Treatment of knee joint osteoarthritis in overweight women in outpatient practice by P. S. Kovalenko, I. S. Dydykina, E. S. Aronova, O. G. Alekseeva, E. L. Shakhramanova, A. V. Kudryavtseva, E. G. Zotkin

“…Objectives: evaluation of the clinical efficacy and safety of the healthy joints maintaining compound Artroflex® in knee osteoarthritis (OA) in postmenopausal overweight women in outpatient clinical practice.Patients and methods. …”
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LncRNA MIAT Upregulates NEGR1 by Competing for miR-150-5p as a Competitive Endogenous RNA in SCIRI Rats by Zheng Wang, Jianguang Liu, Qiuxiang Yang, Mengjie Ma

“…Objective. Spinal cord ischemia–reperfusion injury (SCIRI) can cause a pathological state of irreversible delayed death of neurons in the spinal cord tissue and a range of complications, such as spinal cord dysfunction and motor function impairment. …”
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Biomechanical and clinical differences in muscle tone, stiffness, range of motion, and pain perception in children with cerebral palsy: a cross-sectional study by Ramón González-Matilla, Ramón González-Matilla, Ramón González-Matilla, Vanesa Abuín-Porras, Isabel Mínguez-Esteban, Alberto M. Heredia-Rizo, Alberto M. Heredia-Rizo, Alberto M. Heredia-Rizo

“…They impact movement, range of motion (ROM), and pain perception, influencing functional abilities and quality of life. Understanding the intrinsic muscle differences in children with CP can help improve clinical assessment and therapeutic interventions. …”
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Effect of adherent perinephric fat on outcomes of nephron-sparing treatment of renal cell cancer by S. V. Kotov, R. I. Guspanov, A. G. Yusufov, A. A. Nemenov, A. A. Mantsov

“…The Mayo Adhesive Probability (MAP) scale aims to identify adherent perinephric fat (APF) or 'complex' paranephric fat preoperatively.Objective. To evaluate the effect of APF on intraoperative and functional outcomes of patients with renal cell cancer (RCC) who underwent laparoscopic partial nephrectomy.Materials & methods. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Secondary objectives To examine the impact of pramipexole on mood and anxiety symptoms, psychosocial function (over 48 weeks), and pleasure (over 12 weeks). …”
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Multidisciplinary Clinical Study on Retinal, Circulatory, and Respiratory Damage in Smoking-Dependent Subjects by Marcella Nebbioso, Annarita Vestri, Magda Gharbiya, Mattia D’Andrea, Matteo Calbucci, Federico Pasqualotto, Serena Esposito, Alessandra D’Amico, Valentina Castellani, Sandra Cinzia Carlesimo, Paolo Giuseppe Limoli, Alessandro Lambiase

“…<i>Background and Objectives</i>: Cigarette smoking is a widely prevalent risk factor in the global population, despite its well-recognized systemic impact. …”
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Prevalence of Sleep Apnea in Patients with Syncope of Unclear Cause: SINCOSAS Study by María-José Muñoz-Martínez, Alberto Fernández-Villar, Manuel Casal-Guisande, Enrique García-Campo, Dolores Corbacho-Abelaira, Ana Souto-Alonso, Bernardo Sopeña

“…<i>Background and Objectives:</i> The association between syncope and sleep apnea (SA) has been scarcely investigated. …”
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Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia by Chenyang Wang, Xiaolu Bu, Mengyao Cao, Yunyu Lian, Haocong Ling, Mo You, Junfei Yi, Xiaoya Gao, Duobin Wu, Yang Li

“…Results Intracerebroventricular administration of miR-199a-3p agomir exacerbated amyloid deposition and impaired cognitive function in AD mice, and promoted microglial polarization toward the M1 phenotype. …”
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Prevalence of hyperuricemia in professional athletes and its role in the genesis of various pathological conditions and metabolic disturbances by M. S. Eliseev, I. Т. Vykhodets, I. V. Kruglova, M. N. Chikina, O. V. Zhelyabina, E. V. Ilyinykh, A. V. Zholinsky, S. V. Dodonov, A. M. Lila, Е. L. Nasonov

“…The high prevalence of HU and its association with indicators reflecting kidney function, lipid metabolic disturbances, and BMI necessitate further investigations aimed at searching the causes of HU and methods of its prevention and treatment in professional athletes.…”
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El mantenimiento en la confiabilidad y disponibilidad de un sistema de generación de vapor // Maintenance on the reliability and availability of steam boiler systems by Mayra Troncoso-Fleitas, Héctor Acosta-Palmer

“…</p><p>__________________________________________________________________</p><p>Abstract<br />This paper has as objective to develop and to group the main findings of safety detected in Steam<br />Boiler Systems that influence in its reliability and availability and they are caused by weaknesses in<br />the function maintenance. …”
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Effect of FTY720 on Angiotensin Ⅱ-mediated chronic kidney diseases by HAN Qi, LI Ming-mei, YANG Guo-sheng, PENG Qing-ping, WANG Xiao-hui

“…Objective To assess effect of fingolimod（FTY720） on functions of the kidney in rats by establishing the rat mode of angiotensin Ⅱ（Ang Ⅱ）-perfused renal injury and using the drug to intervene the rat model; and to explore action of FTY720 on renal inflammation changes and its potentially involved mechanism in the angiotensin Ⅱ-perfused rat, so as to provide a new strategy for treatment of kidney diseases. …”
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Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: study protocol by Roshan das Nair, Nor Asiah Muhamad, Avril Drummond, Mazlina Mazlan, Norhamizan Hamzah, Vairavan Narayanan, Norlisah Ramli, Nor Atikah Mustapha, Nor Adibah Mohammad Tahir, Li Kuo Tan, Mahmoud Danaee, Sing Yau Goh

“…Objectives To measure the clinical, structural and functional changes of an individualised structured cognitive rehabilitation in mild traumatic brain injury (mTBI) population.Setting A single centre study, Malaysia.Participants Adults aged between 18 and 60 years with mTBI as a result of road traffic accident, with no previous history of head trauma, minimum of 9 years education and abnormal cognition at 3 months will be included. …”
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Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a by YANG Hongyan, LIAO Qirong, HOU Mingliang

“…Water maze test was used to evaluate the effect of circ-Olfm1 knockout on cognitive function, and immunofluorescence assay was employed to observe the deposition of amyloid β (Aβ) plaque in the brain. ④ The interaction between circ-Olfm1 and miR-330-5p was verified by double luciferase reporter gene analysis. ⑤ The protein levels of AMPK and FOXO3a were detected by Western blotting. ⑥ Transmission electron microscopy was utilized to observe the mitochondria of the hippocampus. ⑦ The levels of inflammatory factors IL-6, IL-1β and TNF-α were detected by ELISA. …”
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Genomic islands and molecular mechanisms relating to drug-resistance in Clostridioides (Clostridium) difficile PCR ribotype 176 by Marcela Krutova, Vojtech Kovarovic, Marie Brajerova, Fanny Demay, Jaroslava Zikova, Suhanya Prasad, Anna Soltesova, Elena Novakova, Hanna Pituch, Ed Kuijper, Wiep Klaas Smits, Gabriela Balikova Novotna

“…Heterologous expression and functional analysis of the newly identified methyltransferase were performed.Results Core genome multilocus sequence typing found 10–37 allele differences. …”
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A Robust Cross-Platform Solution With the Sense2Quit System to Enhance Smoking Gesture Recognition: Model Development and Validation Study by Anarghya Das, Juntao Feng, Maeve Brin, Patricia Cioe, Rebecca Schnall, Ming-Chun Huang, Wenyao Xu

“…The app was developed using the Flutter framework to ensure seamless functionality across Android and iOS platforms, with robust synchronization between the smartwatch and smartphone for real-time monitoring. …”
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Gait analysis with smart insoles can identify patients at risk of tibial shaft fracture nonunion as early as six weeks after surgery: longitudinal and cross-sectional study by Elke Warmerdam, Marcel Orth, Max Müller, Tim Pohlemann, Bergita Ganse, Bergita Ganse

“…Unfortunately, it often takes months of observation until the indication for revision surgery or other interventions is given, which is why additional methods are desirable to enhance the ability to predict and prevent nonunion earlier.ObjectiveAs gait patterns and subjective outcomes obtained by questionnaires improved during regular fracture healing, the aim of this study was to determine whether gait analyses with instrumented insoles and patient-reported outcome measurement information system (PROMIS) questionnaires could be used to detect patients at risk of developing nonunion during the healing phase after tibial shaft fracture.MethodsData were collected from a longitudinal and a cross-sectional tibial fracture cohort via gait analysis with instrumented insoles (OpenGO, Moticon GmbH, Munich, Germany) and in addition via PROMIS questionnaires. …”
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Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population by Lijie Nie, Yan Sun, Ruiqi Li, Qiulian Liang, Guocun Deng, Xinyu He, Yifei Zeng, Hui Zheng, Xinhe Xiao, Xiaodong Ding, Jian Huang, Xiangyuan Yu, Xiangyuan Yu

“…HLA-DQA1/DQB1 genes play a crucial role in the regulation of the human immune and endocrine systems, potentially influencing the pathogenesis of GDM.ObjectiveTo explore the associations between single nucleotide polymorphisms (SNPs) in HLA-DQA1/DQB1 genes and the risk of GDM.MethodsSeven functional SNPs of HLA-DQA1/DQB1 genes were selected and genotyped in 523 GDM patients and 638 normal pregnant women. …”
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Thalamic nuclei volumes are related to disease stage in patients with amyotrophic lateral sclerosis by Tianrui Wen, Tianrui Wen, Jun Zhu, Jun Zhu, Sujuan Sun, Sujuan Sun, Yujing Chen, Yujing Chen, Ninglu Gao, Ninglu Gao, Mingjie Ma, Xinyue Chen, Shuangwu Liu, Shuangwu Liu, Pengfei Lin, Yan Deng

“…In these patients, the volume of the bilateral motor nuclei was associated with the revised ALS Functional Rating Scale scores, and that of the right pulvinar-limitans independently correlated with MMSE scores.ConclusionOur study provides a comprehensive profile of thalamic atrophy in ALS patients. …”
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Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice by Shiyan Wang, Ye Zhou, Yucheng Wu, Yali Lang, Yajun Mao, Guoyuan Pan, Zhenzhen Gao

“…ObjectiveTo examine the effects of long-term aerobic exercise on oxidative stress and learning memory ability of APP/PS1 mice, focusing on the hippocampal Keap1, Nrf2, HO-1, and GPX4 proteins.MethodsThirty APP/PS1 double transgenic AD mice were randomly divided into three groups: model group, short-term exercise group, and long-term exercise group, with 10 mice in each group. …”
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Differential patterns of the relationship between exercise dose and mortality risk across severities of airflow limitation: a prospective cohort study with a 5-year follow-up perio... by Yide Wang, Hongxia Duan, Yingqi Wang, Yidie Bao, Linhong Jiang, Xiaoyu Han, Fengsen Li, Peijun Li, Weibing Wu, Xiaodan Liu

“…Cox proportional hazards models were used to evaluate PA–mortality associations, with penalized spline analysis detecting threshold effects. Results: Identified thresholds were 41.50 MET·h/week (95% CI: 23.03–64.22) for normal lung function and 13.21 MET·h/week (95% CI: 9.67–16.14) for GOLD 1. …”
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