Comparative efficacy, cognitive effects and acceptability of electroconvulsive therapies for the treatment of depression: protocol for a systematic review and network meta-analysis by Anna Chaimani, Pascal Sienaert, Declan M McLoughlin, Michael Bull, Stevan Nikolin, Colleen Loo, Kieran Owens, Rohan Francis-Taylor, Donel M Martin, Harold A Sackeim, Charles H Kellner

“…Primary outcomes will be symptom severity on a validated continuous clinician-rated scale of depression, cognitive functioning measured using anterograde verbal recall, and acceptability calculated using all-cause drop-outs. …”
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Test methods for adhesive polymer compositions in development and quality control for stoma care products on the example of adhesive baseplates (review) by I. A. Sadkovskii, L. A. Korol, A. B. Karabanova, A. V. Korolenko, E. A. Shemetova, I. I. Krasnyuk, G. V. Ramenskaya, M. A. Mandrik

“…Adhesive baseplates, designed to fix ostomy bags and protect the skin of the peristomal area of ostomy patients, are a key element of an ostomy bag or urine bag. The functionality of adhesive baseplates is ensured by a set of their technical characteristics and design features, which makes the choice of appropriate baseplate testing methods an important aspect in the development, production and quality control of these medical devices.Text. …”
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Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling by Zongjuan Li, Yang Zhang, Weifeng Hong, Biao Wang, Yixing Chen, Ping Yang, Jian Zhou, Jia Fan, Zhaochong Zeng, Shisuo Du

“…Mechanistically, gut microbiome dysbiosis impairs antitumor immune responses by suppressing antigen presentation and inhibiting effector T cell functions through the cGAS–STING–IFN-I pathway. Cyclic-di-AMP – an emerging second messenger of bacteria – may act as a STING agonist and is thus a potential target for the prediction and modulation of responses to RT in HCC patients. …”
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Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor by Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun, Honggang Li, Yun Bai, Hongkui Deng

“…Experiments utilizing both cell line- and patient-derived xenotransplantation tumor models showed that CISR-CAR T cells exhibit robust infiltration and anti-tumor efficiency in vivo. …”
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Population and habitat assessments for conservation: Comparing national strategies for Canadian boreal caribou and Norwegian wild reindeer by Lucie Lelotte, Manuela Panzacchi, Cheryl A. Johnson, Atle Mysterud, Brage B. Hansen, Bernardo Brandão Niebuhr, Mark S. Boyce, Audun Stien, Evelyn H. Merrill, Christer M. Rolandsen, Torkild Tveraa, Vegard Gundersen, Bram Van Moorter

“…This study highlights the need to intensify research to quantify cumulative anthropogenic impacts on the loss of functionally connected habitat, and their consequences on population viability. …”
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Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness by Zhisen Shen, Hao Jiang, Shuaijun Lu, Hailong Tian, Feng Gao, Hongxia Deng, Canhua Huang

“…DSPE-PEG-Biotin surface functionalization enables active tumor targeting. The nanoplatform exploits high intratumoral glutathione (GSH) to trigger disassembly, releasing curcumin monomers and T780. …”
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The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study by Yi-Ting Lin, Sergi Sayols-Baixeras, Gabriel Baldanzi, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Nynne Nielsen, Aron C. Eklund, Georgios Varotsis, Jacob B. Holm, H. Bjørn Nielsen, Lars Lind, Göran Bergström, J. Gustav Smith, Gunnar Engström, Johan Ärnlöv, Johan Sundström, Marju Orho-Melander, Tove Fall

“…Methods The association of gut microbial species and microbial functions, determined by shotgun metagenomic sequencing of fecal samples, with 24-h ambulatory blood pressure measurements in 3695 participants and office blood pressure was assessed in multivariable-adjusted models in 2770 participants without antihypertensive medication from the Swedish CArdioPulmonary bioImage Study. …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…In conclusion, PDK1 functions as an oncogene, facilitating EOC progression by upregulating BGN and activating the NF-κB pathway. …”
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Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis by Josefin Bjurling, Nicholas W. Chavkin, Jonatan Halvardson, Mark C. Thel, Jonas Mattisson, John S. Kim, Ammar Zaghlool, Shwu-Fan Ma, Fernando J. Martinez, Kevin Anstrom, Imre Noth, Kenneth Walsh, Lars A. Forsberg

“…Results We find that men with mLOY in blood display an increased risk for IPF diagnosis and death caused by IPF in UK Biobank, and that mLOY is associated with reduced lung functions in two cohorts. Approximately 80% of the male excess in IPF prevalence occurs in the group of men with mLOY in blood leukocytes. …”
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Bio-Organic Fertilizer Application Enhances Silage Maize Yield by Regulating Soil Physicochemical and Microbial Properties by Ying Tang, Lili Nian, Xu Zhao, Juan Li, Zining Wang, Liuwen Dong

“…Random forest and structural equation modeling (SEM) identified soil carbon storage and bacterial diversity as key drivers of EMF, which integrates soil functions such as nutrient cycling, decomposition, enzyme activity, and microbial diversity. …”
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Development of IT-consulting in the system of foreign economic activity of agriculture in the region by Andrii Zavhorodnii, Ruslan Skupskyi, Ruslan Zubkov, Liudmyla Dombrovska, Olena Fridman, Olena Shcherbyna

“…The basic elements of development and functioning of the international infrastructure of regulation and self-regulation of IT-consulting services are investigated. …”
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ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression by Fangyuan Zhong, Hengyuan Zhang, Xinning Guo, Yichao Zhao, Yufei Wang, Wenli Li, Yuyan Lyu, Heng Ge, Xiyuan Lu, Jun Pu

“…Multi-omics analysis integrating RNA sequencing, CUT&Tag, and protein interactome profiling revealed that nuclear CD147 directly interacts with the STAT1/STAT2 complex to activate the IRF7-IFNα/β axis under oxidative stress (H2O2 exposure), thereby driving VSMC senescence and inflammatory reprogramming. Functionally, CD147 deletion in VSMCs significantly mitigated Angiotensin II- and CaPO4-induced AAA formation, accompanied by improved VSMC phenotype, reduced vascular inflammation and extracellular matrix degradation in vivo. …”
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Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells by Ruben A. Bartolomé, Laura Pintado-Berninches, Javier Robles, Tania Calvo-López, Issam Boukich, Pablo Otero-Núñez, Jose Manuel Gonzalez-Sancho, J. Ignacio Casal

“…To further elucidate the molecular mechanisms involving CDH17 functions in CRC, we examined global expression alterations following CDH17 silencing in various metastatic cell lines. …”
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Thermal analysis and experimental design of PVDF-trfe-based pyroelectric sensors for infrared applications by Mohamed Behloul, Essaid Bousbiat, Dalila Yamani, Riyadh Bouddou, Nour Eddine Derguini, Ayodeji Olalekan Salau, Djamel Kendil, Sarra Adiche

“…The finite element method (FEM) and analytical models were then used to analyze the specific parameters determining the sensor's performance. …”
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Modus Ethical Categories as a Condition for the Emergence of Phraseological Semantics, their Application in Political Discourse by Klara Abisheva, Marzhan Akosheva, Gulbagira Ayupova, Aiman Nurgazina, Bulat Ayapbergenov, Assel Baikadamova

“…Cognitive semantics offers new principles for analysing phraseological units: equality of cognitive and communicative functions of language, interdisciplinarity, multifactoriality, anthropocentricity and multilevelness. …”
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The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci by Jinghan Huang, Yixuan Wang, Thor D. Stein, Ting Fang Alvin Ang, Yibo Zhu, Qiushan Tao, Kathryn L. Lunetta, Jesse Mez, Rhoda Au, Lindsay A. Farrer, Wei Qiao Qiu, Xiaoling Zhang

“…Given that NAV3 and UNC5C are involved in regulating neurite outgrowth and guidance, increased MCP-1 levels may disturb the functions of vulnerable gene carriers to increase AD risk.…”
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Rosuvastatin mitigates blood–brain barrier disruption in sepsis-associated encephalopathy by restoring occludin levels by Qin Shen, Qian Yu, Taojiang Chen, Lijuan Zhang

“…Rosuvastatin, a third-generation statin, exhibits diverse pharmacological functions beyond its lipid-lowering capacity. However, its potential neuroprotective role in SAE remains unclear. …”
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Prospects of Predicting the Polar Motion Based on the Results of the Second Earth Orientation Parameters Prediction Comparison Campaign by Tomasz Kur, Justyna Śliwińska‐Bronowicz, Malgorzata Wińska, Henryk Dobslaw, Jolanta Nastula, Aleksander Partyka, Santiago Belda, Christian Bizouard, Dale Boggs, Sara Bruni, Lue Chen, Mike Chin, Sujata Dhar, Robert Dill, PengShuo Duan, Jose M. Ferrandiz, Junyang Gou, Richard Gross, Sonia Guessoum, Songtao Han, Robert Heinkelmann, ChengLi Huang, Christopher Irrgang, Jacek Kudrys, Jia Li, Marcin Ligas, Lintao Liu, Weitao Lu, Volker Mayer, Wei Miao, Maciej Michalczak, Sadegh Modiri, Michiel Otten, Todd Ratcliff, Shrishail Raut, Jan Saynisch‐Wagner, Matthias Schartner, Erik Schoenemann, Harald Schuh, M. Kiani Shahvandi, Benedikt Soja, Xiaoqing Su, Daniela Thaller, Maik Thomas, Guocheng Wang, Yuanwei Wu, CanCan Xu, Xueqing Xu, Xinyu Yang, Xin Zhao, Zhijin Zhou

“…Abstract Growing interest in Earth Orientation Parameters (EOP) resulted in various approaches to the EOP prediction algorithms, as well as in the exploitation of distinct input data, including the observed EOP values from various operational data centers and modeled effective angular momentum functions. Considering these developments and recently emerged new methodologies, the Second Earth Orientation Parameters Prediction Comparison Campaign (2nd EOP PCC) was pursued in 2021–2022. …”
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Examining alterations in subjective sleep ratings in individuals with major depressive disorder receiving daily theta burst stimulation by Jennifer Cuda, David Smith, Arthur R. Chaves, Karina L. Fonseca, Jessica Drodge, Stacey Shim, Youssef Nasr, Maya El-Outa, Ram Brender, Ruxandra Antochi, Lisa McMurray, Rebecca Robillard, Sara Tremblay

“…Additionally, changes in depression more closely aligned with changes in sleep-related daytime functioning than with sleep quality per se. Further work is required to delineate how sleep improvements following neuromodulation may contribute to the antidepressant response.…”
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Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19 by Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova

“…COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the molecular and cellular processes depending on the sickness severity and virus variants. …”
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