PROVIDING FACILITATION OF FLOWS OF EMOTIONAL INFORMATION IN PEDAGOGICAL ACTIVITIES OF A HIGHER SCHOOL TEACHER by Olga Sergeevna Veritova

“…The content of training of teachers of special disciplines included familiarizing themselves with the concepts of “intelligence” and “emotional intelligence”, the study of models of emotional intelligence, the content and sequence of the organization of project activities of students, during which all mechanisms of functioning of emotional intelligence can be involved. …”
Get full text

Informar i formar: cap a una pedagogia dels mitjans com a dinamitzadors de la interculturalitat Informing and training: towards a pedagogy of the media as a dynamizer of intercultu... by Nicolás Lorite

“…<br>Abstract: This paper presents some examples of the functions of the media (press, radio, television and the Internet) as catalyst of intercultural relations in local, regional, national and international contexts. …”
Get full text

Smart diabetes management: remote monitoring and predictive health insights by K.S. Smelyakov, I.A. Lurin, K.V. Misiura, A.S. Chupryna, T.V. Tyzhnenko, O.D. Dolhanenko, V.M. Repikhov

“…It supports offline functionality for rural or under-resourced areas, and offers intuitive dashboards for patients and healthcare providers, boosting engagement and treatment adherence. …”
Get full text

Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs). …”
Get full text

Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Least-squares mean changes from baseline in PRO scale scores were estimated using mixed models for repeated measures; time to deterioration and improvement were assessed using Cox proportional hazards models. …”
Get full text

Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data by Erli Wu, Xuan Yin, Feng Liang, Xianqing Zhou, Jiamin Hu, Wanting Yuan, Feihan Gu, Jingxin Zhao, Ziyang Gao, Ming Cheng, Shouxiang Yang, Lei Zhang, Qingqing Wang, Qingqing Wang, Xiaoyu Sun, Xiaoyu Sun, Wei Shao, Wei Shao

“…Consensus cluster analysis based on these 5 genes showed that there were differences in immune cells and immune functions among subtypes associated with ICD. Finally, qPCR and immunohistochemistry confirmed the ability of these five genes as biomarkers for the diagnosis of periodontitis.ConclusionFibroblasts may be the main cell source of ICD in periodontitis. …”
Get full text

Simulation and analysis of a high-k electron-scale turbulence diagnostic for MAST-U by D.C. Speirs, J. Ruiz Ruiz, M. Giacomin, V.H. Hall-Chen, A.D.R. Phelps, R. Vann, P.G. Huggard, H. Wang, A. Field, K. Ronald

“…Using a novel synthetic diagnostic approach, we present simulated measurement specifications of a proposed highly optimised mm-wave based collective scattering instrument for measuring both normal and bi-normal electron scale turbulence in the core and edge of MAST-U. A powerful modelling framework has been developed that combines beam-tracing techniques with gyrokinetic simulations to predict the sensitivity and spectral range of measurement, with a quasi-numerical approach used to analyse the corresponding instrument selectivity functions. …”
Get full text

FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…Mouse orthotopic HCC models and a coculture system were constructed, and cytometry by time-of-flight analysis was performed to investigate the functions and mechanisms of specific CAFs in the immune context of HCC.Results We identified a distinct flavin-containing monooxygenase 2 (FMO2)+ CAF subset associated with a favorable response to anti-PD-1 therapy and better clinical outcomes. …”
Get full text

Succinimidyl Alginate-Modified Fibrin Hydrogels from Human Plasma for Skin Tissue Engineering by Ana Matesanz, Raúl Sanz-Horta, Alberto Gallardo, Cristina Quílez, Helmut Reinecke, Pablo Acedo, Diego Velasco, Enrique Martínez-Campos, José Luis Jorcano, Carlos Elvira

“…Overall, these results suggest that SA-functionalized fibrin hydrogels are promising candidates for creating more stable in vitro skin models and engineered skin grafts, as well as for other types of engineered tissues, potentially.…”
Get full text

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…NeoExpand led to improved phenotypes and functions of neoantigen-reactive TILs. Our data warrant its clinical evaluation.Trial registration number NCT00068003, NCT01174121, and NCT03412877.…”
Get full text

Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease by Guo-Lin Miao, Wen-Xi Zhang, Yi-Tong Xu, Yi-Ran Liu, Ping-Ping Lai, Jia-Bao Guo, Gong-Lie Chen, Jing-Xuan Chen, Zi-Hao Zhou, Yan-Wei Li, Chong Zhang, Yang Ding, Lian-Xin Zhang, Yu-Fei Han, Jin-Xuan Chen, Jing-Dong Wu, Yin-Qi Zhao, Si Mei, Yang Zhao, Yuan-Wu Ma, Ling Zhang, Wei Huang, Dong-Yu Zhao, Er-Dan Dong, Yu-Hui Wang, Xun-De Xian

“…Abstract Background Kinesin family member 13B (KIF13B), a crucial motor protein, exerts multiple cellular biological functions. However, the implication of KIF13B in metabolic dysfunction-associated fatty liver disease (MAFLD) has not been explored yet. …”
Get full text

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation by Antje Isernhagen, Dörthe Malzahn, Elena Viktorova, Leslie Elsner, Sebastian Monecke, Frederike von Bonin, Markus Kilisch, Janne Marieke Wermuth, Neele Walther, Yesilda Balavarca, Christiane Stahl‐Hennig, Michael Engelke, Lutz Walter, Heike Bickeböller, Dieter Kube, Gerald Wulf, Ralf Dressel

Get full text

Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells by Mimi Zhou, Yali Feng, Xiaoli Zhang, Jianguo Chen, Naijuan Yao, Shan Fu, Tianzhi Ni, Yi Chen, Fei Xie, Sahasrabda Roy, Jinfeng Liu, Yuan Yang, Yingli He, Yingren Zhao, Nan Yang

“…Additionally, integrin β3 functioned as a positive immunomodulatory molecule to facilitate T-cell infiltration and T helper 1-type immune response in vitro. …”
Get full text

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer by Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou

“…Here, using RNA sequencing of tumor small extracellular vesicles (sEVs) from HGSOC patients, the lncRNA CATED is identified as significantly upregulated in both tumors and tumor‐derived sEVs in platinum‐resistant HGSOC, and low CATED levels correlate with good prognosis. Functionally, CATED enhances cisplatin resistance by promoting cell proliferation and inhibiting apoptosis in vitro and in vivo. …”
Get full text

Childhood socioeconomic position and healthy ageing: results from five harmonised cohort studies in the ATHLOS consortium by Rachel Cooper, Sam Gnanapragasam, Seppo Koskinen, Muhammad Zakir Hossin, Matthew Prina, Albert Sanchez-Niubo, Yu-Tzu Wu, Ilona Grünberger

“…Addressing socioeconomic disadvantage, such as improving education attainment, may moderate the impacts of adversity in early life and support health and functioning in later life.…”
Get full text

A Janus Amyloid-like Nanofilm Inhibits Colorectal Cancer Postoperative Recurrence and Abdominal Adhesion via Synergistic Enzyme Cascade by Man Zhang, Junhao Kou, Zhenyi Song, Ling Qiu, Chunzhao Yang, Qi Xue

“…This study presents a biologically safe and functionally synergistic approach to addressing dual complications following colorectal cancer surgery, offering potential insights for future research on multifunctional Janus materials.…”
Get full text

Designing CITOBOT: A portable device for cervical cancer screening using human-centered design, smart prototyping, and artificial intelligence by Marcela Arrivillaga, Paula C. Bermúdez, Juan Pablo García-Cifuentes, Hernán Darío Vargas-Cardona, Daniela Neira, Maria del Mar Torres, Mérida Rodríguez-López, Daniela Morales, Bleider Arizala

“…Feedback was crucial in assessing and refining the device's functionality, focusing on capturing high-quality cervical images. …”
Get full text

CORONARY SLOW FLOW AND CHA2 DS2 -VASC-HSF SCORE IN STABLE ISCHEMIC HEART DISEASE by Pelin Karaca Özer, Mustafa Lütfi Yavuz, Emre Yalçın, Elif Ayduk Gövdeli, Mehmet Aydoğan, Samim Emet, Ali Elitok

“…We investigated the functionality and usefulness of the CHA2DS2-VASc-HSF score in the diagnosis of CSFP in stable ischemic heart disease.Material and Methods: Patients with no obstructive coronary artery disease (CAD) and CSFP detected as a result of coronary angiography were included in the study. …”
Get full text

Dorsal root ganglion-targeted analgesic delivery for effective relief of neuropathic pain by Jiajia Sun, Jia Gu, Yan Ding, Xinyi Tu, Xiaohui Cai, Baochun Jiang, Zhongping Chen

“…In vitro and in vivo results revealed that LNPs extended the duration of action of the free analgesic from less than 6 h to more than 24 h and particularly, showed therapeutic superiority over conventional liposomes, achieved by their good structural stability for a more sustained release kinetics. After functionalized with a specific ADAM8 inhibitory peptide, the intravenously injected LNPs facilitated analgesic accumulation in the DRG in SNI and CINP. …”
Get full text

Correlates of avian extinction timing around the world since 1500 CE by Kyle D. Kittelberger, Colby J. Tanner, Amy N. Buxton, Amira Prewett, Çağan Hakkı Şekercioğlu

“…In order to provide a more comprehensive and robust assessment of trait-based drivers of global bird loss in comparison to prior studies, we included extinct species recognized by any of the three major avian taxonomies as well as those birds that lack recent confirmed sightings and are at least functionally extinct. We found that insular, flightless, larger-bodied, ecologically specialized species, as well as those with high aspect ratio wings, were likely to go extinct earlier in time. …”
Get full text