Pirfenidone alleviates smoke inhalation lung injury of rats via the NF‐κB signaling pathway by Tingting Lv, Kaiyuan Yang, Jinxiang Wang

“…Pirfenidone (PFD), a new small‐molecule drug, has been shown to improve lung function and inhibit pulmonary fibrosis and inflammation. …”
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Stage‐Dependent Inhibitory Connectivity in Striatal‐Motor Circuit in Huntington's Disease by Yinghua Jing, Imis Dogan, Rena Theda Overbeck, Kathrin Reetz, Sandro Romanzetti

“…Conclusions Our results indicate that striatal atrophy and hyper‐inhibition of caudate‐motorial connectivity might contribute to the regional function alterations in HD. Furthermore, disruption of inhibitory connectivity in the striatal‐motor circuit may play an important role in the emergence of motor symptoms.…”
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User satisfaction with train fares: A comparative analysis in five Australian cities. by Puteri Paramita, Zuduo Zheng, Md Mazharul Haque, Simon Washington, Paul Hyland

“…In particular, satisfaction with train fares is modelled as a function of socio-economic factors and train trip characteristics, using a random parameters ordered Logit model that accounts for unobserved heterogeneity in the population. …”
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Effect and mechanism of Huangkui capsule inhibiting oxidative stress and fibrosis indicators in patients with diabetic nephropathy with stage Ⅲ-Ⅳ by XU Ji-yao, ZHANG Yu, ZENG Qiao

“…Objective To study the effect of Huangkui capsule inhibiting oxidative stress and fibrosis index in patients with diabetic kidney disease(DKD)with stageⅢ-Ⅳ,so as to explore the mechanism of Huangkui capsule in the treatment of DKD.Methods 100 patients with DKD with stageⅢ-Ⅳfrom June 2014 to October 2015 were randomly divided into two groups,50 in each group.The patients in the control group were given conventional treatment,and those in the treatment group additionally received Huangkui capsule orally,5 capsules each time,3 times every day for 6 months.The kidney function,and urine and serum levels of oxidative stress and fibrosis indicators were detected.Results The SCr,BUN,andβ2-MG levels in two groups after treatment decreased,CCr increased,and there was statistically significant significance between two groups(P <0.05).The UAER and 24-h urine proteinin two groups after treatment were significantly lower than those before treatment,and those in the treatment group were significantly lower than those in the control group(P<0.05 for all).The MDA and MPO concentrations intwo groups after treatment were significantly lower than before treatment,SOD activity was significantly higher than before treatment,and there was statistically significant difference between two groups(P<0.05).There was no statistically significant difference in 8-OHdG in two groups before and after treatment(P>0.05).The serum IV-C,PC Ⅲ,LN and HA levels after treatment in two groups were significantly lower than before treatment,and those in study group were significantly lower than those in the control group(P<0.05 for all).Conclusions Huangkui capsule can antagonize the oxidative stress injury in kidney tissues probably by influencing the release of fibrosis factor and improving the renal fibrosis.…”
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Aucubin Promotes Osteogenic Differentiation and Facilitates Bone Formation through the lncRNA-H19 Driven Wnt/β-Catenin Signaling Regulatory Axis by Yong-xin Mai, Zhi-peng Li, Feng-xiang Pang, Shu-ting Zhou, Nan Li, Yu-yan Wang, Jin-fang Zhang

“…In the present study, our aim was to explore its function in bone regeneration and elucidate the underlying mechanism. …”
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Adverse drug reactions to atezolizumab in combination with bevacizumab in hepatocellular carcinoma patients: an analysis of the food and drug administration adverse event reporting... by Wanming He, Lihua Tong, Yanling Yuan, Xia Yang, Wen Yang, Xingxi Pan

“…The WSP test indicated that patients with abnormal hepatic function and hepatic failure exhibited early failure-type profiles. …”
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On Explainability of Reinforcement Learning-Based Machine Learning Agents Trained with Proximal Policy Optimization That Utilizes Visual Sensor Data by Tomasz Hachaj, Marcin Piekarczyk

“…This estimation makes it possible to determine whether the network makes decisions as expected (decision-making is related to the model’s observation of objects belonging to different semantic classes in the environment) and to detect unexpected, seemingly chaotic behavior that might be, for example, the result of data bias, bad design of the reward function or insufficient generalization abilities of the model. …”
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Expressions of nephrin and desmin in podocyte of HUA rats and intervention of febuxostat by Wu Wei-bin, Zhang Ji-qiang, Gao Qin, Yin Xiao-li, Sang Miao-miao, Yang Ping, Liu Lei, Chen Wei-dong

“…Objective To explore the role and mechanism of podocytes in rat model with uric acid-induce renal damage.Methods By using a random number table, a total of 24 male Sprague-Dawley rats were randomly divided into three groups of control（NC）,model（HUA）and febuxostat（FX）（n=8 each）.After 8 weeks, the rats were weighted and sacrificed.The levels of uric acid（UA）,blood urea nitrogen（BUN）,serum creatinine（Scr）and 24 h urinary protein（24 h UP）were recorded.Renal pathological changes were observed under transmission electron microscope（TEM）after hematoxylin-eosin（HE）staining.The renal expression levels of nephrin and desmin were detected by immunohistochemical staining and Western blot.Results At Week 8,the levels of UA,Scr, BUN,24 h UP and the expression level of desmin increased markedly in HUA group than those in NC group（P<0.01）;The expression of nephrin decreased obviously in HUA group.Compared with HUA group, the levels of UA,Scr, BUN,24 h UP and the expression level of desmin decreased obviously in FX group.Massive urate crystals deposited in renal tubules and foot process effacement in HUA group.However, it was lighter in FX group.Conclusion Hyperuricemia causes renal podocyte damage and impairs renal function.Febuxostat treatment can effectively lesson the degree of podocyte damage in hyperuricemia rats.A positive correlation exists between serum uric acid level and desmin expression in renal tissue（P<0.01）;a negative correlation between serum level of uric acid and nephrin expression in renal tissue（P<0.01）.A linear correlation exists between the level of uric acid and the degree of podocyte injury.Podocyte injury may be one of the causes of uric acid nephropathy.…”
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EVL Promotes Osteo-/Odontogenic Differentiation of Dental Pulp Stem Cells via Activating JNK Signaling Pathway by Kangrui Zeng, Qiongyi Kang, Yutong Li, Weiping Li, Qing Cheng, Wenwei Xia

“…Objective. Human dental pulp stem cells (hDPSCs) were recognized as a suitable and promising source of stem cells in dental pulp regeneration. …”
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Effects of Anti-GPIbαantibody on the expression of platelet GPIbα,CD62P and CD63 in maintenance hemodialysis patients by LUO Min-hong, YANG Tie-cheng, ZHU Lang-jing, CHEN Zhen-wei, ZENG Hai-ou, MO Cai-ju, WU Qiang, XIAO Jie

“…Objective To explore the effects of anti-platelet membrane glycoprotein Ib alpha(GPIbα)antibody on the expression of peripheral GPIbα,alpha particle membrane glycoprotein(CD62 P)and lysosomal membrane protein(CD63)in maintenance hemodialysis(MHD)patients.Methods Thirty-seven patients with chronic renal failure undergoing MHD from March 2016 to March 2018 in the Department of Nephrology in Eighth Affiliated Hospital of Sun Yat-sen University and 31 healthy people in the Physical Examination Center were enrolled in this study.Using flow cytomery,the expression of platelet member GPIbα,CD62 P and CD63 was detected before and after addition of anti-GPIbαantibody in MHD patients.Results The expression of platelet membrane GPIbαin no antibody treatment group(29.9±4.9)% was significantly lower than in control group(63.8±9.0)%and antibody treatment group(42.3±6.5)%(both P<0.01).The expression of CD62 P and CD63 in no antibody treatment group(50.9±7.5)% and(54.1±5.5)% was significantly higher than that in the control group(23.3±8.7% and 30.9±6.2%)and antibody treatment group(36.5±2.0)% and(47.2±2.2)%(P<0.01,P<0.05).Conclusions Anti-GPIbαantibody can regulate platelet function and activity by up-regulating the expression of platelet membrane GPIbα,and down-regulating the expression of CD62 P and CD63 in MHD patients,as a result to suppress adhesion and aggregation of platelets and thrombosis,and reduce the possibility of thromboembolism events in MHD patients.…”
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Expression of m6A-modified methyltransferase-like 14 in the hippocampus of depression-like mice

“…Conclusions m6A methylation function has been proved to be more active in the hippocampus of depressed mice.…”
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Base Station Placement Algorithm for Large-Scale LTE Heterogeneous Networks. by Seungseob Lee, SuKyoung Lee, Kyungsoo Kim, Yoon Hyuk Kim

“…Both the simulation and analytical results indicate that the proposed solution outperforms the random-grouping based EA as well as an EA that detects interacting variables by monitoring the changes in the objective function algorithm in terms of system throughput performance.…”
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Artificial Intelligence-Driven Models for Predicting Chloride Diffusion in Concrete: A Comparative Regression Analysis by Yongjie Zhang, Yuhan Zhang

“…A comprehensive index includes various kinds of metrics depicts that the SJSO value of objective function (OFU) was roughly 50% smaller at 0.3769 compared to the SHGSO at 0.7284. …”
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Menstrual and Hormonal Changes in Breast Cancer Patients Treated By Ad- juvant, Adriamycin and Cyclophosphamide Chemotherapy by Jangi Shawkat Muhialdin Salai, Nermin Jamal Abdulqadr, Kawa Faeq Dizaye

“… Background and Objective: The long term effects of adjuvant chemotherapy are very important in patients with breast cancer. …”
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Evaluation of the effect of phellodendrin application on rats creating an experimental model of non-compression lumbar disc herniation on the NF-κB-related inflammatory signaling p... by Panlin Tan, Jianbing Mei, Dong Wang

“…Abstract Objective To explore the therapeutic effects of phellodendrine on non-compression lumbar disc herniation (NCLDH). …”
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Atmospheric mixed Rossby–gravity waves over the tropical Pacific during the austral summer by H. A. Braga, V. Magaña

“…Using an empirical orthogonal function (EOF) analysis of the high-frequency meridional component anomalies of the wind at 200 hPa, for zonal wavenumbers 4–6, episodes of intense MRGW activity are detected. …”
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Electrophysiological Study in Patients with Cervical Radiculopathy by Hussein Kaddoori

“…Electromyography (EMG), nerve conduction studies (NCS), and somatosensory evoked potentials (SEPs) are frequently used to evaluate spinal cord and nerve root function. Objective: To evaluate the sensitivity of different SEP components in detecting cervical nerve root lesions, as well as to test the NCS, and EMG, in patients with cervical radiculopathy. …”
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Mathematical Modeling of COVID-19 Disease Dynamics With Contact Tracing: A Case Study in Ethiopia by Shimelis Bekele Zerefe, Tigabu Kasie Ayele, Surafel Luleseged Tilahun

“…Based on the data reported, we estimated the values of the parameters using the least squares method together with the fmin function in the MATLAB optimization toolbox. The sensitivity analysis of the model is explored numerically to illustrate the impact of the parameters on disease transmission. …”
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Role of caveolae in smooth muscle cells-mediated enhanced vasoconstriction of interlobar renal artery to angiotensin Ⅱ in SHR rats by ZHANG Hai-jun, ZHANG Xi, XIE Xiao-ping, CHANG Yao-ming, BAO Jun-xiang

“…Objective To investigate the role of caveolae in higher vasoconstriction of interlobar renal artery(IRA) of spontaneously hypertensive rat(SHR) to angiotensin Ⅱ(Ang Ⅱ).Methods Isometric force recording system was used to detect the vascular function.Methyl-beta-cyclodextrin(MCD) was employed to reduce the caveolae abundance.Real-time polymerase chain reaction(RTPCR) and Western blotting were conducted to examine the expression of mRNA and protein of angiotensin type 1 receptor(AT1R).Immumoprecipitation followed by Western blotting was carried out to test the binding of caveolin-1 and AT1 R.Results As compared to Wistar Kyoto(WKY) rats,the constriction of IRA to Ang Ⅱ was increased by 32.7%in SHR(P<0.05).Meanwhile,the abundance of caveolae on vascular smooth muscle cells(VSMCs) was enhanced significantly(P<0.05).After reducing the caveolae by MCD,the intensity and sensitivity of vasoconstriction to Ang Ⅱ in IRA of SHR were partly and entirely reversed,respectively.Moreover,AT1 R protein expression was higher in IRA of SHR group than in WKY group in which the AT1 R protein expression was lowered in part by MCD incubation.In IRA of both WKY group and SHR group,Ang Ⅱ could promote the binding of AT1 R to caveolin-1(P<0.05),which was by a larger extent in SHR group than in WKY group(P<0.05).After treatment with MCD,the binding of the two proteins in IRA of SHR group was restored to the level of WKY rats.Conclusions Caveolae regulates the enhanced intensity and sensitivity of vasoconstriction to Ang Ⅱ in IRA of SHR by raising AT1 R protein content and binding of AT1 R to caveolin-1.…”
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Endocannabinoid 2-arachidonoylglycerol is elevated in the coronary circulation during acute coronary syndrome. by Julian Jehle, Hanna Goerich, Laura Bindila, Beat Lutz, Georg Nickenig, Vedat Tiyerili

“…<h4>Objectives</h4>The endocannabinoid system modulates coronary circulatory function and atherogenesis. …”
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