Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential by Pengfei Bao, Taiwei Wang, Xiaofan Liu, Shaozhen Xing, Hanjin Ruan, Hongli Ma, Yuhuan Tao, Qing Zhan, Efres Belmonte-Reche, Lizheng Qin, Zhengxue Han, Minghui Mao, Mengtao Li, Zhi John Lu

“…Results We present cfPeak, a novel method combining statistics and machine learning models to detect the fragmented cfRNA signals effectively. …”
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The concept of creating an automated information and computing complex for substantiating projects of programs and plans for the development of arms and means of radiation, chemica... by D. N. Cheshev, A. S. Durnov, S. V. Skoblikov, D. A. Egorushkin

“…The new stage of military construction makes it necessary to apply more advanced approaches to the functioning of the program management system for the development of weapons in order to adequately respond to emerging problems related to the formation, implementation and adjustment of plans to strengthen the country's defense in accordance with the current military – political and economic conditions of their implementation. …”
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Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin by Irene García-Jiménez, Irene García-Jiménez, Lídia Sans-de San Nicolàs, Sandra Díez-Ribas, Laia Curto-Barredo, Marta Bertolín-Colilla, Ana Vivancos-Melenchón, Ignasi Figueras-Nart, Montserrat Bonfill-Ortí, Anna Ryzhkova, Marta Ferran, Tali Czarnowicki, Ramon M. Pujol, Luis F. Santamaria-Babí

“…BackgroundCurrent understanding of IL-22 in atopic dermatitis (AD) mostly relies on animal models, intracellular staining of polyclonally activated peripheral lymphocytes, and biological therapies.MethodsWe evaluated the IL-22 response to house dust mite (HDM) extract in 58 patients with moderate-to-severe AD using a coculture system made of circulating memory cutaneous lymphocyte associated antigen (CLA)+/− T cells with autologous lesional epidermal cells. …”
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Disease-derived circulating extracellular vesicle preconditioning: A promising strategy for precision mesenchymal stem cell therapy by Ke Lv, Tian Wu, Shuyun Liu, Peng Lou, Pingya Zhou, Yizhuo Wang, Xiyue Zhou, Shu Zhang, Dan Du, Yanrong Lu, Meihua Wan, Jingping Liu

“…Circulating extracellular vesicles (EVs) from diseased states carry diverse pathological information and affect the functions of recipient cells. Based on this unique property, we report that disease-derived circulating EV (disease-EV) preconditioning is a potent strategy for precisely enhancing the tissue repair potency of MSCs in diverse disease models. …”
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Pursuing the goal of carbon neutrality in China: path for realization of carbon sequestration in planted forests by Lei DENG, Haitao HU, Jiwei LI, Xue LI, Chunbo HUANG, Zhijing YU, Hailong ZHANG, Qing QU, Xiaozhen WANG, Lingbo DONG, Zhouping SHANGGUAN

“…As the area and standing volume of tree plantations in China have increased, issues such as unreasonable structure, low productivity, limited ecological functionality and diminishing ecological stability have occurred, which hinder the ability of tree plantations to enhance carbon sequestration. …”
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Systemic administration of a viral nanoparticle neoadjuvant prevents lung metastasis development through emergency myelopoiesis by Léa Bourguignon, Roxann Hétu-Arbour, Tania Charpentier, Marilène Bolduc, Denis Leclerc, Krista M. Heinonen, Alain Lamarre

“…This study unveils a novel aspect of PapMV’s functionality. By bolstering the immune system, PapMV confers robust protection against metastasis at an early stage of disease progression. …”
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Understanding the moderating role of chronotypes for online mobile gaming in-app purchase intention by Beenish Tariq, Thurasamy Ramayah, Mark D. Griffiths, Antonio Ariza-Montes, Heesup Han

“…Moreover, evening type individuals had higher inclination toward in-app purchase intention compared to morning type individuals. Loyalty functioned as a mediator between addiction and in-app purchase intention. …”
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DISPEL: A Python Framework for Developing Measures From Digital Health Technologies by A. Scotland, G. Cosne, A. Juraver, A. Karatsidis, J. Penalver-Andres, E. Bartholome, C. M. Kanzler, C. Mazza, D. Roggen, C. Hinchliffe, S. Del Din, S. Belachew

“…Additionally, a functionality was designed to implement systematic flagging of missing data and unexpected user behaviors, both frequent in unsupervised monitoring. …”
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Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways by Jie Ji, Qiang Yu, Weiqi Dai, Liwei Wu, Jiao Feng, Yuanyuan Zheng, Yan Li, Chuanyong Guo

“…The aim of this study is to confirm the hepatocellular protective functions of apigenin and the molecular mechanism on liver fibrosis in mice. …”
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Validating Flow-Based Arrival Management for En Route Airspace: Human-In-The-Loop Simulation Experiment with ESCAPE Light Simulator by Katsuhiro Sekine, Daiki Iwata, Philippe Bouchaudon, Tomoaki Tatsukawa, Kozo Fujii, Koji Tominaga, Eri Itoh

“…This study evaluates the operational feasibility and effectiveness of an innovative AMAN designed for en route airspace, the so-called En Route AMAN. The En Route AMAN functions as a controller support system, facilitating the sharing of information between en route air traffic controllers (ATCos), approach controllers (current AMAN), and airport controllers (Departure Managers) in airports with multiple runways. …”
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The impact of Alzheimer's disease on cortical complexity and its underlying biological mechanisms by Leian Chen, Xiao Zhou, Yanan Qiao, Yu Wang, Zhi Zhou, Shuhong Jia, Yu Sun, Dantao Peng

“…Five machine learning (ML) models combining SBM parameters were established to predict AD. …”
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U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study by Yu Pan, Yan Yuan, Juan Yang, Zhu Qing Feng, Xue Yin Tang, Yi Jiang, Gui Ming Hu, Jiang Chuan Dong

“…A 40-item frailty index scale, encompassing various dimensions of somatic functioning, psychological evaluation, and illness, was developed and individually evaluated for each participant. …”
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P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma by Zengpeng Chi, Qimin Wang, Xin Wang, Dagang Li, Lei Tong, Yu Shi, Fang Yang, Qingyuan Guo, Jiawei Zheng, Zhenggang Chen

“…This study focused on investigating the expression patterns, carcinogenic functions, and underlying mechanisms of P4HA2 in OSCC cells. …”
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Sex-Specific Inflammatory Profiles Affect Neuropsychiatric Issues in COVID-19 Survivors by Mariagrazia Palladini, Mario Gennaro Mazza, Beatrice Bravi, Margherita Bessi, Maria Cristina Lorenzi, Sara Spadini, Rebecca De Lorenzo, Patrizia Rovere-Querini, Roberto Furlan, Francesco Benedetti

“…In females, a lingering imbalance between pro- and anti-inflammatory responses—likely reflecting the long-lasting immune alterations triggered by COVID-19—significantly affects cognitive functioning and shows a marginal, though not statistically significant, association with depressive symptoms. …”
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Global warming exacerbates the risk of habitat loss for regional mangrove species by Jian Liao, Gaocong Li, Shuiyuan Zhang, Yuanfeng Yang, Yiyang Li, Zhongdian Dong, Yusong Guo, Zhongduo Wang

“…In the field of ecology, scholars generally agree that climatic drivers, particularly temperature and precipitation patterns, play a crucial role in regulating the global distribution, structure, and functions of mangroves. However, there are still significant challenges in research exploring the relationship between climate and mangrove distribution. …”
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Distributed decision making for unmanned aerial vehicle inspection with limited energy constraint by Qi Wang, Haomin Zhu, Gang Pan, Jianguo Wei, Chen Zhang, Zhu Huang, Guowei Ling

“…Establishing a UAV airport network that integrates energy supply and information exchange functionalities represents an ideal solution for enabling synergistic UAV operations. …”
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A Systematic Review of Marine Habitat Mapping in the Central-Eastern Atlantic Archipelagos: Methodologies, Current Trends, and Knowledge Gaps by Marcial Cosme De Esteban, Fernando Tuya, Ricardo Haroun, Francisco Otero-Ferrer

“…Beyond biodiversity, macrophytes, rhodolith beds, and coral reefs deliver key ecosystem services—carbon sequestration, coastal protection, nursery functions, and fisheries support—essential to local socioeconomies. …”
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Advanced Interpretation of Bullet-Affected Chest X-Rays Using Deep Transfer Learning by Shaheer Khan, Nirban Bhowmick, Azib Farooq, Muhammad Zahid, Sultan Shoaib, Saqlain Razzaq, Abdul Razzaq, Yasar Amin

“…Our research examined various deep learning models that functioned either as classifiers or as object detectors to develop effective solutions for ballistic trauma detection in X-ray images. …”
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Controlling endotoxin contamination in PDMS-based microfluidic systems for organ-on-chip technologies by V. Guarino, E. Perrone, A. Zizzari, M. Bianco, G. Giancane, R. Rella, M.G. Manera, V. Arima

“…These microfluidic devices allow in vitro cell cultures at the microscale, integrating biophysical and biochemical cues that traditional cell culture models cannot reproduce. A critical aspect of their functionality is sterilization, which is necessary to eliminate bacterial contamination. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…A protein-protein interaction (PPI) network was then constructed, and core targets were screened with the Cytoscape plug-in. Molecular functions and pathways were analyzed through GO and KEGG pathway enrichment analyses. …”
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