Exosome Derived from Human Umbilical Cord Mesenchymal Cell Exerts Immunomodulatory Effects on B Cells from SLE Patients by Ying Zhao, Wenbin Song, Zilin Yuan, Min Li, Gang Wang, Liping Wang, Yueping Liu, Bo Diao

“…MicroRNA-155 (miR-155) has a powerful regulatory function in B cells. It was demonstrated that hucMSCs-Exo acts synergistically with miR-155 inhibitors to target SHIP-1 to B cells more effectively than exosomes alone. …”
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Effect of Regular Physical Exercise on Gut Microbiota and Depressive Behaviors in Rats by Liangju Sheng, Yuxuan Wang, Anqi Jiang, Yan Zhou, Hong Zhou

“…Objective. The gut microbiota, as the critical mediator of the gut-brain axis, can produce and transport neuroactive substances, thus playing a significant role in the pathogenesis of depression. …”
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Protective effect of L-carnitine on rhabdomyolysis-induced acute kidney injury via Nrf2/HO-1 activation by ZHANG Yuan-yuan, ZHANG Jian-rong, GENG Yan-qiu, ZHANG Yan-xia

“…Objective To observe the protective effects of L-carnitine on renal function in rhabdomyolysis-induced acute kidney injury(AKI) in rats and the underlying mechanism.Methods Thirty-six adult rats were randomly divided into 3 groups:control group,AKI model group,and L-carnitine treatment group[rhabdomyolysis-induced AKI rats given L-carnitine(200 mg/kg)].50%glycerin was intramuscularlly injected to establish rhabdomyolysis-induced AKI models in rats.Blood samples were taken from the heart from rats and the kidneys were harvested.Serum creatine kinase(CK),blood urea nitrogen(BUN),serum creatinine(SCr) levels were measured,and renal pathological changes were observed under light microscope.RT-PCR and immunohistochemistry were used to detect the expression of Nrf2 and HO-1 in renal tissues.Enzyme linked immunosorbent assay(ELISA) was applied to detect the expression of SOD and MDA in renal tissues.Results As compared with control group,CK,BUN,SCr,Nrf2,HO-1,MDA and ATN were significantly elevated,and SOD was significantly reduced in model group and L-carnitine treatment group(F = 8.78-200.77,q=S.42-19.40,P<0.05).As compared with model group,CK,BUN,SCr,MDA and ATN were significantly decreased,and Nrf2,HO-1 and SOD were significantly elevated in L-carnitine treatment group(q = 4.15-15.39,P<0.05).Conclusions L-carnitine can ameliorate rhabdomyolysis-induced AKI,which may be related with its anti-oxidative stress.…”
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The Role of CXCR3 in the Induction of Primary Biliary Cirrhosis by Wen Zhang, Yunyun Fei, Jinming Gao, Bin Liu, Fengchun Zhang

“…Objective. Investigate whether CXCR3 and its ligands were involved in the pathogenesis of primary biliary cirrhosis (PBC) in an autoimmune cholangitis animal model. …”
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Central Hemodynamics and Intracranial and Cerebral Perfusion Pressures in Acute Cerebral Circulatory Disorders by K. V. Lukashev, A. Z. Valiakhmedov, Yu. A., Churlyaev, L. Yu. Redkokasha, T. I. Borshchikova, P. G. Sitnikov, T. P. Aikina

“…Objective: to study the central hemodynamics (CH) and intracranial and cerebral perfusion pressures (ICP and CPP) in acute cerebral circulatory disorders (ACCD) and their possible relationships for further development of intensive differential therapy for the detected disorders. …”
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Meloxicam Alleviates Sepsis-Induced Kidney Injury by Suppression of Inflammation and Apoptosis via Upregulating GPNMB by Shilei Zhao, Lei Cui, Xiufeng Zheng, Ying Ji, Chengyuan Yu

“…The HK-2 cells were treated with LPS (1 μg/mL) and Mel (40 μM). The renal function and renal pathological changes as well as renal inflammation and apoptosis were detected in SAKI mice. …”
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A case of polymorphic leukocytoclastic vasculitis associated with renal neoplasia by A. A. Klimenko, N. A. Shostak, A. S. Gaffarova, A. A. Kondrashov, E. I. Schmidt

“…Objective: to describe a clinical case of polymorphic leukocytoclastic vasculitis (PLCV) associated with renal neoplasia.Materials and methods. …”
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Evaluation of Complete Blood Count Parameters in Patients with Methylmalonic Acidemia by Mehmet Cihan Balcı, Meryem Karaca, Gülden Gökçay

“…Objective: We aimed to evaluate the frequency of pathological changes in blood parameters and their relationship with serum creatinine and glomerular filtration rate (GFR) in patients with methylmalonic acidemia. …”
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Thrombotic Microangiopathy Complicating Cyclosporine in Renal Transplant Patients by Safa Al-Mukhtar

“…Regular follow up with blood film and counts, reticulocyte count, liver enzymes, renal function tests, lactic dehydrogenas, haptoglobin and serum electrolytes were performed. …”
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Analysis of the correlation between cognitive impairment and non-traditional risk factors in maintenance hemodialysis patients by ZHONG Xin, LI Zhao-hui, CHEN Rui-juan, HE Gui-fang, SUN Dong-ni, ZHANG Chun-hua

“…Objective To evaluate the incidence of cognitive impairment(CI) and the correlation between CI and non- traditional risk factors among maintenance hemodialysis(MHD) patients.Methods 140 MHD patients were surveyed in this study.The Montreal cognitive assessment scale(MoCA) was used to make cognitive function score.Cross-sectional survey of age,gender,years of education,disease and complications was done.High sensitivity c-reactive protein(hs-CRP),albumin,homocysteine(Hcy),and hemoglobin were assayed.The patients were then assigned into the CI group or the CI-free groups.The clinical and laboratory data were compared between the two groups.Results CI was detected in 80 patients(57.1%).In the CI group,the score of MoCA was(18.70 ± 2.74),the morbidity of combined diabetic nephropathy was 41.3%,hs-CRP was(13.6 ± 7.6) mg/L,and Hcy was(29.6 ± 6.2) μmol/L.Patients with CI had a significantly higher ratio of age>60,longer period of hemodialysis,higher morbidity of combined diabetic nephropathy and hypertension,and higher level of hs-CRP and Hcy(P<0.05).The education years,hemoglobin and albumin level were significantly lower in the CI group(P<0.05).Logistic regression analysis revealed that age,diabetic nephropathy,hemoglobin,Hcy,and hs-CRP were independent risk factors for CIO.Conclusions The incidence of CI in MHD patients is similar to that reported form other countries.Inflammation,homocysteine and anemia as non-traditional risk factors were relevant with the CI in MHD patients.…”
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Caveolae in smooth muscle cells mediates vasoconstriction of renal artery in rats by ZHANG Hai-jun, SU Yu-ting, MENG Xing-xing, CHENG Yao-ping, XIE Xiao-ping, CHANG Yao-ming, BAO Junxiang

“…Objective To investigate the role of caveolae on vascular smooth muscle cells(VSMCs)in vasoconstriction of renal artery(RA)and the possible mechanisms.Methods The RA was pretreated with methyl-beta-cyclodextrin(MCD)and cholesterol(CHO)to reduce and enhance the formation of caveolae,respectively.Isometric force recording system was used to detect the vascular function.Real-time polymerase chain reaction(RT-PCR) and Western blotting were conducted to examine the expression of mRNA and protein of caveolin-1 and Angiotensin type 1 receptor(AT1R).Immumoprecipitation with Western blotting was carried out to test the binding of caveolin-1 and AT1 R.Results Incubation with MCD reduced the caveolae number in VSMCs significantly(P<0.05),which could be reversed by CHO treatment.Neither the MCD nor CHO influenced the gene or protein expression of caveolin-1.The vasoconstriction of RA to KCl or PE did not change after MCD or CHO incubation.However,MCD could inhibit the vasoconstriction of the artery to Ang Ⅱ with lower Emax(P<0.05)and higher EC50(P<0.05),which again could be reversed by CHO pretreatment The protein expression of AT1 R was not affected by MCD or CHO incubation.In the case of normal RA,Ang Ⅱ would promote the binding of AT1 R to caveolin-1(P<0.05),while the response was blocked substantially in MCD-incubated RA,which was restored if the RA was treated by MCD and CHO simultaneously.Conclusions The caveolae regulate the vasoconstriction of RA to Ang Ⅱ by controlling the binding of caveolin-1 with AT1 R.…”
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Gone and forgotten? Predictors of birth history omissions in India by Sharan Sharma, Sonalde Desai, Debasis Barik, Om Prakash Sharma

“…Omissions in the second wave are modeled as a function of several child, mother, household, and survey interviewer variables. …”
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Hypomethylation of the LncRNA H19 promoter accelerates osteogenic differentiation of vascular smooth muscle cells by activating the Erk1/2 pathways by Taoxia Wang, Meijuan Cheng, Jingjing Jin, Yaling Bai, Dongxue Zhang, Shenglei Zhang, Jinsheng Xu

“…Objective Vascular calcification is a common chronic kidney disease complication. …”
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Otoacoustic Emissions Testing to Identify Hearing Loss in the ICU: A Feasibility Study by Ramya Kaushik, MD, Nicholas Reed, AuD, PhD, Lauren E. Ferrante, MD, MHS

“…OBJECTIVES:. Hearing impairment is associated with delirium among ICU patients and a lack of functional recovery among older ICU survivors. …”
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Identification of UDP-Glucuronosyltransferase mRNA in human platelets: differential levels in smokers and non-smokers by Yazun Jarrar, Mansour Almansour, Dina Abulebdeh, Wesam Nasser, Qais Jarrar, Sara Abudahab, Su-Jun Lee

“…Further research, including pharmacokinetic studies and protein-level validation, is needed to understand their functional significance.…”
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The Specific Features of the Course of Critical Conditions in Miners by V. V. Moroz, Yu. A. Churlyaev, S. L. Kan

“…Objective: to improve treatment results in miners, by studying the specific features of the course of their critical conditions caused by severe traumatic injuries, and to develop differentiated intensive therapeutic regimens for detected abnormalities. …”
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Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease by Juan Chen, YongHong Shi, XiaoPing Wang, Heqing Huang, Dana Ascherman

“…The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of identifying asymptomatic, preclinical forms of RA-ILD that may represent precursors to more severe fibrotic lung disease. …”
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Increase in Strength After Multimodal Pain Management Concept in Patients with Cervical Radiculopathy—A Non-Randomized, Uncontrolled Clinical Trial by Gerd Zirkl, Jens Schaumburger, Matthias Gehentges, Moritz Kaiser

“…<i>Background and Objective</i>: Although multimodal pain therapy (MPT) is widely used in pain management for chronic cervical radiculopathy, its effect on increasing muscle strength in patients with cervical radiculopathy is not well documented. …”
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Early Results after Thulium Laser Enucleation of the Prostate in Patients with Urodynamically Proven Detrusor Underactivity by Pawel Trotsenko, Christian Wetterauer, Martin Haydter, Lukas Lusuardi, Thomas R. W. Herrmann

“…<b>Objectives</b>: Benign prostatic hyperplasia is one of the most common urological diseases. …”
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The impact of automation on the safety of drug dispensing in nursing homes by Idoia Beobide Telleria, Alex Ferro Uriguen, Blanca Miró Isasi, Silvia Martínez Arrechea, Maria Isabel Genua Goena

“…We analyze patient function, cognition and pharmacological data in two time periods. …”
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