Distribuição espacial de valores prováveis de precipitação pluvial para períodos quinzenais, em Guiné-Bissau Spatial distribution of probable rainfall in Guinea-Bissau by Sadjo Danfá, Antônio M. da Silva, Carlos R. de Mello, Gilberto Coelho, Marcelo R. Viola, Léo F. Ávila

“…<br>The aim of this study was to estimate the probable values of rainfall in the first and second halves of the months and its spatial distribution in Guinea-Bissau. Distribution functions Log-normal 2 parameters were used to estimate the probable values of rainfall adopting the probability level of 75%. …”
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LPM electrode loaded with RAPA-PLGA drug sustained-release system can reduce local fibrous tissue hyperplasia and local bioelectrical impedance by Xiu Wang, Wentao Du, Yunyun Wang, Ahsan Riaz Khan, Haijun Zhang

“…This drug-loaded electrode has been deemed safe for implantation in animal models. It can effectively inhibit local fibrous tissue proliferation and reduce local bioelectrical impedance, offering a technical strategy to prolong the in vivo functionality of LPMs and enhance clinical procedures.…”
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PEDAGOGICAL FRAMEWORKS OF EDUCATION POLICY FOR SUSTAINABLE DEVELOPMENT OF THE EURASIAN SPACE by Zh. O. Zhilbayev, L. V. Moiseeva, M. V. Barsanova

“…The possibilities for creation of the educational ecosystem environment functioning are shown by the experience of the Republic of Kazakhstan where the Green Economy Transition (GET) is actively implemented.Practical significance. …”
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2, 2′, 4, 4′-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells by Guangshan Xie, Jinping Lu, Jiayi Song, Jianqing Zhang

“…Given the pivotal role of the V-Raf murine sarcoma viral oncogene homolog B (BRAF) and the downstream mitogen-activated protein kinase kinase (MEK)- signal-regulated kinase (ERK) pathway in cell proliferation, differentiation, cell cycle and thyroid functions, in this study, we constructed BRAF knockout (BRAF-KO) and overexpression (BRAF-OE) cell models using Nthy-ori 3-1 cells, to evaluate the effect of BDE-47 on human thyroid cells and explore the potential mechanisms. …”
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When, where, and how prey pair antipredator behaviors to natural and anthropogenic mortality risks by Michael E. Egan, Abigail M. Weber, Nicole Gorman, Michael W. Eichholz, Daniel Skinner, Peter E. Schlichting, Guillaume Bastille-Rousseau

“…We used hidden Markov models to determine whether each covariate impacted the probability of transitioning between behavioral states and selection functions to determine whether deer spatially avoided each covariate. …”
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Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis: a comparative study by Kirill Reshetnikov, Daria Bykova, Daria Bykova, Konstantin Kuleshov, Konstantin Kuleshov, Konstantin Chukreev, Egor Guguchkin, Alexey Neverov, Gennady Fedonin

“…In this study, we evaluated several such methods, namely, logistic regression with different regularization penalty functions, a recently introduced algorithm for solving the best-subset selection problem (ABESS) and “Hungry, Hungry SNPos” (HHS) a heuristic algorithm specifically developed to identify resistance-associated genetic variants in the presence of resistance co-occurrence. …”
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Regulation of mesenchymal stem cell-derived exosomes on helper T cells in periodontitis by WEN Yuqi, GUO Shujuan, DING Yi

“…In addition, microRNAs exhibit immunoregulatory functions: periodontal ligament stem cell-derived exosomes contain miRNA-155-5p, which targets sirtuin-1 to suppress Th17 cell differentiation. …”
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Development of enterprise architecture management methodology for teaching purposes by Dmitry V. Kudryavtsev, Evgeny P. Zaramenskikh, Maxim Y. Arzumanyan

“…Enterprise architecture allows describing, analyzing and designing the company from the point of view of its structure, functioning and goal setting (motivation).In the context of this approach, the enterprise is viewed as a system of services, processes, goals and performance indicators, organizational units, information systems, data, technical facilities, etc. …”
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Serum proteomic correlates of mental health symptoms in a representative UK population sample by Anna Dearman, Yanchun Bao, Leonard Schalkwyk, Meena Kumari

“…We perform multiple linear regressions in up to 5304 participants using two mental health symptom-based outcomes: psychological distress assessed with the general health questionnaire (GHQ-12) and mental health functioning assessed with the 12-Item Short Form Survey, Mental Component Summary (SF12-MCS) using the proteomic factors as explanatory variables and adjusting for demographic covariates. …”
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BePresent Universal Internet-Based Parenting Intervention: Single-Arm Pre-Post Intervention Study by Kaisa Mishina, Amit Baumel, Malin Kinnunen, Terja Ristkari, Emmi Heinonen, Susanna Hinkka-Yli-Salomäki, Andre Sourander

“…Linear mixed-effects models were used to analyze the changes from baseline to follow-up. …”
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Problems of using phenol (hydroxybenzene) and parabens as pharmaceutical stabilizers: analysis using machine learning methods by I. Yu. Torshin, O. A. Gromova

“…Keywords were sorted by empirical Rudakov–Torshin informativeness functionals in the context of combinatorial theory of solvability, followed by combinatorial testing of solvability to find terms with the greatest informativeness.Results. …”
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A Hybridization of Machine Learning and NSGA-II for Multi-Objective Optimization of Surface Roughness and Cutting Force in ANSI 4340 Alloy Steel Turning by Anh-Tu Nguyen, Van-Hai Nguyen, Tien-Thinh Le, Nhu-Tung Nguyen

“…The present study uses five ML models – namely SVR, CAT, RFR, GBR, and ANN – to predict Ra and cutting force. …”
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Host Immune Response to Mycobacterium tuberculosis Infection: Implications for Vaccine Development by Liu Q, Que S, Qiu Y, Tang M, Liu S, Yang G, Wang Y, Deng A, Hu X, Lian X, Gao Q

“…In this review, we delve into the overview of animal models of TB infection and the host’s innate and adaptive immune responses to Mtb infection. …”
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Development of a novel SupraChoroidal-to-Optic-NervE (SCONE) drug delivery system by Bryce Chiang, Kathleen Heng, Kyeongwoo Jang, Roopa Dalal, Yaping Joyce Liao, David Myung, Jeffrey L Goldberg

“…In eyes with successful SCONE delivery, latency and amplitude of visual evoked potentials was not different than the naïve untreated eye.Conclusions SCONE delivery can be used for targeted drug delivery to the optic nerve head of rabbits without measurable toxicity measured anatomically or functionally. Successful development of this system may yield novel opportunities to study optic nerve head-specific drug delivery in animal models, and paradigm-shifting management strategies for treating optic neuropathies.Translational Relevance Here we demonstrate data on a new method for targeted delivery to the optic nerve head, addressing a significant unmet need in therapeutics for optic neuropathies.…”
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Engineering students' perceptions and actual use of AI-based math tools for solving mathematical problems by Kimberly F. Garcia, Ardvin Kester S. Ong, Ma. Janice J. Gumasing, Cesar Romeo V. Delos Reyes

“…From the result, perceived autonomy was deemed insignificant to behavioral intentions, suggesting that students utilize AI tools for functionality and benefits in their academic performance rather than the adaptability of the tools. …”
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Whole-Body Cryotherapy Reduces Systemic Inflammation in Healthy Adults: Pilot Cohort Study by Elizabeth Chun, Richard Joseph, Rachele Pojednic

“…MethodsFifteen individuals (n=9 female) participated in frequent recreational W-BC (3 minutes of cold exposure at –110 ℃) over approximately 9 months and had blood draws at baseline plus follow-up visits. Biomarkers were modeled as linear functions of W-BC sessions received in the month prior to blood draw. …”
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IP3R2-Mediated Astrocytic Ca²⁺ Transients Are Critical to Sustain Modulatory Effects of Locomotion on Neurons in Mouse Somatosensory Cortex by Mario Fernández de la Puebla, Xiaoyi Zhang, Erlend A. Nagelhus, Magnar Bjørås, Wannan Tang

“…Our study suggests a non-synaptic modulatory mechanism on functions of astrocytic IP3R2-dependent Ca²⁺ transients to local neurons.…”
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Real world analysis of the efficacy and safety of eribulin compared to utidelone in combination with capecitabine for the treatment of metastatic breast cancer by Mengya Feng, Pingping Bi, Yihua Kang, Dechun Yang, Shengnan Ren, Xianping Lu, Guojian Xie, Hai Lei, Dan Mo

“…The most common adverse reactions were neurotoxicity, hand‒foot syndrome, hematological toxicity, gastrointestinal toxicity, and abnormalities in hepatic and renal functions. Conclusions In conclusion, either utidelone/capecitabine or eribulin chemotherapy may result in a survival benefit with a tolerable adverse effect profile and favorable safety profile in patients with metastatic breast cancer. …”
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Non-linear relationship between lipid accumulation products and risk of diabetes in Japanese adults by Fubing Zha, Miaoling Chen, Linlin Shan, Jingpu Zhao, Changchun Cao, Yulong Wang

“…The association between LAP and incident diabetes was analyzed using Cox proportional hazards regression models, incorporating cubic spline functions and smooth curve fitting to identify potential non-linear relationships. …”
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Evaluation of a savings-led family-based economic empowerment intervention for AIDS-affected adolescents in Uganda: A four-year follow-up on efficacy and cost-effectiveness. by Yesim Tozan, Sicong Sun, Ariadna Capasso, Julia Shu-Huah Wang, Torsten B Neilands, Ozge Sensoy Bahar, Christopher Damulira, Fred M Ssewamala

“…<h4>Methods</h4>Intent-to-treat analyses using multilevel models compared the effects of two savings-led treatment arms: Bridges (1:1 matched incentive) and BridgesPLUS (2:1 matched incentive) to a usual care control group on the following outcomes: self-rated health, sexual health, and mental health functioning. …”
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