A Porcine Model of Laparoscopic Intersphincteric Resection for Ultra-Low Rectal Cancer by Min-Wei Zhou, Ji-Xin Ma, Zheng-Qing Yan, Zheng-Dong Qiao, Zhen-Yang Li, Xiao-Dong Gu, Sen Yan, Yi-Wen Zang, Zong-You Chen, Yi-Ming Zhou, Jian-Hua Ding, Jian-Bin Xiang

“…Incontinence scores, evaluated three months post ISR surgery, revealed no significant abnormalities in anal function compared to preoperative assessments.Conclusions This study established a replicable porcine model for laparoscopic ISR, demonstrating its potential utility in clinical and fundamental research related to ultra-low rectal cancer treatment.…”
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A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome by Moritz Güttes, Marianna Lucio, Adam Skornia, Eva Rühl, Fritz Steußloff, Julia Zott, Christian Mardin, Wolfgang Mehringer, Marion Ganslmayer, Georg Michelson, Bettina Hohberger

“…The present data suggested that the mentioned variables uniquely contributed to explain the variation of the response variable (RT, CR). RT and CR detecting 3D-stimuli in a virtual 3D- environment might offer novel functional diagnostic approaches in PCS.…”
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Genetic Determinants of Resistance among ESBL-Producing Enterobacteriaceae in Community and Hospital Settings in East, Central, and Southern Africa: A Systematic Review and Meta-An... by Onduru G. Onduru, Rajhab S. Mkakosya, Said Aboud, Susan F. Rumisha

“…Prevalence was higher in hospital settings 41% (95% CI = 23–58%) compared to community settings 34% (95% CI = 8–60%). ESBL genes detected from clinical isolates with ESBL-E phenotypes in ECSA were those of Ambler molecular class A [1] that belongs to both functional groups 2be and 2d of Bush and Jacob classification of 2010 [2]. …”
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Dose effects of ultraviolet and terahertz laser radiation on the plasma membrane of erythrocytes by Лариса Січевська, Тетяна Овсяннікова, Ірина Забєліна, Аліна Коваленко, Олександр Левченко, Олег Гурін

“…Ultraviolet (UV) and terahertz (THz) ranges of electromagnetic radiation are classified as biogenic; therefore, establishing their effects at the level of blood cells will allow them to be recommended for use in medical and biotechnological practice after the development of appropriate exposure methods. The objective was to study the biogenic activity of ultraviolet (UV) and terahertz (THz) ranges of LLLR on the structural and functional state of red blood cells of rats in vitro. …”
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Clinical and instrumental characteristics of osteoarthritis in hyperuricemia by E. A. Taskina, A. M. Lila, L. I. Alekseeva, N. G. Kashevarova, K. M. Mikhailov, A. R. Halmetova, E. A. Strebkova, E. P. Sharapova, N. M. Savushkina, D. M. Kudinskiy, T. A. Raskina, I. B. Vinogradova

“…Objective: to investigate in a multicentre single-stage study the relationships between hyperuricemia (HU) and clinical, instrumental and laboratory parameters of osteoarthritis (OA).Material and methods. …”
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Construction of DF-1 Cell Line of Stably Expressing Cas9 Protein Mediated by Lentivirus and Verification of Its Activity by Xiaojiao LI, Xinyu ZHU, Xian ZOU, Xia YAN, Yanhua HE, Chenglong LUO

“…【Objective】The chicken fibroblast cell line (DF-1) of stably expressing Cas9 protein was screened, and combined with the reporter vector system based on single strand annealing (SSA) repair mechanism, the Cas9 nuclease activity in the established DF-1 cell line was detected.…”
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High-resolution genetic and physical mapping reveals a peanut spotted wilt disease resistance locus, PSWDR-1, to Tomato spotted wilt virus (TSWV), within a recombination cold-spot... by Dongliang Wu, Chuanzhi Zhao, Walid Korani, Ethan A. Thompson, Hui Wang, Gaurav Agarwal, Jake C. Fountain, Albert Culbreath, C. Corley Holbrook, Xingjun Wang, Josh P. Clevenger, Baozhu Guo

“…These findings provide a foundation for future functional studies to validate the roles of these candidate genes in resistance and application in breeding TSWV-resistant peanut cultivars.…”
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STUDY OF THE STATE OF ENT-ORGANS IN CHILDREN WITH ANOMALIES AND DEFORMATIONS OF DENTOALVEOLAR APPARATUS AND SPEECH DISORDERS by P.S. Flis, N.V. Raschenko, A.O. Melnyk, V.V. Filonenko, O.I. Kotov

“…According to our clinical study in children of the main group and of the comparison group, the apparent pathology of the nose and oropharynx was not detected. Subjective and objective methods of hearing examination also did not reveal deviations from the norm. …”
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Methylglyoxal Alone or Combined with Light-Emitting Diodes/Complex Electromagnetic Fields Represent an Effective Response to Microbial Chronic Wound Infections by Firas Diban, Paola Di Fermo, Silvia Di Lodovico, Morena Petrini, Serena Pilato, Antonella Fontana, Morena Pinti, Mara Di Giulio, Emilio Lence, Concepción González-Bello, Luigina Cellini, Simonetta D’Ercole

“…Major CFU reduction was detected after CMFs/MGO+CMFs application on <i>C. albicans</i>. …”
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Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway by Yingli Xuan, Ting-ting Ding, Xiao-lei Mao, Shiqing Pang, Ruibin He, Li Qin, Jiang zi Yuan

“…Objective Liraglutide, a glucagon-like peptide-1 receptor agonist, has been shown to regulate blood sugar and control body weight, but its ability to treat obesity-related nephropathy has been poorly studied. …”
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Efficacy and safety of combination therapy with lenvatinib and pembrolizumab in elderly patients with advanced endometrial cancer by M. V. Volkonskiy, A. A. Akopyan, T. A. Zhelezkova, R. S. Zhikhorev, E. P. Krasnorutskaya, N. R. Abidova, T. A. Makarkina, M. O. Skorina, V. M. Filippova, I. A. Luev, Yu. V. Vasilyeva, G. D. Malina, L. P. Veshkina, B. L. Nersesyan

“…Additional studies are required to evaluate the efficacy and safety of the combination therapy of lenvatinib and pembrolizumab in patients with a more severe functional status.…”
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Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…Lingmei Jia,1,* Siqi Yang,1,* Jun Yin,2 Ouhua Feng,2 Zhigang Wang,1&nbsp;Min Jia,1&nbsp;1Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People&rsquo;s Republic of China; 2Cardiovascular Medicine Department, Jingxing County Hospital, Shijiazhuang, People&rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Min Jia; Zhigang Wang, Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People&rsquo;s Republic of China, Tel +86-13732219367 ; +86-15131127511, Email jiamin10086@163.com; 15131127511@163.comObjective: This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and to elucidate its underlying mechanism.Methods: The in vivo model of myocardial I/R injury was established by transient ligation of the left anterior descending coronary artery in Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, and I/R+bergenin+erastin (an agonist of ferroptosis) groups.After the model was established, the rats underwent echocardiography to assess the cardiac function. …”
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Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa by Muhammad Bilal Habib, Naseer Ali Shah, Afreenish Amir, Huda Ahmed Alghamdi, Muhammad Haseeb Tariq, Kiran Nisa, Mariam Ammoun

“…ObjectiveEmerging drug resistance in Pseudomonas aeruginosa is of great concern in clinical settings. …”
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Umbilical Cord Blood-Derived Cells Can Reconstruct Hematopoiesis in an Aplastic Anemia Animal Model by Zesong Chen, Chen Yang, Jiang Ji, Miao Chen, Bing Han

“…Transcriptome sequencing was performed for cells from CsA + UC-MSC, CsA + UCB-Treg, and CsA groups to detect the possible related genes. Gene function cluster and signal pathway enrichment analysis were also performed. …”
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Epidemiologic, Clinical, Ultrasonographic, and Cytological Features of Thyroid Nodules in Predicting Malignancy Risk: A Retrospective Study of 442 French Afro-Caribbean Patients by Johan Joseph-Auguste, Lucien Lin, Magalie Demar, Olivier Duffas, Vincent Molinie, Caroline Sulpicy, Marie-Josée Dorival, Olivier Luxembourger, Nadia Sabbah

“…There was no significant difference in age, nodule localization, number of nodules, or thyroid function test between benign and malignant nodules. …”
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Progression from isolated growth hormone deficiency to a combined pituitary hormone deficiency in a cohort of paediatrics patients with pituitary morphology abnormalities on MRI by Cristina Aguilar-Riera, Diego Yeste, Núria González-Llorens, Eduard Mogas, Ariadna Campos-Martorell, Paula Fernandez-Alvarez, Elida Vázquez, María Clemente

“…Regular follow up of pituitary hormonal function in such patients is advisable due to the risk of new added deficiencies.…”
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Cloning and Analysis of the Expansin Gene BdEXP1 from Migration Plant parasitic Nematode (Bursaphelenchus doui) by Kaiyang GUO, Shifeng LIN, Rengang WANG, Li LI, Jie ZHANG, Shizhou YU, Zili WANG, Guoqin LIU

“…【Objective】An expansin gene BdEXP1 was cloned from Bursaphelenchus doui, and its expression characteristics were investigated in order to provide reference for the in-depth study of the function of BdEXP1 gene in the interactions between B. doui and hosts.…”
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Relationship between serum ECP and TIgE levels and the risk of postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps by Qing Zhang, Hui Li, Di Xie, SiJian Fan

“…Univariate analysis indicated that neutrophil ratio, lymphocyte ratio, Lund-Kennedy score, Lund-Mackay score, SNOT-22 score, olfactory function score, and postoperative recurrence were significantly correlated with serum ECP and TIgE levels. …”
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Remodelling Features of Heart and Postinfarction Cardiosclerosis Type 2 Diabetes: Relationship to Gene Polymorphisms LEPR Q223R by Stanislavchuk M. A., Al Salim A.

“…Objective. To establish the features of cardiac remodeling in patients with postinfarction cardiosclerosis and type 2 diabetes based on gene polymorphism leptin receptors LEPR Q223R. …”
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A 30-Day Randomized Crossover Human Study on the Safety and Tolerability of a New Micellar Berberine Formulation with Improved Bioavailability by Afoke Ibi, Chuck Chang, Yun Chai Kuo, Yiming Zhang, Min Du, Yoon Seok Roh, Roland Gahler, Mary Hardy, Julia Solnier

“…<b>Background/Objectives:</b> Berberine is a naturally occurring compound found in several plants and has been traditionally used for its various health benefits. …”
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