Modulation of Peripheral Mast Cell and Brain Microglia Axis via Kinase Inhibition by Xiaoguang Liu, Michaeline Hebron, Kaluvu Balaraman, Louis Ballard, Kimberly Liu, Max Stevenson, Charbel Moussa

“…BK40196 significantly reduces the levels of hyper-phosphorylated tau and attenuates cell loss, while improving motor, cognitive and behavioral (anxiety) functions in models of neurodegeneration. BK40196 reduces microglial activity and the levels of brain tryptase in parallel with mast cell activation. …”
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Experiences of Home‐Based Pulmonary Rehabilitation With mHealth and Centre‐Based Pulmonary Rehabilitation in People With Chronic Obstructive Pulmonary Disease: A Qualitative Study... by Hannah Rutherford, Marita Dale, Sally Wootton, Rashmi Pithavadian, Sarah Dennis, Sarah Brown, Jennifer A. Alison, Andrew S. L. Chan, Ian A. Yang, Zoe McKeough

“…Motivators for both programmes included improved fitness levels, feeling accountable to the programme and reinforcement from staff and peers. The m‐PR in‐app functionalities such as the daily task list were additionally motivational. m‐PR participants arranged the programme around their schedule while centred‐based participants arranged their schedule around the programme. …”
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Cerium oxide nanoparticles: a promising nanotherapy approach for chronic degenerative diseases by Hugo Christian Monroy-Ramirez, Jorge Salto-Sevilla, Scarlet Arceo-Orozco, Fernando Caloca-Camarena, Roberto Flores-Peña, Edgar Lopez-Mena, Marina Galicia-Moreno, Juan Armendariz-Borunda

“…Despite the above, several preclinical and clinical studies evaluating these therapies have shown some contradictory results since sometimes the use of these molecules has not shown the desired therapeutic efficacy, or in some cases, the use of these antioxidants has been related to the appearance of harmful effects due to their lack of specificity, to the associated adverse effects, in addition to the fact that some ROS are essential for normal physiological functions. On the other hand, nanotechnology is one of the most widely used technological advances in the drug industry. …”
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Contribution of gait speed, grip strength, and depression on the risk of serious falls among older adults by Temam Beshir Raru, Julie A. Pasco, Mojtaba Lotfaliany, Shiva Ganjali, Malcolm Forbes, Alice J. Owen, Robyn L Woods, Anna Barker, Suzanne G. Orchard, Joanne Ryan, John J. McNeil, Michael Berk, Mohammadreza Mohebbi

“…Cox proportional hazard models were employed to estimate adjusted hazard ratios (AHR). …”
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Analysis of Coupled and Coordinated Development of Cultivated Land Multifunction and Agricultural Mechanization in China by Yuan Qin, Zhongbo Li, Enwei Huang, Dale Lu, Shiming Fang, Xin Duan, Lulu Gao, Yinuo Zhao, Hanzhe Kang, Zixuan Liu, Zhen Yang

“…By employing entropy weight TOPSIS and coupling coordination models, it conducted an in-depth analysis of long-term temporal changes and revealed the internal mechanisms of regional coordinated development through spatial econometric methods. …”
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Application of Deep Learning to the Classification of Stokes Profiles: From the Quiet Sun to Sunspots by Ryan J. Campbell, M. Mathioudakis, Carlos Quintero Noda, P. H. Keys, D. Orozco Suárez

“…Asymmetrical (symmetrical) profiles are less (more) common in GREGOR than DKIST or Hinode data, consistent with narrower response functions in the 1564.85 nm line. Single-lobed profiles are extremely rare in GREGOR data. …”
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Fuzzy logic-based IoT system for optimizing irrigation with cloud computing: Enhancing water sustainability in smart agriculture by Abdennabi Morchid, Zafar Said, Almoataz Y. Abdelaziz, Pierluigi Siano, Hassan Qjidaa

“…MATLAB is used to simulate and visualize fuzzy membership functions, enabling optimized decision-making. Results show that the system reduces water losses by adjusting watering periods according to soil temperature and humidity. …”
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Schizophrenia genetic risk and labour market outcomes in the Finnish general population: Are schizophrenia-related traits penalised or rewarded? by Aaro Hazak, Johanna Liuhanen, Katri Kantojärvi, Sonja Sulkava, Tuija Jääskeläinen, Veikko Salomaa, Seppo Koskinen, Markus Perola, Tiina Paunio

“…Background: Schizophrenia polygenic risk scores (SCZPRS) have been linked to cognitive functioning, creativity, behavioural traits, and psychiatric conditions beyond schizophrenia. …”
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Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis by Sichuan Xi, Jigui Shan, Xinwei Wu, Haitao Wang, Mary R. Zhang, Shakirat Oyetunji, Hong Xu, Zuoxiang Xiao, Tuana Tolunay, Shamus R. Carr, Chuong D. Hoang, David S. Schrump

“…Phenotypic experiments indicated that ZFAS1 is an oncogene, whereas ZNFX1 functions as a tumor suppressor in lung cancer cells. …”
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The m6A reader YTHDF2 protects vascular smooth muscle cells against the osteogenic differentiation through targeting Runx2 by Lanmei Li, Meijuan Cheng, Jingjing Jin, Yunfeng Zhao, Weiwei Bai, Dongxue Zhang, Shenglei Zhang, Yaling Bai, Jinsheng Xu

“…It was found that YTHDF2 was markedly downregulated in both in vivo and in vitro calcified models. Functionally, YTHDF2 plays a protective role in VC. …”
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Demethylzeylasteral inhibits proliferation and metastasis of osteosarcoma cells by modulating the PI3K/AKT/Autophagy pathways by Xuhui Yuan, Jiayu Li, Bo Yu, Feng Cai, Binqi Chen, Jun Liu, Yuanxiang Peng, Duo Zeng, Qi Liao, Lang Liu

“…Methods: OS cell lines (MG63 and 143B) were exposed to varying concentrations of DEM, followed by assessment of diverse cell functions. RNA sequencing was implemented to identify the molecular pathways affected by DEM exposure. …”
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Interorgan and Transcellular Communication in Metabolic Disease: Insights From Recent CMGH Studies by Tien S. Dong, Emeran Mayer

“…The gut microbiome and its metabolites, enteroendocrine signaling, bile acid regulation, and epithelial barrier functions now occupy center stage in dissecting the pathophysiology not only of gastroenterologic conditions, such as obesity, metabolic dysfunction-associated steatotic liver disease, and cirrhosis, but also of several disorders making up the chronic noncontagious disease epidemic.This paradigm shift is being driven by advances in molecular biology, systems biology, and computational modeling, which have enabled a holistic understanding of how communication between organs orchestrates metabolic homeostasis.1 Key to this understanding is the realization that local perturbations in 1 organ, such as gut microbial dysbiosis, can have systemic repercussions that affect distant organs, such as the liver or brain.2,3 This has redefined how researchers conceptualize disease progression and therapeutic interventions. …”
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Enhancing Ion Transport in Polymer Electrolytes by Regulating Solvation Structure via Hydrogen Bond Networks by Yuqing Gao, Yankui Mo, Shengguang Qi, Mianrui Li, Tongmei Ma, Li Du

“…Herein, we demonstrate a molecular design strategy to overcome these limitations by regulating the Li⁺ solvation structure through the synergistic interplay of conventional Lewis acid–base coordination and engineered hydrogen bond (H–bond) networks, achieved by incorporating specific H–bond donor functionalities (N,N′–methylenebis(acrylamide), MBA) into the polymer architecture. …”
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EIN3/EIL (Ethylene Insensitive3 / Ethylene Insensitive3 Like) Protein Family in Phaseolus vulgaris: Identification, Evolution and Expression Analysis within the Genome by Simay Ezgi Akbulut, Zehra Şafak, Aybüke Okay, Kimia Amirina, Ilker Büyük

“…According to cis-element analysis, Pvul-EIL genes are engaged in a wide range of functions, including tissue-specific, stress, and hormone-sensitive expression. …”
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MUC2 expression modulates immune infiltration in colorectal cancer by Christophe M. Raynaud, Ayesha Jabeen, Eiman I. Ahmed, Eiman I. Ahmed, Satanay Hubrack, Apryl Sanchez, Shimaa Sherif, Ahmad A. Al-Shaibi, Bernice Lo, Bernice Lo, Jessica Roelands, Davide Bedognetti, Davide Bedognetti, Wouter Hendrickx, Wouter Hendrickx

“…We revealed that the removal of MUC2 protein was compensated in LS-174T by the expression of other gel-forming mucin proteins (MUC6, MUC5B) commonly expressed in the gastrointestinal epithelium, while this was not observed in HT-29 cell line.ConclusionOur study is the first to demonstrate that MUC2 functions as a physical barrier to immune infiltration in colorectal cancer (CRC) in vitro. …”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

“…The inclusion of blue-blocking functionality and the surgeon’s recommendation had minimal influence on patient choice. …”
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Small and medium-sized enterprises dynamic capabilities and competitive advantage: The mediating effect of digitalization by Murry Harmawan Saputra, Mohamad Nur Utomo, Kasmad Ariansyah, Yanuar Farida Wismayanti, Rahmat Husein Andri Ansyah, Koeswinarno, Suradi

“…Moreover, we utilized Partial Least Squares Structural Equation Modelling (PLS-SEM) analysis on 230 collected responses to examine the proposed hypotheses on the relationships among dynamic capabilities, digitalization, and competitive advantage. …”
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CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2α deubiquitination by Ke Ma, Qinyu Li, Yi Zhang, Jiuyi Wang, Wei Jia, Jihong Liu, Bo Liu, Qiang Li, Qinzhang Wang, Kai Zeng

“…Transcriptomic and genomic profiling revealed that CYP1B1 overexpression in resistant tumours functionally contributes to enhanced angiogenic potential and maintenance of the resistant phenotype. …”
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HIV Protein TAT Dysregulates Multiple Pathways in Human iPSCs-Derived Microglia by Liam Liyang Guo, Robert Jiang, Yan Cheng, Brooke Russell, Sanders Y. Yan, Ming-Lei Guo

“…HIV protein transactivator of transcription (TAT) has been well-accepted as a risk factor contributing to NeuroHIV through dysregulating microglia (Mg) functions. Previous studies have demonstrated that HIV-TAT can affect lipid metabolism, immune responses, autophagy, and senescence in rodent Mg. …”
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Rapid adsorption of industrial cationic dye pollutant using base-activated rice straw biochar: performance, isotherm, kinetic and thermodynamic evaluation by Soumyaranjan Senapati, Jyotirmayee Giri, Laxmidhar Mallick, Dipankar Singha, Tapan Kumar Bastia, Prasanta Rath, Malay Kumar Rana, Alok Kumar Panda

“…The physicochemical scrutinization of the non-activated and the base-activated biochar materials showed that the materials have promising textural properties and surface functionalization, leading to high and fast capability to retrieve MB from aqueous solutions in alkaline conditions. …”
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