Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis. by Serena De Vita, Rebekka K Schneider, Michael Garcia, Jenna Wood, Mathilde Gavillet, Benjamin L Ebert, Alexander Gerbaulet, Axel Roers, Ross L Levine, Ann Mullally, David A Williams

“…In this report, we demonstrate the cooperation between KIT D816V and loss of function of TET2 in mast cell transformation and demonstrate a more aggressive phenotype in a murine model of SM when both mutations are present in progenitor cells. …”
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GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model by Ana Abril Vidal Escobedo, Facundo Peralta, Gustavo Ramón Morel, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pardo

“…These findings demonstrate the capacity of the AAV-GFAP-GDNF-TdTom construct to induce astrocytic branching and partially preserve memory function. They also underscore its partial therapeutic potential in a neuroinflammatory, metabolically compromised and neurodegenerative context.…”
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Koopman-Based Model Predictive Control of Functional Electrical Stimulation for Ankle Dorsiflexion and Plantarflexion Assistance by Mayank Singh, Noor Hakam, Trisha M. Kesar, Nitin Sharma

Subjects: “…Functional electrical stimulation (FES)…”
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Sufficient and Necessary Conditions for the Permanence of a Discrete Model with Beddington-DeAngelis Functional Response by Yong-Hong Fan, Lin-Lin Wang

“…We give a sufficient and necessary condition for the permanence of a discrete model with Beddington-DeAngelis functional response with the form x(n+1) = x(n)exp{a(n)-b(n)x(n)-c(n)y(n)/(α(n)+β(n)x(n)+γ(n)y(n))},y(n+1)=y(n)exp{-d(n)+f(n)x(n)/(α(n)+β(n)x(n)+γ(n)y(n))}, where a(n),b(n),c(n),d(n),f(n),α(n),β(n), and γ(n) are periodic sequences with the common period ω;b(n) is nonnegative; c(n),d(n),f(n),α(n),β(n), and γ(n) are positive. …”
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The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model by Arafat Hassan Razon, Md. Alauddin, Nisat Farzana, Sanaullah Mazumdar, Md. Ruhul Amin, Md. Mahedi Hassan Tusher, Md. Asrafuzzaman, Nahid Hasan, Mahfuzur Rahman, Muhammad Saiedullah, Begum Rokeya, Md. Omar Faruque

“…This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)–activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells. …”
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Sarcopenia, functional capacity, and physical components of quality of life in older adults Mexicans: An explanatory model by Isaí Arturo Medina-Fernández, Sandra Cecilia Esparza-González, Nissa Yaing Torres Soto, Ana Laura Carrillo-Cervantes, Pedro Enrique Trujillo-Hernández, Josué Arturo Medina-Fernández

“…Among Mexican seniors, this condition exacerbates physical limitations, compromising daily activities and independence. The objective was to model the effect of sarcopenia on functional capacity and physical components of health-related QoL in older adults. …”
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Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats by Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

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Model of simulation of the process of formation of functional surfaces of micro-opto-electro-mechanical systems’ components by І.Ш. Невлюдов, О.О. Чала, О.І. Филипенко, І.В. Боцман

Subjects: “…micro-opto-electro-mechanical systems’, functional component, shaping, physical and technological parameters, mathematical model, modeling, abrasive processing, grinding, polishing.…”
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Transient Subcooled Boiling in Minichannels: Experimental Study and Numerical Modelling Using Trefftz Functions and ADINA by Beata Maciejewska, Magdalena Piasecka, Paweł Łabędzki

“…One used the Trefftz function formulation, while the other relied on simulations performed using the commercial software ADINA (version 9.2). …”
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Spatiotemporal patterns and prediction of multi-region house prices via functional mixed effects model by Yilin Chen, Haitao Zheng

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Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models by Juan Liu, Ariel Hanson, Wenzhen Yin, Qiao Wu, Eliane Wauthier, Jinmei Diao, Timothy Dinh, Jeff Macdonald, Ruihong Li, Masahiko Terajima, Mitsuo Yamauchi, Ziye Chen, Praveen Sethupathy, Jiahong Dong, Lola M. Reid, Yunfang Wang

“…We have developed a bioengineered, perfused, organ-level human liver model that accurately replicates key liver functions, including metabolic activities, and protein synthesis, thus addressing some of the limitations associated with traditional liver monolayers, organoids, and matrix-embedded liver cells. …”
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The exponential correlation function in the mathematical model of the investigated channel differential correlator with unmanned aerial vehicles by Vladimir Pavlovich Gerasimov, Vladimir Danilovich Kovalev, Sergey Vladimirovich Gerasimov, Alexander Yurievich Darzhania

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Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model by Chun Tang, Qi-Qi Zhou, Xiu-Feng Huang, Ya-Yi Ju, Bi-Lin Rao, Zhi-Cong Liu, Yi-An Jia, Zhan-Pei Bai, Qing-Yang Lin, Lin Liu, Jia Qu, Jun Zhang, Mei-Ling Gao

“…However, the limitations of rodent models in accurately representing human microglia have posed significant challenges in the study of retinal diseases. …”
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Functional efficiency of pancreatic cell-engineered construct in an animal experimental model for type I diabetes by N. V. Baranova, A. S. Ponomareva, L. A. Kirsanova, A. O. Nikolskaya, G. N. Bubentsova, Yu. B. Basok, V. I. Sevastianov

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Cognitive model of the national financial market: creating process and prospects for assessing the security of its functioning by E. A. Loktionova

“…The aim of the study is to develop a cognitive model of the Russian financial market to assess the security of its functioning. …”
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Fractal phototherapy: impact on the structure and function of the retina of rabbits with modelled retinal pigment epithelium atrophy by D. V. Fadeev, N. V. Neroeva, M. V. Zueva, I. V. Tsapenko, V. I. Kotelin, T. A. Pavlenko, O. V. Beznos, T. D. Okhotsimskaya, P. A. Ilyukhin, Yu. S. Timofeev

“…The purpose of this work is to study the effect of FF on the functional activity and morphology of the retina in rabbits with a model of retinal pathology. …”
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Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia by Mengying Zheng, Bingnan Liu, Yuanyuan Shao, Luogang Hua, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao, Chunyan Liu

“…This study is aimed at investigating the effects of shikonin, a pyruvate kinase M2 (PKM2) inhibitor, on the functions of myeloid dendritic cells (mDCs) in a mouse model of severe aplastic anemia (AA) generated by total body irradiation and lymphocyte infusion. …”
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The Role of Social Functioning Between Vitality and Mental Distress in Hypertension: A Partial Mediation Model by Sara Guidotti, Francesca Giordano, Carlo Pruneti

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Brain organoid models for studying the function of iPSC-derived microglia in neurodegeneration and brain tumours by Angelica Maria Sabogal-Guaqueta, Teresa Mitchell-Garcia, Jasmijn Hunneman, Daniëlle Voshart, Arun Thiruvalluvan, Floris Foijer, Frank Kruyt, Marina Trombetta-Lima, Bart J.L. Eggen, Erik Boddeke, Lara Barazzuol, Amalia M. Dolga

“…The interplay between microglia and other cells in the central nervous system, such as neurons or other glial cells, influences the function and ability of microglia to respond to various stimuli. …”
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Research on Seismic Test and Calculation Model for Improving Factor of Composite Board with Heat Preservation Function by Shaochun Ma, Hongyuan Fang

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