal Antibody Against the Pancreatic Ductal Adenocarcinoma Target, Anterior Gradient-2 (AGR2/PDIA17) by Reeder M. Robinson, Leticia Reyes, Benjamin N. Christopher, Ravyn M. Duncan, Rachel A. Burge, Julie Siegel, Patrick Nasarre, Pingping Wang, John P. O’Bryan, G. Aaron Hobbs, Nancy Klauber-DeMore, Nathan G. Dolloff

“…Background/Objectives: Anterior Gradient-2 (AGR2/PDIA17) is a member of the protein disulfide isomerase (PDI) family of oxidoreductases. …”
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Protective effect of exercise induced metabolite-3 in ischemia-reperfusion injury by Zijie CHENG, Xuejun WANG, Zimu WANG, Juying QIAN

“…ObjectiveTo explore the protective effect of exercise-induced metabolite-3 (EIM-3) on myocardial ischemia-reperfusion (I/R) injury and explore its underlying molecular mechanisms. …”
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An AI recognition method for children's clinical operative pain by skin potential (SP) signal by Mingxuan Huang, Cangcang Fu, Linbo Chui, Jiadong He, Xiaozhi Wang, Jikui Luo, Bin Wu, Yonggang Chen, Shaohua Hu, Jihua Zhu, Yubo Li

“…Objective and rationale: Children's clinical pain phenotypes are complex, and there is a lack of objective biological diagnostic markers and cognitive patterns. …”
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Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis by Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie, Tiao Lin

“…CCK-8 and colony formation assays were used to detect cell proliferation and drug resistance. Transwell experiments were used to detect cell migration and invasion. …”
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Validation of a Set of Clinical Criteria for the Diagnosis of Secondary Progressive Multiple Sclerosis by Alin Ciubotaru, Daniel Alexa, Cristina Grosu, Lilia Böckels, Ioana Păvăleanu, Alexandra Maștaleru, Maria Magdalena Leon, Roxana Covali, Emanuel Matei Roman, Cătălina Elena Bistriceanu, Cristina Mihaela Ghiciuc, Doina Azoicăi, Emilian Bogdan Ignat

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