Sagittal Plane Kinematic Deviations and Spatio-Temporal Gait Characteristics in Children with Idiopathic Toe Walking: A Comparative Analysis Using Statistical Parametric Mapping by Rocio Pozuelo-Calvo, Almudena Serrano-Garcia, Yolanda Archilla-Bonilla, Angel Ruiz-Zafra, Manuel Noguera-Garcia, Kawtar Benghazi-Akhlaki, Miguel Membrilla-Mesa, Carla DiCaudo, Jose Heredia-Jimenez

“…<b>Background/Objectives</b>: Idiopathic Toe Walking (ITW) is a pediatric gait disorder characterized by persistent toe-to-heel ambulation in the absence of neurological, orthopedic, or developmental abnormalities. …”
Get full text

Potential liquid biopsy markers of exosomal microRNAs in renal interstitial fibrosis blood and urine by Chunyan Lv, Yuan Zhong, Yao Hu, Yan Tang

“…Objective: To explore more and better liquid biopsy markers of exosomal microRNAs (exo-miRNAs) in renal interstitial fibrosis (RIF) and to preliminary investigate the biological functions and signaling pathways involved in these markers. …”
Get full text

hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NF-&#954;B Signaling Pathway by Jian Wang, Binghui Du

“…Objective: Deep vein thrombosis (DVT) is a vascular disorder with an incidence rate of about 0.1%. …”
Get full text

Mechanism of Electroacupuncture Quchi (LI 11) -Yanglingquan (GB 34) in Rats with Spasticity of Cerebral Apoplexy by Bin GUO, Penghan WANG, Linxing HUANG, Zhiqiang XIE, Lina XIE, Weiai LIU, Lizhen YI, Xin LIU, Zenghui YUE

“…High expression of the neurotrophic factor in hippocampus may promote the remodeling of synapses and improve the motor function of the central nervous system, thus achieving the relief of spasticity.…”
Get full text

Age- and Post-Based Complex Analyses of Heart Rate Variability in Young Male Handball Players for Potential Prevention of Overload-induced Injuries by Zita Petrovszki, Olivér Czimbalmos, Vera Gal, Gabor Korosi, Edit Nagy, Rita Mikulan, Gyongyi Horvath

“…Background/objective: Cardiovascular measures are important for prescription of appropriate training load; however, little data exist in this respect on handball players. …”
Get full text

Analysis of the prevalence and role of maladaptive left ventricular remodeling in the risk of early renal graft dysfunction by R. A. Ibadov, D. A. Chernov, S. Kh. Ibragimov, Z. U. Abdugafurov, Z. T. Matkarimov

“…Objective: to study the prevalence of maladaptive left ventricular remodeling (MLVR) among kidney transplant (KT) candidates and the role of MLVR in the development of early graft dysfunction (EGD). …”
Get full text

Role of Circulating X-Chromosome Inactivation and <i>Xist</i> as Biomarkers in Female Carriers of Fabry Disease by Salvatore Rossi, Arcangelo Fargnoli, Daniele Di Natale, Gianmarco Dalla Zanna, Antonio Funcis, Federica Re, Vincenza Gragnaniello, Elena Verrecchia, Alberto Burlina, Elisabetta Tabolacci, Gabriella Silvestri

“…In skewed FD females, the renal function and mean cardiologic MSSI subscore were significantly worse, and systemic arterial hypertension was more frequent. …”
Get full text

Impact of a pharmacist driven antimicrobial stewardship program on inpatient antibiotic consumption in a Chinese Tertiary Hospital: a 5-year retrospective study by Can Qian, Ting Yuan, Fuyong Zhang, Shiyuan Gou, Chunmei Jiang, Xuebing Chen, Ya Huang, Xiaolin Zhao, You Du, Chenglong Li, Yangyun Han, Huaiyu Su

“…Pharmacists play a critical role in AMS due to their combined management functions and professional expertise.ObjectiveTo investigate the impact of a Pharmacist-Driven Antimicrobial Stewardship program on the consumption of antibiotics in a hospital.MethodsUnder the support of a hospital top-level design, we implemented a Pharmacist-Driven Antimicrobial Stewardship program led by pharmacists and involving multiple disciplines. …”
Get full text

Aplicación de técnicas SIG, Sensoramiento Remoto y Análisis Multicriterio para la Detección de Impactos Antropogénicos en la Cobertura de Suelos y su Proyección para el 2010. Caso... by Paola Almeida, M. Duriavich, R. Napolitano, E. Feoli

“…Future tendencies forecasting was performed by the application of fuzzysets functions and multicriteria analysis (MCA) based on a series of factors and constraints that characterize anddescribe the study area. …”
Get full text

Aplicación de técnicas SIG, Sensoramiento Remoto y Análisis Multicriterio para la Detección de Impactos Antropogénicos en la Cobertura de Suelos y su Proyección para el 2010. Caso... by Paola Almeida, M. Duriavich, R. Napolitano, E. Feoli

“…Future tendencies forecasting was performed by the application of fuzzysets functions and multicriteria analysis (MCA) based on a series of factors and constraints that characterize anddescribe the study area. …”
Get full text

Aplicación de técnicas SIG, Sensoramiento Remoto y Análisis Multicriterio para la Detección de Impactos Antropogénicos en la Cobertura de Suelos y su Proyección para el 2010. Caso... by Paola Almeida, M. Duriavich, R. Napolitano, E. Feoli

“…Future tendencies forecasting was performed by the application of fuzzysets functions and multicriteria analysis (MCA) based on a series of factors and constraints that characterize anddescribe the study area. …”
Get full text

Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance M... by Zeid Kuzbari, Charlie F. Rowlands, Isaac Wade, Alice Garrett, Chey Loveday, Subin Choi, Beth Torr, Kevin Litchfield, Alison Reid, Robert Huddart, Peter Broderick, Richard S. Houlston, Clare Turnbull

“…Background and objective: Testicular germ cell tumour (TGCT) is the most common cancer in young men, and over half of its high estimated heritability is unexplained. …”
Get full text

A Study on the relationship between the changes of lymphocyte subgroups and chronic kidney disease and mineral and bone disorder in maintenance hemodialysis patients with HBV infec... by 李侃, 王荣珍, 史陇珍, 刘天喜, 魏琪琦, 杨蓉, 薛潇, 杨凯莉, 刘明龙, 吕红, 史慧敏, 尚兰兰, 崔治华

“…Objective To compare the changes of lymphocyte subgroup percentages,mineral and bone metabolism levels and microinflammation status in maintenance hemodialysis(MHD)patients with and without hepatitis B virus(HBV)infection,and to observe the correlation between lymphocyte subgroup changes and chronic kidney disease and mineral and bone disorder(CKD-MBD)in patients with HBV infection.Methods A total of 62 patients with end-stage renal disease who had been treated with MHD for more than 3 months were divided into two groups:HD group(33 cases)and HBV-HD group(29 cases).The percentage of lymphocyte subgroups was detected by monoclonal antibody flow cytometry,the level of parathyroid hormone(PTH)was detected by radioisotope method,and microinflammatory factors were detected by enzyme-linked immunosorbent assay.Results In routine blood examination,16.13%(10/62)patients were observed to show a decrease in white blood cell count with an increase in 5 cases,53.23%(33/62)patients had a decrease in lymphocyte percentage with an increase in 3 cases.Compared with the HD group,the percentage and absolute value of lymphocyte in the HBV-HD group were significantly decreased(P<0.05),and the percentage of T lymphocyte was significantly increased(P<0.05).The percentage of Th cells,and CD4~+/CD8~+ratio decreased(P<0.05),the percentage of Treg cells increased(P<0.01),and the change of Ts cells had no significant difference(P>0.05).Compared with the HD group,the percentage of B lymphocytes in the HBV-HD group had no significant difference(P>0.05),and the percentage of NK lymphocytes decreased significantly(P<0.05).Compared with the HD group,the level of PTH and calcium-phosphorus product increased in the HBV-HD group(P<0.05),the levels of C-reactive protein,TNF-α and IL-6 increased(P<0.05),while the levels of serum Ca,P,beta-2 microglobulin and bone alkaline phosphatase had no significant difference(P>0.05).The correlation analysis showed that there was a negative correlation between Th cell percentage,CD4~+/CD8~+ ratio,NK lymphocyte percentage and the level of PTH and calcium-phosphorus product in the two groups.Conclusions In MHD patients,the number of lymphocyte subgroups decreases to different degrees,and the numbers of T lymphocyte and NK lymphocyte subgroups decrease to a greater extent after HBV infection.CKD-MBD is more likely to occur in patients with HBV infection.CKD-MBD may be involved in the suppression of immune function of T lymphocytes.Since immune deficiency can induce and aggravate infection,the microinflammation of MHD patients infected with HBV may be more serious.…”
Get full text

SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Abstract Objective Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with a high metastasis rate and a poor prognosis. …”
Get full text

Dynamic evolution of microstructure in thalamic subregions of patients with cirrhosis: A study based on diffusion kurtosis imaging by Qi Zhang, Zhi-Jing Zhang, Yi-Ning Zhang, Wen-Ting Ma, Xiao-Di Zhang, Zi-Ning Lu, Xiao-Dong Zhang, Wen Shen, Yue Cheng

“…Objectives: To investigate the cross-sectional and longitudinal dynamics of the thalamic subregion microstructure in patients with liver cirrhosis by diffusion kurtosis imaging (DKI) and explore its relationship with cognitive function. …”
Get full text

Expression of toll-like receptors and inflammatory mediators in primary human glioma cells (low- and high-grade) compared to primary cells from epileptic human brain by Negin Masoomabadi, Safieh Ebrahimi, Farshid Noorbakhsh, Alireza Tabibkhooei, Gisou Mohaddes, Saeed Sadigh-Eteghad, Maryam Khaleghi Ghadiri, Tahereh Ghadiri, Ali Gorji

“…Objective(s): Toll-like receptors (TLRs) have been implicated in the pathogenesis of glioma as principal regulators of inflammation and innate immune function. …”
Get full text

The influence of type 2 diabetes mellitus on clinical manifestations of osteoarthritis by E. A. Taskina, L. I. Alekseeva, N. G. Kashevarova, E. A. Strebkova, E. P. Sharapova, N. M. Savushkina, K. M. Mikhailov, T. A. Raskina, I. B. Vinogradova, E. N. Otteva, E. V. Zonova, O. N. Anoshenkova, A. M. Lila

“…Objective: to investigate in a multicenter study relationship between type 2 diabetes mellitus (DM) and clinical manifestations of osteoarthritis (OA). …”
Get full text

LONG TERM FOLLOW-UP ON EFFECTIVENESS AND SAFETY OF ETANERCEPT IN JUVENILE IDIOPATHIC ARTHRITIS WITHOUT SYSTEMIC MANIFESTATIONS by A. A. Baranov, E. I. Alexeeva, T. M. Bzarova, S. I. Valieva, K. B. Isaeva, E. G. Chistyakova, A. M. Chomakhidze, R. V. Denisova, T. V. Sleptsova, A. N. Fetisova, O. L. Lomakina

“…According to the results of Childhood Health Assessment Questionnaire (CHAQ) functional activity fully recovered in 65 and 79%; 30 and 58% of children in a period of 6 and 12 months of follow-up. …”
Get full text

Use of quantitative CT chest imaging to derive and assess a radiographic phenotype of deployment-related constrictive bronchiolitis by Alexander J. Bell, Maria Masotti, Sundaresh Ram, Gregory Pappas, Robert F. Miller, Ella A. Kazerooni, Charles R. Hatt, MeiLan K. Han, Bradley W. Richmond, Michael J. Falvo, Craig J. Galban, John J. Osterholzer

“…Results Individual unadjusted QCT metrics for functional small airways disease and high attenuation area were elevated in DRCB and FDSV cohorts (relative to Control). …”
Get full text

Pulmonary complications in children and adolescents after allogeneic hematopoietic stem cell transplantation by A. S. Frolova, A. G. Volkova, O. V. Paina, P. V. Kozhokar, K. A. Ekushov, Zh. Z. Rakhmanova, L. A. Cvetkova, E. D. Dobrovolskaya, B. I. Smirnov, E. A. Kulagin, T. A. Bykova, E. V. Semenova, L. S. Zubarovskaya

“…However to date, the effect of HSCT on functional and morphological pulmonary changes in recipients remains insufficiently studied.The objective of current study was to evaluate risk factors affecting long-term survival in children and adolescents after allo-HSCT.Methods and materials. …”
Get full text