scQTLtools: An R/Bioconductor Package for Comprehensive Identification and Visualization of Single-Cell eQTLs by Xiaofeng Wu, Xin Huang, Pinjing Chen, Jingtong Kang, Jin Yang, Zhanpeng Huang, Siwen Xu

“…The toolkit supports flexible input formats, including Seurat and SingleCellExperiment objects, handles both binary and three-class genotype encodings, and provides dedicated functions for gene expression normalization, SNP and gene filtering, eQTL mapping, and versatile result visualization. …”
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Low-viscosity oligoether esters (OEEs) as high-efficiency lubricating oils: Insight on their structure–lubricity relationship by Hanwen Wang, Ying Wang, Ping Wen, Lin Ma, Mingjin Fan, Rui Dong, Chunhua Zhang

“…Results showed that glycol chains contribute positively to lubrication with the ether functional groups increasing the sites of adsorption. …”
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The Role of Circulating Biomarkers in Patients with Coronary Microvascular Disease by Rossella Quarta, Giovanni Martino, Letizia Rosa Romano, Giovanni Lopes, Francesco Fabio Greco, Carmen Anna Maria Spaccarotella, Ciro Indolfi, Antonio Curcio, Alberto Polimeni

“…Coronary microvascular disease (CMD) comprises a spectrum of conditions characterized by the functional and structural abnormalities of coronary microcirculation, affecting vessels typically smaller than 500 μm. …”
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Cell-free DNA profiles of dermatomyositis and its potential role in discriminating phenotypes by Zhuang-li Tang, Peng-yu Chen, Heng Zhang, Hua-li Cao, Ru Dai, Yu-chen Lou, Yan-hong Sun, Yuan Zhou, Xue-yan Chen, Mei-jie Zhang, Ya-qi Wang, Xiao-yong Man

“…BackgroundCell-free DNA (cfDNA) functions in the early-detection and monitoring of autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis. …”
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A Step Forward in Long COVID Research: Validating the Post-COVID Cognitive Impairment Scale by Somayeh Pour Mohammadi, Razieh Etesamipour, Francisco Mercado Romero, Irene Peláez

“…The persistent symptoms encompass fatigue, breathing difficulties, musculoskeletal pain, and cognitive impairments, which can significantly affect daily functioning and overall quality of life. The objective of this study was to create and validate the accuracy of the Post-COVID Cognitive Impairment Scale, which is used to evaluate cognitive impairments resulting from a COVID-19 infection. …”
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Preliminary Design of a GNSS Interference Mapping CubeSat Mission: JamSail by Luis Cormier, Tasneem Yousif, Samuel Thompson, Angel Arcia Gil, Nishanth Pushparaj, Paul Blunt, Chantal Cappelletti

“…When launched, JamSail will demonstrate the functionality of two new payloads in low Earth orbit. …”
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Dynamic Neural Network States During Social and Non-Social Cueing in Virtual Reality Working Memory Tasks: A Leading Eigenvector Dynamics Analysis Approach by Pinar Ozel

“…Background/Objectives: This research investigates brain connectivity patterns in reaction to social and non-social stimuli within a virtual reality environment, emphasizing their impact on cognitive functions, specifically working memory. …”
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The development of postoperative pain in patients with late-stage knee osteoarthritis is associated with impaired metabolism and transport of fatty acids in blood cells by E. B. Chetina, G. A. Markova, K. E. Glemba, M. A. Makarov

“…In addition, pain, stiffness and physical functioning were assessed using WOMAC index and the presence of neuropathic pain was assessed using the DN4 and PainDETECT questionnaires. …”
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Mechanism of Modified Tongyou Decoction and Its Separated Formulas Inhibiting Vasculogenic Mimicry in Esophageal Cancer TE-1 Cells via NF-κB/HIF-1α Axis by Qian Wang MS, Yingying Tian MS, Lingyu Kong MD, Zeyi Chen MS, Xin Yan PhD, Chenxi Wu PhD, Huijuan Cao PhD, Fanwu Wu PhD, Yongsen Jia PhD, Prof.

“…The 4 medications inhibited HIF-1α protein secretion, among which MTD and the AB formula showed stronger function. However, the 4 medications showed no obvious function on E-cadherin protein secretion. …”
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Clinicopathologic classification of diabetic nephropathy and expression of Ang-2 in renal tissues by WEIZhi-min, MARui-xia, LIU Li-qiu

“…Objective To investigate the clinical value of new pathological classification of diabetic nephropathy(DN) by published Research Committee of the Renal Pathology Society in 2010,and explore the expression and signification of angiopoietin-2(Ang-2) in renal tissues.Methods Renal biopsy was performed on 57 patients with impaired renal function.The tissues were split to be stained by HE,PAS,Masson and PASM for light microscope and stained by IgA,IgG,IgM and C3 for immunofluorescence microscope,and for electron microscope also.All cases were re-classified according to the new pathological classification for DN,and the relationship between the different types of DN and the tubulointerstitial injury was observed.The Ang-2 expression in the renal tissues was detected by immunohistochemistry.Results Before the 2010,19 patients were diagnosed as having DN.After re-analysis according to the new pathological classification,the patients diagnosed with DN were increased to 22,while 32 patients were diagnosed as DN after 2010.In these 54 DN patients,2 cases were classified as type Ⅰ,5 as type Ⅱ a,5 as type Ⅱ b,37 as type Ⅲ and 5 as type Ⅳ.Twenty patients had mild interstitial injury,25 had midrange interstitial injury,and 9 had severe interstitial injury.For all DN research subjects,Ang-2 was detectable to varying degrees in capillaries clump of glomeruli and endothelial cells of blood vessels.The Ang-2 staining was observed in the very early stage of DN.Conclusions The new pathological classification of DN can decrease the misdiagnosis rate and attract more attention to interstitial damage and vessel damage in DN.And for diabetic mellitus patients,Ang-2 detected by renal biopsy could be used for contributing to the early diagnosis and would be beneficial for patients’ individual treatment.…”
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Early prediction of long COVID-19 syndrome persistence at 12 months after hospitalisation: a prospective observational study from Ukraine by Dmytro Chumachenko, Tetyana Chumachenko, Oleksii Honchar, Tetiana Ashcheulova

“…Patients who reported incomplete recovery at 1 year were characterised by a higher burden of comorbidities (Charlson index of 0.69±0.96 vs 0.31±0.51, p=0.001) and residual pulmonary consolidations (1.56±1.78 vs 0.98±1.56, p=0.034), worse blood pressure (BP) control (systolic BP of 138.1±16.2 vs 132.2±15.8 mm Hg, p=0.041), renal (estimated glomerular filtration rate of 59.5±14.7 vs 69.8±20.7 mL/min/1.73 m2, p=0.007) and endothelial function (flow-mediated dilation of the brachial artery of 10.4±5.4 vs 12.4±5.6%, p=0.048), higher in-hospital levels of liver enzymes (alanine aminotransferase (ALT) of 76.3±60.8 vs 46.3±25.3 IU/L, p=0.002) and erythrocyte sedimentation rate (ESR) (34.3±12.1 vs 28.3±12.6 mm/h, p=0.008), slightly higher indices of ventricular longitudinal function (left ventricular (LV) global longitudinal strain (GLS) of 18.0±2.4 vs 17.0±2.3%, p=0011) and higher levels of Hospital Anxiety and Depression Scale anxiety (7.3±4.2 vs 5.6±3.8, p=0.011) and depression scores (6.4±3.9 vs 4.9±4.3, p=0.022) and EFTER-COVID study physical symptoms score (12.3±3.8 vs 9.2±4.2, p<0.001). …”
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Neuronal expression of CaMKⅡ and BDNF isoforms in mice with cognitive dysfunction induced by repetitive mild traumatic brain injury by LIU Dianqing, LIU Dianqing, LI Yun, LI Yun, ZHANG Jietao

“…Conclusion‍　‍In the chronic phase of rmTBI， prognosis of good cognitive function is accompanied by up-regulation of CaMKⅡ signaling pathway， and the difference in cognitive function is accompanied by the change in proportions of different AMPAR subunits on the postsynaptic membrane. …”
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Do management practices which enhance nature-based processes improve soil health in olive groves? by Gustavo Ruiz-Cátedra, Julio Calero, Pablo Domouso, Roberto García-Ruiz

“…Compared to conventional groves, NBS-managed soils exhibited 52–285 % higher levels of soil organic carbon, total nitrogen, and microbiological activity, all of which were significantly correlated with ASI scores. Soil functional α-diversity was also significantly higher in NBS groves and comparable to or exceeding that of forest soils. …”
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Effect of Dexamethasone and Lidocaine on the Cytokine Profile and Bleeding during Endoscopic Rhinosinus Surgery by V. E. Pavlov, M. Yu. Pervakova, D. A. Kuznetsova, T. V. Blinova, E. A. Surkova, S. V. Lapin, Yu. S. Polushin

“…The objective: to evaluate the feasibility of using dexamethasone and lidocaine to potentiate the effect of anesthesia in patients with chronic polypous rhinosinusitis during functional endoscopic sinus surgery (FESS) interventions.Subjects and Methods. …”
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IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar by Olifara Herinirina Andriatefy, Anjanirina Rahantamalala, Matthieu Schoenhals, Robin Shattock, Nicola J. Walker, Ethel Diane Williamson, Minoarisoa Rajerison, Voahangy Andrianaivoarimanana

“…Abstract Objective Plague (Yersinia pestis infection) is a flea-borne zoonotic disease mainly affecting African countries, with most human cases reported from Madagascar and the Democratic Republic of Congo. …”
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Comparative Forced Degradation Study of Anticomplement C5 Biosimilar and Originator Monoclonal Antibodies by Merve Celik Yamaci, Ceren Pamukcu, Yigit Erdemgil, Ahmet Emin Atik, Zeynep Zulfiye Yildirim Keles, Ozge Can

“…<b>Background/Objectives</b>: The stress testing of biotherapeutic products is a critical component of drug development, enabling the assessment of stability, biosimilarity, and degradation pathways. …”
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Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b by Jian Hao, Hui Li, Weimin Yu

“…The relationship between lncRNA SNHG10 and miR-378b was confirmed by luciferase reporter assay.ResultsXanthohumol effectively improves DN-stimulated kidney structural and functional abnormalities. LncRNA SNHG10 was downregulated in the renal tissues of DN mice and HG induced HK-2 cells, while this inhibition was reversed by xanthohumol treatment. …”
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Role of mir-32-3p in the diagnosis and risk assessment of osteoporotic fractures by Jingda Zhang, Tao Qian, Xifan Zheng, Huiling Qin

“…Furthermore, miR-32-3p was correlated with the development of OPF and was a risk factor for OPF (P < 0.001). Functional assays revealed that transfection with miR-32-3p mimic could promote proliferation and inhibit apoptosis, whereas transfection with miR-32-3p inhibitor had the opposite effect. …”
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Robustness of viral load over CD4 cell count in measuring the quality of life of people with HIV at second line regimen in Amhara region by Awoke Seyoum Tegegne

“…Therefore, the main objective of the current study was to assess the quality of life comparing viral load and CD4 cell count and factors affecting the variable of interest among HIV-positive people under the second-line regimens. …”
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Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis. by Yuqian Ma, David Vilanova, Kerem Atalar, Olivier Delfour, Jonathan Edgeworth, Marlies Ostermann, Maria Hernandez-Fuentes, Sandrine Razafimahatratra, Bernard Michot, David H Persing, Ingrid Ziegler, Bianca Törös, Paula Mölling, Per Olcén, Richard Beale, Graham M Lord

“…Fractionating the cellular components of blood reveals miR-4772-5p-iso is expressed differentially in monocytes. Functional experiments using primary human monocytes demonstrate that it expressed in response to TLR ligation.…”
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