Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways by Qingshan Tang, Jiachen Dong, Feng Zhang, Dan Zhao, Qi Yang, Jiayu Wen, Yuhao Sun, Jifu Wei, Zhixian Liu

“…Gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) analysis and gene set enrichment analysis (GSEA) were applied to predict the potential functions of DEGs. Quantitative real time polymerase chain reaction (qRT-PCR) and Western blotting assays were performed to measure the expressions of thrombospondin-1 (THBS1), TGF-β1, PI3K, AKT and phosphorylated AKT (p-AKT) in the entrectinib-treated nerve cells. …”
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Potential therapeutic effects of ibudilast and retinoic acid against cuprizone-induced behavioral and biochemical changes in mouse brain by Kholoud A. Alyami, Gadah A. Alshahrany, Kholoud M. Al-Otaibi, Kholoud M. Al-Otaibi, Mohammad Z. Alam, Mohammad Z. Alam, Badrah S. Alghamdi, Badrah S. Alghamdi, Hadeil M. Alsufiani, Hadeil M. Alsufiani, Nouf O. Alshareef, Hanna M. Alhoraibi, Sahar A. Alkhodair, Ulfat M. Omar, Ulfat M. Omar

“…This was indicated as an improvement in locomotor activity, motor coordination and muscular strength as well as improving the cognition and memory functions. The mRNA expression pattern of various MS associated genes indicated that the treatments effectively mitigated the detrimental effects of CPZ in mouse brain. …”
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Association between malnutrition determined by hand grip strength and the presence of minimal hepatic encephalopathy in women with liver cirrhosis by Valeria Rangel-Espinosa, Marlene López-Sánchez, Aldo Allende-López, Nayeli Ortiz-Olvera, Aleida Bautista-Santos, Rosalba Moreno-Alcántar, Segundo Morán

“…Hand grip strength (HGS) serves as a marker of muscle functionality; however, the relationship between HGS values and the presence of MHE remains uncertain. …”
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The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and -Resistant Neuroblastoma Cells by Silvana Alfei, Paolo Giannoni, Maria Grazia Signorello, Carola Torazza, Guendalina Zuccari, Constantinos M. Athanassopoulos, Cinzia Domenicotti, Barbara Marengo

“…Triphenyl phosphonium salts (TPPs) are mitochondria-targeting compounds that exert anticancer effects, impair mitochondria functions, and damage DNA at the same time. Despite several biochemical applications, TPP-based bola-amphiphiles self-assembling nanoparticles (NPs) in water have never been tested as antitumor agents. …”
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Crisis Communication About the Maui Wildfires on TikTok: Content Analysis of Engagement With Maui Wildfire–Related Posts Over 1 Year by Jim P Stimpson, Aditi Srivastava, Ketan Tamirisa, Joseph Keaweʻaimoku Kaholokula, Alexander N Ortega

“…Using TikTok’s search functionality, we identified and reviewed public posts that contained relevant hashtags. …”
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Análisis espacial de datos para clasificar Musáceas en zonas Bananeras no tradicionales del Ecuador by Patricia Gómez, Omar Ruíz Barzola, Hernán Garcés, Esther Lilia Peralta García

“…It is important to identify varieties of Musa in nontraditional banana´s areas of the country, in order to obtain from them new functions. As a contribution to the statistics on this issue, this project is carried out aimed at identifying physiological descriptors by plants (height of the pseudostem, leaf area, width of margins of the petiole, petiole length, leaf ratio) in areas where there are plants that have characteristics that may be easy to exploit. …”
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Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate gene functions, while clinical feature correlation analysis and single-sample gene set enrichment analysis (ssGSEA) were utilized to assess immune infiltration characteristics. …”
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In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells by Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter

“…Transcriptomic analysis further revealed seven overlapping DEGs between IFN-γ– and TGF-β1–licensed MSCs, including both upregulated (GPR68, LIMK2, LIPG) and downregulated (EFNA5, PRKG1, DCLK1, TRIM2) genes, several of which are functionally implicated in EV-mediated immune regulation. …”
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Análisis espacial de datos para clasificar Musáceas en zonas Bananeras no tradicionales del Ecuador by Patricia Gómez, Omar Ruíz Barzola, Hernán Garcés, Esther Lilia Peralta García

“…It is important to identify varieties of Musa in nontraditional banana´s areas of the country, in order to obtain from them new functions. As a contribution to the statistics on this issue, this project is carried out aimed at identifying physiological descriptors by plants (height of the pseudostem, leaf area, width of margins of the petiole, petiole length, leaf ratio) in areas where there are plants that have characteristics that may be easy to exploit. …”
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Análisis espacial de datos para clasificar Musáceas en zonas Bananeras no tradicionales del Ecuador by Patricia Gómez, Omar Ruíz Barzola, Hernán Garcés, Esther Lilia Peralta García

“…It is important to identify varieties of Musa in nontraditional banana´s areas of the country, in order to obtain from them new functions. As a contribution to the statistics on this issue, this project is carried out aimed at identifying physiological descriptors by plants (height of the pseudostem, leaf area, width of margins of the petiole, petiole length, leaf ratio) in areas where there are plants that have characteristics that may be easy to exploit. …”
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Estradiol Downregulates MicroRNA-193a to Mediate Its Anti-Mitogenic Actions on Human Coronary Artery Smooth Muscle Cell Growth by Lisa Rigassi, Marinella Rosselli, Brigitte Leeners, Mirel Adrian Popa, Raghvendra Krishna Dubey

“…Importantly, miR-193a is actively involved in regulating SMC functions. The ectopic expression of miR-193a induced vascular SMC proliferation and migration, while its suppression with antimir abrogated PDGF-BB-induced growth, effects that were similar to E2. …”
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Agreement Between Child Self- and Parent Proxy-Reports of Health-Related Quality of Life in Spinal Muscular Atrophy: Preliminary Insights from a Nationwide Patient Registry in Germ... by Landfeldt E, Leibrock B, Hussong J, Thiele S, Walter MC, Moehler E, Zemlin M, Dillmann U, Flotats-Bastardas M

“…The lowest levels of concordance were found for school and family life, as well as mental well-being, as opposed to physical functioning and disability.Conclusion: We show that the agreement between child self- and parent proxy-reports of HRQoL in SMA varies markedly across HRQoL measures and examined domains, ranging from poor/fair to excellent. …”
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Introduction by Verena Balz

“…They all sought for comprehensiveness through considering a multitude of aspects that influence the form and functioning of this development. In all practices, the production of spatial representations, maps and models, was a core activity. …”
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Requirements for Becoming a Startup: A Study with an Economic Sociology Approach (Case Study: Managers of Startups in Isfahan City) by Rahmatollah Torkan, Seyed Samad Beheshty, Ramin Moradi

“…IntroductionIn today's fast-paced world, the growing dynamics of the global economy, society, and technology have given rise to new business models. Among these, startups have emerged as vital engines of economic development due to their innovative potential. …”
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The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Meta‐analyses, inverse variance weighted using random effects statistical models, were conducted on post‐traumatic stress disorder (PTSD), depression, and anxiety. …”
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Long-Term Outcomes Associated with Traumatic Brain Injury in Childhood and Adolescence: A Nationwide Swedish Cohort Study of a Wide Range of Medical and Social Outcomes. by Amir Sariaslan, David J Sharp, Brian M D'Onofrio, Henrik Larsson, Seena Fazel

“…We used logistic and Cox regression models to quantify the association between TBI and specified adverse outcomes on the individual level. …”
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THE PREHISTORY OF THE MAGIC OF SCREENS. MOTIVES FROM THE “ILLIAD” AND THE “ODYSSEY” / ПРЕДЫСТОРИЯ ВОЛШЕБСТВА ЭКРАНОВ. МОТИВЫ «ИЛИАДЫ» И «ОДИССЕИ»... by SALNIKOVA EKATERINA V. / САЛЬНИКОВА ЕКАТЕРИНА ВИКТОРОВНА

“…The wall built by the Achaeans functions as another platitude of the screen. It also presents a kind of decoration, a background against which the battle scenes unfold. …”
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The Relationship Between Psychosocial Factors and Response to Epidural Steroid Injection for Chronic Lumbosacral Radicular Pain: A Prospective Pilot Study by Stensland M, Sanford E, Houle TT, McGeary C, Cobos BA, Lugosi S, Lehman L, Nabity PS, Covell C, Fitzgerald E, Mojallal M, Reed DE, Pangarkar S, Eapen BC, Nanda U, McCormick ZL, McGeary D

“…Future research with a larger sample should focus on deepening our understanding of the role of psychosocial functioning as a potential mechanism of treatment response in patients undergoing ESI procedures. …”
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Plasma microRNA-210 is associated with VEGF-A and EphrinA3 and relates to coronary collateral circulation in patients with coronary heart disease: a cross-sectional study by Ning Zhao, Kun Na, Wei Sun, Henghe Shi, Xiaolin Zhang, Bin Liu, Yaling Han

“…Notably, mediation analysis revealed that miR-210 functions as a pivotal intermediary in pathways connecting both VEGF-A and EphrinA3 to CCC formation, mediating 77.18% and 49.90% of their respective effects. …”
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Optimization of 44gSc Production Using Cyclotron-irradiated Liquid Target by WANG Yizheng1, 2, 3, MAQBOOL Sahil1, 2, 4, ZHANG Yuxuan2, 3, YANG Wenjiang1, 2, 3, , WEI Long1, 2, 3, 4

“…To calculate theoretical yield and radionuclidic purity, excitation functions were simulated using TALYS 2.0, ALICE-IPPE, and EMPIRE 3.2 nuclear reaction codes. …”