Analysis of the effectiveness of selection of women for coronarography in real clinical practice by N. V. Izmozherova, A. A. Popov, V. E. Sherstobitov

“…Severe angina (3 and 4 functional class) was significantly more often diagnosed in women with identified coronary atherosclerosis. …”
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Migraine Prevalence and Productivity Impact in Healthcare Professionals: A MIDAS Assessment by Maheen Asim, Rabbia Aslam, Sadaf Nasir, Khawar Shabbir, Mehdi Naqvi, Safeena Hameed Qureshi

“…Objective: To detect the frequency of migraine headaches among healthcare professionals and to determine the associated triggering factors and level of functional disability using the Migraine Disability Assessment Score (MIDAS). …”
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Assessing the carcinogenic potential and molecular mechanisms of arecoline in human lungs: from in silico methods to in vitro validation by Wenwen Wang

“…Next, we utilized these proteins for functional enrichment analyses to explore their correlation with cancer. …”
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QUALITY OF LIFE OF MALE GOUTY PATIENTS: ARE THERE DIFFERENCES FROM THE POPULATION? RESULTS OF A COMPARATIVE STUDY by M. V. Mukagova, V. G. Barskova, M. S. Eliseev

“…Objective: to assess quality of life of male gouty patients with SF-36 questionnaire versus the standardized indicators of population-based control. …”
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Secretomes of Gingival Fibroblasts From Periodontally Diseased Tissues: A Proteomic Analysis by Anne Kari Smedås, Lovise Gangeskar Paris, Niyaz Al‐Sharabi, Einar K. Kristoffersen, Mariano Sanz, Kamal Mustafa, Dagmar Fosså Bunæs, Siddharth Shanbhag

“…ABSTRACT Objective Cell secretomes represent a promising strategy for periodontal and bone regeneration. …”
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Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential by John Olichney, Jiangyi Xia, Kevin J. Church, Hans J. Moebius

“…Through the application of standardized electroencephalography (EEG) described here, ERP P300 can be reliably measured. The P300 waveform objectively measures large-scale neuronal network functioning and working memory processes. …”
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Quality of life of children with respiratory pathology against the background of connective tissue dysplasia by V. S. Ledneva, L. V. Ulianova, A. N. Gaponenko

“…Without health, social functioning becomes impossible. The study of the quality of life reflects a more complete picture of the disease, and also shows the effectiveness of therapeutic and restorative measures in patients. …”
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Hypercalciuria and nephrocalcinosis in cystic fibrosis patients by Uğur Ozçelik, Nesrin Beşbaş, Ayhan Göçmen, Deniz Akata, Okan Akhan, Meral Ozgüç, Nural Kiper

“… The objective of this study was to determine the frequency of nephrocalcinosis and hypercalciuria in cystic fibrosis (CF) patients, and to search possible causes of this phenomenon. …”
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Effect of CYP2C9 on the migration, invasion and proliferation of hepatocellular carcinoma cells by ZHANG Tuo, LI Dajun, WANG Haitao, ZHANG Peng

“…Objective To explore whether CYP2C9 is involved in the occurrence and development of hepatocellular carcinoma (HCC) and its function in the migration, invasion and proliferation of HCC cells.Methods The transcriptome data of HCC were retrieved from the TCGA database to analyze the expression of CYP2C9 and role of CYP2C9 in the prognosis of HCC; Constructing stable CYP2C9 overexpression cell lines of HepG2 and MHCC97H, detecting the effects of CYP2C9 overexpression on the migration, invasion and epithelial mesenchymal transition (EMT) process of HCC cells through Transwell migration assay, Transwell invasion assay, and Western Blot assay, respectively; The effect of CYP2C9 overexpression on the proliferation ability of HCC cells was detected through CCK-8 assay, colony formation assay, and Western Blot assay.Results Bioinformatics analysis showed that the expression of CYP2C9 was significantly downregulated in HCC , and the expression of CYP2C9 was positively correlated with the clinical prognosis of HCC patients; The results of cellular and molecular experiments showed that CYP2C9 overexpression significantly inhibited the migration, invasion and EMT process of HepG2 and MHCC97H cells, whereas had no significant effect on cell proliferation.Conclusion CYP2C9 may affect the progression of HCC by inhibiting the migration, invasion, and EMT processes of HCC cells.…”
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Major Vault Protein in Macrophages Reprograms Immune Microenvironment and Inhibits Occurrence and Development of Liver Cancer by Shimeng ZHOU, Mengmeng LI, Shouyu WANG

“…Objective To explore the role and molecular mechanism of major vault protein (MVP) in tumor-associated macrophages in the occurrence and development of liver cancer. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…However, since extra scanning takes additional time, and therefore it might delay treatment decisions, the balance of risks and benefits requires to be investigated. Objectives In patients being evaluated for possible treatment with intravenous thrombolysis, to investigate whether multimodal CT is associated with differences in treatment rates, time to treatment decisions, and functional and safety outcomes, compared to NCCT imaging alone. …”
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Optimization of Sensor Positions and Orientations for Multiple Load Case Scenarios by Wacław Kuś, Waldemar Mucha, Iyasu Tafese Jiregna

“…The novelty lies in a newly formulated objective function, allowing for optimization of sensor number, positions, and orientations across multiple load cases and measurement types. …”
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Yishenyangsui granule for degenerative cervical myelopathy: a randomized, double-blind, placebo-controlled trial with long-term follow-up by He Yin, Xin Chen, Zhiwei Liu, Zhiwei Liu, Bo Xu, Zhefeng Jin, Yan Liu, Baoyu Qi, Bin Tang, Ping Wang, Fanping Xu, Xu Wei, Jie Yu, Liguo Zhu, Liguo Zhu

“…Furthermore, improvements in motor function of upper/lower extremities, sensory function of upper extremities, reading ability, and recreation domain scores were also significantly superior in the Yishenyangsui granule group compared to the placebo group (P < 0.05). …”
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Initial experience in direct graft perfusion assessment following orthotopic liver transplant by A. V. Moiseenko, A. A. Polikarpov, P. G. Tarazov, D. A. Granov

“…Objective: classical methods of determining arterial blood supply of the graft following orthotopic liver transplantation (OLT) reflect the presence of blood flow in the trunk and large branches of the A. hepatica, without the characteristic of completeness of blood filling of peripheral sections, which is very important for objective evaluation of function. …”
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Development and validation of a set of novel and robust 4-lncRNA-based nomogram predicting prostate cancer survival by bioinformatics analysis. by Peng Zhang, Xiaodong Tan, Daoqiang Zhang, Qi Gong, Xuefeng Zhang

“…<h4>Background and objective</h4>Accumulating evidence shows that long noncoding RNAs (lncRNAs) possess great potential in the diagnosis and prognosis of prostate cancer (PCa). …”
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The relationship between serum level of fibroblast growth factor 23 and valvular calcification in chronic kidney disease patients by XU Feng-bo, LIU Hui-lan, SUN Yi, LI Guo-gang, ZHU Ying-hui

“…Objective To determine the serum level of fibroblast growth factor 23（PGF23） in chronic kidney disease（CKD） patients and explore the relationship between FGF23 and valvular calcificatioa Methods eighty-nine CKD patients and twenty-eight people（control group） whose renal functions were normal were enrolled in this study.The patients in CKD were divided into CKD 1-2 group（16 patients）,CKD 3-4 group（20 patients）,CKD 5 group（16 patients） and CKD 5D（37 patients）.Phosphate,calcium,triacylglycerol,total cholesterol.Low density lipoprotein cholesterol high density lipoprotein cholesterol,parathyroid hormone and FGF23 in their serum were determined.The level of FGF23 in serum were detected by the method of ELISA.All the peoples were divided to VC group and non-VC group according to echocardiogram.Results（1）The Log iPTH,Log FGF23 and valvular calcification in CKD 5D group was much higher than other groups.（2）The Log FGF23 and Dialysis proportion in VC group was much higher than non-VC group.（3） Logistic regression analysis revealed that the level of Log FGF23,age,Hypercholesterolemia and history of diabetes mellitus was the influencing factor of CKD patients.Conclusions The serum level of FGF23 in CKD patients is higher.With the worsening of renal function,FGF23 increased,and the elevation of FGF23 is relative to the valvular calcificatioa…”
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Mechanism of electroacupuncture on rats with primary dysmenorrhea based on microRNA expression spectrum and PI3K/Akt/mTOR signaling pathway by Si-an PAN, Shao-hua WANG, Han-yu YUAN, Juan LI, Xiao XUE, Zeng-hui YUE, Yu LIU

“…With RNA-seq method, the changes of miRNA expression spectrum in rat uterine tissue were detected. Bioinformatics analysis such as GO functional annotation and KEGG pathway was performed according to differentially expressed miRNAs. …”
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Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study by Zi-Han Yin, Qiong-Nan Bao, Ya-Qin Li, Yi-Wei Liu, Zi-Qi Wang, Fang Ye, Xia He, Xin-Yue Zhang, Wan-Qi Zhong, Ke-Xin Wu, Jin Yao, Zi-Wen Chen, Ling Zhao, Fan-Rong Liang

“…In addition, multi-omics was performed to detect changes in brain function, gut microbiota, and serum metabolites. …”
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Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer by Donghui Liu, Mingzhu Liu, Juan Du

“…Abstract Objective Liquid–liquid phase separation (LLPS) is the membrane-less formation of functional assemblies from specific molecules. …”
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Comparison of clinical manifestations of rheumatoid arthritis in patients with moderate or high disease activity depending on the presence or absence of symptoms of neuropathic pai... by E. Yu. Polishchuk, E. S. Filatova, A. E. Karateev, V. N. Amirdzhanova, V. A. Nesterenko

“…Objective: to study the effect of neuropathic pain symptoms (SNP) on the clinical manifestations of rheumatoid arthritis (RA) in patients with moderate or high disease activity.Patients and methods. …”
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