Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation by Junbin Liu, Junbin Liu, Junbin Liu, Xiaoting Zhang, Xiaoting Zhang, Xiaoting Zhang, Jingpei Guo, Jingpei Guo, Jingpei Guo, Yun Zhang, Yun Zhang, Yun Zhang, Jinming Fan, Jinming Fan, Jinming Fan, Junfeng Liu, Jiawen Chen, Jiawen Chen, Jiawen Chen, Jiawei Jiang, Benshuai Yu, Benshuai Yu, Ke Zhang, Ke Zhang, Ke Zhang, Bin Zhou, Bin Zhou

“…Open field test and novel object recognition test were conducted to evaluate anxiety-like behavior and hippocampal-related memory. …”
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Thyroid-stimulating hormone and thyroid hormone levels in association with occupational hazards in male coal miners by Yingshi DAI, Yingjun CHEN, Yingqi LUO, Yanhui LIU, Liuquan JIANG, Fan YANG, Gaisheng LIU, Qingsong CHEN

“…Height, weight, thyroid function test results, and occupational hazard exposure of the study subjects were obtained through occupational health examinations and routine workplace occupational hazard detection records. …”
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Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study by Sten Rasmussen, Christopher Aboo, Jacob Skallerup, Allan Stensballe

“…Clinical outcome measures at inclusion, 8 weeks, and 2 years, were the PainDetect questionnaire, WOMAC pain, stiffness, and function. …”
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Community, facility and individual level impact of integrating mental health screening and treatment into the primary healthcare system in Sehore district, Madhya Pradesh, India by Crick Lund, Vikram Patel, Rahul Shidhaye, Emily Baron, Vaibhav Murhar, Sujit Rathod, Azaz Khan, Abhishek Singh, Sanjay Shrivastava, Shital Muke, Ritu Shrivastava

“…Introduction Programme for Improving Mental Health Care (PRIME) designed a comprehensive mental healthcare plan (MHCP) for Sehore district, Madhya Pradesh, India. The objective of this paper is to describe the findings of the district-level impact evaluation of the MHCP.Methods Repeat community-based CS were conducted to measure change in population-level contact coverage for depression and alcohol use disorders (AUD), repeat FDS were conducted to assess change in detection and initiation of treatment for depression and AUD, and the effect of treatment on patient outcomes was assessed using disorder-specific prospective cohort studies.Results PRIME MHCP did not have any impact on contact coverage/treatment seeking for depression (14.8% at the baseline and 10.5% at the follow-up) and AUD (7.7% at the baseline and 7.3% at the follow-up) and had a small impact on detection and initiation of treatment for depression and AUD (9.7% for depression and 17.8% for AUD compared with 0% for both at the baseline) in the health facilities. …”
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Enhancing neurological disease diagnostics: fusion of deep transfer learning with optimization algorithm for acute brain stroke prediction using facial images by Fadwa Alrowais, Mohammed Alqahtani, Jahangir Khan, Achraf Ben Miled, Da’ad Albalawneh, Abdulwhab Alkharashi, Samah Al Zanin, Radwa Marzouk

“…It contains a nervous illness, which can result from haemorrhage or ischemia of the brain veins, and regular mains to assorted motor and cognitive damages that cooperate with functionality. Screening for stroke comprises physical examination, history taking, and valuation of risk features like age or certain cardiovascular illnesses. …”
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Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease by Jeremy William, Haider Muthana, Joseph Hogarty, Andrew Taylor, James L. Hare, Justin Mariani, Hitesh Patel, Geoff Wong, Dion Stub, David M. Kaye, Sandeep Prabhu, Peter M. Kistler, Aleksandr Voskoboinik

“…Timely diagnosis of underlying cardiomyopathy has significant implications for clinical management, guiding both disease‐modifying medical therapy and decisions around device implantation. Objective We sought to investigate the utility of cardiac magnetic resonance imaging (CMR) in patients with conduction system disease and preserved LV function on echocardiography. …”
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Ultrasonic Predictors of Dry Eye Syndrome in Sarcoidosis by T. N. Safonova, S. I. Kharlap, O. V. Eksarenko

“…Different types of lacrimal gland structural changes in sarcoidosis were detected. Comparing the acoustic and functional findings revealed a high correlation (r > 0.7) between these parameters as vascularization index, a reflex component of tear secretion, and the presence of tubular structures. …”
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Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment by Ziqin Wei, Ziqin Wei, Hongfang Mu, Fangfang Qiu, Fangfang Qiu, Minghui Zhao, Minghui Zhao, Xiaojing Zhang, Wenbin Li, Hai Jia, Rong Wang, Rong Wang

“…Rhodamine 123 accumulation assay was performed to examine the effect of HDAC inhibitors on ABCB1 functional activity. HDAC5 was targeted by siRNA technology to detect ABCB1 and H3K9ac expression. …”
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Dactylitis in psoriatic arthritis: clinical features, diagnosis, immunopathogenesis, and treatment by T. V. Korotaeva, E. Yu. Loginova

“…When dactylitis is detected in a patient with psoriatic arthritis (PsA), it is necessary to use active treatment as soon as possible, since in the absence of therapy the disease progresses to joint erosion and  functional disorders. …”
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SIGNIFICANCE OF PERIPHERAL ARTHRITIS IN ANKYLOSING SPONDYLITIS by Sh. F. Erdes, E. V. Volnukhin

“…Objective: to elucidate the role of peripheral arthritis in ankylosing spondylitis (AS) and its impact on therapy choice in daily practice of rheumatologists. …”
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Unmasking Pulmonary Parenchymal Changes in Psoriasis Patients: A Radiological Perspective by Müfide Arzu Özkarafakılı, Mustafa İlteriş Bardakçı, Onur Sivaz, İlknur Kıvanç Altunay

“…Psoriasis patients may exert pulmonary disease without clinical manifestation. Pulmonary function tests and radiological evaluation with CT are highly recommended in detecting pulmonary parenchymal changes when indications such as age and current smoking history are present.…”
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Microsurgical treatment of recurrent and residual previously clipped/or coiled intracranial aneurysms: a single center series of 22 patients by Jo Ee Sam, Dragan Janković, Yasuhiro Yamada, Riki Tanaka, Kento Sasaki, Takamitsu Tamura, Fuminari Komatsu, Yoko Kato

“…Objective: Recurrent and residual intracranial aneurysms (RA) are encountered with both clipping and endovascular treatment, and microsurgical treatment may be the only option at times. …”
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Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? by Sergei E. Titov, Evgeniya S. Kozorezova, Sergei A. Lukyanov, Sergei V. Sergiyko, Pavel S. Demenkov, Yulia A. Veryaskina, Sergey L. Vorobyev, Ilya V. Sleptsov, Roman A. Chernikov, Natalia I. Timofeeva, Svetlana V. Barashkova, Elena L. Lushnikova, Anna A. Uspenskaya, Anna V. Zolotoukho, Olga V. Romanova, Igor F. Zhimulev

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Simulation and analysis of geometric errors in high-precision bevel gear rolling testers by SHI Jian, LI Jinfeng, XIAO Jianming, ZHANG Jingcai

“…ObjectiveIn fields such as aviation, requirements for the vibration performance and service life reliability of bevel gear transmissions are continuously increasing, driving the upgrading of bevel gear rolling testers towards higher detection accuracy and multi-functionality. …”
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Intergalactic Wandering Stars in the Local Universe: Theoretical Predictions for Their Distance and Luminosity Distribution by Jia-Hui Wang, Maosheng Xiang, Ji-Feng Liu

“…Such stars, if they exist, are supposed to be wandering objects as they are not bound by the gravitational potential of any galaxy. …”
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肉苁蓉总苷经PI3K-Akt信号通路对大鼠脑缺血再灌注损伤的神经保护作用及机制研究 Neuroprotective Effect and Mechanism of Glycosides of Cistanche on Cerebral Ischemia-Reperfusion Injury in Rats Based on PI3K-Akt Signal... by 王璐1，张士滨2，吕雪2，杨占君3，贾建新3，吴丽娥1 (WANG Lu1, ZHANG Shibin2, LYU Xue2, YANG Zhanjun3, JIA Jianxin3, WU Li’e1 )

“…Results Compared with the sham group, the CIRI model rats exhibited severe neurological deficit symptoms, increased neurological function scores (P<0.05), reduced motor function, enlarged cerebral infarction area, increased apoptotic cells, and elevated expression of pro-apoptotic factors B-cell lymphoma-2 (Bcl-2) associated X protein (Bax) and cytochrome C (CytC) (P<0.05). …”
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Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures by Sylvain Rheims, Fatima Chorfa, Véronique Michel, Edouard Hirsch, Louis Maillard, Luc Valton, Fabrice Bartolomei, Philippe Derambure, Vincent Navarro, Julien Biberon, Arielle Crespel, Anca Nica, Martine Lemesle Martin, Laure Mazzola, Jerome Petit, Vincent Rossero, Sébastien Boulogne, Mathilde Leclercq, Laurent Bezin, Catherine Mercier, Pascal Roy, Philippe Ryvlin, the ENALEPSY Study Group

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An Analysis of Primary Hyperparathyroidism in Individuals Diagnosed with Multiple Endocrine Neoplasia Type 2 by Ana-Maria Gheorghe, Claudiu Nistor, Alexandru-Florin Florescu, Mara Carsote

“…Familial forms of PHPT (affecting up to 10% of the cases) involve a particular category that encompasses a large range of hereditary syndromes, including parathyroid hyper-function, frequently in the setting of a multi-glandular disease. …”
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Electroacupuncture posttreatment attenuates the inflammatory injury in rats after MIRI through PPARγ/NF-κb pathway by Xinxue Jiang, Xinxue Jiang, Chuchu Shen, Chuchu Shen, Xing Li, Xing Li, Xuefeng Xia, Xuefeng Xia, Senlei Xu, Hongru Zhang

“…ObjectiveThis study aims to investigate the activation of the PPARγ/NF-κB pathway and its influence on macrophage M2 polarization induced by acupuncture at the Neiguan acupoint. …”
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Macrostructural and microstructural alterations of hippocampal subregions in T2DM: NODDI provides added value to DTI and volumetric analyses by Xuan Huang, Ziyu Diao, Die Shen, Jianyu Li, Jiahe Wang, Kun Wang, Shijun Qiu

“…Objective: We explored macrostructural and microstructural changes in the hippocampal subregions of patients with type 2 diabetes mellitus (T2DM) and compared the effectiveness of neurite orientation dispersion and density imaging (NODDI) with that of traditional diffusion tensor imaging (DTI) and volumetric analysis in detecting structural alterations. …”
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