Correction: Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington’s Disease

Get full text

Improved immersed boundary/wall modeling method for RANS solver coupled with wall functions: application to Cartesian grid systems by Xueying Yu, David R. Fuhrman, Yanlin Shao

Subjects: Get full text

Synthesis of a Transfer Function With Real Poles From Tabulated Frequency Response Data for Transmission-Line Impedance Modeling by Taku Noda

“…Especially in transmission line (TL) modeling, the impedance of a TL must be synthesized in the form of a transfer function of complex frequency, for instance, to be used in time-domain simulations. …”
Get full text

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…This study identified protein kinase C-α (PKCα) as a novel target for managing excretory liver function during sepsis. Using a preclinical murine sepsis model, we found that both PKCα knockout and the use of a PKCα-inhibitor midostaurin successfully restored liver function without hindering the host’s response or ability to clear the pathogen, highlighting PKCα’s vital role in excretory liver failure. …”
Get full text

Mathematical analysis of soliton solutions in space-time fractional Klein-Gordon model with generalized exponential rational function method by Rasel Islam, M. Abul Kawser, M. Sohel Rana, M. Nurul Islam

Subjects: Get full text

Boundary Conditions in 2D Numerical and 3D Exact Models for Cylindrical Bending Analysis of Functionally Graded Structures by F. Tornabene, S. Brischetto, N. Fantuzzi, M. Bacciocchi

“…The cylindrical bending condition for structural models is very common in the literature because it allows an incisive and simple verification of the proposed plate and shell models. …”
Get full text

CHARACTERISTICS OF THE FUNCTIONAL CAPABILITIES OF NATIONAL COMPETITORS IN GRECO-ROMAN WRESTLING AFTER SPECIALIZED TRAINING – PRE-COMPETITION MODELED WRESTLINGS by D. Chamishki

“…Purpose: Our goal is to construct a high-intensity modelled training (wrestling) suitable for the functional preparation before a competition and to determine their biochemical and physiological load characteristics by measuring heart rate and lactate concentration in the peripheral blood. …”
Get full text

Functional organotypic human lymph node model with native immune cells benefits from fibroblastic reticular cell enrichment by Andrew I. Morrison, Jesse E. Kuipers, Henk P. Roest, Luc J. W. van der Laan, Charlotte M. de Winde, Jasper J. Koning, Susan Gibbs, Reina E. Mebius

“…FRCs enhanced the production of immune-related cytokines and chemokines, such as B cell activating factor from the TNF family (BAFF), CXC motif chemokine ligand 12 (CXCL12), CC motif chemokine ligand 19 (CCL19) and interleukin-6 (IL-6). Functionality of the LN model was assessed through T cell activation by CD3 stimulation or initiation of an allogenic reaction with different maturation statuses of monocyte-derived dendritic cells (moDCs). …”
Get full text

Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models by Alexia K Martin, Uksha Saini, Ilse Hernandez-Aguirre, Yeaseul Kim, Kevin A Cassady, Jack Hedberg, Doyeon Kim, Ravi Dhital

“…In the CT-2A model, IL-27-expressing oHSV treatment was associated with increased intratumoral multifunctional effector CTLs and functional T cell populations systemically. …”
Get full text

Proposal of Damping Function for Low-Reynolds-Number k-ε Model Applicable in Prediction of Turbulent Viscoelastic-Fluid Flow by Takahiro Tsukahara, Yasuo Kawaguchi

“…In this model, an additional damping function was introduced into the model of eddy viscosity, while the treatment of the turbulent kinetic energy (k) and its dissipation rate (ε) is an extension of the model for Newtonian fluids. …”
Get full text

Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods by Mehmet Cengiz Baloglu, Lutfiye Yildiz Ozer, Buket Pirci, Yasemin Celik Altunoglu, Sanam Iram Soomro, Gokhan Zengin, Mehmet Veysi Cetiz, Simone Carradori, Zoltán Cziáky, József Jekő

Get full text

Distribution probability functions for models applied to hydraulic works in urban areas: LOG-GUMBEL vs LOG-PEARSON IIIRaúl by Raúl Montes-Pajuelo, Ángel Mariano Rodríguez-Pérez, Julio José Caparrós-Mancera, César Antonio Rodríguez-González

Subjects: “…modelling…”
Get full text

A Modified Kalman Filter Based on Radial Basis Function Neural Networks for the Improvement of Numerical Weather Prediction Models by Athanasios Donas, George Galanis, Ioannis Pytharoulis, Ioannis Th. Famelis

Subjects: Get full text

Rooting depth projections of global plant functional types and driving factors analysis based on a hybrid modeling framework by Qinggong Han, Bo Liu, Yunuo Liu, Jielin Zhang, Yongxia Ding, Shouzhang Peng

Subjects: Get full text

Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment by Fangxu Sun, Huafeng Wang, Jing Wu, Imran H. Quraishi, Yalan Zhang, Maysam Pedram, Benbo Gao, Elizabeth A. Jonas, Viet Nguyen, Sijia Wu, Omar S. Mabrouk, Paymaan Jafar-nejad, Leonard K. Kaczmarek

“…The potassium sodium-activated channel subtype T member 1 (<i>KCNT1</i>) gene encodes the Slack channel K_Na1.1, which is expressed in neurons throughout the brain. Gain-of-function variants in <i>KCNT1</i> are associated with a spectrum of epilepsy syndromes, and mice carrying those variants exhibit a robust phenotype similar to that observed in patients. …”
Get full text

Gender Differences in Predictors of Physical Functioning Limitations Among the Elderly Population in Serbia: A Population-Based Modeling Study by Dejan Nikolic, Natasa Mujovic, Milena Santric-Milicevic, Sindi Mitrovic, Nevena Krstic, Ana Radic, Diana Radovic, Ardak Nurbakyt, Dinara Sukenova, Milena Kostadinovic

“…Logistic regression analysis was performed to assess predictors of physical functioning. The models’ performance was presented. …”
Get full text

Intracoronary-Cardiosphere-Derived Cell Secretome Therapy: Effects on Ventricular Tachycardia Inducibility and Cardiac Function in a Swine Model by Claudia Báez-Díaz, Axiel Torrescusa-Bermejo, Francisco Miguel Sánchez-Margallo, Fátima Vázquez-López, María Pulido, Esther López, Ángel Arenal, Verónica Crisóstomo

“…Our objective was to evaluate the effects of an intracoronary (IC) administration of cardiosphere-derived cell secretome (S-CDCs) on VT inducibility and cardiac function in a swine model of MI. <b>Methods:</b> Fourteen pigs underwent endovascular MI model creation. …”
Get full text

Expression of Concern: Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells

Get full text

A Lattice Boltzmann BGK Model with an Amending Function for Two-Dimensional Second-Order Nonlinear Partial Differential Equations by Xiaohua Bi, Junbo Lei, Demei Li, Lindong Lai, Huilin Lai, Zhipeng Liu

“…A mesoscopic lattice Boltzmann method based on the BGK model is proposed to solve a class of two-dimensional second-order nonlinear partial differential equations by incorporating an amending function. …”
Get full text

Effect of neurohormonal therapeutic in left ventricle global and regional function in Chagas cardiomyopathy in a translational animal experimental model by Denise Mayumi Tanaka, Beatriz de Paula Dias Zara, André Timoteo Sapalo, Arthur Lauand Vargas, José Antonio Marin-Neto, Antônio Carlos Leite de Barros-Filho, Cibele M. Prado Zinni, Keila Cardoso Barbosa Fonseca, Maykon Tavares de Oliveira, João Santana Silva, Felix Jose Alvarez Ramires, Maria de Lourdes Higuchi, Marcus Vinicius Simões, Minna Moreira Dias Romano

Subjects: Get full text