Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-Mediated deacetylation of P53 by Zhili Xiong, Zhili Xiong, Zhili Xiong, Zhili Xiong, Xinyu Hu, Rui Wang, Rui Wang, Rui Wang, Chengyin Li, Chengyin Li, Chengyin Li, Huanbo Cheng, Wei Zhao, Yinfeng Shen, Linqun Wang, Weinan Li, Weinan Li, Weinan Li, Xiaoyun Zhu, Yuanming Ba, Yuanming Ba, Yuanming Ba

“…The protein levels of SIRT3, P53, glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11) were detected by Western blot. Subsequently, under the premise of SIRT3 knockout, renal function, fibrosis level, iron metabolism level, and lipid peroxidation level were detected, and mitochondrial damage was observed by transmission electron microscope (TEM). …”
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Partial Analysis of the Capsid Protein (VP1) of Human Sapovirus Isolated from Children with Diarrhoea in Rural Communities of South Africa by Mpho Magwalivha, Jean-Pierre Kabue Ngandu, Afsatou Ndama Traore, Natasha Potgieter

“…Through the partial analysis of the VP1 region, this study provides more data to add on the human sapovirus genetic characterization of circulating strains in South Africa, with the proposition of further analysis of sapovirus VP1 fragments for the viral structure and function.…”
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Lactate alleviates trigeminal neuralgia symptoms in mice by suppressing neuroinflammation by Xiangbo Liu, Feiyu Long, Wujun Zou, Tao Qi

“…Objectives Trigeminal neuralgia is a neuropathic pain syndrome that undesirably affects patient’s quality of life. …”
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Effects of Alprostadil on experimental peritoneal fibrosis in rats by ZHANG Yan-min, CHEN Wei-dong, WAN Sheng, CHEN Dan, CHEN Fang, DING Yan-qiong, WANG Zeng-si, TIAN Hong-dan, XIONG Fei

“…Objective To investigate the effects and possible action mechanism of Alprostadil in the treatment of experimental peritoneal fibrosis in rats.Methods The rat peritoneal fibrosis model was induced by high glucose dialysate and lipopolysaccharide(LPS).The rats were randomly divided into five groups:control group,model group,low-dose Alprostadil-treated group,middle-dose Alprostadil-treated group and high-dose Alprostadil-treated group.The Alprostadil-treated groups received daily intraperitoneal injection of different doses of Alprostadil.Six weeks later all rats were anaesthetized.The peritoneal membrane function was investigated by peritoneal equilibration test(PET).The abdominal membrane was stained with HE and Masson method.The levels of TGF-β and TLR4 in peritoneum were detected by immunohistochemical method.Results The number of vascularity in model group was greater than that in Alprostadil-treated groups.The concentrations of TGFβand TLR4 in blood and dialysate were also decreased obviously in Alprostadil-treated groups.The levels of TGFβ and TLR4 in peritoneumin in Alprostadil-treated groups were significantly lower than those in model group.Conclusions Alprostadil are beneficial to the prevention and treatment of peritoneal fibrosis in experimental model rats.…”
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Lymphocyte Activation Gene 3 Single-Nucleotide Polymorphisms in Bone Marrow Failure Diseases by Yingying Sun, Qiuying Cao, Xiaoyu Zhao, Chunyan Liu, Zonghong Shao

“…Lymphocyte activation gene 3 (LAG3) is an inhibitory checkpoint protein expressed on activated T effector, T regulatory, and natural killer cells. The main function of LAG3 is the regulation of immune homeostasis. …”
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Adipose tissue oxylipin profile changes with subclinical ketosis and depot in postpartum dairy cows by Bridger B. Sparks, Hunter Ford, Tainara C. Michelotti, Clarissa Strieder-Barboza

“…Additionally, PUFA can become oxidized into oxylipins, which modulate inflammation and metabolism. The objective of this work was to identify depot-specific differences on adipose tissue oxylipin profile in dairy cows with and without subclinical ketosis and assess the effects of oxylipins on adipocyte function in vitro. …”
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Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Postoperative Cognitive Dysfunction in Elderly Mice Based on BDNF/TrkB Signaling Pathway by LI Min, YANG Xiao, REN Lulu, WU Tingmei, ZHANG Hong

“…On the third day after operation，the locomotor activity of mice was evaluated by open field test （percentage of stay time in the central area，total distance and average speed of movement）; On the fourth day after operation，the cognitive function of mice was evaluated by Y-maze test （the percentage of times to enter the new arm，the percentage of time to stay in the new arm，and the total distance to move the new arm）; After the Y-maze test，the protein expression levels of brain-derived neurotrophic factor （BDNF），tropomyosin related kinase B （TrkB） and nerve growth factor （NGF） in mice hippocampus were detected by immunoblotting.Results（1） Exercise capacity：there was no significant difference in the percentage of time spent in the central area of the open field，total distance and average speed among the three groups （<italic>P</italic>&gt;0. 05）. （2） Cognitive function：there was no significant difference among the three groups in the percentage of times of exploring new forearm （<italic>P</italic>&gt;0. 05）; Compared with the control group，the percentage of stay time in the new arm and the total distance of new arm movement in the operation group were significantly reduced，and the differences were statistically significant （<italic>P</italic>&lt;0. 05）. …”
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Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats by Ding YB, Zhao Y, Chen BY, Wang Q, Wang ZY, Luan Z, Yi B

“…Furthermore, Hematoxylin-eosin (HE) staining and neurological function was assessed at 12 weeks post-implantation.Results: After implantation, hNSCs survived for a duration of 12 weeks. …”
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Crystallographic and Orientation Features of Nanocrystals in Thin Film Condensates PbTe-Bi2Te3 on Glass Ceramics by Ya.P. Saliy, D.M. Freik, І.S. Bylina, M.O. Galushchak

“…With the help of the AFM-images analysis, using the discrete Fourier transformation, the autocorrelation function for the azimuthal angle φ and the amount of normal distributions for the polar angle ρ we have investigated the orientation process of structure formation of the nanocrystals in vapor-phase condensates of PbTe-Bi2Te3 solid solution on glass ceramics. …”
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Chronical kidney disease in clinical practice: non progredi est regredi (lat. not to go forward is to go back) by A. L. Vertkin, N. A. Burakova, Yu. V. Sedyakina, S. S. Kurdzhieva, M. M. Shamuilova, E. M. Ledeneva

“…When these changes were detected, the patient was consulted twice by a nephrologist, and a decision was made to conduct sessions of replacement kidney therapy due to severe azotemia with persistent restoration of kidney function. …”
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Role of BDNF-TrkB signaling pathway in early-life cadmium exposure induced cognitive dysfunction in mice by Yan SHI, Siqi YANG, Yougang WANG, Qiumei WU, Jinquan LI

“…The cadmium content in brain was detected and the learning and memory ability was tested by Y maze and Morris water maze to evaluate cognitive function of offspring mice. …”
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AN ANALYSIS OF FIGURATIVE LANGUAGE FOUND IN SONG LYRICS OF THE ALBUM OF GG BB XX BY LANY by Danisa Salsabila, Ratini Setyowati

“…Therefore, this study analyzes about figurative language found in LANY's song lyrics in the "gg bb xx" album. The objectives of this study are to analyze the types and meaning of figurative language, and to explain the function of figurative language, also to find out the most dominant of figurative language. …”
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Fibulin‐2: A potential regulator of immune dysfunction after bone trauma by Shidan Li, Hao Jiang, Shaochuan Wang, Youbin Li, Debin Guo, Jijie Zhan, Qiaohui Li, Hao Meng, Ankang Chen, Limin Chen, Xiaoyan Dai, Xiaoming Li, Wei Xing, Lei Li, Jun Fei

“…Abstract Objectives To reveal the relationship between the fibulin‐2 protein and immune dysfunction after bone trauma. …”
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DDC_Calc, software to diagnose developmental dysplasia of the hip in infants (version 1) by José Julio Requeiro Molina, Ernesto Pérez Pérez, Ana María Machado Consuegra, Karina Leonor Fernández Sánchez, Roberto Díaz Amador, José Julio Requeiro Morejón

“…<br /><strong>Results</strong>: the software integrated the necessary tools to carry out the measurements used (angles, distances, positions) in the radiographic diagnosis of developmental dysplasia of the hip. Its functionalities, requirements and operation of the application were described, based on a real clinical case, all illustrated with images. …”
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Effect of major royal jelly proteins (MRJPs) on proliferation activity of Chang's liver cell line and their mechanism of action by Yu Zhangying, Chen Di, Wang Yiran, Shen Lirong

“…MRJP1-MRJP9 and MRJPψ, whose biological functions include enhancing cell proliferation, inducing differentiation, modulating immune responses, accelerating wound healing, etc. …”
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Research on Parameter Influence of Offshore Wind Turbines Based on Measured Data Analysis by Renfei Kuang, Jinhai Zhao, Tuo Zhang, Chengyang Li

“…The update efficiencies of different objective functions and the impacts of neural network hyperparameters on the surrogate model were examined. …”
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THE CURRENT STATE OF ARTIFICIAL INTELLIGENCE IN RADIOLOGY – A REVIEW OF THE BASIC CONCEPTS, APPLICATIONS, AND CHALLENGES by Mariana Yordanova

“…There are numerous applications of AI in radiology - image segmentation, objective quantification, detecting and highlighting suspicious areas, image processing and optimization, longitudinal analysis, potentially diagnosis recognition, triage, and reporting aid. …”
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Development of Cyber Security Platform for Experiential Learning by Abhishek Vaish, Ravindra Kumar, Samo Bobek, Simona Sternad

“…Platform-based education is a potential direction to achieve the objective and address the skill gap required in cyber security. …”
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Specific features of accumulation of heavy metals in the body of mollusks (Molluska: Limacidae) of the southern slope of the Aragats mountain range by V. S. Hovhannisyan, L. D. Arutyunova, L. S. Mirumyan, M. Z. Magomedova, P. D. Magomedova, T. E. Poghosyan

“…Slugs, living in upper soil horizons (mesofauna) and under stones and plant litter, actively respond to the slightest changes in the environment and are perspective objects allowing the detection of deviations in the functioning of soils and the natural complex as a whole.Conclusion. …”
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Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss by Chenyang Yuan, Tianyu Ma, Mengting Liu, Li Jiang, Gongrui Tang, Qi Hu, Tianhong Zhang

“…ObjectivesFerroptosis, a regulated form of cell death, has attracted significant attention in hearing loss research; however, the role of ferroptosis-related genes remains unclear. …”
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