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49241
Fused-MemBrain: a spiking processor combining CMOS and self-assembled memristive networks
Published 2025-01-01“…Our proposal is inspired by Golgi’s theory modeling the brain as a syncytial continuum, in contrast to Cajal’s theory of neurons and synapses being discrete elements. …”
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49242
A high-throughput framework for pile-up correction in high-speed nanoindentation maps
Published 2025-03-01“…By correlating these roughness changes with the Atomic Force Microscopy-measured pile-up height, we derived universal calibration functions for a wide range of bulk materials and thin films, validated through Finite Element Modeling. …”
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49243
Examining Turbulence in Galactic Molecular Clouds. I. A Statistical Analysis of Velocity Structures
Published 2025-01-01“…We present a systematic analysis of the velocity structure functions (VSFs) of 167 molecular clouds with angular sizes greater than ~176 arcmin ^2 in three sectors of the Galactic midplane. …”
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49244
The association between insomnia and suicide attempts among Chinese adolescents: a prospective cohort study
Published 2024-12-01“…Abstract Objective This study aimed to investigate a range of insomnia-related factors, including difficulty with sleep induction, nocturnal awakenings, early awakenings, total sleep time, overall sleep quality, well-being, functioning, and daytime drowsiness, to determine which variables were significantly associated with subsequent adolescent suicide attempts. …”
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49245
Whole exome sequencing identifies ABHD14A and MRNIP as novel candidate genes for developmental language disorder
Published 2025-01-01“…Complementary analyses showed that these variants are predicted pathogenic and the missense variant Leu230Arg significantly affects the stability and structure modelling of the ABHD14A protein. Biological functions and interconnections analyses predicted the potential roles of ABHD14A and MRNIP in neuronal development pathways. …”
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49246
Ideas and perspectives: Microorganisms in the air through the lenses of atmospheric chemistry and microphysics
Published 2025-01-01“…., oxidative, osmotic, UV-induced), affecting the functioning and survival of atmospheric bacteria. We illustrate that these factors could impact stress levels under polluted conditions, indicating that conclusions about the role of pollutants in directly causing changes to microbial abundance can be erroneous. …”
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49247
Evaluation of NFκB-dependent inflammatory responses induced by TNFα in 3D human microvessels
Published 2025-05-01“…Recently, advances in three-dimensional (3D) in vitro models that recapitulate human microvessel functions have been increasingly described. …”
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49248
3-D Flood mapping from SWOT observations during extreme rainfall: a case study of Gangnan Reservoir
Published 2025-08-01“…A monthly flood estimation method was developed based on SWOT features and traditional hydrological models, using probability distribution functions and time series reconstruction to identify flood characteristics such as water level, volume, and peak timing. …”
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49249
Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha
Published 2025-08-01“…Collectively, our findings indicate that Bufalin functions as a molecular glue to degrade ERα, offering a potential therapeutic strategy for reversing Tamoxifen resistance.…”
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49250
From data on gross activity to the characterization of animal behaviour: which metrics for which purposes?
Published 2024-11-01“…Complex patterns of activity within or between individuals, such as cyclic patterns and synchrony, can inform on the biological functioning, the health status, or the welfare of an animal. …”
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49251
SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis
Published 2025-04-01“…Collectively, these findings demonstrated that SDCCAG3 functioned as a beneficial positive regulator of adipose tissue expansion and metabolic homeostasis, indicating its potential as a therapeutic target for metabolic diseases associated with nutrient excess.…”
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49252
Harnessing artificial intelligence of things for cardiac sensing: current advances and network-based perspectives
Published 2025-07-01“…A total of 2,128 papers were included in the analysis.ConclusionFrom our perspective, current advancements in AI-powered IoT cardiac sensors primarily focus on optimizing AI algorithms, such as deep learning techniques, and enhancing the functionality of smart wearable devices for precision medicine. …”
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49253
Integrated ecological quality assessment of the sea area adjacent to the Yellow River estuary under multiple pollutants
Published 2025-02-01“…Estuaries are increasingly threatened by pollutants derived from human activities, which severely impair their water quality, biodiversity, and ecological functions. Therefore, within this context, it is essential to conduct comprehensive and scientifically rigorous assessments of estuarine ecological quality. …”
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49254
Design and Performance Optimization of a 3D-Printed SIW Antenna for Free-Space Applications
Published 2025-03-01“…The proposed antenna integrates an SIW structure with a horn antenna concept, effectively combining the transmitter and receiver functions into a compact, monolithic substrate. This approach provides a miniaturized alternative to conventional free-space material characterization setups, leveraging SIW technology to replace bulky horn antennas with integrated structures. …”
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49255
Tissue engineering strategies for ocular regeneration; from bench to the bedside
Published 2024-10-01“…This approach offers new functionalities and improves therapeutic outcomes over traditional drug delivery methods, creating opportunities for treating various eye disorders, from corneal injuries to retinal degeneration. …”
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49256
Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor
Published 2025-03-01“…This strategy will suggest a promising avenue for the development of targeted therapies against the critical functions of STAT3 in human cancers and potentially other diseases.…”
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49257
Using of transporter proteins to improve the uptake efficiency of hydrophobic compounds by Escherichia coli: a coordinated synthesis of START protein and P450scc system proteins to...
Published 2025-07-01“…This study proposes a fundamentally new approach to optimizing the functioning of the P450scc system in microbial cells, which uses the cholesterol transfer protein to increase the uptake efficiency of a poorly soluble steroid substrate by bacteria. …”
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49258
MicroRNA-32-5p promotes the proliferation and metastasis of gastric cancer cells
Published 2025-01-01“…Clonal formation, MTT, caspase-3 activity, sperm DNA fragmentation, flow cytometry assay, cell adhesion, transwell assays were performed to detect the functions of miR-32-5p or anti-miR-32-5p on the growth and metastasis of GC cells. …”
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49259
Retinotopic biases in contextual feedback signals to V1 for object and scene processing
Published 2025-06-01“…In the case of a cognitive task however, feedback pathways project content to foveal retinotopic space, potentially for introspection, functioning as a cognitive active blackboard and not necessarily predicting the object's location. …”
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49260
Novel Mutation at Cys225 in GNAO1‐Associated Developmental and Epileptic Encephalopathies: Clinical, Molecular, and Pharmacological Profiling of Case Studies
Published 2025-05-01“…Being the immediate transducer of a number of neuronal G protein‐coupled receptors, Gαo plays crucial functions in brain development and physiology. Here, we discover a novel mutation site in GNAO1, Cys225 mutated to Tyr or Arg in pediatric individuals from France and China (p.…”
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