Results from AD-HEARING (ADherence to and adjustment of HEARING aids in clinical routine care as preventive dementia strategy): a prospective 6-month follow-up study on cognition a... by Michael Belz, Sebastian Gmeinwieser, Mona Abdel-Hamid, Mona Abdel-Hamid, Robert Kühler, Jenny Blum, Philipp Hessmann, Nicola Strenzke, Claudia Bartels

“…Hearing aid use might reduce this risk by preserving cognitive and psychological functions.ObjectiveThis study aims to investigate the influence of ARHL and hearing aid use on cognition and different aspects of psychological well-being.MethodsDuring 05/2021 and 05/2023, 31 subjects with audiometrically confirmed ARHL were included and 28 underwent follow-up 6 months later (final analysis sample). …”
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Cross-lagged analysis of physical fitness and cognitive control in Chinese early adolescents by Lei Xu, Fengling Zhang, Jianbo Zhu

“…Eight-month follow-up (T2: November–December 2023) retained 143 participants (mean age: 12.7 ± 0.52). Cross-lagged path modeling in Mplus 8.0 examined bidirectional causation relationships between fitness domains and cognitive functions, supplemented by SPSS 26.0-based correlational analyses. …”
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Generation of a Transgenic <i>Plasmodium cynomolgi</i> Parasite Expressing <i>Plasmodium vivax</i> Circumsporozoite Protein for Testing <i>P. vivax</i> CSP-Based Malaria Vaccines i... by Maya Aleshnick, Shreeya Hegde, Charlie Jennison, Sebastian A. Mikolajczak, Ashley M. Vaughan, Derek Haumpy, Thomas Martinson, Judith Straimer, Brandon K. Wilder

“…<b>Results</b>: We show that the in vitro-generated transgenic <i>Pcy</i>[<i>Pv</i>CSP] parasite expresses both serotypes of <i>P. vivax</i> CSP and retains full functionality in vivo, including the ability to transmit to laboratory-reared <i>Anopheles</i> mosquitoes and cause relapsing infections in rhesus macaques. …”
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Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia by Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y

“…The expression patterns of this axis in the prefrontal cortex were consistent with those observed in peripheral blood samples from clinical patients.Conclusion: This study identified a specific multi-molecular axis in early-onset schizophrenia, wherein hsa-circ-0000713 functioned as a sponge to reduce the inhibitory effects of hsa-miR-370-3p on ANK3 and MGLL. …”
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The Molecular Mechanism by Which miR-211-5p Regulates the Proliferation and Differentiation of Preadipocytes in Meat Rabbits by Targeting TPK1 by Xiaoxiao Zhang, Meigui Wang, Tao Tang, Jing Zhou, Wenqiang Sun, Xianbo Jia, Jie Wang, Hengwei Yu, Songjia Lai

“…However, the precise functions of miR-211-5p in lipid deposition and lipogenesis in rabbit preadipocytes remain unclear. …”
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A systematic review of behaviour change interventions to improve maternal health outcomes in sub-Saharan Africa. by Francis G Muriithi, Aduragbemi Banke-Thomas, Gillian Forbes, Ruth W Gakuo, Eleanor Thomas, Ioannis D Gallos, Adam Devall, Arri Coomarasamy, Fabiana Lorencatto

“…We categorised the behaviour change strategies using the intervention functions described in the Behaviour Change Wheel (BCW). …”
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Interpersonal psychotherapy delivered by nonspecialists for depression and posttraumatic stress disorder among Kenyan HIV-positive women affected by gender-based violence: Randomiz... by Susan M Meffert, Thomas C Neylan, Charles E McCulloch, Kelly Blum, Craig R Cohen, Elizabeth A Bukusi, Helen Verdeli, John C Markowitz, James G Kahn, David Bukusi, Harsha Thirumurthy, Grace Rota, Ray Rota, Grace Oketch, Elizabeth Opiyo, Linnet Ongeri

“…<h4>Conclusions</h4>IPT for MDD and PTSD delivered by nonspecialists in the context of HIV care yielded significant improvements in HIV-positive women's mental health, functioning, and GBV (IPV) exposure, compared to controls.…”
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Mixed Reality Ultrasound-Guided Mini-ECIRS with Apple Vision Pro™ - First Case Report by Roberto Montoro Neto, Fabio C. Vicentini, Ricardo T.S. Ugino, Alexandre Danilovic, Giovanni S. Marchini, Fabio C.M. Torricelli, Carlos A. Batagello, Anderson B. Pellanda, Alexandre Silva, William C. Nahas, Eduardo Mazzucchi

“…Apple Vision Pro (AVP) is a spatial computing device developed by Apple that incorporates virtual reality (VR) for life-like simulations, realistic medical scenarios, interactive anatomical models, and augmented reality (AR) technologies (3). …”
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Experimental study on the biomechanical loading of a four-dimensional plate for the fixation of femoral shaft fractures by Meiling Song, Jian Wen, Zhe Wang, Yu Zeng, Jun Lu, Wei Lu, Changsheng Chen, Xieping Dong

“…Abstract Objective To explore the biomechanical properties of a four-dimensional structure locking osteosynthesis plate that can alter its structure and functionality over time. Methods According to the AO classification (AO-A2) standard, 18 artificial femoral shaft oblique fracture models with the same position and shape were generated and subsequently randomly divided into 2 groups (n = 9). …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Ruihua Wei, Jing Fu, Bidan Zhu

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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Arianna Romani, Giada Lodi, Fabio Casciano, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Olga Bortolini, Giuseppe Valacchi, Daniele Ragno, Agnese Bondi, Mascia Benedusi, Elisabetta Esposito, Rebecca Voltan

“…The potential of nutlin-3a-loaded ethosomes was investigated on two in vitro models of melanoma: the HT144 cell line p53^wild-type and the SK-MEL-28 cell line p53^mutated. …”
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Ecological Concrete-Based Modular System for Heavy Metal Removal in Riparian Transition Zones: Design, Optimization and Performance Evaluation by Guangbing Liu, Da Ke, Hasnain Moavia, Chen Ling, Yanhong Zhang, Yu Shen

“…Through systematic optimization, we developed a C25-grade ecological concrete module (100 mm × 100 mm × 100 mm) with a specialized cavity design (φ61 mm × H60 mm) that achieves optimal balance between structural integrity (20–30 MPa compressive strength) and environmental functionality (>15% porosity, >1 × 10⁻⁴ cm s⁻¹ permeability). …”
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Mycorrhizal and nutrient controls of carbon sequestration in tropical rainforest soil by Jie Chen, Xin Tang, Han Xu, Yanpeng Li, Adriana Corrales, Yide Li, Yakov Kuzyakov, Zhanfeng Liu, Shirong Liu

“…This study characterized the performances of AM and ECM trees, SOC content, and soil microbial functions under variable soil nitrogen (N) and phosphorus (P) content across an intact tropical rainforest based on the spatial dataset from a 60-ha dynamic plot and fitted statistical models to examine the mycorrhizal and nutrient controls on SOC stocks. …”
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NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…The high NRF2 expression levels were at least partially induced by fat mass and obesity-associated protein (FTO) via m6A modification. Functionally, NRF2 exerts its antioxidant effects by transcriptionally upregulating malic enzyme 1 (ME1) expression and enhancing its activity. …”
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Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study by Jia Liao, Xiaoqun Hu, Xing Wei, Wei Dai, Hongfan Yu, Xin Tian, Yaqin Wang, Qin Qin, Na Xu, Yuanyuan Li, Qiang Li, Qiuling Shi, Xiaoqin Liu

“…On a daily assessment schedule, we evaluated patients’ symptoms and their impact on functioning from the day before surgery until discharge using the MD Anderson Symptom Inventory–Lung Cancer module. …”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…Linear mixed-effects models determined significant improvements in PHQ-9 and GAD-7 scores for participants across both conditions (ps < 0.001). …”
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Impact of Climate and Soil on Plant Dynamics and Ecosystem Stability in Argan Orchards by Maryem Telmoudi, Chaima Afi, Naima Chabbi, Said Labbassi, Assma Oumasst, Mohamed Ouknin, Rachid Bouharroud, Abdelaziz Mimouni, Mimoun El Kaoua, Driss Hsissou, Abdelghani Tahiri, Naima Ait Aabd

“…Seasonal changes were predominantly influenced by temperature and precipitation, while diverse soil types shaped by relief, climate, and water balance contributed to different ecological functions. The key findings indicated the highest plant diversity in “Tioughza” and the most significant plant density in “Imoulass” and “Ezzaouite”. …”
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Early cardiac events after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide. subanalysis exploring cardiac toxicity conducted on behalf of GE... by Filipe R. Pinto, Enric Cascos, Estefanía Pérez-López, Mónica Baile-González, Carlos Martín Rodríguez, María Jesús Pascual Cascón, Marta Luque, Albert Esquirol, Carmen Martín Calvo, Felipe Peña-Muñóz, Inmaculada Heras Fernando, Itziar Oiartzabal Ormtegi, Adolfo Jesús Sáez Marín, Sara Fernández-Luis, Juan José Domínguez-García, Sara Villar Fernández, José Luis López Lorenzo, Miguel Fernández de Sanmamed Girón, Leslie González Pinedo, Lucía García, Ana Pilar González-Rodriguez, Tamara Torrado, Silvia Filaferro, Pascual Basalobre, Alberto López-García, Guillermo Ortí, Guillermo Ortí, Manuel Jurado Chacón, Manuel Jurado Chacón, María Queralt Salas, María Queralt Salas

“…ECEs, defined as any new cardiac event within 100 days post-transplant, were analyzed using cumulative incidence functions considering death and relapse as competing risks. …”
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Urban Tree Canopy Mapping and Analysis Using Iterative Annotation Method and Deep Learning: A Case Study in Beijing by Yulong Ding, Ximin Cui, Zhengchao Chen, Zeqing Wang, Debao Yuan, Xiang Meng, Xuan Yang, Yue Xu, Xiangyu Tian

“…Urban trees have significant ecological and social functions, and generating urban tree canopy (UTC) maps is an effective method for understanding their distribution. …”
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Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases by Rebecca Zirnbauer, Daphni Ammon, Annalena Renner, Noam Hartman, Polina Kalinina, Patrick Starlinger, Stefan Stremitzer, Christoph Schwarz, Klaus Kaczirek, Michael Bergmann, Dietmar Pils, Johannes Laengle

“…Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNAs (sncRNA), regulate gene expression, stress response, and immune functions in cancer. While increasingly implicated in CRC progression, their prognostic significance in CRLM remains unknown. …”
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