Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study by Sijia Yang, Kun Liao, Lu Zhou, Shengbo Zhang, Jianchao Wu

“…BackgroundMuscle strength is strongly associated with various physiological functions and health risks, with grip strength serving as a key indicator for its assessment. …”
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Identifying Current Practices and Areas for Improvement in Medication Management During Care Transition Through an Interprofessional Collaboration Framework by Solh Dost L, Maillard G, Cardoso E, Schneider MP

“…Role clarification: unclearly defined, causing inefficiencies; 4. Team functioning: common in hospital settings, but inconsistent during transition; 5. …”
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3D CMZ. II. Hierarchical Structure Analysis of the Central Molecular Zone by Cara Battersby, Daniel L. Walker, Ashley Barnes, Adam Ginsburg, Dani Lipman, Danya Alboslani, H Perry Hatchfield, John Bally, Simon C. O. Glover, Jonathan D. Henshaw, Katharina Immer, Ralf S. Klessen, Steven N. Longmore, Elisabeth A. C. Mills, Sergio Molinari, Rowan Smith, Mattia C. Sormani, Robin G. Tress, Qizhou Zhang

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Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer by Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which exert anti-T-cell functions through multiple mechanisms, especially JAK2/STAT3-regulated arginase activity. …”
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5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth by Xinning Guo, Meng Jiang, Zhengyu Tao, Huijuan Dai, Chen Wu, Yinan Wang, Zi Wang, Xiaoning Wang, Zhixuan Zhang, Kun Qian, Shanshan Zeng, Yihua Bei, Jun Pu

“…Conclusions: This study reveals a previously unrecognized dual role of 5-oxoproline, which functions both as an early biomarker for DOX-induced cardiotoxicity detection and as a therapeutic target that simultaneously inhibits cancer growth and protects the myocardium.…”
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SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…IntroductionThis randomized clinical trial (RCT) compared the efficacy of two cognitive rehabilitation (CR) protocols—Strategic Memory Advanced Reasoning Training (SMART) and Study of Cognitive Rehabilitation Effectiveness (SCORE)—in improving higher-order cognitive functions among active-duty service members (ADSMs) with mild traumatic brain injury (mTBI) and varying levels of post-traumatic stress disorder (PTSD) symptoms. …”
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Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression by Genta Kakiyama, Nanah Bai-Kamara, Daniel Rodriguez-Agudo, Hajime Takei, Kei Minowa, Michael Fuchs, Sudha Biddinger, Jolene J. Windle, Mark A. Subler, Tsuyoshi Murai, Mitsuyoshi Suzuki, Hiroshi Nittono, Arun Sanyal, William M. Pandak

“…Among various hepatic genes impacted during MASLD development, CYP7B1 is consistently suppressed in multiple MASLD mouse models and in human MASLD cohorts. CYP7B1 enzyme suppression leads to accumulations of bioactive oxysterols such as (25R)26-hydroxycholesterol (26HC) and 25-hydroxycholesterol (25HC). …”
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A strain of Lactobacillus plantarum from piglet intestines enhances the anti-PoRV effect via the STING-IFN-I pathway by Anqi Sun, Xin Shan, Ruihan Liu, Zhengxu Tang, Jingshu Huang, Shihan Zhang, Lihong Bian, Yumeng Shi, Zixuan Liu, Jingtao Hu, Chunfeng Wang

“…Lactobacillus plantarum, a ubiquitous probiotic in natural ecosystems, has demonstrated multifaceted biological functions. The stimulator of the interferon gene (STING) is involved in type I interferon (IFN-I) mediated host antiviral innate immunity, which is a pivotal adaptor in response to the microbial DNA/RNA-activated signaling pathways. …”
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Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in pancreatic cancer by Mengge Li, Huimin Li, Dejun Liu, Shunan Liu, Hui Yuan, Yan Wu, Min Du, Yuan Fang, Jin Li, Hui Cong, Dan Zhao, Chunsun Fan, Qing Wang, Cenkai Shen, Yu Gan, Yongwei Sun, Hong Tu

“…Methods High‐throughput sequencing‐based approach was employed to identify HBV integrations in tumour and para‐tumour tissues of PDAC. The biological functions of KMT2B were evaluated in PDAC cell lines as well as in subcutaneous and orthotopic mouse models of PDAC. …”
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Development and validation of a fluency rating scale for Swiss German Sign Language by Tobias Haug, Nivja H. de Jong, Franz Holzknecht, Katja Tissi, Sandra Sidler-Miserez, Alessia Battisti, Regula Perrollaz, Sarah Ebling, Sabine Reinhard, Sarah Caminada

“…Overall, the rating scale functioned well, with each score category being modal at some point on the continuum. …”
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The Arabic Satisfaction with Life Scale (SWLS) and its three-item version: Factor structure and measurement invariance among university students by Amira Mohammed Ali, Saeed A. Al-Dossary, Musheer A. Aljaberi, Maha Atout, Rasmieh Alamer, Mohamed M.H. Suliman, Feten Fekih-Romdhane

“…Satisfaction with life implicates the psychological, social, and educational functioning of students—justifying its use for clinical screening and monitoring of treatment outcomes. …”
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Association of long-term exposure to PM2.5 with hypertension prevalence and blood pressure in China: a cross-sectional study by Jing Li, Shuang Hu, Yan Gao, Di Zhang, Jiali Song, Matteo Renzi, Emanuela Medda, Guigang Tang, Wenbo Zhang, Maria Antonietta Stazi

“…The associations of PM2.5 exposure with hypertension prevalence and blood pressure were investigated by generalised linear models, with PM2.5 included as either linear or spline functions.Results The 1-year PM2.5 exposure of the study population ranged from 8.8 to 93.8 µg/m3 (mean 49.2 µg/m3). …”
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<i>Heortia vitessoides</i> Infests <i>Aquilaria sinensis</i>: A Systematic Review of Climate Drivers, Management Strategies, and Molecular Mechanisms by Zongyu Yin, Yingying Chen, Huanrong Xue, Xiaofei Li, Baocai Li, Jiaming Liang, Yongjin Zhu, Keyu Long, Jinming Yang, Jiao Pang, Kaixiang Li, Shaoming Ye

“…Current research has preliminarily revealed its biological traits and gene functions. However, significant gaps persist in integrating climate adaptation mechanisms, control technologies, and host interaction networks across disciplines. …”
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N6‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastasis by Song Li, Jianyuan Zhou, Shuang Wang, Qian Yang, Shulun Nie, Chunwang Ji, Xue Zhang, Shuhan Li, Xuanyu Zhou, Jiahui Chu, Xuehui Wu, Jianqiao Jiao, Ruitao Xu, Qian Xu, Miao Huang, Qiushi Wang, Liliang Dou, Qinqin Hu, Fan Jiang, Xin Dai, Zhaodi Nan, Xinyu Song, Di Zhang, Lian Liu

“…Macrophage and T‐cell functions were assessed using enzyme‐linked immunosorbent assay, flow cytometry, and cytotoxicity assays. …”
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Causal estimation of the relationship between reproductive performance and the fecal bacteriome in cattle by Yutaka Taguchi, Haruki Yamano, Yudai Inabu, Hirokuni Miyamoto, Koki Hayasaki, Noriyuki Maeda, Yoshiro Kanmera, Seiji Yamasaki, Noboru Ota, Kenji Mukawa, Atsushi Kurotani, Shigeharu Moriya, Teruno Nakaguma, Chitose Ishii, Makiko Matsuura, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Motoaki Udagawa, Satoshi Wada, Jun Kikuchi, Hiroshi Ohno, Hideyuki Takahashi

“…Abstract Background The gut bacteriome influences host metabolic and physiological functions. However, its relationship with reproductive performance remains unclear. …”
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Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids by Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes, Alexandra Bergholtz, Magnus Sundbom, Martin Skogar, Wilhelm Graf, Kajsa Björner, Johan Vessby, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

“…Taken together, the study reveals how a small set of virulence factors shapes divergent epithelial colonization strategies by related enterobacteria.IMPORTANCEPathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. …”
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Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context by Anne M. Gehrels, Pauline A.J. Vissers, Mirjam A.G. Sprangers, Nienke M. Fijnheer, Esther N. Pijnappel, Lydia G. van der Geest, Geert A. Cirkel, Judith de Vos-Geelen, Marjolein Y.V. Homs, Geert- Jan Creemers, Martijn W.J. Stommel, Lois A. Daamen, Marc G. Besselink, Johanna W. Wilmink, Hanneke W.M. van Laarhoven

“…In R-PAC, hepatic symptoms and health care satisfaction improved while role and social functioning deteriorated and eating related problems, side effects and fear of future health increased during treatment. …”
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Building a Digital Health Research Platform to Enable Recruitment, Enrollment, Data Collection, and Follow-Up for a Highly Diverse Longitudinal US Cohort of 1 Million People in the... by Dave Klein, Aisha Montgomery, Mark Begale, Scott Sutherland, Sherilyn Sawyer, Jacob L McCauley, Letheshia Husbands, Deepti Joshi, Alan Ashbeck, Marcy Palmer, Praduman Jain

“… BackgroundLongitudinal cohort studies have traditionally relied on clinic-based recruitment models, which limit cohort diversity and the generalizability of research outcomes. …”
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Navigating Nepal's health financing system: A road to universal health coverage amid epidemiological and demographic transitions. by Resham B Khatri, Pratik Khanal, Dipendra Singh Thakuri, Prabesh Ghimire, Mihajlo Jakovljevic

“…Policies and content related to the health financing system were reviewed to understand the status, issues and challenges of health financing functions, and UHC . A framework-guided deductive content analysis approach was employed, and findings were interpreted using the three UHC components: service coverage, population coverage, and financial coverage.…”
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Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. by Claudia P Cabrera, Joanna Manson, Joanna M Shepherd, Hew D Torrance, David Watson, M Paula Longhi, Mimoza Hoti, Minal B Patel, Michael O'Dwyer, Sussan Nourshargh, Daniel J Pennington, Michael R Barnes, Karim Brohi

“…MODS transcripts differentially expressed in the hyperacute window showed enrichment among diseases and biological functions associated with cell survival and organismal death rather than inflammatory pathways. …”
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