Heart rate transition patterns reveal autonomic dysfunction in heart failure with renal function decline: a symbolic and Markov model approach by Namareq Widatalla, Sona Al Younis, Ahsan Khandoker

“…Conventional heart rate variability (HRV) metrics serve as non-invasive markers of autonomic nervous system (ANS) function; however, they are limited in their ability to capture directional and nonlinear dynamics associated with autonomic impairment during renal function decline. …”
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Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice model of Charcot-Marie-Tooth disease by Maximiliano Anzibar Fialho, Mariana Martínez Barreiro, Lucia Vázquez Alberdi, Juan Pablo Damián, Maria Vittoria Di Tomaso, Jérôme Baranger, Mickael Tanter, Miguel Calero, Carlos Negreira, Nicolás Rubido, Alejandra Kun, Javier Brum

“…The Trembler-J (TrJ) mice serve as a high fidelity model of this disease. Here, we use functional ultrasound (fUS) and functional connectivity (FC) to analyze TrJ mice’s brain activity during sensory stimulation and resting state experiments against wild type (WT) mice - the healthy counterpart. fUS is an imaging technique that measures cerebral blood volume (CBV) temporal changes. …”
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Dynamical Analysis of a Class of Prey-Predator Model with Beddington-DeAngelis Functional Response, Stochastic Perturbation, and Impulsive Toxicant Input by Feifei Bian, Wencai Zhao, Yi Song, Rong Yue

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A Model for Analyzing a Five-Phase Fractional-Slot Permanent Magnet Tubular Linear Motor with Modified Winding Function Approach by Bo Zhang, Rong Qi, Hui Lin, Julius Mwaniki

“…This paper presents a model for analyzing a five-phase fractional-slot permanent magnet tubular linear motor (FSPMTLM) with the modified winding function approach (MWFA). …”
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Inhibition of Transglutaminase 2 by a Selective Small Molecule Inhibitor Reduces Fibrosis and Improves Pulmonary Function in a Bleomycin Mouse Model by Zhuo Wang, Sriniwas Sriram, Cynthia Ugwoke, Zoe Gale, Maral Tabrizi, Martin Griffin

“…For the first time, our study demonstrates the effectiveness of a selective small molecule TG2 inhibitor in reducing pulmonary fibrosis in a pre-clinical model. Importantly, we were able to correlate this effect of 1-155 with the improvement of animal lung function showing the potential of the use of TG2 inhibitors as a therapeutic treatment for fibrotic lung conditions like IPF.…”
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Generalized (ℱ,b,ϕ,ρ,θ)-univex n-set functions and semiparametric duality models in multiobjective fractional subset programming by G. J. Zalmai

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Ranking factors involved in product design using a hybrid model of Quality Function Deployment, Data Envelopment Analysis and TOPSIS technique by Davood Feiz, Seyyed Mohammad Tabatabai Mehrizi

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A New Model for Predicting Settlement Within the Influence Area of Shield Construction Based on Dynamic Weight Function and Asymptotic Decay Term by ZongYang Li, Aiqing Zhang, Xin Zou, Zhengxin Du

“…In this article, a new settlement prediction model based on dynamic weight function and asymptotic decay term is proposed to address this problem. …”
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BDS-PPP-B2b-Based Smartphone Precise Positioning Model Enhanced by Mixed-Frequency Data and Hybrid Weight Function by Zhouzheng Gao, Zhixiong Wu, Shiyu Liu, Cheng Yang

“…The results illustrated that the hybrid weight function led to 5.13%, 18.00%, and 15.15% positioning improvements compared to the results of the C/N₀-dependent model in the east, north, and vertical components, and it exhibited improvements of 71.10%, 72.53%, and 53.93% compared to the results of the satellite-elevation-angle-dependent model. …”
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Empirical Functions for Highly Charged Ion Abundances in Solar Wind Charge Exchange Models: Addressing Post‐2011 ACE Data Limitations by D. Koutroumpa, K. D. Kuntz, J. A. Carter, J. Raines, S. T. Lepri, L. Zhao

“…To address this, we developed empirical functions using ion ratios (O7+/O6+,O8+/O6+,C6+/C5+) still available from ACE, partially compensating for missing composition data. …”
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Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells. by Sayandip Mukherjee, Giorgia Santilli, Michael P Blundell, Susana Navarro, Juan A Bueren, Adrian J Thrasher

“…Murine models of human genetic disorders provide a valuable tool for investigating the scope for application of induced pluripotent stem cells (iPSC). …”
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A requirements model for AI algorithms in functional safety-critical systems with an explainable self-enforcing network from a developer perspective by Klüver Christina, Greisbach Anneliesa, Kindermann Michael, Püttmann Bernd

“…The requirements for ensuring functional safety have always been very high. Modern safety-related systems are becoming increasingly complex, making also the safety integrity assessment more complex and time-consuming. …”
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Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds. by Fei Cai, Yuehua Wei, Daniel Kirchhofer, Andrew Chang, Yingnan Zhang

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Reprogrammed human lateral ganglionic eminence precursors generate striatal neurons and restore motor function in a rat model of Huntington’s disease by Amy McCaughey-Chapman, Anne Lieke Burgers, Catharina Combrinck, Laura Marriott, David Gordon, Bronwen Connor

“…We investigated the ability for hiLGEPs to survive transplantation, differentiate to medium spiny-like striatal neurons and improve motor function in the QA lesion rat model of HD. Fourteen weeks after transplantation, we observed STEM121 + neurons co-expressing MAP2, DARPP32, GAD65/67, or GABA. …”
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Determination of Recovery by Total Restitution or Compensation Using Multifrequency Vestibular Tests and Subjective Functional Scales in a Human Model of Vestibular Neuritis by Enrico Armato, Georges Dumas, Flavio Perottino, Matthieu Casteran, Philippe Perrin

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GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

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Multi-Period Operational Modelling and Optimization for Large-Scale Natural Gas Networks Considering Linepack Functions in Long-Distance Transmission Pipelines by Wenwen Zhang, Qiaoqiao Tang, Xuenong Gao, Rujin Zhou

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Almost Periodic Solution of a Modified Leslie-Gower Predator-Prey Model with Beddington-DeAngelis Functional Response and Feedback Controls by Kerong Zhang, Jianli Li, Aiwen Yu

“…We consider a modified Leslie-Gower predator-prey model with the Beddington-DeAngelis functional response and feedback controls as follows: x˙t=xta1t-btxt-ctyt/αt+βtxt+γtyt-e1tut, u˙t=-d1tut+p1txt-τ, y˙t=yta2t-rtyt/xt+kt-e2tνt, and ν˙(t)=-d2(t)ν(t)+p2(t)y(t-τ). …”
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Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination by Melanie Lohrberg, Lena Sünke Mortensen, Carolina Thomas, Franziska Fries, Franziska van der Meer, Alexander Götz, Carolin Landt, Hong Jun Rhee, JeongSeop Rhee, David Gómez-Varela, Manuela Schmidt, Wiebke Möbius, Torben Ruhwedel, Luis A. Pardo, Linus Remling, Nadine Kramann, Claudia Wrzos, Erik Bahn, Christine Stadelmann, Alonso Barrantes-Freer

“…At the functional level, synaptic changes manifested as a reduction in frequency-dependent facilitation at the parallel fiber– Purkinje cell synapse. …”
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Flood Classification and Improved Loss Function by Combining Deep Learning Models to Improve Water Level Prediction in a Small Mountain Watershed by Rukai Wang, Ximin Yuan, Fuchang Tian, Minghui Liu, Xiujie Wang, Xiaobin Li, Minrui Wu

“…The optimized loss function further improves the prediction performance, resulting in a significant improvement in the accuracy of flood peak prediction, with a reduction of 0.26% in the relative error of the peak prediction by the GWN model. …”
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